107 results about "Covalent Interaction" patented technology

The invention relates to the field of preparation of polyurethane damping materials, in particular to a preparation method of a repairable polyurethane damping material based on multiple hydrogen bonds and metal coordination. Compared with a traditional damping material, the damping material has a higher damping temperature range and has a good damping effect at the temperature of-20 DEG C to 60 DEG C. Multiple reversible hydrogen bonds are introduced through diamine containing amido bonds, the material is endowed with self-repairing and high mechanical strength, and damping and self-repairing performance is further enhanced through pyridine nitrogen atom metal coordination. Starting from molecular structure design, multiple hydrogen bonds and metal-ligand coordination bonds constructed on a polyurethane molecular main chain play a role in synergistic enhancement, energy can be effectively dissipated through dissociation and recombination of the multiple hydrogen bonds and fracture and association of the metal coordination bonds, and the energy consumption is reduced. The polyurethane material is endowed with excellent damping performance and self-healing capability by the dual dynamic action.

The invention discloses a synthesis method and application of a non-condensed ring electron acceptor, which are different from a traditional condensed ring structure or a single alkyl chain side chain, and a dichlorobenzene unit is introduced as a conformation regulating group. As chlorine atoms have strong electronegativity and proper atomic radius, remarkable non-covalent interaction such as Cl-S and Cl-pi can be generated among molecules. The interaction is similar to a set of precise molecular guide rails, molecules are guided to perform highly ordered pi-pi accumulation, so that electron cloud overlapping is remarkably enhanced, and an efficient electron transmission channel is constructed. According to the organic solar cell prepared based on the non-condensed ring electron acceptor material designed by the invention, the electron mobility is remarkably improved, and meanwhile, the charge recombination loss of a device is effectively reduced.

The invention provides a production system and a production method of 3-methoxy-N, N-bis (2-ethoxyl) aniline. According to the production method, functionalized ionic liquid ([HEMIM] HSO4, [HEMIM] H2PO4, [APMIM] HSO4 and [APMIM] H2PO4) and triethylamine are adopted to construct an efficient synergistic catalysis system. Amino (-NH2) or hydroxyl (-OH) of a cation side chain of the ionic liquid is combined with nitrogen atoms of triethylamine through hydrogen bonds, meanwhile, acidic anions (HSO4 <-> / H2PO4 <->) of the ionic liquid and protonated triethylamine ([H-TEA] < + >) generated in the reaction can form strong ion pairs, and the overall stability of a catalytic system is remarkably enhanced through the multiple non-covalent interaction. Compared with traditional acid catalysis or single ionic liquid catalysis, the synergistic catalysis system is high in catalytic activity, excellent in selectivity and high in stability, and the yield and purity of the target product 3-methoxy-N, N-bis (2-ethoxyl) aniline can be remarkably improved.

The application provides a cucurbituril fluorescent probe and a preparation method and application thereof, and a qualitative and quantitative detection method of melamine, and belongs to the field of substance detection. The application provides a cucurbituril fluorescent probe, which comprises cucurbit[8]uril (CB[8]) and rhodamine, and the rhodamine is included in the cavity of the cucurbit[8]uril. The application contains the rhodamine in the cavity of CB[8] through host-guest non-covalent interaction, and aims at detecting melamine; the probe has high sensitivity, simple operation and the characteristics of rapid detection.

This invention relates to a hyaluronic acid composite hydrogel based on the supramolecular self-assembly of natural molecules and its preparation method, belonging to the field of gel formulation technology. The invention first involves the self-assembly of specific natural molecules or their derivatives possessing hyaluronidase inhibitory and anti-inflammatory activities into stable supramolecular self-assemblies through intermolecular non-covalent interactions. Subsequently, this supramolecular self-assembly is combined with hyaluronic acid through various interactions such as physical entanglement, hydrogen bonding, van der Waals forces, or appropriate chemical cross-linking to construct a composite hydrogel with a uniform internal structure and stable performance. This invention not only achieves long-term, controllable sustained release of natural active ingredients in the gel through supramolecular loading, continuously inhibiting hyaluronidase activity and local inflammatory responses, but also avoids the residual risks associated with high dosages of traditional chemical cross-linking agents, ultimately obtaining a high-quality product that meets the appearance and performance requirements of medical hyaluronic acid gels.

This invention discloses a magnetic covalent organic framework composite material modified with nucleic acid aptamers, its preparation method, and its applications. The composite material uses magnetic iron oxide microspheres as the core, with the surface of the core coated with a shell of covalent organic framework material. Nucleic acid aptamers capable of specifically recognizing tetracycline antibiotics are stably assembled onto the shell surface through non-covalent interactions. This invention fully utilizes the large specific surface area and electron-rich framework of magnetic covalent organic framework materials as efficient carriers for nucleic acid aptamers, effectively overcoming the shortcomings of traditional adsorption materials in terms of poor selectivity and limited adsorption capacity in complex matrices, while avoiding cumbersome covalent modification processes. This composite material exhibits excellent adsorption capacity and superior selectivity for tetracycline antibiotics, and is particularly suitable for rapid and efficient magnetic solid-phase extraction of trace tetracycline antibiotics in complex animal-derived food matrices, significantly improving the detection sensitivity and accuracy of subsequent instrumental analysis.

This invention relates to a mixed solvent-induced highly fluorescent silver nanoclusters, its preparation method, and its application in LEDs. These highly fluorescent silver nanoclusters are formed by the self-assembly of Ag6 in a mixed solvent of water and NMP through non-covalent interactions such as hydrogen bonding and π-π / π* interactions. Due to the restriction of ligand rotation and vibration, the silver nanoclusters exhibit significant fluorescence properties, with fluorescence intensity reaching 10⁻⁶. 7 The fluorescence lifetime is 11.77 μs and the quantum yield is 17.57%. The method for preparing high-fluorescence silver nanoclusters of the present invention is simple and inexpensive; when mixed with commercial phosphors, it can modulate white LEDs and can be used as a light conversion material for environmentally friendly WLEDs.

The invention relates to a supramolecular self-assembly hydrophobic surfactant as well as a preparation method and application thereof, and belongs to the technical fields of supramolecular self-assembly, surface modification engineering and hydrophobic coatings. The surfactant comprises a fluorine-containing compound and absolute ethyl alcohol, and the fluorine-containing compound is self-assembled in the absolute ethyl alcohol to form uniformly dispersed nano small particles; the fluorine-containing compound is obtained by reacting 4-aldehyde imidazole with hexamethylene diisocyanate and then grafting the reaction product on 1H, 1H, 2H, 2H-perfluoro-1-alcohol. Self-assembly in absolute ethyl alcohol is achieved through non-covalent interaction of fluorine-containing compounds, a nano-scale lotus leaf bionic structure is constructed, and the nano-structure material has hydrophobicity and also has a lotus leaf-imitated microcosmic hydrophobic structure and has good hydrophobicity. And when the catalyst is used for Al surface modification, the hydrophobic protection performance of Al can be improved, and a large number of active sites are reserved.

Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.

This invention discloses a ternary composite foaming agent of flaxseed protein-fucose-rutin, its preparation method, and its application in meringue cookies. The foaming agent is a non-covalent complex formed by flaxseed protein isolate (FPI), fucoidan (FUC), and rutin (RU) through electrostatic interactions, hydrogen bonds, and hydrophobic interactions, with a mass ratio of FPI:FUC:RU = 1:2:(0.2~0.4). This invention forms a structurally stable composite system through the non-covalent interactions of FPI, FUC, and rutin, achieving a foaming height of 95.69±8.77%. The foam retention rate after 30 minutes is more than double that of natural FPI, and the interfacial tension is reduced to below 25 mN / m, overcoming the shortcomings of poor foaming properties and insufficient stability of single plant proteins. Even after high-temperature baking, the foam retention rate remains above 75%, meeting the processing requirements of meringue cookies.

The invention discloses a protein ligand binding affinity prediction method based on two-channel hierarchical interactive learning, and particularly relates to an affinity prediction method based on two-channel hierarchical interactive learning. The method comprises the following steps: S1, based on a protein-ligand compound space structure containing a three-dimensional structure and chemical data, constructing six chemical entity interaction diagram networks from an atomic scale to a substructure scale; s2, extracting covalent and non-covalent interaction information of protein-ligands from the internal and external channels at the same time by taking a dual-channel coding framework as a backbone; and S3, adopting a hierarchical interactive learning strategy. According to the affinity prediction method based on the two-channel hierarchical interactive learning, provided by the invention, understanding of protein-ligand complex interaction is enhanced through a technology of modeling richness and complexity of protein-ligand interaction information, so that the protein-ligand binding affinity is comprehensively and accurately predicted.

An amphiphilic drug carrier and the use thereof in the ocular delivery of a biomacromolecular drug. The amphiphilic drug carrier is capable of penetrating the ocular mucus barrier, loading a biomacromolecular drug by means of non-covalent interaction, and delivering the biomacromolecular drug for the treatment of fundus diseases.

Described are affinity purification system that includes a carrier / surface that is non-cellular, and sliding clamp (SC) protein, and methods for purifying proteins that bind to the SC. The SC is associated with the carrier / surface via covalent / non-covalent interactions. To attain control of coupling site, the SC can be mutated via site-directed mutagenesis to introduce an exogenous residue and, the exogenous internal residue is conjugated to the non-cellular surface through the linker. The SC can also be coupled to the carrier via non-covalent interactions such as the affinity interactions involved in ligand / binding partner complex formation.The SC-based affinity purification system are used in a purification column as bait proteins, to isolate SC binding partners or non SC-binding proteins engineered to contain a SC binding site prior to its purification.

The invention belongs to the technical field of environmental restoration, and particularly relates to cyclodextrin cross-linked supramolecular hydrogel as well as a preparation method and application thereof. A construction unit of the supramolecular hydrogel comprises double-bond modified beta-cyclodextrin and acrylic acid interacting with the double-bond modified beta-cyclodextrin through a covalent bond; plant hormones are included in a cavity of the double-bond modified beta-cyclodextrin. The supramolecular hydrogel adhesive tape is provided with charges and cavities, can include plant hormones, and can be used together with soil improvement plants such as green manure to enhance the saline-alkali soil improvement effect by regulating and controlling the salinity of plant rhizosphere soil, improving the emergence rate, promoting plant growth and improving the environmental stress resistance of the plants. Cavities of the double-bond modified beta-cyclodextrin can effectively include plant hormones, and the supramolecular hydrogel is formed through covalent interaction between the acrylic acid and the double-bond modified beta-cyclodextrin. Based on multi-covalent and non-covalent interaction, the supramolecular hydrogel has the advantage of controllably releasing plant hormones, and realizes sustainable environmental remediation by cooperating with plant remediation.

The invention belongs to the technical field of biomedical materials and tissue engineering, and particularly relates to hydrogel for treating ulcerative colitis and a preparation method thereof. The hydrogel is prepared from four functional components including oxidized dextran, chitosan, L-arginine and trithiohydracrylic acid through synergistic crosslinking, wherein the four functional components include the oxidized dextran, the chitosan, the L-arginine and the trithiohydracrylic acid; an aldehyde group of the oxidized dextran and an amino group of the chitosan are subjected to a Schiff base reaction to form a dynamic covalent cross-linked network, and a basic skeleton of the hydrogel is formed; l-arginine and guanidyl are integrated into the dynamic covalent cross-linked network through amino of the L-arginine, and trimercaptopropionic acid and carboxyl of the trimercaptopropionic acid are integrated into the dynamic covalent cross-linked network through a covalent bond or a non-covalent effect through sulfydryl of the trimercaptopropionic acid, so that a multi-site synergistic cross-linked structure is formed. The invention can solve the technical problems of single function, weak targeting property, insufficient oxidation resistance, short mucous membrane residence time, side effect risk caused by loading of exogenous drugs, limited curative effect, drug resistance and the like of the traditional treatment material.

The application belongs to the technical field of water body remediation, and particularly relates to a method for removing heavy metals in water bodies by using supramolecular hydrogel. The supramolecular hydrogel used in the application is amino clay and carboxymethyl beta-cyclodextrin supramolecular hydrogel. The supramolecular hydrogel used in the application has charges and a porous structure, can produce adsorption on heavy metal ions, and can remove heavy metal ions in water bodies, has high environmental remediation efficiency, has a short remediation period, and has a water body heavy metal ion removal rate of more than 99% at 14 days. The supramolecular hydrogel used in the application has high-performance capture of chemical pollutants based on the porous structure and orthogonal non-covalent interaction-electrostatic interaction, and can be an efficient platform for sustainable water body environmental remediation.

The application provides a platelet-responsive self-gelation hemostatic material and a preparation method and application thereof, and belongs to the medical field. Based on a multiple cross-linking strategy of dynamic covalent bonds and non-covalent interactions, a hemostatic material capable of realizing self-gelation quickly is designed by using modified sodium alginate and hydroxylated porcine small intestinal submucosa as raw materials. The hemostatic material has good hydrophilicity and liquid absorption capacity, can realize powder-gelation transformation in a short time, form a stable physical barrier, has platelet response characteristics, can promote platelet adhesion and activation, accelerate the blood coagulation process of the body, and improve the mechanical properties and tissue adhesion of the material, and has a good application prospect.

This invention discloses a method and system for training and identifying non-covalent interaction models. The identification method includes: acquiring the spatial structure information of the molecular structure to be identified; inputting the spatial structure information of the molecular structure to be identified into an identification model based on a preset electron density; and generating the position coordinates and topological features of non-covalent interactions in the molecular structure to be identified through the identification model. The technical solution provided by this invention solves the problem of inaccurate identification of non-covalent interactions in molecular systems.

This application discloses a glass powder, a conductive paste, a conductive electrode, and a crystalline silicon solar cell, relating to the field of semiconductor technology. The glass powder, by weight, comprises the following components: 56.5 mol%–72.5 mol% of a first glass forming body; 12 mol%–22 mol% of a glass intermediate; 7.5 mol%–14.5 mol% of a corrosive oxide; and 2.5 mol%–10 mol% of a modifier. In this application, the amount of corrosive oxide is limited to provide the etching activity required for effective contact formation while suppressing excessive chemical etching. The glass intermediate provides cations with high field strength, which form strong ionic covalent interactions with oxygen, thereby enhancing the bonding strength of the glass network. The modifier provides high-valence cations to adjust the charge compensation and coordination environment in the network to obtain good structural stability.

The invention belongs to the technical field of adhesives, and particularly relates to an adhesive as well as a preparation method, application and a use method thereof. According to the method, bamboo wood is disintegrated to obtain an extract with lignin as a main component, and the extract and cellulose are assembled through non-covalent interaction to construct the adhesive; the obtained adhesive is adhered to a base material in a high-temperature hot pressing manner, so that the use of toxic reagents such as formaldehyde is avoided while high-strength adhesion is realized. The adhesive obtained by the invention can stably bond wood and various substrates, is waterproof, formaldehyde-free, green and environment-friendly, and the preparation method is simple and does not need precious precise instruments.

This invention relates to the field of medical materials technology, providing a hydrogel containing antler mesenchymal stem cell exosomes, its preparation method, and applications. The method includes the following steps: preparation of antler mesenchymal stem cell exosomes; preparation of PVP-HA composite hydrogel; uniformly mixing AMSC-Exos with a hydrogel precursor solution, and forming a hydrogel containing antler mesenchymal stem cell exosomes through physical embedding and non-covalent interactions. This invention utilizes the three-dimensional porous network structure of the hydrogel to achieve long-term sustained release of exosomes, protecting them from rapid degradation; it leverages the unique regenerative advantages of antler-derived exosomes to synergistically promote angiogenesis, inhibit inflammatory responses, and regulate macrophage polarization; it promotes angiogenesis through the miR-486-5p / FGF9 axis, achieving efficient repair of chronic diabetic wounds; and it provides a novel, efficient, safe, and clinically translational strategy for the treatment of chronic diabetic skin lesions.

The application discloses a preparation method and application of a nano self-assembly composition of arbutin-berberine, and comprises the following steps: dissolving berberine in methanol at 38-42 DEG C, adding an arbutin super-pure water solution at 38-42 DEG C, and stirring and keeping warm for 0.8-1.2 h to obtain a self-assembly solution; then, the self-assembly solution is subjected to vacuum rotary evaporation and freeze drying in sequence, and the nano self-assembly composition of arbutin-berberine is obtained. The traditional Chinese medicine nano self-assembly system based on arbutin and berberine is successfully constructed, the nanoparticles are spontaneously formed under mild conditions through intermolecular non-covalent interaction, the preparation process is simple and convenient, the conditions are mild, the damage of high temperature and other harsh conditions to active ingredients is effectively avoided, and the process adaptability is high.

The invention discloses a fluorinated metal organic framework material as well as a preparation method and application thereof, and belongs to the technical field of metal organic framework materials. Under the condition of room temperature, adding the deprotonation agent solution into the 2-trifluoromethylimidazole solution, uniformly mixing, and dropwise adding the zinc salt solution into the mixed solution under vigorous stirring; and after dropwise adding is finished, continuously stirring and reacting, and then standing, centrifuging, washing and drying in vacuum to obtain the fluorinated metal organic framework material. The fluorinated metal organic framework material prepared by the invention is based on an F-F non-covalent interaction mechanism, and can directly realize high-efficiency adsorption of long-chain perfluorinated and polyfluoroalkyl substances (PFAS) in a neutral water body under the condition that the salinity does not need to be adjusted. The maximum adsorption capacities of the material to PFOA (perfluorooctanoic acid), PFOS (perfluorooctanoic acid), PFNA (perfluorooctanoic acid), PFNS (perfluorooctanoic acid) and HFPO-TeA (hexafluoropropylene oxide-TeA) respectively reach 529.64 mg / g, 585.33 mg / g, 1135.18 mg / g, 1346.72 mg / g

The application discloses a high-flux fiber physiological electrode, a preparation method, an electrode array and application thereof, and belongs to the field of flexible electronics and biomedical sensing. The electrode adopts a three-layer coaxial fiber structure, the inner layer is a high-conductivity core layer containing MXene, carbon nanotubes and poly 3,4-ethylenedioxythiophene, the middle layer is an insulating layer such as polydimethylsiloxane, and the outer layer is a self-adhesive layer based on dynamic bond cross-linked polyvinyl alcohol and polyacrylic acid. The diameter of a single fiber is 50-100 mu m. By utilizing the reversible adhesion characteristics of the outer layer dynamic bond and / or non-covalent interaction, multiple fibers can be freely assembled into a high-density and reconfigurable electrode array. The array has excellent electrochemical performance, mechanical matching, interface adhesion stability and biocompatibility, and has a stimulation response and self-healing ability, is suitable for long-term stable wearable physiological monitoring and implantable closed-loop neural interface, and can realize high spatiotemporal resolution bioelectric signal recording and regulation.

This invention discloses a butyrate prodrug co-assembled with artesunate, its preparation method, and its application in kidney diseases, belonging to the field of biomedical technology. The invention first uses docosahexaenoic acid (DHA) as a hydrophobic framework, coupling it with 2,2'-dithiodiethanol to introduce disulfide bonds, and then grafts butyrate via esterification to obtain a butyrate prodrug. The butyrate prodrug and artesunate self-assemble through non-covalent interactions to obtain a co-assembled drug in nanoparticle form. This nanomedicine possesses excellent long-term in vivo circulation and passive targeted accumulation in the kidneys, and can achieve targeted drug release in response to the high-glutathione microenvironment within lesion cells. The two active ingredients synergistically exert metabolic regulation, anti-inflammatory, and antioxidant effects, inhibiting kidney inflammation and oxidative stress at multiple targets, protecting renal tubular epithelial cells, and effectively intervening in the pathological process of acute kidney injury. Furthermore, this drug has high biosafety, is simple to prepare, and is easy to scale up, showing broad application prospects in the prevention and treatment of kidney diseases.

The invention belongs to the technical field of biological medicine and nano delivery, and particularly relates to a protein crown delivery system and a preparation method and application thereof. According to the protein crown delivery system provided by the invention, the specific bifunctional polypeptide is utilized to modify the surfaces of the gold nanoparticles, and various active proteins can be efficiently and stably combined to form the protein crown, so that the active proteins can be delivered in cells. Specifically, rich side chain groups of bifunctional polypeptide molecules are utilized to solve the problem of few binding sites between a protein crown delivery system and protein molecules, so that the protein crown delivery system and the protein molecules are combined and assembled through non-covalent interaction to form a uniform and stable protein crown structure, and the binding efficiency of a carrier and protein is improved; therefore, a universal, efficient and safe protein nano intracellular delivery carrier is constructed. The protein crown delivery system provided by the invention can be coupled with various types of proteins, and keeps the biological activity and function of the proteins, so that intracellular delivery can be performed on the proteins with different activities.

The invention belongs to the technical field of pest control, and relates to application of an azo compound as an arginine kinase inhibitor and prevention and control of ampullaria gigas. The azo compound 4-[2-(2-isopropyl-5-methylphenoxy) ethyoxyl]-3-methoxybenzaldehyde (4, 6-dipyrrolidine-1-yl-1, 3, 5-triazine-2-yl) hydrazone obtained through screening can be jointly and stably combined with arginine kinase through multiple types of non-covalent interaction, and the function of an arginine kinase inhibitor is played. When the azo compound provided by the invention is used for preventing and treating ampullaria gigas, an excellent poisoning effect is shown, the activity of the azo compound is higher than that of an existing arginine kinase inhibitor quercetin, and the azo compound is good in selectivity and low in toxicity to vertebrates compared with a traditional molluscicide metaldehyde.

The invention discloses a signal-drift-free and low-lag ionization type capacitance pressure sensor and a preparation method and application thereof. The ionization type capacitance pressure sensor comprises a capacitance medium and substrates which are attached to the upper surface and the lower surface of the capacitance medium and comprise electrodes. The capacitor medium takes silicone rubber foam as a matrix, the surface of the silicone rubber foam is uniformly coated with a layer of polydopamine, the polydopamine is combined on the surface of the silicone rubber foam through multi-covalent and non-covalent interaction, and a bis (fluorosulfonyl) imide ion layer is formed on the surface of the polydopamine through protonation and ion exchange. The ionizing capacitive pressure sensor provided by the invention shows excellent detection performance in a wider pressure range, is high in sensitivity, high in response speed, good in long-term stability, capable of working in a wider temperature range and good in high and low temperature resistance stability, and the stability is remarkably superior to that of a traditional ion electronic sensor; and a solid foundation is laid for the development of real-time physiological signal monitoring and intelligent man-machine interaction systems.

The present application belongs to the cross field of acoustics, medicine and hydrogel materials, and discloses a single-side adhered solid ultrasonic coupling pad and application thereof. The single-side adhered solid ultrasonic coupling pad comprises a polyol moisturizing agent component, a phenolic adhesive component and a polyacrylic adhesive component, and is a homogeneous hydrogel sheet formed through covalent and non-covalent interactions. The content of the phenolic component is lower than that of the polyacrylic component. The phenolic component comprises polydopamine and tannic acid. The mass ratio of tannic acid to acrylic acid contained in the polyacrylic component is 1:15-3:15. Of the upper and lower surfaces of the homogeneous hydrogel sheet, only one surface is subjected to chitosan oligosaccharide solution immersion treatment and loses adhesion, and the other surface retains adhesion. The single-side adhered full-flexible solid coupling pad made of pure hydrogel in the present application can be used as a coupling medium for ultrasonic detection, the single-side adhered surface of the patch can be closely adhered to an ultrasonic probe, and the other surface can slide on the skin surface for imaging.

Elastomer-based styrene-type block copolymer (SBC) compositions are provided. The compositions comprise one or more SBCs and one or more polymers miscible with the styrene-type end blocks of the one or more SBCs. The block copolymer compositions are physically crosslinked and chemically crosslinked, wherein the chemical crosslinking includes covalent bonds between the chains of the SBCs, and the physical crosslinking includes non-covalent interactions between the styrene-type end blocks of the one or more SBCs and the one or more polymers miscible with the styrene-type end blocks. The block copolymer compositions can be used to form impregnated articles such as surgical gloves.