216 results about "Covalent Interaction" patented technology

The invention discloses a probiotic-polyphenol nanoparticle colon-targeted co-delivery system as well as a preparation method and application thereof, and belongs to the field of biological medicines. The FCPs and hyaluronic acid (HA) are combined through non-covalent interaction, so that the hydrogel has colon targeting property and mucosal adhesion at the same time, and delivery of probiotics is facilitated. The hydrogel (HF) based on polysaccharide has good biocompatibility, and can be used for effectively encapsulating the probiotics and the natural products. Then, the PDA-TH NPs and BA are incorporated into the polysaccharide chain network of HF, and finally the BA-HF-PDAT targeted co-delivery system is constructed. The BA (at) HF-PDAT targeted co-delivery system can protect BA from serious gastrointestinal stress, and is jointly assembled with PDT-TH NPs to realize dual slow release of thymol (Thy), so that the treatment effect of BA and Thy is improved, and the BA (at) HF-PDAT targeted co-delivery system contributes to treatment of clostridium difficile infection (CDI).

The invention discloses a beta-lactoglobulin fluorescent probe as well as a preparation method and application thereof, the structural formula of the probe is (C30H25N4I), the probe is combined with beta-lactoglobulin through non-covalent interaction, a fluorescence signal is triggered to be remarkably enhanced, and low-background fluorescence detection of the beta-lactoglobulin is realized. The probe has low cytotoxicity and excellent mitochondrial targeting ability, and provides a powerful tool for visualization of beta-lactoglobulin in living cells. After being combined with beta-lactoglobulin, a sample can generate obvious color change under the irradiation of an ultraviolet lamp, and the change can be used for evaluating the content of active beta-lactoglobulin in the sample, so that the rapid detection of the milk protein level in a beverage is realized. The beta-lactoglobulin fluorescent probe disclosed by the invention has a wide application prospect in the fields of biological imaging, milk protein detection, beverage quality control and the like.

The invention belongs to the technical field of membrane material preparation and water treatment, and discloses a La-MOF-COOH / AO-PAN composite membrane material and a preparation method and application thereof, and the preparation method of the membrane comprises the following steps: preparing a PAN membrane; preparing an AO-PAN membrane; the preparation method comprises the following steps: preparing La-MOF-COOH; and the preparation of the La-MOF-COOH / AO-PAN film is carried out. The composite membrane material is composed of modified polyacrylonitrile fibers, metal lanthanum and an organic ligand. Amino groups and hydroxyl groups in amidoximated PAN participate in hydrogen bonds and covalent interaction, so that the interfacial compatibility and stability of La-MOF-COOH and AO-PAN are improved, agglomeration of La-MOF-COOH filler is avoided, the structural uniformity, stability and functionality of the La-MOF-COOH / AO-PAN composite membrane are improved, and the composite membrane has a good application prospect.

The invention relates to the field of preparation of polyurethane damping materials, in particular to a preparation method of a repairable polyurethane damping material based on multiple hydrogen bonds and metal coordination. Compared with a traditional damping material, the damping material has a higher damping temperature range and has a good damping effect at the temperature of-20 DEG C to 60 DEG C. Multiple reversible hydrogen bonds are introduced through diamine containing amido bonds, the material is endowed with self-repairing and high mechanical strength, and damping and self-repairing performance is further enhanced through pyridine nitrogen atom metal coordination. Starting from molecular structure design, multiple hydrogen bonds and metal-ligand coordination bonds constructed on a polyurethane molecular main chain play a role in synergistic enhancement, energy can be effectively dissipated through dissociation and recombination of the multiple hydrogen bonds and fracture and association of the metal coordination bonds, and the energy consumption is reduced. The polyurethane material is endowed with excellent damping performance and self-healing capability by the dual dynamic action.

The invention belongs to the technical field of emulsion materials, and particularly relates to metal-polyphenol network modified coconut protein composite particles as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing a coconut protein-pectin compound by taking coconut protein and pectin as raw materials, adding a tannic acid solution into the coconut protein-pectin compound, mixing, adding a Fe < 3 + > solution, and mixing to obtain metal-polyphenol network modified coconut protein composite particles; according to the preparation method, tannic acid and the coconut protein-pectin compound are subjected to non-covalent interaction, Fe < 3 + > and phenolic hydroxyl groups on the tannic acid are subjected to coordination reaction, a metal-polyphenol network is formed through cross-linking of Fe-O coordination bonds, and a compact modification layer is constructed on the surface of the coconut protein-pectin compound, so that on one hand, waste coconut protein resources are utilized; on the other hand, the problem that composite particles prepared from pectin and coconut protein are prone to depolymerization is solved, the structural stability is improved, and meanwhile iron and polyphenol are supplemented.

The invention discloses a phenoxazine derivative as well as a preparation method and application thereof, and belongs to the field of biological medicine synthesis. A series of phenoxazine derivatives are synthesized by using a simple, efficient and low-toxicity method, circular dichroism, fluorescence spectrum and ultraviolet absorption spectrum prove that the molecules not only have non-covalent interaction with DNA, but also can be subjected to transamidation reaction with the DNA to covalently modify the DNA, and meanwhile, the phenoxazine derivatives are relatively good in anti-tumor cell activity and relatively good in anti-tumor effect. And a new strategy is provided for the research of DNA targeted drugs.

The invention relates to a fluorescent array sensor, in particular to a difunctional fluorescent array sensor containing a modified high-molecular polymer, a preparation method of the difunctional fluorescent array sensor and application of the difunctional fluorescent array sensor in bacterial detection and fermentation carbohydrate detection. The array sensor comprises at least two different fluorescent sensing units, each fluorescent sensing unit is a PN-coumarin dye compound formed by covalent interaction of PN and coumarin dye, PN is a nitrophenylboronic acid modified high-molecular polymer PEI, the coumarin dye is 6, 7-diphenyl-1, 3, 4-triazole-3-carboxylic acid, and the coumarin dye is a coumarin dye compound. The compound is selected from the group consisting of 2, 7-dihydroxy-2H-benzopyran-2-one ES or 4-methylesculetin MS. The compound fluorescent array sensor disclosed by the invention can simultaneously realize distinguishing detection of thirteen types of bacteria related to IBS and fourteen FODMAPs, and has the advantages of high sensitivity, short detection time, low cost, good repeatability, high accuracy, no need of professional technicians and the like.

The invention discloses an oligonucleotide intracellular nano delivery system based on polypeptide modification and application thereof. The system is composed of a periostin targeting sequence (SDSSD), a matrix metalloproteinase 2 (MMP2) response sequence (GPAGLLG), a cell penetrating sequence (RRRRRRRR, R9), a reactive oxygen species (ROS) scavenging and adhesion enhancing group (Gly-DOPA)) and a terminal dibenzocyclooctyne (DBCO) modified engineered polypeptide SDSSD-PEG5-YGFGG-GPAGLLG-R9-(G-DOPA) 3-K4-C-DBCO, and a target oligonucleotide miRNA-26a-A5-Azido modified by 5-polyadenylic acid (AAAAA) and an azide group (Azido), and the target oligonucleotide miRNA-26a-A5-Azido, the target oligonucleotide and assembling through a click chemical reaction and a non-covalent interaction. The nano system has good bone targeting, enzyme responsiveness, intracellular delivery effect and biological safety, can realize stable and efficient delivery of therapeutic oligonucleotides in vivo, and significantly improves the utilization efficiency and therapeutic potential of oligonucleotides. The oligonucleotide intracellular nano delivery system has a wide application prospect in the fields of clinical transformation and precise treatment of oligonucleotide drugs.

The invention discloses a symmetric nucleoside microneedle patch loaded with polymer vesicles as well as a preparation method and application of the symmetric nucleoside microneedle patch. The symmetric nucleoside microneedle patch loaded with the polymer vesicles comprises a guanosine-quadruplex hydrogel microneedle tip doped with drug-loading polymer vesicles, the raw material of the drug-loaded polymer vesicle comprises a polycaprolactone-polyglutamic acid copolymer; the guanosine-quadruplex hydrogel is prepared from the following raw materials: guanosine and KB (OH) 4. The microneedle patch is constructed on the basis of dynamic covalent bond and non-covalent interaction, has a sharp tip array capable of penetrating the epithelium and the lower layer of a mucous membrane, can efficiently deliver a drug to a canker lesion part by bypassing a mucous membrane barrier, can be controllably broken under a high ROS condition of an inflammation microenvironment, has the characteristics of high drug delivery efficiency and high accuracy, and can be used for preparing a medicine for treating the canker lesion part. The effect of effectively improving chemotherapy-induced oral ulceration can be achieved by reducing inflammatory response, relieving pain feeling and inhibiting pain sensitization.

The invention is applicable to the technical field of polymer biomedical hydrogel materials, and provides a preparation method and application of multifunctional agarose-based particle composite hydrogel based on liquid-liquid phase separation, and the agarose-based particle composite hydrogel is a product formed by introducing microsphere particles into an agarose hydrogel body matrix; the microsphere particles are formed by a prepolymer and sodium lignin sulfonate through phase separation mediated by a composite behavior based on non-covalent interaction; the prepolymer is obtained by carrying out amine-epoxy reaction on an amino compound and an epoxy compound in water. According to the prepared agarose-based particle composite hydrogel, a microsphere particle structure is formed on the surface of an agarose matrix while positively charged amino groups and sodium lignin sulfonate are introduced, so that the multifunctional agarose-based particle composite hydrogel is prepared.

The invention provides a polyurethane urea elastomer, a preparation method and application thereof, and an ionic conductive elastomer, and belongs to the field of polymer materials. A soft-segment substance, isocyanate and a catalyst are subjected to a prepolymerization reaction to obtain a prepolymer, the prepolymer, a chain extender and an organic solvent are subjected to a chain extension reaction to obtain the PUU elastomer, the soft-segment substance contains hydroxyl, and the chain extender contains phenyl and a bishydrazide substituent. According to the invention, PUU is synthesized by a chain extender simultaneously containing phenyl and a bishydrazide substituent, the phenyl in the PUU can be assembled in situ based on pi-pi interaction to form an aggregate, and the aggregate and multiple hydrogen bonds between amido urea bonds on two sides of the aggregate jointly form a double-lock hard domain which has high binding energy and is cross-linked based on non-covalent interaction in the PUU. The unique structure of PUU improves the mechanical properties, including strength, elasticity and tear resistance, of the material on one hand, and endows the material with a function of repairing mechanical damage on the other hand.

The invention discloses a preparation process and application of a cationized exosome nucleic acid delivery system, the delivery system is prepared from an exosome and a cationic material through charge non-covalent interaction, and a nucleic acid therapeutic agent is loaded in the delivery system; the surface of the exosome is modified and transformed, so that the cellular uptake is enhanced, the delivery efficiency of the nucleic acid carrying drug of the exosome can be remarkably improved, and particularly, the targeted delivery effect of the exosome on the respiratory tract part is improved; by optimizing the modification ratio of the exosome to cations, the stability and expression level of the exosome carrying nucleic acid medicine are improved, and the exosome carrying nucleic acid medicine has efficient lung delivery capacity, shows remarkable treatment potential in tumor treatment, has a certain clinical application prospect, and has a wide application prospect. The invention further provides a preparation method of the efficient nucleic acid cationization exosome delivery system and application of the delivery system to treatment and / or prevention of related diseases or symptoms.

The invention discloses high-toughness recoverable bio-based polyurethane and a preparation method thereof. The preparation method comprises the following steps: dissolving dithiol, methacrylic acid-2-(tert-butylamino) ethyl ester and a photoinitiator in a good solvent according to a certain molar ratio to prepare a precursor 1 containing di-tert-butylamino; the preparation method comprises the following steps: dissolving 2, 5-furandimethanol, oligomer polyol, a precursor 1, diisocyanate and a catalyst in a good solvent according to a certain molar ratio to prepare a linear polymer; the linear polymer and the maleimide modified cellulose are dissolved in a good solvent according to a certain mass ratio and then poured into a mold, and the high-toughness recoverable bio-based polyurethane is prepared after the solvent is volatilized. The bio-based polyurethane disclosed by the invention contains double dynamic covalent bonds and multiple dynamic non-covalent bonds, and the advantages of high toughness and recoverability of the bio-based polyurethane are realized through dynamic covalent-non-covalent interaction.

The invention relates to a cationic tannin and prolamin composite nano system and a preparation method and application thereof.The cationic tannin and prolamin composite nano system is prepared through the steps that cationic tannin and prolamin are dissolved in an alcoholic solution through an anti-solvent dispersion method, then the alcoholic solution is dropwise added and dispersed in water, and the cationic tannin and prolamin composite nano system is obtained. Nano-particles are formed through self-assembly under the interaction of non-covalent acting force between cationic tannin and prolamin in an aqueous solution, and the composite nano-system is applied to water treatment. Compared with the prior art, the water treatment agent is good in storage stability and has excellent performance of removing antibiotic pollution in a water body.

The invention discloses a synthesis method and application of a non-condensed ring electron acceptor, which are different from a traditional condensed ring structure or a single alkyl chain side chain, and a dichlorobenzene unit is introduced as a conformation regulating group. As chlorine atoms have strong electronegativity and proper atomic radius, remarkable non-covalent interaction such as Cl-S and Cl-pi can be generated among molecules. The interaction is similar to a set of precise molecular guide rails, molecules are guided to perform highly ordered pi-pi accumulation, so that electron cloud overlapping is remarkably enhanced, and an efficient electron transmission channel is constructed. According to the organic solar cell prepared based on the non-condensed ring electron acceptor material designed by the invention, the electron mobility is remarkably improved, and meanwhile, the charge recombination loss of a device is effectively reduced.

The invention belongs to the field of natural plant extraction, and particularly relates to a method for extracting volatile oil from pepper. The method comprises the following steps: pulverizing a pepper raw material to obtain pepper powder, protecting an active component and modified maltodextrin, mixing, soaking the pepper powder in an obtained efficient leaching suspension, ultrasonically crushing the soaked mixture, and carrying out primary extraction to obtain primary extracted oil with obviously improved purity; the preparation method comprises the following steps: mixing a composite solvent formed through non-covalent interaction and combination with primarily extracted oil, filtering, carrying out molecular distillation on the obtained permeate, reducing the boiling point of an active ingredient by the composite solvent through a solvation effect, reducing thermal degradation, and remarkably improving the purity of the active ingredient while retaining the flavor through non-covalent pre-assembly-molecular distillation synergy. Light-phase fractions are collected after molecular distillation, and the prepared pepper volatile oil is high in active ingredient content, good in flavor retention, few in impurities and pure in color.

The invention discloses a drawing rope type supramolecular subject-guest as well as a preparation method and application of the drawing rope type supramolecular subject-guest. The construction unit of the drawing rope type supramolecular subject-object is an assembly constructed by taking a structure as shown in a formula I as a subject macroring and a structure as shown in a formula II as a guest molecule through non-covalent interaction. The drawing rope type supramolecular host-guest is high in thermal stability and can resist high temperature, mechanical properties of a polymer in the aspects of hardness, toughness and strength can be comprehensively improved by adding the drawing rope type supramolecular host-guest into a polymerizable system, and regulation and control of the mechanical properties of the polymer can be achieved by changing the proportion of host macrocycles to guest molecules. Therefore, the functional polymer with various mechanical properties is obtained.

The invention provides a production system and a production method of 3-methoxy-N, N-bis (2-ethoxyl) aniline. According to the production method, functionalized ionic liquid ([HEMIM] HSO4, [HEMIM] H2PO4, [APMIM] HSO4 and [APMIM] H2PO4) and triethylamine are adopted to construct an efficient synergistic catalysis system. Amino (-NH2) or hydroxyl (-OH) of a cation side chain of the ionic liquid is combined with nitrogen atoms of triethylamine through hydrogen bonds, meanwhile, acidic anions (HSO4 <-> / H2PO4 <->) of the ionic liquid and protonated triethylamine ([H-TEA] < + >) generated in the reaction can form strong ion pairs, and the overall stability of a catalytic system is remarkably enhanced through the multiple non-covalent interaction. Compared with traditional acid catalysis or single ionic liquid catalysis, the synergistic catalysis system is high in catalytic activity, excellent in selectivity and high in stability, and the yield and purity of the target product 3-methoxy-N, N-bis (2-ethoxyl) aniline can be remarkably improved.

The application provides a cucurbituril fluorescent probe and a preparation method and application thereof, and a qualitative and quantitative detection method of melamine, and belongs to the field of substance detection. The application provides a cucurbituril fluorescent probe, which comprises cucurbit[8]uril (CB[8]) and rhodamine, and the rhodamine is included in the cavity of the cucurbit[8]uril. The application contains the rhodamine in the cavity of CB[8] through host-guest non-covalent interaction, and aims at detecting melamine; the probe has high sensitivity, simple operation and the characteristics of rapid detection.

This invention relates to a hyaluronic acid composite hydrogel based on the supramolecular self-assembly of natural molecules and its preparation method, belonging to the field of gel formulation technology. The invention first involves the self-assembly of specific natural molecules or their derivatives possessing hyaluronidase inhibitory and anti-inflammatory activities into stable supramolecular self-assemblies through intermolecular non-covalent interactions. Subsequently, this supramolecular self-assembly is combined with hyaluronic acid through various interactions such as physical entanglement, hydrogen bonding, van der Waals forces, or appropriate chemical cross-linking to construct a composite hydrogel with a uniform internal structure and stable performance. This invention not only achieves long-term, controllable sustained release of natural active ingredients in the gel through supramolecular loading, continuously inhibiting hyaluronidase activity and local inflammatory responses, but also avoids the residual risks associated with high dosages of traditional chemical cross-linking agents, ultimately obtaining a high-quality product that meets the appearance and performance requirements of medical hyaluronic acid gels.

The invention relates to organic gel as well as a preparation method and application thereof. The organic gel comprises an organic gelling agent and a solvent A. The preparation method comprises the following steps: mixing the organic gelling agent with the solvent A to prepare the organic gel. A stable gel system with a three-dimensional network structure is formed through non-covalent interaction of intermolecular hydrogen bonds, Van der Waals force and the like, the gel system is endowed with thermodynamic reversibility, self-repairing capability and environmental adaptability, the solvent A is wide in application range, and absolute configuration of chiral carbon atoms has no obvious influence on the property of the organic gel.

The present invention discloses a micro-foamed and micro-crosslinked low-VOC antibacterial sealing material and its manufacturing method. The material includes ethylene propylene diene monomer (EPDM), unsaturated polyurethane prepolymer (USPU), ionized polyurethane elastomer (i-TPU), reinforcing agent, and other additives. Among them, USPU is a polyurethane prepolymer with double bonds in the side chain, which can perform surface coating treatment on the reinforcing agent and chemically crosslink with the EPDM matrix to form a multi-level network. i-TPU is a polyurethane elastomer containing quaternary ammonium ions, which forms a solid filler network structure through non-covalent interaction with inorganic particles, and the ionic moiety endows the material with antibacterial and antistatic properties. The micro-foaming process during the vulcanization of the material promotes the rapid volatilization of VOC small molecules, and USPU vulcanizes to form a chemical crosslinking network, which cooperates with the non-covalent interaction of i-TPU to achieve the barrier effect on VOC small molecules after the material is formed. The material can be used as a low-VOC, antibacterial, antistatic, anti-aging, and fatigue-resistant sealing material for high-speed trains such as maglev trains and passenger cars.

This invention discloses a magnetic covalent organic framework composite material modified with nucleic acid aptamers, its preparation method, and its applications. The composite material uses magnetic iron oxide microspheres as the core, with the surface of the core coated with a shell of covalent organic framework material. Nucleic acid aptamers capable of specifically recognizing tetracycline antibiotics are stably assembled onto the shell surface through non-covalent interactions. This invention fully utilizes the large specific surface area and electron-rich framework of magnetic covalent organic framework materials as efficient carriers for nucleic acid aptamers, effectively overcoming the shortcomings of traditional adsorption materials in terms of poor selectivity and limited adsorption capacity in complex matrices, while avoiding cumbersome covalent modification processes. This composite material exhibits excellent adsorption capacity and superior selectivity for tetracycline antibiotics, and is particularly suitable for rapid and efficient magnetic solid-phase extraction of trace tetracycline antibiotics in complex animal-derived food matrices, significantly improving the detection sensitivity and accuracy of subsequent instrumental analysis.

The invention discloses a selenium molybdate compound constructed by rigid binary / polybasic carboxylic acid ligands as well as a preparation method and application of the selenium molybdate compound. The molecular formula of the compound is as follows: compound 1, (Me2NH2) 14 [(Se2Mo12O42) 2 {O2CC2H2CO2} 3]. 12H2O; a compound 2 is (Me2NH2) 14 [(Se2Mo12O42) 2 {O2CC4H4CO2} 3]. 9H2O; the compound 3 is (TEAH) 28 [(Se2Mo12O42) 4 {C6H4 (CO2) 3} 4]. 27H2O. The polyoxometallate-based proton conductor constructed by the invention has good thermal stability and structural stability at the same time. The polyoxometallate-based proton conductor can maintain the structural stability through the covalent interaction between the ligand and the polyoxometallate (selenium molybdenum oxygen cluster), can realize rapid transmission of protons under the conditions of medium temperature (100 DEG C) and high humidity (98% RH), and meets the requirements of high-performance proton conductive materials in the solid electrolyte material market.

The invention provides an SPI-CS-EGCG ternary complex as well as a preparation method and application thereof. The preparation method of the ternary complex comprises the following steps: respectively preparing an SPI solution, a CS solution and an EGCG solution; adjusting the pH value of the SPI solution, and heating to obtain SPI microgel; the SPI microgel and a CS solution are mixed and stirred, and an SPI-CS mixed solution is obtained; and mixing and stirring the SPI-CS mixed solution and the EGCG solution, and centrifuging to obtain the SPI-CS-EGCG ternary complex. According to the SPI-CS-EGCG ternary complex, the functional characteristics of SPI are remarkably improved through non-covalent interaction (hydrogen bonds, hydrophobic interaction and Van der Waals' force), and the SPI-CS-EGCG ternary complex has good thermal stability, rheology and tribology characteristics, so that the SPI-CS-EGCG ternary complex has wide application prospects in the food industry.

This invention relates to a mixed solvent-induced highly fluorescent silver nanoclusters, its preparation method, and its application in LEDs. These highly fluorescent silver nanoclusters are formed by the self-assembly of Ag6 in a mixed solvent of water and NMP through non-covalent interactions such as hydrogen bonding and π-π / π* interactions. Due to the restriction of ligand rotation and vibration, the silver nanoclusters exhibit significant fluorescence properties, with fluorescence intensity reaching 10⁻⁶. 7 The fluorescence lifetime is 11.77 μs and the quantum yield is 17.57%. The method for preparing high-fluorescence silver nanoclusters of the present invention is simple and inexpensive; when mixed with commercial phosphors, it can modulate white LEDs and can be used as a light conversion material for environmentally friendly WLEDs.

The application relates to a kind of room temperature phosphorescence composite films based on covalent cross-linking strong mechanical performance and preparation method, belong to room temperature phosphorescence film preparation technical field.Synthetic and configure inorganic suspension, polymer and phosphorescent molecule solution, make phosphorescent molecule, inorganic and polymer simultaneously occur multiple covalent reaction;Remove solvent to obtain organic-inorganic composite room temperature phosphorescence film with covalent network structure.The covalent rigid network between polymer-phosphorescent molecule-inorganic effectively limits the non-radiative transition of phosphorescent molecule, and high-efficiency room temperature phosphorescence performance is obtained.The external stress received by the composite material can be dissipated or transferred to the inorganic phase through covalent bond, thereby obtaining a composite film with high mechanical strength.The application proposes a method based on multiple covalent interactions between organic and inorganic units to construct a material with mechanical performance and room temperature phosphorescence performance, which can be effectively controlled according to the number of covalent bonds, has high luminous efficiency, good mechanical performance and shows high sensitivity phosphorescence response to mechanical deformation.

The invention relates to a supramolecular self-assembly hydrophobic surfactant as well as a preparation method and application thereof, and belongs to the technical fields of supramolecular self-assembly, surface modification engineering and hydrophobic coatings. The surfactant comprises a fluorine-containing compound and absolute ethyl alcohol, and the fluorine-containing compound is self-assembled in the absolute ethyl alcohol to form uniformly dispersed nano small particles; the fluorine-containing compound is obtained by reacting 4-aldehyde imidazole with hexamethylene diisocyanate and then grafting the reaction product on 1H, 1H, 2H, 2H-perfluoro-1-alcohol. Self-assembly in absolute ethyl alcohol is achieved through non-covalent interaction of fluorine-containing compounds, a nano-scale lotus leaf bionic structure is constructed, and the nano-structure material has hydrophobicity and also has a lotus leaf-imitated microcosmic hydrophobic structure and has good hydrophobicity. And when the catalyst is used for Al surface modification, the hydrophobic protection performance of Al can be improved, and a large number of active sites are reserved.

The invention discloses a compound protein stabilizer for a high-internal-phase Pickering emulsion. The compound protein stabilizer is formed by compounding plant protein isolate and animal protein through non-covalent interaction, the plant protein isolate is quinoa protein, the animal protein is whey protein, the particle size of nanoparticles formed after compounding is smaller than or equal to 300 nm, and the Zeta potential is smaller than or equal to-25 mV. The invention provides reliable experimental basis and theoretical basis for further development of edible materials loaded with antioxidant active ingredients in the field of food health.

Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.