9results about How to "Protective function" patented technology

The application discloses an application of an SIAH2 inhibitor to treating heart failure or improving myocardial cell function, relates to the technical field of medicine, and is used for researching the treatment effect and mechanism of SIAH2 on heart failure. The application provides an application of an SIAH2 gene or protein inhibitor to preparing a heart failure medicine, uses the SIAH2 inhibitor to intervene in a TAC-induced mouse heart failure model, finds that the SIAH2 inhibitor can improve myocardial energy metabolism and protect heart function, and provides a new target and strategy for clinically diagnosing and treating heart failure or improving myocardial cell function.

The utility model discloses an anti-impact wheel steel ring, and relates to the technical field of wheel steel rings. The wheel comprises a wheel rim, a supporting inner ring is fixedly installed on the inner wall of the wheel rim, an impact buffering assembly is arranged on the supporting inner ring, the end of the impact buffering assembly is connected with an annular protection plate which is used for protecting the surface of the wheel rim, impact force is buffered and absorbed through the impact buffering assembly, the wheel rim comprises a rim body, and the rim body is fixedly connected with the supporting inner ring. The spoke is fixedly installed on the inner wall of the rim, the supporting inner ring is fixedly installed on the inner wall of the rim, and the hub is fixedly installed at the end of the spoke. The supporting inner ring is used for enhancing the internal supporting structure of the rim and improving the overall strength, the annular protection plate is connected with the impact buffering assembly and used for preventing the surface of the rim from being directly impacted, impact force can be buffered and absorbed through the impact buffering assembly, damage of the impact force to the rim is effectively reduced, and the service life of the rim is prolonged. And the integrity and the functionality of the wheel rim are protected when the wheel rim is impacted.

The utility model discloses a welding cooling device, including support seat, set up the water storage groove on support seat, set up the flow guide spare on support seat, and the cavity that extends to the top is equipped in flow guide spare, and set up the water inlet and overflow port on flow guide spare, and water inlet and overflow port all are linked together with the cavity, and overflow port is linked together with water storage groove. This welding cooling device passes through the structural combination of support seat, water storage groove and is equipped with the flow guide spare of through cavity, has realized the complete cooling path of cooling medium from water inlet, flows through flow guide spare top, and then from overflow port flows to water storage groove. This design makes cooling medium to be able to directly contact welding area, effectively takes away the heat generated in the process of welding, solves the uneven cooling and the problem of low efficiency of traditional indirect type heat dissipation.

The present application relates to a kind of cartilage-like biomimetic double-sided hydrogel and its preparation method and application, belong to biomaterials technical field.The cartilage-like biomimetic double-sided hydrogel of the present application mainly includes ion salt bridge regulation self-assembly I type collagen, doped modified hyaluronic acid and metabolic regulator, wherein ion salt bridge regulation self-assembly I type collagen as main chain is crosslinked with doped modified hyaluronic acid by the combination mediated by covalent interaction, including Michael addition and Schiff base reaction and non-covalent hydrogen bond, the metabolic regulator is loaded in the hydrogel net cavity formed by self-assembly I type collagen and doped modified hyaluronic acid.The main chain of the hydrogel is I type collagen and doped modified hyaluronic acid chain with biocompatibility, biodegradability, gelation is rapid, efficient, and can be used for in situ gelation.By synergistic in situ mechanical metabolic regulation, become the new idea in the clinical management of osteoarthritis.

The utility model discloses a kind of double-row hole oil flinger fuel flow measuring devices, including support frame, outer collector, inner collector. Outer collector is installed in support frame;Inner collector is fixed in outer collector;Outer collector and inner collector are including oil collection end and outlet end, and the oil collection end of outer collector protrudes in the oil collection end of inner collector;Outer collector is close to inner collector, and fuel flow channel is left between the two, double-row hole oil flinger is closely attached to inner collector;The second row hole of double-row hole oil flinger is located in the oil collection end of inner collector, and the first row hole of double-row hole oil flinger is located in the oil collection end of outer collector;Double-row hole oil flinger one end is communicated with hollow shaft. The utility model is compact by modularization design, oil mist is isolated from source, without modification test bed, significantly improve the measurement accuracy and fuel collection rate, and easy to operate, data is reliable.

This invention belongs to the field of genetic engineering technology, and more specifically, relates to a drought-responsive gene in larch trees. LgLEA10 Proteins and their applications. This invention provides a larch drought response gene. LgLEA10 The nucleotide sequence of the protein is shown in SEQ ID NO.1, and the amino acid sequence of the protein it expresses is shown in SEQ ID NO.2. This invention is the first to demonstrate that the Dahurian larch... LgLEA10 The gene is a regulatory gene for the larch's response to drought. This invention demonstrates through experiments that... LgLEA10 Gene overexpression can enhance the drought resistance of larch by significantly increasing the activity of antioxidant enzymes and osmotic regulators. This discovery provides important genetic resources and theoretical basis for breeding new larch varieties with strong drought resistance.

The invention relates to probiotics with an effect of reducing uric acid and application of the probiotics in the field of microorganisms. The probiotic is lactobacillus rhamnosus, is named as CHP003, is preserved in the China General Microbiological Culture Collection Center on December 8, 2022, and has the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.26176. The invention further discloses a preparation method of the probiotic. The lactobacillus rhamnosus CHP003 strain has a plurality of probiotic effects, including reduction of the activity of xanthine oxidase (XOD) and effective reduction of the serum uric acid level of a hyperuricemia model, and provides a new thought and means for treatment and prevention of metabolic diseases such as hyperuricemia, gout and the like.

The invention belongs to the technical field of biology, and particularly relates to a mesenchymal stem cell exosome for overexpressing miR-29 and application of the mesenchymal stem cell exosome. The miR-29 is overexpressed by the mesenchymal stem cells, so that the content of key miRNA in the exosome is remarkably increased, and the function of the exosome in cerebral ischemia treatment is enhanced; the exosome is used as a cell-free treatment mode, so that the risks of cell proliferation, differentiation, immunological rejection and the like possibly caused by MSC transplantation are avoided, and standardization and large-scale preparation are easier; the mesenchymal stem cell exosome of the overexpressed miR-29 can simultaneously realize multiple effects, such as protecting neurons, promoting vascular regeneration, inhibiting inflammatory response, repairing blood-brain barrier and the like, so that cerebral arterial thrombosis can be more comprehensively treated; according to the scheme, through miRNA function enhancement, a stronger treatment effect is provided, and the problems of insufficient function, low miRNA content and weak targeting in existing mesenchymal stem cell exosome treatment are solved.

The application provides a pretreatment method for improving the freezing-recovery success rate of human embryonic stem cell differentiation middle stage cells and application, and comprises the following steps: before starting kidney organoid induction differentiation, culturing human embryonic stem cells in a composite culture system for a period of time; wherein the composite culture system comprises a basic culture medium and an additive, and the additive comprises a PD0332991 reagent. Through pretreatment of human embryonic stem cells before starting induction differentiation, the PD0332991 improves the tolerance of differentiation middle stage cells to freezing stress through a double mechanism of cell cycle regulation and stress defense enhancement, can obviously improve the freezing-recovery survival rate of Day4 differentiation middle stage cells under the premise of not affecting the differentiation potential of hESC, and ensures that most of the recovered cells continue to differentiate into kidney organoids with complete structure and normal marker expression.