489results about "Preparation by reductive alkylation" patented technology

Provided herein are catalysts useful in reductive amination, which include nickel, copper, zirconium and/or chromium, oxygen, and tin. The presence of the tin increases the selectivity of the catalyst in reductive aminations over the catalysts of the prior art.

Methods and compositions are provided for synthesizing ionic liquids from lignin derived compounds comprising: contacting a starting material comprising lignin with a depolymerization agent to depolymerize the lignin and form a mixture of aldehyde containing compounds; contacting the mixture of aldehyde containing compounds with an amine under conditions suitable to convert the mixture of aldehyde containing compounds to a mixture of amine containing compounds; and contacting the mixture of amine containing compounds with an acid under conditions suitable to form an ammonium salt, thereby preparing the ionic liquid.

The invention discloses a preparation method of hexamethylenediamine. The method is used for preparing 1, 6-hexamethylenediamine by virtue of carrying out ammoniation and catalytic hydrogenation on 1, 6-adipaldehyde. The method is simple in process, low in cost, high in yield, low in energy consumption and free from industrial three wastes.

The invention provides a process for the preparation of polyamines of the diphenylmethane series. This process comprises a) reacting aniline and formaldehyde in a molar ratio of 1.5:1 to 6:1, in the presence of an acid catalyst at temperatures of 20° C. to 100° C., in which the water content in the acid reaction mixture is <20 wt. % and a degree of protonation of <15% is established, and b) increasing the temperature of the reaction to a temperature of 110° C. to 250° C. when the ratio of the weight contents of p-aminobenzylaniline to 4,4′-MDA in the reaction mixture falls below a value of 1.00.

The invention discloses a catalytic synthesizing technique of 4, 4'-diamino diphenylmethane, which comprises the following steps: adopting phenylamine and formaldehyde as raw material to do one-step condensed reaction intervally acted by solid acid catalyst; setting the molar rate of phenylamine and formaldehyde at 10/1-2/1 under 100-200 deg.c for 1-8h; circulating diamino diphenylmethane; recycling USY to synthesize the product with high activity.

The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.

PCT No. PCT/JP98/00192 Sec. 371 Date Sep. 10, 1998 Sec. 102(e) Date Sep. 10, 1998 PCT Filed Jan. 20, 1998 PCT Pub. No. WO98/32729 PCT Pub. Date Jul. 30, 1998An alicyclic polyamine of the formula (1) wherein Y1 represents a saturated aliphatic hydrocarbon group and R1 through R4 are the same or different and each represents hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group. The alicyclic polyamine can be obtained by subjecting a 3-formylcycloalkanone or 3-formylcycloalkenone to reductive amination reaction.

The invention discloses a method for synthesizing isopropamide, belonging to the technical field of synthesizing fatty amine. In order to improve the conversion efficiency and the selectivity of catalysts for synthesizing isopropamide, propanone or isopropanol is used as the raw material, in the presence of hydrogen and a nickel-based catalyst, amination is carried out to synthesize isopropamide under the conditions that the reaction temperature is 110-200 DEG C, the reaction pressure is 0.1-1.0MPa, and the mole ratio of propanone or isopropanol to hydrogen to ammonia is 1:(1-5):(1-5), wherein the catalyst contains a carrier and nickel active components loaded on the carrier, and over 90 percent of the nickel active components are distributed in a region with the depth of 0.7 mm from the surface of the carrier. The method in the invention can ensure that the conversion efficiency of the propanone is improved, has higher propanone conversion efficiency under the condition of same nickel content and better selectivity, reduces the generation amount of diisopropylamine, simplifies the production process flows of the isopropamide, and lowers the production cost of the isopropamide.

Processes comprising: (i) providing a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones and mixtures thereof; and (ii) reacting the reactant with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a catalyst comprising a zirconium dioxide- and nickel-containing catalytically active composition, to form an amine; wherein the catalytically active composition, prior to reduction with hydrogen, comprises oxygen compounds of zirconium, copper, nickel and cobalt, and one or more oxygen compounds of molybdenum in an amount of 5.5 to 12% by weight, calculated as MoO₃.

The invention discloses a catalyst for preparing C2-C6 low-grade aliphatic amine. The catalyst comprises a carrier and an active component, wherein the active component accounts for 10 to 60 percent of the total weight of the catalyst, and the active component is Co or consists of Co, Ni and Fe. The invention also discloses a method for producing the catalyst, which comprises the steps of putting the carrier into an aqueous solution of the active component for impregnation, loading the active component onto the carrier, drying the impregnated carrier at a temperature between 100 and 180 DEG C and then decomposing the carrier at a temperature between 250 and 550 DEG C, using hydrogen to perform reduction treatment at a temperature between 250 and 650 DEG C and obtaining the catalyst. The catalyst adopted to prepare the C2-C6 low-grade aliphatic amine can be more beneficial to the generation of tertiary amine.

Processes comprising: (i) providing a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones and mixtures thereof; and (ii) reacting the reactant with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a catalyst comprising a zirconium dioxide- and nickel-containing catalytically active composition, to form an amine; wherein the catalytically active composition, prior to reduction with hydrogen, comprises oxygen compounds of zirconium, copper, and nickel, and one or more oxygen compounds of silver in an amount of 0.5 to 6% by weight, calculated as AgO.

The invention relates to a preparation method for a cyclopropylamine spiro(hetero)cyclic compound and a composition containing the same, and application of the compound and the composition as an inhibitor for human lysine-specific demethylase (LSD1). The inhibitor is the cyclopropylamine spiro(hetero)cyclic compound as shown in a formula (I) which is described in the specification, or a pharmaceutically acceptable salt, predrug, solvate, polymorphic crystal or stable isotope derivative thereof. The compound can be used for treating or preventing diseases related to human lysine-specific demethylase, e.g., cancers and nerve diseases.

This application claims the benefit of German priority Application No. 10138140.9, filed on Aug. 9, 2001, and International Application No. PCT/EP02/08748, filed on Aug. 6, 2002. The invention relates to the production of amines by the reaction of aldehydes or ketones with ammonia or primary or secondary amines in the presence of a hydrogen-donor and the presence of homogeneous metal catalysts of the eighth sub-group under mild conditions.

Production of secondary amine compound is carried out by taking nitro-compound, phenol or aldehyde compound as raw materials, catalytic hydrogenation reacting for 1-20hrs at 0.5-5.0MPa and 30-200 degree under the existence of solvent and catalyst, and separation purifying to obtain the final product. The solvent is fatty alcohol containing 1-4 atoms or its solution or water; the catalyst can be Raney Ni catalyst or nickel-carried catalyst or noble- metal-carried catalyst; the noble-metal-carried catalyst can be palladium-carried or platinum-carried or ruthenium-carried catalyst. It's simple and cheap, has higher conversion percent and better selectivity.

Disclosed herein is a process for the reductive alkylation of primary amines to form secondary amines, by high pressure reaction of the primary amine with an alkylating agent and hydrogen in the presence of a catalyst which comprises metallic palladium. A process of the present invention is characterized in having high conversion rates and high selectivities, both greater than 95% on a first pass through the reactor. According to a preferred embodiment, the secondary amine produced comprises at least one 2-alkyl group bonded to the nitrogen atom of the primary amine product.

The present invention discloses a nitrogen-doped carbon material encapsulated cobalt catalyst and a method of using the catalyst to prepare secondary amine compounds. The preparation method of the catalyst comprises the following steps: 1) silica sol is added into a 2-methylimidazole solution and dispersed uniformly to obtain liquid sol, a stirring is conducted while adding cobalt nitrate liquid into the liquid sol, a stirring reaction is conducted for 3-10 h, and after the reaction is completed, centrifuging, filtering, washing and drying are conducted to obtain ZIF-67@SiO<2> materials; 2) under nitrogen protection, the ZIF-67@SiO<2> materials are calcined at 400-1,200 DEG C for 6-10 h, the calcined materials are soaked with hydrofluoric acid solution, the soaked calcined materials are water washed to neutral, the washed calcined materials are dried to obtain CN@Co materials. The method of using the catalyst to prepare the secondary amine compounds is as follows: in an organic solvent, nitro-compounds, formic acids, carbonyl compounds and the CN@Co materials are added, nitrogen is ventilated to replace oxygen in the reaction system, and the reaction is conducted at 90-220 DEG C for 15-18 hours in an air isolation condition to obtain the secondary amine compounds. The catalyst can be used in the preparation of the secondary amine compounds, reduces the requirements and costs of the reaction to devices and is relatively high in reaction selectivity and yield.

The invention relates to a chemical preparation method, and particularly relates to a preparation method of dibenzylamine. The invention prepares dibenzylamine by using benzaldehyde and ammonia as raw materials; the reaction temperature is 10-100 DEG C; the gauge pressure meter hydrogen reaction pressure is 1.0-5.0 Mpa; water, or lower aliphatic alcohol with 1-4 carbon atoms, or a mixture is used as a solvent; and the reaction is performed under the action of a catalyst for 0.1-5 hours; the catalyst comprises precious metal palladium used as a main catalyst; at least one of Ni, Ru, Os, Ir, Cu, Sn is selected and added as a cocatalyst; at least one of TiO2, SiO2, CeO2, SnO2 is used as a carrier; the advantages of the invention are that the preparation catalyst has a prolonged service life; the preparation cost is reduced; the conversion rate of benzaldehyde is high; and the dibenzylamine yield is increased.

A process for reducing the percentage by weight of formaldehyde present in a composition comprising glycolaldehyde, wherein formaldehyde is transformed into one or more formaldehyde acetal(s) and removed from the reactive distillation reaction solution by reactive distillation in the presence of at least one alcohol and a catalyst.

Processes comprising: (i) providing a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones and mixtures thereof; and (ii) reacting the reactant with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a catalyst comprising a zirconium dioxide- and nickel-containing catalytically active composition, to form an amine; wherein the catalytically active composition, prior to reduction with hydrogen, comprises oxygen compounds of zirconium, copper, and nickel, and one or more oxygen compounds of one or more metals selected from the group consisting of Sb, Pb, Bi, and In.