Production of secondary-amine compound

Abstract

Production of secondary amine compound is carried out by taking nitro-compound, phenol or aldehyde compound as raw materials, catalytic hydrogenation reacting for 1-20hrs at 0.5-5.0MPa and 30-200 degree under the existence of solvent and catalyst, and separation purifying to obtain the final product. The solvent is fatty alcohol containing 1-4 atoms or its solution or water; the catalyst can be Raney Ni catalyst or nickel-carried catalyst or noble- metal-carried catalyst; the noble-metal-carried catalyst can be palladium-carried or platinum-carried or ruthenium-carried catalyst. It's simple and cheap, has higher conversion percent and better selectivity.

Description

(1) Technical field

[0001] The invention relates to a method for preparing secondary amine compounds by using nitro compounds, aldehyde or ketone compounds and hydrogen as raw materials in the presence of a catalyst in one pot. (2) Background technology

[0002] Secondary amine compounds are an important class of organic synthesis intermediates, widely used in the dye industry, pharmaceutical industry, food industry, pesticide industry and other fields.

[0003] Methods for preparing organic amines are numerous and have been known for a long time. For example: the N-alkylation reaction of halogenated hydrocarbons with ammonia, primary amines, and secondary amines to prepare amine compounds. In this method, the structure of the reactants has a significant impact on the resulting products. When the activity of the halogenated hydrocarbon is high, the basicity of the primary amine is relatively high, and both have no steric hindrance, mixed amines are often obtained; when the ...

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