5 results about "Traumatic Hemorrhage" patented technology

This invention belongs to the fields of biomedical materials, flexible electronic devices, and trauma emergency treatment technology, specifically relating to a wireless closed-loop thermal hemostasis system, its preparation method, and its application. This invention utilizes dopamine-modified chitosan to prepare a porous chitosan gel, and introduces a conductive phase into the gel to prepare a composite conductive cryogel. This composite conductive cryogel is connected to a flexible circuit, a temperature sensing array, a flexible heating unit, and a wireless PCB control module to prepare a wireless closed-loop thermal hemostasis system. When used in traumatic massive hemorrhage, the cryogel exhibits a volume-dependent resistance change after absorbing blood. The system utilizes this resistance change to achieve real-time monitoring of the bleeding, hemostasis, and rebleeding processes. The flexible heating unit is controlled via temperature array feedback to rapidly raise the local temperature of the wound within a safe range to the procoagulant zone, thereby achieving automatically triggered and terminated thermal-assisted hemostasis.

Provided herein are adjustable internal tourniquet device and system having an inflatable segmented balloon configured to exert pressure on a site of injury. Further provided are methods of using the same for controlling traumatic hemorrhage wounds.

The invention relates to application of a cytoskeleton regulator in preparation of a blood coagulation promoting drug, and belongs to the technical field of biological medicines, and the blood coagulation promoting drug is a drug for treating or preventing hemorrhagic diseases related to low blood coagulation function. The hemorrhagic diseases comprise traumatic hemorrhage, surgical operation related hemorrhage, hepatopathy related hemorrhage, postpartum hemorrhage, hemophilia, hemorrhage caused by excessive anticoagulant drugs, thrombocytopenia or dysfunction related hemorrhage; the cytoskeleton regulator is one or more of a compound for inhibiting polymerization of actin microfilaments, a compound for inhibiting shrinkage of myosin and a ROCK kinase inhibitor; the cytoskeleton regulator can be used for preparing a procoagulant treatment drug, the effect is played by inducing endogenous cells of a body to release procoagulant particles, a brand new strategy is provided for a clinical hemostatic drug, and the cytoskeleton regulator can remarkably shorten the coagulation time of whole blood; the bleeding time can be remarkably shortened, the total blood loss amount is reduced, and the powerful in-vivo bleeding stopping effect is achieved.

The application relates to the technical field of traditional Chinese medicine preparation, and particularly discloses a waterproof hemostatic wound patch and a preparation method thereof. The waterproof hemostatic wound patch comprises a backing layer, a medicinal gel layer and a protective layer, the medicinal gel layer is composed of traditional Chinese medicine thick paste and a carbomer gel matrix, the traditional Chinese medicine thick paste is made of 11 kinds of traditional Chinese medicinal materials such as radix notoginseng, herba cistanches and herba thistle, the carbomer gel matrix is made of carbomer 940 as a skeleton and auxiliary materials such as glycerol and propylene glycol. The preparation method comprises the following steps: medicinal material soaking and extraction, filtration and concentration, matrix swelling and preparation, medicinal gel mixing, vacuum degassing, pH rechecking and sterilization and molding, and purified water is used for extraction in the whole process, and the process condition is mild and controllable. The wound patch can be used for emergency treatment and wound care of various traumatic hemorrhage, solves the problem of poor compatibility of traditional Chinese medicine water extract and carbomer gel, the product is not prone to stratification and water seepage, has good storage stability, has the effects of rapid hemostasis and promotion of wound healing, and is suitable for industrialized production.

The invention belongs to the technical field of critical disease monitoring, and particularly relates to a staged liquid resuscitation capacity regulation and control method and system for traumatic hemorrhagic shock patients, and the resuscitation process is sequentially divided into four core stages of initial resuscitation, resuscitation optimization, stable monitoring and capacity reactivity evaluation. And clear physiological targets, monitoring parameters and advanced or return standards are set in each stage. According to the method, multiple vital signs and laboratory indexes are subjected to dynamic and tendency analysis, and a complete and standardized decision path from positive resuscitation to stable evacuation is provided for clinicians. The invention not only aims at effectively recovering tissue perfusion, but also aims at reducing the risk of complications such as rebleeding, blood clotting disease and cardiac insufficiency caused by excessive resuscitation or misjudgment of illness conditions to the greatest extent, so that a safer and more reliable practice framework is provided for improving clinical prognosis of patients suffering from traumatic hemorrhage shock.