521 results about "Aldehyde formation" patented technology

Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A

The invention relates to the technical field of automobile air purification, and particularly discloses a filtering material, a preparation method of the filtering material and a novel automobile air conditioner multi-effect catalytic formaldehyde removal filter. The filtering material comprises a PET (Polyethylene Terephthalate) supporting layer, a gas filtering layer and a PP (Polypropylene) electrostatic filtering layer which are arranged in sequence, the gas filtering layer is prepared from the following raw materials in parts by weight: 30 to 90 parts of activated carbon and 10 to 70 parts of manganese catalyst. The gas filtering layer composed of the activated carbon and the manganese catalyst is matched with the filtering material composed of the PET supporting layer and the PP electrostatic filtering layer, four gases of n-butane, methylbenzene, sulfur dioxide and nitrogen dioxide can be adsorbed, the manganese catalyst degrades formaldehyde at normal temperature, meanwhile, the reaction on the formaldehyde is a catalytic reaction, and the environment-friendly effect is achieved. Therefore, the filter material disclosed by the invention also has longer service life, so that a filter made of the filter material has a better formaldehyde removal effect and longer service life.

The invention relates to a low-ice-adhesion super-hydrophobic anti-icing coating as well as a preparation method and application thereof. Single-end amino fluorosilicone oil is grafted to the surface of an aldehyde group functionalized metal organic framework material through an amino-aldehyde group condensation reaction to obtain a hydrophobically modified metal organic framework material, the hydrophobically modified metal organic framework material is compounded with a synthesized fluorinated acrylate copolymer, and the coating is prepared through ultrasonic dispersion and spraying curing processes. According to the prepared low-ice-adhesion super-hydrophobic anti-icing coating, through the synergistic effect of fluorosilane grafting modification and a micro-nano structure, the excellent performance that the static water contact angle is larger than or equal to 160 degrees, the rolling angle is smaller than or equal to 2 degrees, and the ice adhesion strength is smaller than or equal to 20 kPa is achieved. Compared with a traditional anti-icing coating, a metal organic framework material functional modification strategy is adopted, the ice adhesion force is remarkably reduced while the mechanical stability of the coating is kept, and uniform film forming on the surfaces of base materials such as aluminum wires can be achieved through the spraying technology. The coating is suitable for anti-icing protection of the aluminum conductor of the power transmission line, and has the characteristics of long-acting icing resistance and low ice adhesion.

The invention discloses a full-bio-based multifunctional antibacterial nylon material as well as a preparation method and application thereof, relates to the technical field of high-molecular polymers, and solves the problems that the preparation process of a nylon material in the prior art depends on petroleum resources, the function is single and the application scene is limited. The method comprises the following steps: reacting an aminocaprolactam solution with corresponding aldehyde / carboxylic acid / halogenated alkane, and purifying to obtain a cyclic lysine derivative monomer M; the preparation method comprises the following steps: mixing and heating a cyclic lysine derivative monomer M, an initiator and a catalyst, reacting, and purifying to obtain a nylon material PM; and carrying out quaternization reaction on the nylon PM solution and alkyl halide, and purifying to obtain the full-bio-based multifunctional nylon material P. The preparation method completely abandons the use of petroleum-based raw materials, realizes the multifunctional synergistic effect of antibacterial property, biocompatibility, antibacterial biofilm property, thermosensitivity and the like, and can be applied to the fields of antibacterial materials, biomedical materials, antibacterial biofilms and thermosensitivity materials.

Provided is a compound and so on having aldehyde dehydrogenase 2 (ALDH2) activation effect. A compound, a pharmaceutically acceptable salt of the compound, or a prodrug of the compound or the salt, the compound being represented by the following formula (1):whereinA is a heterocycle,R1 and R2 are each independently hydrogen, an alkyl, an alkenyl, or an alkynyl,R3 is an alkyl, an alkenyl, or an alkynyl, andX1 and X2 are each independently a halogen.

In a secondary battery including an electrolyte layer containing a sulfide solid electrolyte, the electrolyte layer has both high voltage resistance and high ionic conductivity. The secondary battery of the present disclosure includes a positive electrode, an electrolyte layer, and a negative electrode, wherein the electrolyte layer contains a sulfide solid electrolyte and a perfluoropolyether represented by formula (1) below:where Rf1 and Rf2 are each independently a C1-16 divalent alkylene group which may be substituted with one or more fluorine atoms, E1 and E2 are each independently a monovalent group selected from the group consisting of a fluorine group, a hydrogen group, a hydroxyl group, an aldehyde group, a carboxylic acid group, a C1-10 alkyl ester group, an amide group which may have one or more substituents, and an amino group which may have one or more substituents, and RF is a divalent fluoropolyether group.

The invention relates to the field of biomedical materials, and particularly provides injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel and application thereof.The hemostatic hydrogel is formed by carboxylated chitosan sol and dialdehyde starch size through Schiff base reaction, hydrogen bond construction and in-situ rapid crosslinking by means of a bidirectional pumping and injecting delivery strategy, and the hemostatic hydrogel is prepared through a two-way pumping and injecting delivery strategy, and the injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel is prepared from the carboxylated chitosan sol, the dialdehyde starch size and the injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel. The hydrogel has the advantages of good biocompatibility, injectability, adhesion, personalized adaptation and the like, integrates multiple hemostasis mechanisms, a physical barrier effect of rapid gelation, an expansion compression effect of water absorption swelling, an electrical neutralization effect of carboxylated chitosan amino and a tissue adhesion effect of dialdehyde starch aldehyde group, realizes multi-scene rapid and efficient hemostasis, and has a wide application prospect. The preparation method of the injectable adhesive hemostatic hydrogel is low in cost, innovative in technology, mild in condition, convenient to store and beneficial to large-scale batch production, and has a wide application prospect in the field of efficient hemostatic hydrogel.

The invention belongs to the field of organic synthesis, and discloses an aldol condensation reaction method and a catalyst thereof.The method comprises the steps that in the presence of a composite catalyst, a substrate 1 and a substrate 2 are subjected to an aldol condensation reaction, after the reaction is finished, an aldol condensation product is collected from reaction products, according to the method, aldol condensation reaction of fatty aldehyde or aromatic aldehyde is catalyzed by adopting the novel composite catalyst, and the method has the advantages of being mild in reaction condition, environmentally friendly, efficient and simple in post-treatment.

The invention discloses modified cellulose nanofiber reinforced bi-crosslinking immunoregulation hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological materials and biomedical engineering. Oxidized sodium alginate and dopamine grafted gelatin are adopted to prepare a main body of the composite hydrogel, aldehyde groups on the oxidized sodium alginate and amino groups on the gelatin can form Schiff base bonds, and borax, the oxidized sodium alginate and vicinal diol structures on modified cellulose nanofibers can form boric acid ester bonds. The double-crosslinking structure enhances the mechanical property of the hydrogel. The borate bond and the Schiff base bond are both dynamic chemical bonds and can respond to pH change, so that the hydrogel is endowed with self-healing performance and pH-responsive drug release ability, the hydrogel can quickly release liposome with an anti-inflammatory function in an acidic inflammatory environment in the early stage of cartilage injury, and the hydrogel recovers to an original state after fracture caused by joint movement. And the overall stability of the hydrogel is ensured by the double-crosslinking structure.

The invention discloses a preparation method of 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole, which comprises the following steps: taking a hydroxylamine oxygen sulfonic acid aqueous solution and isopentenal as raw materials, carrying out oximation reaction in an organic solvent under an alkaline condition, then directly adding an acid or an organic base catalyst into the reaction system, and reacting for 2-4 hours to obtain 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole, thereby obtaining the 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole. Under the catalytic action of the catalyst, a cyclization reaction is carried out, after the reaction is finished, an intermediate solution containing 5, 5-dimethyl-4, 5-dihydroisoxazole is obtained, and the next step is directly carried out; and carrying out a chlorination reaction by taking the intermediate solution as a raw material and sodium hypochloride or chlorine as a chlorination reagent, and after the reaction is finished, carrying out post-treatment to obtain the 3-chloro-5, 5-dimethyl-4, 5-dihydroisoxazole. The hydroxylamine oxygen sulfonic acid is used for enabling the isopentenal to be subjected to oximation reaction under the alkaline condition, then cyclization is carried out under the catalytic action of acid or alkali, the 5, 5-dimethyl-4, 5-dihydroisoxazole is generated, and the process has the advantages that the yield is high, the production steps are simplified, and the production cost is reduced.

The invention discloses a production system and method for preparing high-carbon aldehyde through carbonyl synthesis of high-carbon olefin. The system comprises a reaction device, a separation device, an aldehyde condensing device, a product tank, a polymer supplementing unit and a recycling unit, the polymer supplementing unit is connected with the separating device; the cyclic utilization unit comprises an extraction separation device connected with a liquid phase outlet of the separation device, a polymer recovery device connected with a water phase outlet of the extraction separation device, and a catalyst regeneration device connected with an organic phase outlet of the extraction separation device. According to the method, a carbonyl metal catalytic system is adopted to catalyze reaction of high-carbon olefin and synthesis gas, and heating separation of reaction liquid is performed by introducing an organic polymer protection catalyst; the separated catalyst liquid phase is subjected to water extraction separation and post-treatment, and the organic polymer and the catalyst are recycled. Recycling of the catalyst and efficient separation of the product are realized, and the stability of the catalyst separation section is enhanced.

The invention relates to the technical field of hard carbon material manufacturing, in particular to a method for preparing a hard carbon negative electrode material from medium and low temperature coal tar based pitch, which comprises the following steps: (S1) uniformly mixing the medium and low temperature coal tar based pitch and a cross-linking modifier, and carrying out heat treatment to obtain cross-linked modified pitch; the cross-linking modifier is a compound of a copolymer and a compound A; (S2) mixing the cross-linked modified asphalt with sulfur-containing polyaldehyde, and oxidizing in an oxygen-containing atmosphere to obtain first oxidized asphalt; (S3) uniformly mixing the first oxidized asphalt and a modifier, and carrying out secondary oxidation crosslinking to obtain second oxidized asphalt; and (S4) uniformly mixing the second oxidized asphalt and a pore-forming agent, and carrying out heat treatment in an inert atmosphere to obtain the product hard carbon material. The hard carbon material prepared by the invention has excellent electrochemical performance, is suitable for a negative electrode material of a sodium-ion battery, and remarkably improves the first effect and cycling stability.

The invention provides a reductive amination catalyst as well as a preparation method and application thereof, and belongs to the field of catalysis. The invention provides a reductive amination catalyst. The reductive amination catalyst comprises layered Al2O3 and an alloy loaded on the surface of the layered Al2O3, the alloy comprises a nickel element and a non-noble metal element; the non-noble metal elements comprise one or more of Cu, Mg, Ca, Co and Zn. The nickel element and the selected non-noble metal element are alloyed to adjust the charge structure of a metal site, so that excessive hydrogenation of HMF is inhibited during catalysis, it is ensured that only the aldehyde group of HMF is subjected to a reductive amination reaction, and therefore the selectivity of HMFA is improved.

The invention provides a bacteriostatic agent aiming at yersinia enterocolitica and application, the bacteriostatic agent comprises a compound solution of lipoic acid and protocatechualdehyde, and when the lipoic acid and the protocatechualdehyde act synergistically, the minimum inhibitory concentrations to the yersinia enterocolitica are 0.625 mg / mL and 0.3125 mg / mL respectively. The yersinia enterocolitica biofilm is inhibited and / or removed through the lipoic acid and protocatechuic aldehyde compound liquid, and the problem that drugs for treating the yersinia enterocolitica infection are prone to drug resistance is solved.

The invention discloses a preparation method of an SGLT2 inhibitor key intermediate, and belongs to the technical field of medicinal chemistry. The preparation method comprises the following steps: 1) reacting a compound B with trimethylchlorosilane under an alkaline condition to generate a compound C; 2) reacting the compound C with an aldehyde group reagent on an aromatic ring to generate a compound D; 3) reacting the compound E with a bromination reagent to generate a compound F; 4) preparing the compound F into a Grignard reagent to generate a compound G; 5) carrying out addition reaction on the compound D and a compound G to generate a compound H; and 6) carrying out dehydroxylation and trimethylsilyl protection on the compound H to generate a compound A. According to the preparation method, the risk caused by amplification of the Sandmeyer reaction in the original route is avoided, and meanwhile, the preparation cost of the key intermediate is greatly reduced.

This invention discloses a quantitative detection kit for arginine peptidase, a qualitative detection kit for arginine peptidase, and their usage methods. The quantitative detection kit utilizes the specific substrate Nα-benzoyl-DL-arginine-4-ylbenzamide hydrochloride, which can be hydrolyzed by arginine peptidase to 4-ylbenzamide. 4-ylbenzamide has a maximum absorption peak at 405 nm, and the specific arginine peptidase activity can be rapidly detected at room temperature using spectrophotometry. The qualitative kit utilizes the specific substrate Nα-benzoyl-DL-arginine-β-naphthamide hydrochloride, which can be hydrolyzed by arginine peptidase to p-β-naphthamide. β-naphthamide combines with 4-(dimethylamino)cinnamaldehyde to form a compound that is visible to the naked eye as a pink color. The disulfide bond cleaving agent cuts the mucus disulfide bonds, exposing bacterial enzyme sites, and the synergistic effect of the enzyme activator enhances the reaction rate of arginine peptidase hydrolysis of the substrate, significantly improving the detection sensitivity of arginine peptidase in tongue coating samples.

The invention discloses a Pd supported catalyst as well as a preparation method and application thereof, and belongs to the technical field of catalysts. The Pd supported catalyst is prepared according to the following steps: dissolving TEOS and MSDS in absolute ethyl alcohol, stirring, adjusting the pH value, aging at room temperature, and drying to obtain a mixture; and extruding the mixture into a long strip shape, calcining to prepare a TiO2-SiO2 composite carrier, dipping the TiO2-SiO2 composite carrier in a palladium nanoparticle solution, filtering, washing, and drying in vacuum to obtain the catalyst. The preparation method is simple and green in process, the reaction process is safe and easy to control, the prepared Pd supported catalyst is good in crystallization, high-dispersion nano-particle morphology, uniform in size and uniform in dispersion, and when the Pd supported catalyst is applied to co-production of methyl isobutyl ketone and methyl isoamyl ketone from mixed aldehyde and ketone, the isobutyraldehyde conversion rate can be effectively increased, and the yield of methyl isobutyl ketone and methyl isoamyl ketone can be effectively increased. The selectivity on methyl isoamyl ketone is good, and organic impurities in the product are few.

The invention discloses a perillaldehyde benzyl derivative, a synthesis method thereof and application of the perillaldehyde benzyl derivative in preparation of a drug for resisting brain neuron dysfunction. According to the technical scheme, the perillaldehyde benzyl derivative is characterized in that the perillaldehyde benzyl derivative is 2-phenyl-1-(4-isopropenylcyclohex-1-ene) ethanone, the structural formula of the perillaldehyde benzyl derivative is shown in the specification, and the invention further specifically discloses a synthesis method of the perillaldehyde benzyl derivative and application of the perillaldehyde benzyl derivative to preparation of drugs for resisting brain neuron dysfunction. The perillaldehyde benzyl derivative synthesized by the invention can be used as an NMDAR2B agonist to act on NMDAR2B in a targeting manner, meanwhile, a p-PI3K / p-AKT signal channel is activated, the expression levels of NOX2 and NOX4 are inhibited, and the effect of resisting neuronal dysfunction is achieved.

The present application relates to a reverse osmosis membrane post-processing method and a reverse osmosis membrane, wherein the reverse osmosis membrane post-processing method comprises the following steps: sequentially placing a reverse osmosis membrane prepared by an interfacial polymerization method in an acid solution containing a dialdehyde, water, an alkaline solution and a hydroxyl polyethylene glycol mercapto aqueous solution for cleaning treatment, wherein the hydroxyl polyethylene glycol mercapto aqueous solution is acidic. The reverse osmosis membrane post-processing method can effectively reduce the content of amino groups and polyamines on the reverse osmosis membrane while still having the performance of high retention and high water flux.

The present invention provides a compound with which a molecular probe capable of distinguishing NSCs from CSCs can be produced, and a method for detecting cancer stem cells using the compound. The present invention relates to a compound having a formyl group, a substrate moiety, a quenching moiety, and a luminescent moiety that is non-luminous due to the quenching moiety, wherein the luminescent moiety may be rendered luminous by detaching the substrate moiety by a substrate-degrading enzyme and also converting the formyl group to a carboxy group by an aldehyde dehydrogenase to allow the quenching moiety to dissociate.

A curable composition includes an alpha-beta diamine compound and an aldehyde-functional organosilicon compound. The composition may cure at room temperature without the use of a tin catalyst. The composition may be used to prepare a sealant or elastomer.

The reaction method comprises the following steps: mixing a raw material aldehyde and a liquid alkali catalyst, feeding the mixture into a condensation reaction coupling device to carry out an aldehyde condensation reaction, and under the action of negative pressure of a steam ejector and tower bottom heating, steaming out a gas-phase component generated by the aldehyde condensation reaction to an extraction separation condenser, after condensation, entering an extraction separator; one part of a mixture of a product and a liquid alkali catalyst after the aldehyde condensation reaction is heated and then returns to a condensation reaction tower coupling device, one part of the mixture is cooled by an oil-alkali separation cooler and then enters an oil-alkali separator, the separated liquid alkali catalyst is led out, one part of the product is led into an extraction separator, and the other part of the product is led out; the raw material aldehyde is extracted in the extraction separator, the extracted oil phase is conveyed back to the distillation section of the condensation reaction tower coupling device, and the water phase is discharged. The condensation reactor and the condensation circulating tower are coupled and transformed, reaction heat and product reflux are fully utilized, the technological process can be simplified, the operation flexibility can be improved, and energy consumption can be reduced.

The invention discloses a glycolaldehyde synthetase mutant and application of the glycolaldehyde synthetase mutant in improving the thermal stability of glycolaldehyde synthetase, and belongs to the technical field of biological catalysis application. According to the glycolaldehyde synthetase mutant disclosed by the invention, on the basis of an amino acid sequence as shown in SEQ ID NO.1, the glycolaldehyde synthetase mutant has the following mutations: A381P / E509F, A381P / K290P, A381P, S61A, A381P / K290P / E509F, A381P / C49A, A381P / T100V, A381P / S61A or A381P / K290P / S61A. The mutant protein can catalyze formaldehyde to prepare hydroxyacetaldehyde (glycolaldehyde). In addition, the mutant protein can also improve the catalytic efficiency from formaldehyde to glycolaldehyde, and due to the improvement of the thermal stability, continuous catalysis of industrial enzyme in actual reaction is facilitated, so that the mutant has a good industrial application prospect.

The invention relates to the field of silkworm breeding, in particular to a composite disinfection method suitable for a silkworm house and a silkworm rearing instrument. The composite disinfection method comprises the following steps: S1, carrying out physical and chemical combined preliminary disinfection; S11, cleaning and airing a movable instrument, and cleaning and disinfecting the silkworm house by using ultraviolet rays; s12, disinfecting the movable appliance and the silkworm house by using a chemical agent; s2, deep disinfection is conducted, specifically, a cinnamyl aldehyde and potassium permanganate mixed solution is taken to disinfect a silkworm house, then sulfur powder is used for fumigation disinfection, exhaust is conducted till no pungent smell is left, and the cinnamyl aldehyde and potassium permanganate mixed solution is prepared from cinnamyl aldehyde, water and potassium permanganate according to the volume ratio of 3-4: 5: 1-2; s3, disinfection before the silkworm period. Compared with the prior art, the disinfection method has the advantages that after the silkworm room and the silkworm rearing instrument are disinfected, few sedimentation bacteria are detected on the silkworm room and the silkworm rearing instrument, nuclear polyhedrosis viruses are not detected in silkworm bodies, the silkworm death rate is reduced to 0.3-1.1% and is far lower than that of other disinfection methods when the silkworm room or the silkworm rearing instrument is used for trial breeding of silkworm eggs, and the effect is extremely good.

The present application relates to a kind of ionic nitrogen heterocyclic carbene covalent organic framework and its preparation method and application, the ionic nitrogen heterocyclic carbene covalent organic framework with amine monomer, aldehyde monomer and vinyl ionic liquid as raw material, by one-pot method, it is prepared by povalorov reaction.The ionic nitrogen heterocyclic carbene covalent organic framework prepared in the present application can be used for the deuterium reaction of a variety of aromatic aldehyde, heterocyclic aldehyde and multi-site substituted aldehyde substrate as catalyst, with high catalytic activity and recyclable performance.

The invention belongs to the technical field of biology, and discloses a biosynthesis method of L-homoserine. According to the biosynthesis method, L-homoserine is synthesized by taking L-aspartic acid and formaldehyde as substrates, aldolase and transaminase are adopted, and oxaloacetic acid decarboxylase can be optionally added to improve the efficiency of a catalytic system. The method can be realized through an in-vitro multi-enzyme catalysis system, and can also be completed in a manner of introducing a way into microorganisms. According to the method, methanol, formaldehyde and other carbon resources can be introduced to synthesize the L-homoserine with high value, the raw materials are low in price, and the whole synthesis method has the advantages of high atom utilization rate and high conversion rate.

The subject of the invention is N-substituted derivatives of l-(l-phenyl-3-aryl)-lH-pyrazol-4-yl)methanamine with the general formula 1, where ¥ represents CH or N, R1 represents hydrogen, R2 represents no substituent, R3 represents hydrogen, while R4 represents N-propylbenzamide, benzo[b]furan, dihydrobenzo [b] furan, methylenedioxybenzene, ethyl benzoate, or propyl benzoate, substituted accordingly, their method of production and application, and the method of obtaining and application of N-substituted derivatives of l-(l-phenyl-3-aryl)-IH-pyrazol-4-yl)methanamine with the general formula 1, where Y represents C, CH, or N, R1 represents hydrogen or a methyl group, R2 represents a methyl group or no substituent, R3 represents hydrogen or a methyl group, while R4 represents dimethylpyrazole, methylpyrazole, dimethylimidazo[l,2-a]pyrimidine, or isopropoxybenzene, substituted accordingly. The compounds that are the subject of the invention are obtained through reductive amination using borohydride derivatives as the reducing agent, advantageously sodium triacetoxyborohydride, in the amount of 1.4-2.0 eq, amine in the amount of 1.0-1.1 eq, advantageously in slight excess, base, advantageously triethylamine in the amount of 1.0-1.1 eq (in the case of using amine in the form of hydrochloride), and the starting aldehyde. The reaction is conducted in a nonpolar solvent environment, advantageously dichloroethane at a concentration of about 0.1 M. The crude product is purified by column chromatography on silica gel using a methanol in dichloromethane mixture as the eluent, in concentration ranges from 2% to 5%. In order to obtain a solid form and improve the physicochemical parameters, the free bases are converted into hydrochloride form, and then crystallized from a polar solvent, advantageously ethanol or propanol.

The application discloses a preparation method of an octene aldehyde liquid-phase hydrogenation catalyst, and the preparation method comprises the following steps: (1) adding a weak acid into a salt solution containing silver, magnesium and aluminum, uniformly stirring, then adding a glycerol aldehyde, continuously stirring until a colloid is formed, grinding the colloid to obtain a powder, sieving, and roasting to obtain a carrier; and (2) preparing a precursor solution containing nickel and zinc, placing the precursor solution and the carrier in an ultrasonic container to shake, pouring the shaken solution into a well-sealed ball mill tank, ball milling, and then drying and roasting to obtain the catalyst. The catalyst is prepared by adding a silver-containing compound when the carrier is prepared and the ball milling method, so that the selectivity and stability of the catalyst are improved.

The invention discloses a preparation method of beta-carotene. The preparation method comprises the following steps: dissolving an aqueous solution of 3-methyl-5-(2, 6, 6-trimethyl-1-cyclohexene-1-yl)-2, 4-pentadienyl triphenylphosphine salt (C15 phosphine salt) and 2, 7-dimethyl-2, 4, 6-octtriene-1, 8-dialdehyde (C10) cis-trans isomer in a solvent, carrying out wittig reaction under the action of alkali, and carrying out isomerization to obtain the product. By controlling the proportion of C10 cis-trans isomers of the reaction system, the content of the C25 aldehyde intermediate can be reduced, and the reaction yield and the product quality can be improved.

Provided is a method for producing a methylene lactone compound, whereby it is possible to efficiently produce a methylene lactone compound. The present invention relates to a method for producing a methylene lactone compound, which is characterized by comprising a step for reacting a specific gamma-butyrolactone compound with a specific aldehyde compound in the presence of an oxide or hydroxide of a metal comprising a group 2 element of the periodic table.