Systematic evolution of ligands by exponential enrichment: Chemi-SELEX

a technology of exponential enrichment and ligands, applied in the field of systematic evolution of ligands by exponential enrichment, can solve the problems of few successes and perform over a somewhat narrow range of chemical possibilities, and achieve the effect of less laborious
US20060088877A1Inactive Publication Date: 2006-04-27GILEAD SCI INC
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Patent Information

Authority / Receiving Office
US Β· United States
Patent Type
Applications(United States)
Current Assignee / Owner
GILEAD SCI INC
Publication Date
2006-04-27
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

This application provides methods for identifying nucleic acid ligands capable of covalently interacting with targets of interest. The nucleic acids can be associated with various functional units. The method also allows for the identification of nucleic acids that have facilitating activities as measured by their ability to facilitate formation of a covalent bond between the nucleic acid, including its associated functional unit, and its target.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation of U.S. patent application Ser. No. 09 / 974,330, filed Oct. 9, 2001, which is a continuation of U.S. patent application Ser. No. 09 / 412,017, filed Oct. 4, 1999, now U.S. Pat. No. 6,300,074, which is a continuation of U.S. patent application Ser. No. 08 / 460,888, filed Jun. 5, 1995, now U.S. Pat. No. 5,962,219, which is a continuation of U.S. patent application Ser. No. 08 / 400,440, filed Mar. 8, 1995, now U.S. Pat. No. 5,705,337, each entitled β€œSystematic Evolution of Ligands by Exponential Enrichment: Chemi-Selex,” which is a continuation-in-part of U.S. patent application Ser. No. 07 / 714,131, filed Jun. 10, 1991, entitled β€œNucleic Acid Ligands,” now U.S. Pat. No. 5,475,096, which was filed as a continuation-in-part of U.S. patent application Ser. No. 07 / 536,428, filed Jun. 11, 1990, entitled β€œSystematic Evolution of Ligands by Exponential Enrichment,” now abandoned. This application is also a continuation-in-part of U.S. ...

Claims

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