Acid choline biomimetic polymers coated carbon-nano tube and preparation method thereof

A carbon nanotube and phosphorylcholine-based technology, applied in the interdisciplinary field of disciplines, can solve the problems of stability, dispersion and biocompatibility, the destruction of the physical structure and mechanical properties of carbon nanotubes, and the limitation of carbon nanotubes. Regardless of practical application and other issues, to achieve good solubility, stable non-covalent interaction, and good biocompatibility

Inactive Publication Date: 2008-05-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

People have used N,N-dimethylacrylamide, N-isopropylacrylamide, (meth) tert-butyl acrylate, poly-p-chloromethyl styrene, (methyl), styrene, methyl acrylate , (meth) hydroxyethyl acrylate, etc., the carbon nanotubes are modified by the method of covalent bond grafting. These grafted hydrophobic polymer strategies enhance the carbon nanotubes Stability in organic solvents, but stability, dispersibility, and biocompatibility in aqueous and physiological environments have not been addressed
Although the covalent modification of hydrophilic polymers such as polyvinylpyrrolidone, polyethylene oxide or polyacrylic acid can improve the water solubility of carbon nanotubes, the harsh conditions in the chemical modification process have a negative impact on the physical structure and mechanical properties of carbon nanotubes. The properties caused great damage, and the resulting carbon nanotubes were not stable in high salt concentration or wide pH range
All these unfavorable factors greatly limit the practical application of carbon nanotubes in the field of biomedicine

Method used

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  • Acid choline biomimetic polymers coated carbon-nano tube and preparation method thereof
  • Acid choline biomimetic polymers coated carbon-nano tube and preparation method thereof
  • Acid choline biomimetic polymers coated carbon-nano tube and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] 1) In a 100mL three-neck flask, add 50mL of dichloromethane, then add 1g of cholesterol, and in the case of argon flow at 10°C, add 4.6g of bromoisobutylyl bromide dropwise to the solution, and react for 5hr to obtain cholesterified Atom transfer radical initiator.

[0031] 2) In a polymerization tube, add 10 mL of methanol, 10 mg of the above atom transfer radical polymerization initiator, and 1 g of phosphorylcholine methacrylate. After the polymerization tube was deoxygenated, 10 mg of cuprous chloride and 10 mg of bipyridine were added to it, the solution was dark brown, and reacted at 25° C. for 8 hours to obtain a phosphorylcholine amphiphilic polymer containing hydrophobic terminal cholesterol.

[0032] 3) In the Erlenmeyer flask, add 1g of carbon nanotubes and 10g of an aqueous solution of phosphorylcholine amphiphilic polymer (I) containing 1wt% cholesterol-containing degree of polymerization n=50, and then use a 40kHz ultrasonic wave to the mixed solution Dis...

Embodiment 2

[0038] 1) In a 100mL three-necked flask, add 50mL of dichloromethane, then add 1g of pyrene, and in the case of argon flow at 25°C, add 10g of bromoisobutylyl bromide dropwise to the solution, and react for 0.1hr to obtain pyrene-containing Atom transfer radical initiator.

[0039] 2) In a polymerization tube, add 10 mL of methanol, 10 mg of the above atom transfer radical polymerization initiator, and 50 mg of phosphorylcholine methacrylate. After the polymerization tube was deoxygenated, 20 mg of cuprous chloride and 50 mg of bipyridine were added to it, and the solution was dark brown. After reacting at 10° C. for 10 hr, a phosphorylcholine amphiphilic polymer containing pyrene at the hydrophobic end was obtained.

[0040] 3) In the Erlenmeyer flask, add 50g of carbon nanotubes and 2000g of an aqueous solution containing 0.05wt% of pyrene-containing phosphorylcholine amphiphilic polymer (I) with a degree of polymerization n=50, and then use a 40 kHz Ultrasonic ultrasonic d...

Embodiment 3

[0046]1) In a 100mL three-necked flask, add 50mL of dichloromethane, then add 1g of PLA, and add 0.1g of bromoisobutylyl bromide dropwise to the solution under the condition of argon flow at 50°C, and react for 10 hours to obtain PLA-containing atoms Transfer radical initiator.

[0047] 2) In a polymerization tube, add 10 mL of methanol, 10 mg of the above atom transfer radical polymerization initiator, and 0.5 g of phosphorylcholine methacrylate. After the polymerization tube was deoxygenated, 50 mg of cuprous chloride and 40 mg of bipyridine were added to it, the solution was dark brown, and reacted at 50° C. for 0.1 hr to obtain a phosphorylcholine amphiphilic polymer containing hydrophobic terminal PLA.

[0048] 3) In the Erlenmeyer flask, add 50g of carbon nanotubes and 2000g of an aqueous solution containing 0.05wt% PLA-containing phosphorylcholine amphiphilic polymer (I) with a degree of polymerization n=50, and then use a 40 kHz Ultrasonic ultrasonic dispersion for 4 ...

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Abstract

The invention discloses a carbon nano-tube covered by phosphorylcholine base biomimetic polymer and a preparation method thereof. The invention utilizes phosphorylcholine amphiphilic polymer comprising a hydrophobic segment to carry out non-covalent coverture of the carbon nano-tube, uses the hydrophobic segment to carry out non-covalent interaction with the carbon nano-tube and uses the phosphorylcholine to improve dissolubility, dispersion stability and blood compatibility of the carbon nano-tube in water. The method uses the phosphorylcholine amphiphilic polymer comprising the hydrophobic segment, the carbon nano-tube and water as raw materials and obtains the carbon nano-tube covered by the phosphorylcholine base biominetic polymer by assistance of ultrasonic dispersion and centrifugal method. The invention has simple technique and good stability, and the dissolubility of the prepared water-soluble carbon nano-tube reaches as high as 3mg / mL, thus having considerable application prospect in the field of drug delivery, gene transmission, molecular diagnosis and detection, separation of biomolecules, biosensor, etc.

Description

technical field [0001] The invention relates to a carbon nanotube coated with a phosphorylcholine-based biomimetic polymer and a preparation method thereof, and belongs to the interdisciplinary field of materials, biology, physics, chemistry and the like. Background technique [0002] Since its discovery in 1991. Carbon nanotubes have attracted great research interest in the field of biomedicine because of their excellent electrical conductivity, electromagnetic properties, excellent mechanical properties and excellent comprehensive properties. Due to the huge specific surface area of ​​carbon nanotubes, there is a very strong agglomeration effect between them. Carbon nanotubes mostly exist in the form of bundles formed by a large number of single carbon nanotubes side by side, making carbon nanotubes almost insoluble in all solvents. This greatly limits the practical application of carbon nanotubes. In addition, non-aqueous dispersed and stabilized carbon nanotubes cannot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B31/02B82B3/00
Inventor 计剑徐建平徐方明金桥沈家骢
Owner ZHEJIANG UNIV
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