140 results about "Coagulation function" patented technology

The invention discloses a blood perfusion device having the anti-coagulation function and the controlled-release function and a manufacturing method of the blood perfusion device. The blood perfusion device comprises a perfusion device body provided with an adsorption chamber. The adsorption chamber contains an adsorbent and anti-coagulation and controlled-release gel having the thermosensitive characteristic. The anti-coagulation and controlled-release gel contains anti-coagulation matter. The anti-coagulation and controlled-release gel can be formed by dissolving the anti-coagulation matter, a compound with the two ends containing double bonds and a N-alkyl acrylamide type monomer having the thermosensitive characteristic in water through polymerization. By the adoption of the blood perfusion device having the anti-coagulation function and the controlled-release function, the anti-coagulation function is integrated with the blood purification function, the convenience of clinical blood perfusion is improved, and the risk of introducing pyrogen additionally is avoided; the thermosensitive characteristic and the mechanical property of the anti-coagulation and controlled-release gel can be adjusted by changing reactant components, the crosslinking density, the ion strength and the water content; when coagulation happens, coagulated blood clots can squeeze the anti-coagulation and controlled-release gel, so that release of the anti-coagulation matter can be instantly accelerated by the anti-coagulation and controlled-release gel, and the effect of effectively preventing the coagulation range from expanding is achieved.

The invention provides a terpenoid shown by the formula I or pharmaceutically acceptable salt, ester or hydrate thereof. The invention also provides a preparation and application of the terpenoid. In the invention, a carbon-drop diterpene new compound separated from leonurus is carbon-drop labdane diterpene obtained from the nature for the first time. The compound can obviously shorten the PT (prothrombin time), APTT (activated partial thromboplastin time) and TT (thrombin time) in vitro and obviously increase the amount of FIB (fibrinogen) in blood, and realizes a certain effect on enhancing the coagulation function, thereby providing a new option for developing a novel natural coagulation drug.

The invention provides a wet electric precipitator with pre-coagulation function aiming at the deficiency that the existing wet electric precipitator has low dedusting efficiency for superfine dust particles. The wet electrostatic precipitator is arranged on the top of the desulfurization absorption tower, and mainly includes a wet electrostatic precipitator and a condensing heat exchanger. The wet electrostatic precipitator is arranged above the condensing heat exchanger. Composed of cathode suspension and anode assembly, the condensing heat exchanger is installed between the outlet of the absorption tower mist eliminator and the wet electrostatic precipitator, and the wet electrostatic precipitator and the condensing heat exchanger are respectively equipped with flushing devices. The flue gas to be treated passes through the desulfurization absorption tower, the outlet flue of the absorption tower, the phase change condensation flow equalization chamber, the wet electrostatic precipitator and the outlet flue of the dust collector in sequence from bottom to top, and then is discharged from the chimney.

The invention provides a production process of French type crispy cakes. The French type crispy cakes are prepared according to the steps as follows: a mixture of grease, white granulated sugar, salt and water is heated to 90-110 DEG C; then wheat flour is added into the mixture, and the mixture and the wheat flour are mixed fully to the temperature of 45-65 DEG C; an egg liquid is added for three times, and then stirring is performed until a paste is smooth, and the blank temperature is 40-60 DEG C; the stirred paste is poured into a crispy cake extruder and extruded into strips; the strips are baked at the tunnel oven temperature of 170-260 DEG C for 17-30 min; and baked semi-finished products are cut into strips, and the strips and a syrup are mixed, stirred and transmitted to a forming machine for cutting and forming. According to the production process of the French type crispy cakes, a braking processing technology and a physical mixing manner are adopted, no artificial addition colors and preservatives are caused, the egg content reaches up to 30%-40%, the nutritional values of products are increased, the golden luster is increased, a coagulation function is realized, and eggs are used as swelling agents, so that sizes of the products are increased, and the products are sweet and mellow in custard, crispy and agreeably sweet in taste; and added wheat flour cannot produce a burning smell, and the overall taste of the French type crispy cakes is improved.

The invention provides a composite type intraoperative stent system which comprises an artificial vessel capable of being anastomosed, a linear control released left subclavian artery covered stent vessel and a balloon-expandable type descending aorta covered stent artificial vessel; the artificial vessel is connected with the balloon-expandable type descending aorta covered stent artificial vessel; the left subclavian artery covered stent vessel is arranged at the connecting part of the artificial vessel and the balloon-expandable type descending aorta covered stent artificial vessel and communicates with the artificial vessel and the balloon-expandable type descending aorta covered stent artificial vessel; and the balloon-expandable type descending aorta covered stent artificial vessel is internally provided with a balloon. The composite type intraoperative stent system can shorten the operation time, reduces influence of deep hypothermic circulatory arrest on the coagulation function of a patient, lowers the difficulties of vascular anatomy and anastomosis and increase the success rate of an operation.

The invention relates to amucous membrane stripper used under the assistance of an endoscope. The mucous membrane stripper comprises a cutter head, a transmission wire, a fixed handle, a rotary handlefor driving the rotation of the transmission wire, and an electric coupling device for connection with high frequency electricity. The front end of the transmission wire protrudes from the fixed handle to be connected with the cutter head, the rotary handle is arranged on the fixed handle, the rotary handle is connected with the transmission wire through a vertical transmission structure. The injection wire and the cutter head are provided with injection channels inside, the injection channel of the transmission wire is communicated with the injection channel of the cutter head, and the rearend of the transmission wire protrudes from the rear end of the fixed handle to be connected with an injection interface. The cutter head of the mucous membrane stripper can be rotated at a high speedso asto improve the efficiency of incision and stripping; under the assistance of an endoscope, the mucous membrane stripper can cut and strip mucous membranes, perform submucous injection without replacing the instrument, shorten the operation time, and save the operation cost; when the mucous membrane stripper is connected with a high frequency electricity, the mucous membrane stripper can alsoswitch to the coagulation function for blood coagulation and hemostasis.

A rapid detection method for detecting a whole blood coagulation function detects the coagulation function of blood by means of ultrasonically detecting conditions of rotation (movement) of a metal bar in a whole blood specimen. In the method, plasma is not required to be separated, whole blood is directly sampled in a detecting cup (anti-coagulation or coagulation), a metal-bar-shaped stirrer (capable of being wrapped by other materials) is arranged in the detecting cup, and during detection, a rotating magnet is additionally mounted at the bottom of the detecting cup. Before the blood is coagulated, the stirrer rotates along with the rotating magnet, and after the blood is coagulated, the stirrer stops rotating due to resistance. An ultrasonic detector is additionally mounted on a side surface of the detecting cup, and a blood coagulation condition is judged by means of detecting rotation/fixation of the stirrer in the blood.

The invention discloses a photochemical inactivating system for circulating tumor cells and/or tumor stem cells in blood or blood products and application of riboflavin in preparation of an agent for inactivating the circulating tumor cells and/or the tumor stem cells in the blood or the blood products in a photochemical way. According to the system and application, the circulating tumor cells and/or the tumor stem cells in the peripheral blood are completely induced to be subjected to apoptosis to lose the proliferation ability, so that blood cells, coagulation function and immune function of a patient are maintained to the utmost extent.

The invention disclose a method for detecting and evaluating blood coagulation function by directly detecting change of erythrocyte and platelet quantity by whole blood after and before a reagent for inducting blood to coagulate is added. The method not only can comprehensively reflect a total blood coagulation function level of a blood sample, but also can respectively directly reflect participation of platelet and erythrocyte in a blood coagulation process and the coagulation function of various blood cells, and can comprehensively reflect blood solidification capability. The method, combining different blood coagulation reagent, by change of the platelet and erythrocyte quantity, reflect a blood coagulation path function in the blood sample, and the function of various blood coagulation factors in the blood.

The invention provides a sample cup for detecting blood coagulation function and application thereof, and relates to the technical field of medical instruments. The sample cup includes a cup body and a cup cover; the cup body is provided with a stirring device and filled with an activator; the cup cover is provided with a through hole for inserting a probe. After adding the blood sample to be tested, the sample cup can be directly placed in the coagulation detector for detection without pretreatment, and has high speed, high efficiency, no pollution and high accuracy. The sample cup is widely used in the detection of coagulation function, and alleviates the technical problem existing in the prior art that lacks a product that can quickly, safely, conveniently and effectively detect the coagulation function.

The invention discloses blood coagulation function index detection test paper and a preparation and signal processing method thereof. The blood coagulation function index detection test paper comprises a substrate layer, a middle interlayer and a hydrophilic layer, wherein the middle interlayer is adhered between the substrate layer and the hydrophilic layer, the substrate layer is provided with an organic electrochemical transistor containing a reaction film for detecting blood coagulation function indexes, and the middle interlayer is provided with a sample introduction channel to the organic electrochemical transistor reaction region. The current change trend of the organic electrochemical transistor is used for reflecting blood coagulation states in different stages, and the current change time inflection point is determined by detecting the current change in different blood coagulation states, so that the detection of blood coagulation function indexes is realized. The invention further provides a signal processing method for improving the precision and accuracy of the test paper for measuring a blood coagulation function index, and reducing the difference of the performance of the test paper, which is influenced by the instability of the production process.

The invention discloses an oligopeptide containing an Hyp-Gly sequence and having antiplatelet and antithrombotic functions. The invention provides the oligopeptide containing the Hyp-Gly sequence orsalt forms thereof. The oligopeptide containing an OG sequence can be prepared through artificial synthesis as well as enzymolysis of fish skin. The molecular weight of the oligopeptide containing theOG sequence is smaller than 1,000 Da, the mass ratio of the oligopeptide to total enzyme-digested products is 65%-95%, and the oligopeptide has a specific inhibition effect on ADP-induced platelet aggregation, can inhibit thrombosis, does not affect the blood coagulation function, does not prolong the bleeding time and is very small in bleeding risk; and the oligopeptide has the characteristics of resistance to gastrointestinal tract digestive enzyme enzymolysis and easiness in absorption.

The invention provides a directionally driven targeted hemostasis micromotor, which is characterized in that microporous starch is used as a carrier for delivering a hemostasis drug, nano Fe3O4 is self-assembled on the surface of the microporous starch to serve as a power system, and the hemostasis drug (thrombin) is loaded on the surface of the microporous starch/nano Fe3O4 by using bovine serum albumin. The thrombin on the micromotor can stably exist on the carrier, and under the stimulation of a magnetic field, the effect of centralized and directional delivery is achieved, so that the blood coagulation function of the thrombin is fully played; and meanwhile, under the stimulation of an external magnetic field, the micromotor can generate power to move towards a target position, and when the position of the magnetic field is changed, the movement direction of the micro motor can be changed, so that the micromotor is suitable for various types of wound surfaces and wounds.

The invention relates to the technical field of cement additives, in particular to an efficient cement grinding aid which is prepared from the following raw materials in weight percentage: 10-15% of triethanolamine, 10-20% of propylene glycol, 10-15% of butanediol, 5-15% of hexanediol, 5-10% of water holding cellulose, 1-2% of graphite, 0.02-0.06% of sodium dodecyl benzene sulfonate and the balance of water. The efficient cement grinding aid is applicable to the field of cement grinding assistance. When cement is ground and the efficient cement grinding aid is added, the cement grinding efficiency can be greatly improved, and the cement strength can be improved; the efficient cement grinding aid has certain delayed coagulation function, and triethanolamine is replaced by part of alcohol, so that the cost is reduced.

The invention discloses a liver disease examination device with a blood coagulation function. The liver disease examination device comprises a bed board, wherein four supporting legs are fixedly connected to the lower side of the bed board; a groove with a downward opening is formed at the lower side of the bed board; a moving block is arranged in the groove; a horizontally arranged threaded through hole is formed in the moving block; a threaded rod is connected in the threaded through hole through threads, and is erected on both side walls of the groove; a disinfection device is fixedly connected to the lower side of the moving block through a connecting block; and the upper side of the bed plate is provided with a sliding groove with an upward opening, and a sliding block is arranged inthe sliding groove. The liver disease examination device provided by the invention has the beneficial effects that in order to accelerate the blood coagulation speed, a heating resistance wire is energized, heat is generated after the heating resistance wire is energized, then a fan is started, the generated heat is blown into a cavity by the fan, and a pricking pin is placed below two air outlets, so that the heat ejected from the two air outlets is concentrated to one place, thus effectively accelerating the blood coagulation speed.

This invention discloses a cruor function system detection apparatus. The pressure constant power is separately connected with control computer, four-path light source, preheat and constant heat controller, data storage and copy machine. The four-path light source is separately connected with pressure constant power, royal purple light switch motor, royal purple light switch, four-path specimen test bench and four-path light sources. The four-path specimen test bench is separately connected with preheat and constant heat controller, specimen mixture motor signal amplifier and controller and royal purple filter switch apparatus. The control computer is separately connected with data storage and copy machine and constant pressure power, signal amplifier and controller.

The invention discloses a bowel-relaxing and toxin-expulsing prescription. The bowel-relaxing and toxin-expulsing prescription is prepared through the steps that radix bupleuri, scutellaria baicalensis, pinellia ternate, immature bitter oranges, radix paeoniae alba, the root bark of the peony tree, curcuma aromatica, bighead atractylodes rhizome, poria cocos, rhizoma alismatis, periostracum cicada, stiff silkworms, turmeric, oriental wormwood, cape jasmine, Phyllanthus urinaria, radix sophorae flavescentis and schisandra chinensis are mixed together and placed in a medicine pot to be decocted, and then 10 g of raw rhubarb is added. The bowel-relaxing and toxin-expulsing prescription has the advantages that it is proved through the use result that the bowel-relaxing and toxin-expulsing prescription can obviously improve the hemodynamic indexes of the liver portal vein system and has the exact treatment effect for restoring liver functions and coagulation functions; the clinic cure rate of chronic severe hepatitis early-to-mid-stage damp-heat type patients is obviously increased, disease pain is greatly relieved, and the clinical symptoms and life quality of the patients are obviously improved; the treatment effect on hypercholesteremia and liver non-alcoholic fat deposition is prominent; the obvious treatment effect on bile reflux gastritis is achieved; the toxic and side effects of the traditional Chinese medicine prescription are low, safety is high, and the cure rate of the patients is increased to 90% or above.