330 results about "Aldehyde formation" patented technology

The invention belongs to the field of organic synthesis, and discloses an aldol condensation reaction method and a catalyst thereof.The method comprises the steps that in the presence of a composite catalyst, a substrate 1 and a substrate 2 are subjected to an aldol condensation reaction, after the reaction is finished, an aldol condensation product is collected from reaction products, according to the method, aldol condensation reaction of fatty aldehyde or aromatic aldehyde is catalyzed by adopting the novel composite catalyst, and the method has the advantages of being mild in reaction condition, environmentally friendly, efficient and simple in post-treatment.

The invention discloses a preparation method of 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole, which comprises the following steps: taking a hydroxylamine oxygen sulfonic acid aqueous solution and isopentenal as raw materials, carrying out oximation reaction in an organic solvent under an alkaline condition, then directly adding an acid or an organic base catalyst into the reaction system, and reacting for 2-4 hours to obtain 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole, thereby obtaining the 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole. Under the catalytic action of the catalyst, a cyclization reaction is carried out, after the reaction is finished, an intermediate solution containing 5, 5-dimethyl-4, 5-dihydroisoxazole is obtained, and the next step is directly carried out; and carrying out a chlorination reaction by taking the intermediate solution as a raw material and sodium hypochloride or chlorine as a chlorination reagent, and after the reaction is finished, carrying out post-treatment to obtain the 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole. The hydroxylamine oxygen sulfonic acid is used for enabling the isopentenal to be subjected to oximation reaction under the alkaline condition, then cyclization is carried out under the catalytic action of acid or alkali, the 5, 5-dimethyl-4, 5-dihydroisoxazole is generated, and the process has the advantages that the yield is high, the production steps are simplified, and the production cost is reduced.

The invention relates to the technical field of hard carbon material manufacturing, in particular to a method for preparing a hard carbon negative electrode material from medium and low temperature coal tar based pitch, which comprises the following steps: (S1) uniformly mixing the medium and low temperature coal tar based pitch and a cross-linking modifier, and carrying out heat treatment to obtain cross-linked modified pitch; the cross-linking modifier is a compound of a copolymer and a compound A; (S2) mixing the cross-linked modified asphalt with sulfur-containing polyaldehyde, and oxidizing in an oxygen-containing atmosphere to obtain first oxidized asphalt; (S3) uniformly mixing the first oxidized asphalt and a modifier, and carrying out secondary oxidation crosslinking to obtain second oxidized asphalt; and (S4) uniformly mixing the second oxidized asphalt and a pore-forming agent, and carrying out heat treatment in an inert atmosphere to obtain the product hard carbon material. The hard carbon material prepared by the invention has excellent electrochemical performance, is suitable for a negative electrode material of a sodium-ion battery, and remarkably improves the first effect and cycling stability.

This invention discloses a quantitative detection kit for arginine peptidase, a qualitative detection kit for arginine peptidase, and their usage methods. The quantitative detection kit utilizes the specific substrate Nα-benzoyl-DL-arginine-4-ylbenzamide hydrochloride, which can be hydrolyzed by arginine peptidase to 4-ylbenzamide. 4-ylbenzamide has a maximum absorption peak at 405 nm, and the specific arginine peptidase activity can be rapidly detected at room temperature using spectrophotometry. The qualitative kit utilizes the specific substrate Nα-benzoyl-DL-arginine-β-naphthamide hydrochloride, which can be hydrolyzed by arginine peptidase to p-β-naphthamide. β-naphthamide combines with 4-(dimethylamino)cinnamaldehyde to form a compound that is visible to the naked eye as a pink color. The disulfide bond cleaving agent cuts the mucus disulfide bonds, exposing bacterial enzyme sites, and the synergistic effect of the enzyme activator enhances the reaction rate of arginine peptidase hydrolysis of the substrate, significantly improving the detection sensitivity of arginine peptidase in tongue coating samples.

The invention discloses a Pd supported catalyst as well as a preparation method and application thereof, and belongs to the technical field of catalysts. The Pd supported catalyst is prepared according to the following steps: dissolving TEOS and MSDS in absolute ethyl alcohol, stirring, adjusting the pH value, aging at room temperature, and drying to obtain a mixture; and extruding the mixture into a long strip shape, calcining to prepare a TiO2-SiO2 composite carrier, dipping the TiO2-SiO2 composite carrier in a palladium nanoparticle solution, filtering, washing, and drying in vacuum to obtain the catalyst. The preparation method is simple and green in process, the reaction process is safe and easy to control, the prepared Pd supported catalyst is good in crystallization, high-dispersion nano-particle morphology, uniform in size and uniform in dispersion, and when the Pd supported catalyst is applied to co-production of methyl isobutyl ketone and methyl isoamyl ketone from mixed aldehyde and ketone, the isobutyraldehyde conversion rate can be effectively increased, and the yield of methyl isobutyl ketone and methyl isoamyl ketone can be effectively increased. The selectivity on methyl isoamyl ketone is good, and organic impurities in the product are few.

The present invention provides a compound with which a molecular probe capable of distinguishing NSCs from CSCs can be produced, and a method for detecting cancer stem cells using the compound. The present invention relates to a compound having a formyl group, a substrate moiety, a quenching moiety, and a luminescent moiety that is non-luminous due to the quenching moiety, wherein the luminescent moiety may be rendered luminous by detaching the substrate moiety by a substrate-degrading enzyme and also converting the formyl group to a carboxy group by an aldehyde dehydrogenase to allow the quenching moiety to dissociate.

The reaction method comprises the following steps: mixing a raw material aldehyde and a liquid alkali catalyst, feeding the mixture into a condensation reaction coupling device to carry out an aldehyde condensation reaction, and under the action of negative pressure of a steam ejector and tower bottom heating, steaming out a gas-phase component generated by the aldehyde condensation reaction to an extraction separation condenser, after condensation, entering an extraction separator; one part of a mixture of a product and a liquid alkali catalyst after the aldehyde condensation reaction is heated and then returns to a condensation reaction tower coupling device, one part of the mixture is cooled by an oil-alkali separation cooler and then enters an oil-alkali separator, the separated liquid alkali catalyst is led out, one part of the product is led into an extraction separator, and the other part of the product is led out; the raw material aldehyde is extracted in the extraction separator, the extracted oil phase is conveyed back to the distillation section of the condensation reaction tower coupling device, and the water phase is discharged. The condensation reactor and the condensation circulating tower are coupled and transformed, reaction heat and product reflux are fully utilized, the technological process can be simplified, the operation flexibility can be improved, and energy consumption can be reduced.

The present application relates to a kind of ionic nitrogen heterocyclic carbene covalent organic framework and its preparation method and application, the ionic nitrogen heterocyclic carbene covalent organic framework with amine monomer, aldehyde monomer and vinyl ionic liquid as raw material, by one-pot method, it is prepared by povalorov reaction.The ionic nitrogen heterocyclic carbene covalent organic framework prepared in the present application can be used for the deuterium reaction of a variety of aromatic aldehyde, heterocyclic aldehyde and multi-site substituted aldehyde substrate as catalyst, with high catalytic activity and recyclable performance.

The application discloses a preparation method of an octene aldehyde liquid-phase hydrogenation catalyst, and the preparation method comprises the following steps: (1) adding a weak acid into a salt solution containing silver, magnesium and aluminum, uniformly stirring, then adding a glycerol aldehyde, continuously stirring until a colloid is formed, grinding the colloid to obtain a powder, sieving, and roasting to obtain a carrier; and (2) preparing a precursor solution containing nickel and zinc, placing the precursor solution and the carrier in an ultrasonic container to shake, pouring the shaken solution into a well-sealed ball mill tank, ball milling, and then drying and roasting to obtain the catalyst. The catalyst is prepared by adding a silver-containing compound when the carrier is prepared and the ball milling method, so that the selectivity and stability of the catalyst are improved.

Provided is a method for producing a methylene lactone compound, whereby it is possible to efficiently produce a methylene lactone compound. The present invention relates to a method for producing a methylene lactone compound, which is characterized by comprising a step for reacting a specific gamma-butyrolactone compound with a specific aldehyde compound in the presence of an oxide or hydroxide of a metal comprising a group 2 element of the periodic table.

This invention provides a method for improving the hydrogen storage performance of covalent organic framework compounds, comprising dehydrating and polycondensing an aromatic polyamino monomer and an aromatic polyaldehyde monomer to form a covalent organic framework compound, wherein the aromatic polyamino monomer and / or the aromatic polyaldehyde monomer contains at least one fluorinated aromatic ring, at least one hydrogen atom on the fluorinated aromatic ring is substituted with fluorine, and there are unsubstituted hydrogen atoms on the fluorinated aromatic ring, wherein the covalent organic framework compound has a two-dimensional or three-dimensional structure.

The application discloses a device for synthesizing new gardenia aldehyde by using a composite catalyst, and relates to the technical field of catalytic synthesis equipment. The device comprises a rack, a catalytic material barrel device is fixedly connected to the inner surface of the rack, a driving roller is rotatably connected to the inner central position of the catalytic material barrel device, a material treatment device is fixedly connected to the outer surface of the driving roller, a deposition prevention device is fixedly connected to the bottom of the material treatment device, the outer surface edge of a material stirring blade is fixedly connected to the outer surface of the driving roller, an oval shell is arranged on the outer surface of the material stirring blade, a raw material hole is formed in the outer surface of the oval shell, a direction changing device is arranged in the oval shell, and a tumbling blade is fixedly connected to the bottom of the outer surface of the material stirring blade. The device for synthesizing new gardenia aldehyde by using a composite catalyst has the effect of high adaptability, can fully mix various catalysts, reduces the raw material deposition, promotes the rapid synthesis of new gardenia aldehyde, and is helpful for subsequent use.

The invention discloses a bimetallic-Salen photocatalyst based on an isomerism effect as well as a preparation method and application of the bimetallic-Salen photocatalyst. The catalyst is synthesized through a solvothermal method, a diamine compound (such as 3, 3 '-diaminobenzidine or 1, 2-diaminobenzene) and a polyaldehyde compound (such as 2, 6-diformyl phenol or 3, 3', 5, 5 '-tetraformyl-4, 4'-biphenol) are used as organic ligands, a plurality of metal acetates (including Sc, In, Zn, Cu and the like) are used as metal sources, and the catalyst is synthesized through a solvothermal method. And the bimetallic-Salen isomer with a one-dimensional chain structure is prepared under a mild condition. The obtained material can form two isomers with zigzag (Z type) and linear (L type) structures according to different coordination orientations. The concept of'coordination oriented isomerization 'provided by the invention realizes accurate regulation and control of photoelectric properties on the molecular level, and provides a new theory and technical route for designing a multi-metal synergistic efficient artificial photosynthesis system. The catalyst material provided by the invention has wide application prospects in the fields of photocatalytic oxygen production, green oxidation reaction, sustainable energy conversion and the like.

The invention provides a hydrofining catalyst for recovering a methanol solvent in an HPPO process and a preparation process of the hydrofining catalyst, and belongs to the field of petrochemical engineering. According to the catalyst, Ni is used as a main active component, SiO2 is used as a carrier, and Zn, Ce and the like are doped to serve as structural auxiliaries and electronic auxiliaries, so that the dispersity of the active component is increased, and the hydrogenation performance of the catalyst is improved. The catalyst can be used for efficiently hydrogenating aldehyde ketones, H2O2 and other impurities in the recovered methanol solvent to generate corresponding alcohol and water, so as to obtain the purified methanol solvent in which the aldehyde ketones impurities are basically removed. The impurity removal process is simple, the reaction condition is mild, meanwhile, the non-noble metal is used as the active component, under the condition of high loading capacity of the active component, the high specific surface area and the dispersity of active species can be kept, and efficient removal of impurities in the methanol solvent is achieved.

The invention belongs to the technical field of catalysts, and particularly discloses a hydrodeoxygenation catalyst and a preparation method and application thereof. The catalyst contains a silicon-zirconium composite oxide carrier and a CuCo alloy loaded on the carrier, the molar ratio of silicon to zirconium in the silicon-zirconium composite oxide is (1-5): 1. The preparation method comprises the following steps: 1) preparing a precursor containing copper, cobalt, silicon and zirconium by adopting a sol-gel method; 2) roasting the precursor to obtain a copper oxide and a cobalt oxide which take the silicon-zirconium composite oxide as a carrier; and 3) carrying out reduction treatment on the material obtained in the step 2) to obtain the catalyst. The catalyst provided by the invention has high activity and alkane selectivity in hydrodeoxygenation reactions of various aldehyde ketone condensates, and can be used for hydrodeoxygenation reactions of aldehyde ketone condensation mixtures to produce aviation fuels.

The utility model relates to the technical field of preparation of dichloropropanol from glycerol, in particular to a production system for producing dichloropropanol through glycerol chlorination. The device comprises an adipaldehyde mixing tank for mixing adipaldehyde and pure water, a gas-liquid reaction kettle for absorbing chlorine in crude hydrogen chloride, a first microporous filter for filtering out a catalyst, a cooler for cooling crystals and a second microporous filter for removing crystals. The method has the effects of improving the problem of side reaction caused by chlorine impurities in crude hydrogen chloride and increasing the conversion rate of glycerol.

This invention discloses a mutant of glycolaldehyde synthase and its application in improving the thermostability of glycolaldehyde synthase, belonging to the field of biocatalysis application technology. The glycolaldehyde synthase mutant disclosed in this invention, based on the amino acid sequence shown in SEQ ID NO.1, contains the following mutations: A381P / E509F, A381P / K290P, A381P, S61A, A381P / K290P / E509F, A381P / C49A, A381P / T100V, A381P / S61A, or A381P / K290P / S61A. This mutant protein can catalyze the preparation of hydroxyacetaldehyde (glycoaldehyde) from formaldehyde. The mutant protein of this invention also improves the catalytic efficiency of the formaldehyde-to-glycoaldehyde conversion. Due to the improved thermostability, it is beneficial for continuous catalysis in actual industrial reactions, thus the mutant shows good prospects for industrial applications.

The application discloses a rhodium-catalyzed desymmetrization hydroformylation method for constructing polychiral center carbon ring nucleosides. The method for constructing polychiral center carbon ring nucleosides comprises the following steps: under the condition of an inert atmosphere, an acetylacetone dicarbonyl rhodium metal precursor and a chiral ligand are added into an organic solvent to prepare a catalyst solution, the catalyst solution is mixed with a substrate, and a reaction is carried out under the condition of a hydrogen atmosphere and a carbon monoxide atmosphere; after the reaction is completed, filtration and purification are carried out, and polychiral center cycloalkyl aldehyde is obtained; and the aldehyde group is converted to obtain the polychiral center carbon ring nucleosides. The method for constructing polychiral center carbon ring nucleosides has the advantages of high selectivity, wide substrate compatibility, high reaction efficiency, easy conversion of products, and the like. The whole reaction process can obtain polychiral center cycloalkyl aldehyde in one step with extremely high enantioselectivity and diastereoselectivity, the aldehyde group is converted, polychiral center carbon rings can be obtained with high yield, high dr value and high ee value, and the method is simple and easy to operate.

The invention discloses hydrogel for ulcers and a preparation method thereof.The hydrogel is obtained through a cross-linking reaction with polyphenol substance modified gelatin, aldehyde natural polymers and methacrylate gelatin as frameworks, and the hydrogel has injectability and can be injected to oral ulcers or pressure ulcers, and the hydrogel can also be used as a hydrogel for ulcers or oral ulcers or pressure ulcers or oral ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers or pressure ulcers. The hydrogel can be prepared into a sheet shape to be applied to the ulcer surface, has good biocompatibility, compression resistance, wet adhesion, angiogenesis promotion, hemostasis, inflammation resistance and oxidation resistance, and is beneficial to healing of oral ulcers and pressure ulcers.

The application discloses copper porphyrin doped COFs, a preparation method and application thereof. The preparation method of the copper porphyrin doped COFs is as follows: 1) preparation of copper porphyrin modified aldehyde monomers; and 2) preparation of copper porphyrin doped COFs. The copper porphyrin doped COFs disclosed by the application can inhibit gram-negative bacteria and gram-positive bacteria under dark conditions; and under the irradiation of 100 mW / cm 2 of white light, efficient sterilization of the gram-negative bacteria and the gram-positive bacteria is realized within 90 min.

This invention belongs to the field of heterogeneous Rh-based catalyst technology, and discloses a method for preparing a heterogeneous rh-based catalyst and its application. This invention prepares a heterogeneous rh-based catalyst using a one-pot method. By employing a reduction-reoxidation process, the content of different valence states of rhino in the rhino species on the surface of the heterogeneous rh-based catalyst is simply and precisely controlled, increasing the content of the most favorable δ+ valence state from 7.31% to 44.78%, thereby giving the catalyst higher hydroformylation activity. Under reaction conditions of 120℃ and a mixed gas pressure of 2 MPa, the styrene conversion rate reaches 73.9% and the aldehyde selectivity reaches 95.9% within 4 hours, which is superior to most heterogeneous rhino-based catalysts and close to that of homogeneous rhino catalysts. The heterogeneous rhino-based catalyst is prepared by the sol-gel method, which is simple in preparation and control. The prepared catalyst has a uniform rhino distribution, stable performance, and is beneficial for industrial applications.

The invention discloses a degradable environment-friendly flame retardant and a preparation method thereof, and relates to the technical field of flame retardant materials, the degradable environment-friendly flame retardant comprises a three-dimensional dynamic covalent network structure formed by cross-linking cystamine-syringaldehyde Schiff base and phytic acid-syringaldehyde ester; the three-dimensional dynamic covalent network structure is loaded with manganese ions coordinated with phosphate groups in a post-introduction mode, through a phytic acid-cystamine-manganese ion ternary synergistic flame-retardant system, the flame-retardant property is remarkably improved, and meanwhile, based on a triple degradable response mechanism of imine bonds, ester bonds and disulfide bonds, the flame-retardant property is remarkably improved. And the material is endowed with excellent degradability.

The present invention relates to a biocatalytic synthesis of esters that can also be implemented on an industrial scale. In particular, the invention relates to a process for the production of esters, via a hemiacetal intermediate, consisting of the following steps: – a step of bringing into contact, in a reaction medium, • a mixture of a C1– Cn alcohol and a C1– Cn aldehyde with an enzymatic catalytic system comprising an oxidized cofactor selected from NAD(P)+ and NAD+ and a polypeptide of the oxidoreductase group having preferential dehydrogenase activity toward the formed hemiacetal and the starting aldehyde, or alternatively • a C1– Cn alcohol with an enzymatic catalytic system comprising an oxidized cofactor selected from NAD(P)+ and NAD+ and a polypeptide of the oxidoreductase group having preferential dehydrogenase activity toward the formed hemiacetal, the starting alcohol, and the formed aldehyde, or alternatively • a C1– Cn aldehyde with an enzymatic catalytic system comprising a reduced cofactor selected from NAD(P)H or NADH and a polypeptide of the oxidoreductase group having preferential dehydrogenase activity toward the starting aldehyde and the formed hemiacetal, where n may be any number, and – a step of isolating the corresponding ester.

The application discloses an olefinic COF catalyst, a preparation method thereof and application of the catalyst in photocatalytic production of hydrogen peroxide. The catalyst is prepared from 2,2',6,6'-tetramethyl-4,4'-bipyridine and an aromatic aldehyde monomer containing two aldehyde groups through a Knoevenagel condensation reaction under a solvent-free condition, and has an olefinic covalent organic framework structure. The preparation method of the application does not need to add any solvent, is simple in operation, mild in reaction condition and easy to scale up, and has significant commercialization potential. The prepared catalyst has a highly conjugated two-dimensional layered porous structure, excellent light absorption capacity and light-generated carrier separation efficiency. When the catalyst is applied to photocatalytic decomposition of water to produce hydrogen peroxide, the catalyst exhibits excellent catalytic activity, and the hydrogen peroxide production rate can reach 1125 μM h ‑1 The application provides a new scheme of green, efficient and industrialized prospect for solving the problems of high energy consumption and high pollution of the traditional hydrogen peroxide production method.

The invention discloses a preparation method of a full-organic ionic liquid confinement nano catalytic material and application of the full-organic ionic liquid confinement nano catalytic material in photocatalytic CO2 methanation, and belongs to the technical field of photocatalytic materials. The invention aims to solve the problems that the existing photocatalytic material is small in specific surface area and insufficient in active sites due to difficulty in regulation and control of microstructure and pore structure, environmental and biological toxicity is caused by dependence on noble metal / transition metal, and preparation of CH4 by photocatalytic CO2 reduction is restricted. The method comprises the following steps: 1, preparing 5, 5 '-(benzo [c] [1, 2, 5] thiadiazole-4, 7-diyl) bipyridine aldehyde; 2, preparing a pyridine tricarboxylate ionic liquid; 3, PTZpy is prepared; 4, preparing PTZpy (+); and 5, preparing the IL (at) PTZpy (+) nano catalytic material. The catalyst is applied to preparation of methane by photocatalytic reduction of carbon dioxide under visible light irradiation and a pure water system. The method has a good application prospect in the fields of solar fuel preparation and carbon resource conversion.

The invention relates to a composite comprising at least one reinforcing element having a surface comprising a copper-zinc alloy, said reinforcing element being embedded in an elastomeric composition based on at least one diene elastomer, a reinforcing filler, a sulfur-based crosslinking system comprising a metal oxide, stearic acid or one of its derivatives and a vulcanization accelerator, and a phenol-aldehyde resin based on: - at least one aromatic polyphenol comprising at least one aromatic ring bearing at least two hydroxyl functions in meta positions relative to each other, the two ortho positions of at least one of the hydroxyl functions being unsubstituted, and - at least one dialdehyde compound comprising two aldehyde functions, in which the phenol-aldehyde resin content ranges from 0.5 to 2 parts per million, and the mass ratio of metal oxide to stearic acid or one of its derivatives is greater than or equal to 8.

The application relates to the technical field of lithium ion batteries, in particular to an ultralow-viscosity manganese iron phosphate lithium material and a preparation method thereof, which comprises the following steps: S1. preparing a manganese iron phosphate precursor; S2. mixing the manganese iron phosphate precursor, lithium hydroxide, goulac gum, vanadium pentoxide and deionized water, and then performing second grinding to obtain a premix; and S3. drying, sintering and airflow crushing the premix to obtain the ultralow-viscosity manganese iron phosphate lithium material. The manganese iron phosphate precursor is synthesized in advance, so that the uniform distribution of manganese iron elements in the material can be ensured; then, the manganese iron phosphate precursor is reacted with lithium hydroxide, goulac gum and other substances; part of the goulac gum releases an aldehyde group in an alkaline environment created by the lithium hydroxide, and serves as a reducing agent; the remaining goulac gum serves as a dispersant, reduces the slurry viscosity and is helpful to the uniform dispersion of components; in addition, the goulac gum can form a dense and uniform coating layer on the surface of the material as a polysaccharide, so that the performance of the manganese iron phosphate lithium material is improved.

The present application belongs to the field of organic photo-functional materials and biomedical materials, and particularly relates to a phenanthraquinone-based covalent organic framework material, a nano-preparation containing the same, a preparation method thereof and biomedical applications. In the present application, a Schiff base condensation reaction is carried out between a bis(formylphenyl) monomer with a phenanthraquinone group or an aza-phenanthraquinone group and N,N,N',N'-tetra(p-aminophenyl)-p-phenylenediamine, and through reversible covalent connection of aldehyde groups and amino groups, the phenanthraquinone-based covalent organic framework material is prepared, and it is found that the phenanthraquinone-based covalent organic framework material can efficiently generate superoxide anion radicals under 808 nm near-infrared light irradiation, thereby destroying the intracellular redox homeostasis, selectively accelerating NADPH consumption, promoting excessive formation of disulfide bonds, and leading to induction of tumor cells to undergo disulfide death. The phenanthraquinone-based covalent organic framework material of the present application provides a new strategy for solving the problem of drug resistance in tumor treatment, and has a broad application prospect.

The invention discloses an intrinsic micropore degradable polymer material based on biomass and hetero-calixarene and a preparation method and application thereof.The method comprises the steps that firstly, cyanuric chloride and resorcinol serve as raw materials, and oxygen atom bridged hetero-calixarene macrocyclic molecules are synthesized in one step under the alkaline condition through a one-pot method; then introducing the lignin derivative into oxygen atom bridged hetero calixarene by utilizing an aromatic nucleophilic substitution reaction on a triazine ring in a macrocyclic molecule, and carrying out a condensation reaction on the obtained multi-aldehyde functionalized oxygen atom bridged hetero calixarene and polyfunctional mercaptan under an acidic condition to obtain the target degradable polymer material. When in use, the material is directly put into an aqueous solution of elemental iodine, iodine negative ions and divalent mercury ions for adsorption. The removal rate of the material to low-concentration iodine simple substances, iodine negative ions and divalent mercury ions can reach 90% or above, and the material after adsorption can be repeatedly used after being washed by an acidic aqueous solution. The material can be degraded under an alkaline condition.

This invention belongs to the field of biomedical materials technology, specifically relating to an oxidized hyaluronic acid / carboxymethyl chitosan hemostatic sponge and its preparation method. The preparation method includes: oxidizing hyaluronic acid with sodium periodate to obtain oxidized hyaluronic acid; preparing aqueous solutions of oxidized hyaluronic acid and carboxymethyl chitosan; mixing the two solutions and forming a hydrogel through a Schiff base reaction between aldehyde and amino groups; cryogelatinizing the hydrogel at low temperature and then freeze-drying it under vacuum to obtain an expandable hemostatic sponge with a three-dimensional interconnected porous structure. Upon contact with blood, the sponge of this invention rapidly absorbs water and expands, increasing in volume by more than three times, forming a tight physical seal. Simultaneously, it adsorbs and activates platelets to accelerate coagulation, achieving highly efficient hemostasis. This sponge exhibits excellent biocompatibility, is completely degradable in vivo, and the preparation process is mild and requires no toxic cross-linking agents. It can be used for rapid hemostasis of deep, irregular, and non-compressible bleeding wounds.