59 results about "Coagulation function" patented technology

The invention provides a multi-module collaborative clinical blood coagulation function intelligent evaluation and drug recommendation system, and relates to the technical field of medical information processing. Comprising a data acquisition and fusion module, a state recognition module, a drug intervention effect evaluation module, a decision recommendation module and a system visualization module. According to the system, continuous integration of clinical scattered data is realized by constructing a unified time sequence structure of multi-source detection indexes and medication records; generating a blood coagulation state vector containing the bleeding risk and the thrombus risk through a state recognition mechanism combining rule judgment and data calculation, outputting a confidence score and an index contribution degree, and forming a state track evolving along with time; performing causal evaluation on the difference of the state change before and after intervention to obtain a drug average treatment effect; and individualized drug suggestion or early warning information is generated based on the state track and the intervention effect. And dynamic evaluation and drug intervention measurement and calculation of the blood coagulation risk are realized.

The invention discloses a multi-parameter thrombelastogram instrument for animal blood coagulation function evaluation. The multi-parameter thrombelastogram instrument comprises a magnetic suspension driving and sensing module, a multi-dimensional signal processing module, a species characteristic database module, a dynamic calibration and quality control module, an artificial intelligence decision module and a multi-mode interaction output module, the magnetic suspension driving and sensing module realizes high-precision blood coagulation monitoring through electromagnetic driving and nanoscale displacement detection; the multi-dimensional signal processing module adopts a composite algorithm to extract key parameters such as an R value and an MA value; the species characteristic database module is used for hierarchically storing multi-species blood coagulation data and supporting dynamic correction; the dynamic calibration and quality control module ensures the stability of the system through a three-level joint control mechanism; the artificial intelligence decision module provides blood coagulation risk assessment and medication suggestions based on the hybrid neural network; and the multi-modal interaction output module dynamically presents a detection result through a visual engine. The system has the characteristics of high sensitivity, interference resistance, cross-species adaptability and low output delay, and is suitable for blood coagulation function evaluation of various animals.

The invention relates to the technical field of biological medicine, in particular to construction and application of a candida patient death risk prediction model. The model is based on traditional SOFA scoring, core variables are screened through single-factor and multi-factor logistic analysis and LASSO regression analysis, respiratory system, blood coagulation function and circulatory system SOFA scoring and key indexes such as the maximum lactic acid value, the minimum albumin value and the maximum blood urea nitrogen (BUN) are integrated, and a prediction model is constructed through logistic regression. Through multi-center data verification, the AUC of an internal verification queue reaches 0.826, the AUC of an external verification queue is 0.813, and a calibration curve shows that the predicted death rate is highly consistent with the actual death rate. Patients can be divided into a high risk group and a low risk group through a 13-score threshold value, and the 28-day survival rate difference is significant (plt; 0.05) of the method. An efficient and convenient early risk assessment tool is provided for critical candida patients, and clinical precise intervention and prognosis improvement are assisted.

The invention relates to a preparation method of exosome-like nano vesicles. The preparation method comprises the following steps: extracting beet juice; performing low-speed centrifugal treatment on the beet juice, and taking supernate; carrying out medium-speed centrifugation treatment on the supernatant obtained by low-speed centrifugation, and taking the supernatant; carrying out high-speed centrifugation treatment on the supernatant obtained by medium-speed centrifugation to obtain a precipitate containing exosome-like nano vesicles; and carrying out sucrose density gradient ultracentrifugation on the obtained precipitate containing the exosome-like nano-vesicles to obtain the purified exosome-like nano-vesicles. The BELNV prepared by the invention can significantly improve the survival rate of sepsis mice, increase blood perfusion of tissues and organs of the sepsis mice, reduce pathological changes, macrophage infiltration and fibrin deposition in lung and liver tissues of the sepsis mice, and reduce blood coagulation indexes and inflammation indexes. The invention provides a novel treatment target and strategy for a treatment means of sepsis-related blood coagulation dysfunction.

The present application relates to a kind of aerosol delivery system toxicology scoring method and storage medium, method includes: setting target group, the test biological of target group is in aerosol exposure environment;Blood physiological index and multi-omics data of control group are obtained, the test biological of control group is in air exposure environment;Blood physiological index of target group is measured, and first toxicology score is determined according to the difference of blood physiological index of target group and control group;Multi-omics data of target group is measured, and second toxicology score is determined according to the difference of multi-omics data of target group and control group;According to first toxicology score and second toxicology score, determine the comprehensive toxicology score of target group;Blood physiological index includes blood biochemistry, coagulation function and hematology index;Multi-omics data includes transcriptomics, proteomics and metabolomics data.The present application is evaluated from macroscopic physiological level and microscopic molecular level by the above setting, the toxicological effect of aerosol such as electronic cigarette liquid etc. is evaluated comprehensively.

The invention belongs to the field of prediction, and particularly relates to a drainage tube blockage risk prediction method and system, specifically, historical flow data and patient physiological parameters in a preset time window are obtained; extracting a flow macroscopic fluctuation degree, screening a matched patient subgroup from the reference database according to the similarity between the patient information and the flow fluctuation degree, constructing a multidimensional normal distribution model in a normal state, and calculating a mahalanobis distance between a current patient feature and the center of the model to obtain a baseline deviation degree; performing time-frequency analysis on the weighted flow sequence to obtain an energy spectrum, calculating physiological association weights of different frequency bands by combining with a blood coagulation function index, and further extracting energy distribution of a key frequency band in the weighted energy spectrum as a flow fluctuation feature; and inputting the baseline deviation degree and the flow fluctuation characteristics into a pre-training model, and outputting a drainage tube blockage risk value.

The present application belongs to the field of photochemical therapy, and particularly relates to a method for photochemical treatment of riboflavin based on multi-wavelength LED and application thereof in treatment of graft-versus-host disease. The present application selects different wavelength LED combinations as light sources to optimize the riboflavin photochemical method, controls the light intensity at 1000-25000 μW / cm², controls the irradiation time at 5-15 minutes, and controls the riboflavin concentration at 20-150 μM, thereby significantly improving the photochemical reaction effect. The method can efficiently induce PBMC apoptosis in a plasma environment, significantly reduces the levels of key pro-inflammatory cytokines such as TNF-α, IL-6 and IFN-γ, and has no significant influence on platelets, hemoglobin and blood clotting function, thereby providing a safe and controllable new cell preparation method for GVHD treatment.

The invention relates to the technical field of medicines, in particular to application of benzbromarone in preparation of antithrombotic drugs. The research finds that benzbromarone clinically used for treating hyperuricemia can be combined with HSP47 on platelets to inhibit the interaction between the HSP47 and collagen so as to reduce platelet activation and thrombosis, which prompts that benzbromarone is an HSP47 inhibitor with an anti-platelet effect; benzbromarone has the effects of inhibiting mouse common carotid artery thrombosis and relieving cerebral ischemia reperfusion injury. Experiments finally confirm that benzbromarone can inhibit formation of common carotid artery thrombosis, does not affect the blood coagulation function, is low in cytotoxicity, has the drug effect similar to that of aspirin and clopidogrel which are commonly used at present, and can become an effective and safe therapeutic drug for cerebral arterial thrombosis.

The invention discloses a blood coagulation index detection system and method based on ultrasonic guided waves, and the method comprises the steps: calculating a blood coagulation index corresponding to a sample according to an obtained viscoelasticity change curve; comprising the following steps: the clot starting time is defined as the time interval from the time when a blood sample is placed in a blood clot index detection system to the time when initial fibrin starts to form, and the R time of a TEG detection result of a gold standard method is marked; the clot stabilization time is defined as the clot formation time of the blood sample and the K time of the TEG detection result of the gold standard method; the theta angle is used for measuring the generation and cross-linking speed of fibrin and the alpha angle of a TEG detection result of a gold standard method; the maximum clot strength is the MA value of the TEG detection result of the gold standard method. Compared with a TEG method, the method has the advantages that the detection time of blood coagulation indexes is remarkably shortened, time guarantee is provided for emergency blood coagulation function evaluation and reasonable application of blood products in an operation, and improvement of clinical prognosis is facilitated.

A system for detecting and quantifying platelet function and coagulation function within a biological sample is provided. The system includes a detection instrument with computing capability. The system includes an assay device capable of receiving a biological sample. Introduction of the biological sample into the assay device results in a biological process by which fibrin and platelets may accumulate at a reaction zone of the assay device. The assay device is capable of receiving one or more chemical reagents compatible with the biological sample and usable for detecting the accumulation of the fibrin and platelets within the reaction zone. The fibrin and platelets, and their associated signals, accumulated at the reaction zone of the assay device are usable to determine at least one of a platelet function, a coagulation function, platelet normalcy, fibrin normalcy, platelet response to a drug, and coagulation response to a drug, within the biological sample.

The invention relates to the technical field of intelligent nursing, in particular to a hemodialysis patient internal fistula pressing hemostasis self-adaptive regulation and control system fused with the NB-IoT technology, and the system comprises a sensor module which collects internal fistula puncture point pressure, local temperature and patient body movement data; the processing module is used for outputting a pressure regulation and control instruction through a self-adaptive control algorithm based on the internal fistula elasticity modulus, the blood coagulation function and the historical hemostasis threshold value of the patient after preprocessing the data, and has a fuzzy PID strategy and an abnormal value elimination function; the execution module adjusts the pressing pressure according to the instruction, and a feedback sensor is arranged in the execution module to form closed-loop control; the NB-IoT communication module encrypts and uploads data to a cloud platform through AES-128, and supports remote viewing and regulation; the power module is designed with low power consumption, and the endurance is longer than or equal to 7 days. Through real-time monitoring, self-adaptive control and remote interactive closed loop, the hemostasis success rate is increased to be larger than or equal to 92%, the subcutaneous hematoma occurrence rate is reduced to be smaller than or equal to 3%, the safety of a patient and the service life of internal fistula are guaranteed, and diagnosis and treatment convenience is improved.

A system for detecting and quantifying platelet function and coagulation function within a biological sample is provided. The system includes a detection instrument with computing capability. The system includes an assay device capable of receiving a biological sample. Introduction of the biological sample into the assay device results in a biological process by which fibrin and platelets may accumulate at a reaction zone of the assay device. The assay device is capable of receiving one or more chemical reagents compatible with the biological sample and usable for detecting the accumulation of the fibrin and platelets within the reaction zone. The fibrin and platelets, and their associated signals, accumulated at the reaction zone of the assay device are usable to determine at least one of a platelet function, a coagulation function, platelet normalcy, fibrin normalcy, platelet response to a drug, and coagulation response to a drug, within the biological sample.

A pulse pressing device for nursing comprises a storage battery, a wireless remote control mechanism, a pulse pressing belt, a fixing shell, a pulse pressing mechanism, a time control circuit, a wireless receiving circuit and a control circuit. The tourniquet is mounted on the wrist of a patient; the tourniquet mechanism comprises an electric push rod and a pressing plate, the upper end of the electric push rod is installed in a fixing shell, the lower end of a movable column of the electric push rod and the upper end of the pressing plate are installed together, and the fixing shell is installed outside the upper end of the tourniquet; the storage battery time control circuit, the wireless receiving circuit and the control circuit are installed in the fixing shell and electrically connected with the power input end of the electric push rod. According to the utility model, pulse pressing operation can be carried out on a surgical incision of a patient at regular intervals, so that automatic control is realized; and the electric push rod can be controlled in a wireless mode to drive the pressing plate to move upwards to press the pulse without manual approaching operation according to needs (some patients have good blood coagulation functions, and the pulse pressing time can be shortened through the operation), so that convenience is brought to nursing personnel, and the working efficiency of the nursing personnel is improved.

A microstructured hemostat comprising multiple layers of microstructure, each layer characterized by one or more length scales, is described. Microstructured hemostats of the present invention, can reduce the time for blood coagulation, control the morphology of the coagulation, and provide a novel diagnostic platform for evaluation of coagulation function from a morphological perspective.

The utility model discloses an anastomat assembly with a blood coagulation function. The anastomat assembly comprises a cutting knife assembly, a nail box inner core, a nail bin assembly and a nail abutting seat assembly. Wherein the cutting knife assembly comprises a cutting knife head, a cutting knife middle piece and a cutting knife side piece, the cutting knife head is located at the far end of the cutting knife middle piece, and the cutting knife head, the cutting knife middle piece and the cutting knife side piece are fixed together; the anastomat assembly further comprises a thermocouple assembly and an electric connection assembly, and the thermocouple assembly is connected with the electric connection assembly. The thermocouple assembly is arranged on the cutting tool bit and can heat the cutting tool bit; when the cutting knife assembly moves, the electric connection assembly and the thermocouple assembly keep a circuit closed. The endoscopic anastomat assembly is matched with an electric endoscopic anastomat to achieve a blood coagulation function on cut tissue capillaries, the amount of bleeding in an operation is reduced, postoperative recovery is faster, and the operation risk and the postoperative risk are reduced; the number of times for medical staff to clean errhysis at an operation site during an operation can be reduced, the labor of the medical staff is reduced, the operation duration can be shortened, and the working intensity of the medical staff is reduced.

The invention relates to the technical field of biomedical materials, and provides zeolite polyvinyl alcohol organic-inorganic composite embolization microspheres as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing nano zeolite with a blood coagulation function through ion exchange, dispersing the nano zeolite in silicone oil to form a continuous phase, and forming W / O type liquid drops from a polyvinyl alcohol dispersed phase solution and the continuous phase containing the nano zeolite by adopting a microfluidic technology; and crosslinking and curing by using an organic acid catalyst to obtain the zeolite polyvinyl alcohol organic-inorganic composite embolism microsphere with a physical embolism function and a procoagulant function. The zeolite polyvinyl alcohol organic-inorganic composite embolism microsphere takes cross-linked polyvinyl alcohol as a matrix, nano zeolite particles with specific functions are uniformly distributed on the surface, and the zeolite polyvinyl alcohol organic-inorganic composite embolism microsphere has a physical embolism function and a procoagulant function and has a wide application prospect in the fields of tumor embolism treatment, vascular malformation embolism, hemorrhagic disease treatment and the like; and a brand-new efficient embolism treatment solution is provided for clinic.

A system for detecting and quantifying platelet function and coagulation function within a biological sample is provided. The system includes a detection instrument with computing capability. The system includes an assay device capable of receiving a biological sample. Introduction of the biological sample into the assay device results in a biological process by which fibrin and platelets may accumulate at a reaction zone of the assay device. The assay device is capable of receiving one or more chemical reagents compatible with the biological sample and usable for detecting the accumulation of the fibrin and platelets within the reaction zone. The fibrin and platelets, and their associated signals, accumulated at the reaction zone of the assay device are usable to determine at least one of a platelet function, a coagulation function, platelet normalcy, fibrin normalcy, platelet response to a drug, and coagulation response to a drug, within the biological sample.

The utility model is suitable for the technical field of slaughter house facilities, and provides a slaughter blood collection pool which comprises a blood collection pool body. The frame is fixedly mounted at the top of the blood collection pool body; the water tank and the liquid storage tank are fixedly mounted at the top of the frame; the lifting mechanism and the spraying mechanism are arranged on the frame, the lifting mechanism is used for controlling the spraying mechanism to move up and down, and the spraying mechanism is used for spraying water or a blood anticoagulant into the blood collection pool body; the stirring mechanism is mounted on the blood collection pool body and used for stirring blood in the blood collection pool body. According to the slaughtering blood collection pool, blood can be collected in the livestock slaughtering process, impurities in the blood can be filtered out, meanwhile, the blood coagulation prevention function is achieved, livestock blood can be prevented from being rapidly coagulated, workers can further treat the livestock blood in the later period conveniently, and the working efficiency is improved. A worker can conveniently clean the inner wall of the blood collection pool.

The invention discloses an artificial blood vessel and a preparation method and application thereof, and relates to the technical field of artificial blood vessels, the artificial blood vessel comprises an artificial blood vessel stent material and a coating material at least partially coating the surface of the artificial blood vessel stent, and the coating material comprises a platelet coating, a GPIIb / IIIa receptor on the surface of a platelet membrane in the platelet coating is in a closed state. The platelet coating on the surface of the artificial blood vessel stent can promote recruitment, migration and proliferation of endothelial cells, so that the endothelialization process of the artificial blood vessel is accelerated; the GPIIb / IIIa receptor on the surface of the platelet membrane is in a closed state, so that the thrombus risk caused by platelets in the subsequent endothelialization process is avoided, and the blood coagulation function and the endothelialization function of the platelet coating are decoupled. The artificial blood vessel does not need additional chemical modification, the coating is biodegradable, and inflammation and foreign matter rejection phenomena caused by a traditional coating are avoided.

The invention relates to the technical field of oral medical monitoring, in particular to an oral postoperative bleeding risk prediction and intervention system based on multi-modal data fusion, and the system comprises the steps: collecting preoperative blood coagulation function detection data, intraoperative wound image data and postoperative continuous physiological sign monitoring data of a patient, and carrying out the standardization processing; extracting three types of parameters, namely a blood vessel exposure area ratio, tissue errhysis point distribution density and a wound edge contraction state, of the intraoperative wound image; carrying out association mapping on the three types of parameters and preoperative blood coagulation function data, and constructing a bleeding risk feature vector; training a bleeding risk classifier by using the vector to obtain a risk prediction model; inputting postoperative real-time physiological sign data into the model, obtaining a bleeding risk probability value and triggering corresponding intervention measures. The system can accurately capture the real-time state of the wound surface, integrates multi-dimensional data, improves the bleeding risk prediction accuracy, triggers intervention in time, and reduces postoperative bleeding complications.

The invention provides a PH-viscosity dual-response fluorescent probe, a preparation method and application, belongs to the technical field of fluorescent probes, and is technically characterized in that the structural formula of a probe molecule is shown in the specification. By optimizing a fluorescent skeleton and hydrophilic modification and calibrating pH / viscosity response mapping, the application can be used for rapidly screening a blood coagulation function, evaluating an anticoagulation treatment effect or researching and developing a portable thrombus detection device.

The application belongs to the technical field of medical decision support, and discloses a knee joint postoperative distal deep vein thrombosis prediction system; by acquiring multi-dimensional parameters such as coagulation function, metabolic function, inflammation ratio index and intra-articular injection history, the sodium hyaluronate injection history is converted into an articular lesion severity score, an inflammation-coagulation coupling characteristic vector and a metabolic disturbance correction model are innovatively constructed, and the synergistic effect among multiple systems is captured. A penalty regression model with cross-validation is used for sparse prediction factor screening, redundant variables are screened out through a regularization path shrinkage technology, and key prediction factors are reserved. Finally, an individualized thrombosis risk probability nomogram is constructed, and the prediction accuracy is verified through resampling calibration. The application realizes the multi-system integration of inflammation, coagulation, metabolism and joint degeneration factors, converts the complex statistical model into a clinically friendly tool, and optimizes the postoperative thrombosis prevention and control strategy.

This invention relates to the field of oral medical monitoring technology, specifically a postoperative oral bleeding risk prediction and intervention system based on multimodal data fusion. The system includes: collecting and standardizing preoperative coagulation function test data, intraoperative wound image data, and postoperative continuous physiological sign monitoring data; extracting three parameters from the intraoperative wound image: the proportion of exposed blood vessels, the density of tissue bleeding points, and the state of wound edge contraction; mapping these three parameters to the preoperative coagulation function data to construct a bleeding risk feature vector; training a bleeding risk classifier using this vector to obtain a risk prediction model; and inputting real-time postoperative physiological sign data into the model to obtain a bleeding risk probability value and trigger corresponding intervention measures. This system can accurately capture the real-time state of the wound, integrate multi-dimensional data, improve the accuracy of bleeding risk prediction, trigger timely intervention, and reduce postoperative bleeding complications.

The invention discloses a blood coagulation function and thrombus marker combined detection platform and method, and belongs to the field of blood detection.The detection device comprises a static magnetic field generation structure, a detection coil, a heating assembly and a magnetoelastic sensor, the heating assembly is used for heating a blood sample, and the magnetoelastic sensor is located in the center of the detection coil; the detection coil is electrically connected with the impedance analysis device, current is applied to the detection coil to generate an alternating magnetic field for working of the magnetoelastic sensor, the static magnetic field generation structure is used for generating a static magnetic field for working of the magnetoelastic sensor, and magnetic lines of the static magnetic field are parallel to magnetic lines of the alternating magnetic field. The impedance analysis device drives the detection coil to generate an alternating magnetic field around the magnetoelastic sensor, the magnetoelastic sensor generates resonance in the alternating magnetic field, the detection coil generates an induction signal, the impedance analysis device collects the induction signal, and through the design, joint detection of the thrombus marker and the blood coagulation function can be achieved on a single platform.

The invention discloses a hemostatic clip with a replaceable head and an insulated electrocoagulation function, and relates to the technical field of medical instruments, the hemostatic clip comprises a handle, an outer tube and a conductive steel wire, the outer tube is fixedly mounted at one end of the handle, the conductive steel wire is located in the outer tube, and one end of the conductive steel wire is connected with the handle. The device has the beneficial effects that through the synergistic effect of the positioning assembly, the connecting assembly and the length adjusting assembly, the performance of the device in the aspects of mechanical connection stability, electrical conduction reliability and mechanical transmission accuracy is comprehensively guaranteed while the chuck is successfully and conveniently replaced.

Provided here are antibodies that bind Protein S, and methods of making and using such antibodies. In some embodiments, the Protein S antibodies provided herein are useful for treating a bleeding disorder or platelet disorder, or a condition characterized by reduced or impaired blood coagulation and / or clotting.

The invention relates to the technical field of nutritious food, and discloses an anti-coagulation function enhanced type Echine 48k gel type sports nutritious food and a process, the food is a soft capsule, and the content of the food is a specific solid-liquid suspension system. The pH sensitive coating layer of the enteric coated enzyme core pellet used as a dispersion phase can protect the earthworm protein active component of nattokinase in the core to safely pass through a gastric acid environment and be subjected to targeted release in small intestines; and the intelligent suspension type self-microemulsifying oil phase system is used as a continuous phase. An oil phase system contains a thixotropic rheological regulator and an emulsifier, so that the pellets can be uniformly suspended in a static state, the physical stability of the product is ensured, a micro-emulsion is spontaneously formed in the digestive tract, and the absorption of functional lipids is promoted. The invention also discloses a preparation method, particularly an infrared-microwave combined vacuum drying process. According to the technical scheme, the synergistic interaction of solid-phase and liquid-phase functional components is realized, the bioavailability of active components is improved, and the production efficiency is improved.

The invention discloses hemostasis freezing gel with a rapid shape memory function as well as a preparation method and application of the hemostasis freezing gel. The preparation method comprises the following steps: preparing an interpenetrating polymer network precursor solution by using an acrylamide monomer, a sodium alginate solution and a chemical cross-linking agent; polymerizing a frozen precursor solution to construct a first network; and carrying out ionic crosslinking on a metal salt solution with a certain concentration to construct a second network, and finally carrying out freeze drying treatment to obtain the double-network hemostatic frozen gel, namely the PAAM / Alg-Mn < + > hemostatic frozen gel. According to the double-network hemostasis freezing gel with the rapid shape memory function, the preparation method and the application of the double-network hemostasis freezing gel, a double-network structure is constructed at the low temperature, the mechanical property and the liquid absorption rate are synchronously improved, and the double-network hemostasis freezing gel has the ultrafast shape memory recovery capacity, the excellent mechanical property and the active blood coagulation function; the material is endowed with multiple functions of active blood coagulation, magnetic response and the like, and rapid and efficient hemostasis on non-compressible deep wounds can be realized.

A system / method for detecting and quantifying platelet function and coagulation function within a biological sample is provided. The system includes a detection instrument with computing capability. The system includes an assay device capable of receiving a biological sample. Introduction of the biological sample into the assay device results in a biological process by which fibrin and platelets may accumulate at a reaction zone of the assay device. The assay device is capable of receiving one or more chemical reagents compatible with the biological sample and usable for detecting the accumulation of the fibrin and platelets within the reaction zone. The fibrin and platelets, and their associated signals, accumulated at the reaction zone of the assay device are usable to determine at least one of a platelet function, a coagulation function, platelet normalcy, fibrin normalcy, platelet response to a drug, and coagulation response to a drug, within the biological sample.

1. The name of the design product: thrombelastograph (Pre CF6000). 2. The use of the design product: for monitoring and analyzing the coagulation process, evaluating coagulation characteristics. A medical test device for monitoring coagulation function during operation, routine coagulation test and assisting clinical evaluation of patients. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.