A modified hydrophilic polyurethane dressing and a preparation method thereof. The dressing comprises the following components: 20-40 parts of polyurethane, 25-40 parts of collagen, 5-10 parts of hyaluronic acid, 5-8 parts of chitosan, 1-4 parts of egg white, 20-30 parts of sodium alginate, 1-4 parts of Cordyceps extract, 8-13 parts of silver nano solution, 10-20 parts of carboxymethyl cellulose, 12-18 parts of bamboo fiber, acetyl fiber 12‑20 parts of plain sodium. Preparation method: Weigh each component by weight; melt polyurethane, collagen, hyaluronic acid, chitosan, egg white and sodium alginate in a reaction kettle, drop to 50-60°C, add other raw materials, and cool down Degassing to obtain the first mixture for later use; coating the first mixture on the colloid layer, drying naturally, and encapsulating to obtain a modified hydrophilic polyurethane dressing. Compared with the prior art, it has better moisturizing performance, no irritation to the skin, good antibacterial effect, and is suitable for large-scale popularization and application.