8 results about "Coagulation function" patented technology

The present application belongs to the field of photochemical therapy, and particularly relates to a method for photochemical treatment of riboflavin based on multi-wavelength LED and application thereof in treatment of graft-versus-host disease. The present application selects different wavelength LED combinations as light sources to optimize the riboflavin photochemical method, controls the light intensity at 1000-25000 μW / cm², controls the irradiation time at 5-15 minutes, and controls the riboflavin concentration at 20-150 μM, thereby significantly improving the photochemical reaction effect. The method can efficiently induce PBMC apoptosis in a plasma environment, significantly reduces the levels of key pro-inflammatory cytokines such as TNF-α, IL-6 and IFN-γ, and has no significant influence on platelets, hemoglobin and blood clotting function, thereby providing a safe and controllable new cell preparation method for GVHD treatment.

The application belongs to the technical field of medical decision support, and discloses a knee joint postoperative distal deep vein thrombosis prediction system; by acquiring multi-dimensional parameters such as coagulation function, metabolic function, inflammation ratio index and intra-articular injection history, the sodium hyaluronate injection history is converted into an articular lesion severity score, an inflammation-coagulation coupling characteristic vector and a metabolic disturbance correction model are innovatively constructed, and the synergistic effect among multiple systems is captured. A penalty regression model with cross-validation is used for sparse prediction factor screening, redundant variables are screened out through a regularization path shrinkage technology, and key prediction factors are reserved. Finally, an individualized thrombosis risk probability nomogram is constructed, and the prediction accuracy is verified through resampling calibration. The application realizes the multi-system integration of inflammation, coagulation, metabolism and joint degeneration factors, converts the complex statistical model into a clinically friendly tool, and optimizes the postoperative thrombosis prevention and control strategy.

This invention relates to the field of oral medical monitoring technology, specifically a postoperative oral bleeding risk prediction and intervention system based on multimodal data fusion. The system includes: collecting and standardizing preoperative coagulation function test data, intraoperative wound image data, and postoperative continuous physiological sign monitoring data; extracting three parameters from the intraoperative wound image: the proportion of exposed blood vessels, the density of tissue bleeding points, and the state of wound edge contraction; mapping these three parameters to the preoperative coagulation function data to construct a bleeding risk feature vector; training a bleeding risk classifier using this vector to obtain a risk prediction model; and inputting real-time postoperative physiological sign data into the model to obtain a bleeding risk probability value and trigger corresponding intervention measures. This system can accurately capture the real-time state of the wound, integrate multi-dimensional data, improve the accuracy of bleeding risk prediction, trigger timely intervention, and reduce postoperative bleeding complications.

A system / method for detecting and quantifying platelet function and coagulation function within a biological sample is provided. The system includes a detection instrument with computing capability. The system includes an assay device capable of receiving a biological sample. Introduction of the biological sample into the assay device results in a biological process by which fibrin and platelets may accumulate at a reaction zone of the assay device. The assay device is capable of receiving one or more chemical reagents compatible with the biological sample and usable for detecting the accumulation of the fibrin and platelets within the reaction zone. The fibrin and platelets, and their associated signals, accumulated at the reaction zone of the assay device are usable to determine at least one of a platelet function, a coagulation function, platelet normalcy, fibrin normalcy, platelet response to a drug, and coagulation response to a drug, within the biological sample.

The application discloses a kind of Miao medicine composition for treating liver fibrosis and cirrhosis ascites and its preparation method and application, belong to traditional Chinese medicine and national medical technology field.The composition is made of specific weight ratio of chases yellow grass, pearl grass, white flower snake tongue grass, bupleurum, vinegar baked turtle shell, Miao medicine soft liver grass (dried whole grass of gold star fern), catpaw grass, rhizoma sparganii, zedoary, peach kernel, rehmannia, astragalus, atractylodes, angelica, salvia miltiorrhiza, calcined oyster, big belly skin, poria cocos, curcuma, prepared rehmannia, white peony root, chuanxiong.The application provides pill, granule, capsule and the like controllable preparation process, and the product quality is stable, and safety is high.Experiment and clinic confirm that the composition can significantly reverse liver fibrosis, quickly subsides cirrhosis ascites and reduces recurrence rate, simultaneously improves liver function, liver elasticity, serum albumin and blood coagulation function, is suitable for long-term treatment of liver fibrosis and cirrhosis ascites, and has good industrial application prospect.

This invention discloses a dynamic hemodynamic monitoring and support system for critically ill ICU patients, relating to the field of medical monitoring technology. Through a multi-parameter synchronous acquisition module, it achieves simultaneous and linked acquisition of hemodynamic parameters and coagulation function indicators. A data preprocessing module performs precise filtering, outlier removal, and missing value completion on the acquired raw data. A dynamic coupling analysis module constructs a quantitative blood flow-coagulation correlation model, which can dynamically adjust parameter warning thresholds based on the patient's individual characteristics and condition, accurately calculate coupling risk values, and determine risk types and levels. An intelligent intervention and control module formulates differentiated treatment plans based on coupling risks and achieves closed-loop intervention through a feedback correction mechanism. A display, alarm, and data storage module realizes the visualization of multi-dimensional information and full-process data retention, achieving dynamic coupling monitoring and intelligent support for hemodynamics and coagulation function.

The application discloses application of a 5'-monophosphate nucleotide composition in preparation of anti-aging and longevity drugs and / or functional foods, and belongs to the technical field of medicines.The composition is composed of 5'-monophosphate adenosine, 5'-monophosphate cytidine, 5'-guanylic acid disodium, 5'-uridylic acid disodium and hypoxanthine nucleotide, and the mass ratio of the acid types of CMP, AMP, UMP, GMP and IMP is respectively as follows: CMP: 15-78%, AMP: 6-44%, UMP: 7-40%, GMP: 7-51%, and IMP is 0 or greater than 0 and not higher than 2.5%. The composition can synergistically enhance various mechanisms such as significantly reducing an insulin resistance index, enhancing body anti-coagulation function, improving blood circulation, regulating metabolism of essential minerals such as lithium and copper and regulating intestinal flora ecology, delays aging and prolongs healthy life span. Animal experiment data show that, compared with a control group, the composition prolongs the median survival time of mice by 9.21-12.6%, and the equivalent human life span is 8.76-12.01 years. Human experiment data show that, compared with the control group, the composition intervention reduces the median age of DNA methylation by 3.08 years, and provides a new idea for developing anti-aging and longevity drugs and / or functional foods.

The application provides a sample analyzer and method for detecting blood clotting time based on a magnetic bead method. The sample analyzer comprises a detection device and a controller, the detection device comprises a driving assembly and a sensing assembly, the controller is used for detecting a first reaction solution in the reaction container by controlling the detection device; and in a time period of 0 to T0 of the detection process, the driving assembly is controlled to drive the magnetic beads to oscillate in the reaction container at the first average power, and in a time period of T0 to T1 of the detection process, the driving assembly is controlled to switch to drive the magnetic beads to oscillate in the reaction container at the second average power; the end time of the reaction is judged based on the amplitude degree of the magnetic beads of the reaction container in the time period of 0-T1, and the blood clotting time of the sample is output. The application adopts a time period detection method for the same reaction solution, so as to improve the accuracy of the detection of samples with low blood clotting function.