5 results about "TEST Mixture" patented technology

The application discloses a detection mixture for predicting the sensitivity of PRMT5 inhibitor in treating tumors, and belongs to the technical field of biological medicine. The detection mixture comprises: a BRCA gene mutation detection agent; and / or, a DNA damage level detection agent; and / or, an IFN pathway level detection agent. The application verifies the use of the BRCA gene mutation, the DNA damage level and the IFN pathway level in the reagent for predicting the sensitivity of the PRMT5 inhibitor in preventing and / or treating solid tumors. The BRCA gene mutation detection agent, the DNA damage level detection agent or the IFN pathway level detection agent can be used for preparing the reagent for predicting the sensitivity of the PRMT5 inhibitor in preventing and / or treating solid tumors.

The application provides a mixture identification method and device based on infrared spectrum and de-peak matching, which comprises the following steps: constructing a to-be-tested characteristic peak set according to a to-be-tested infrared spectrum of a to-be-tested mixture, and constructing a sample characteristic peak set according to sample infrared spectrum of a plurality of sample substances; iteratively performing de-peak matching on the to-be-tested characteristic peak in the to-be-tested characteristic peak set and the sample characteristic peak in the sample characteristic peak set, performing similarity matching on the characteristic peaks in the to-be-tested characteristic peak set and the sample characteristic peak set corresponding to each de-peak matching, deleting the to-be-tested characteristic peak with the maximum similarity from the to-be-tested characteristic peak set after each de-peak matching, and deleting all sample characteristic peaks of the sample substance corresponding to the sample characteristic peak with the maximum similarity from the sample characteristic peak set, so as to obtain a sample substance set matched with the to-be-tested mixture, and further automatically identifying the component result of the to-be-tested mixture. The application realizes automatic and accurate mixture identification.

This application relates to a method and its application for improving the detection signal value of photo-induced chemiluminescence (PET). The method includes: mixing a companion reagent with antibody-coated luminescent microparticles, antibody-coated biotin, avidin-coated photosensitive microparticles, and a sample to be tested, reacting the mixture to generate a test mixture; exciting the test mixture at least once with excitation light, and measuring the amount of emitted photons to obtain a light signal value; wherein the companion reagent includes an oxygen-generating agent and a catalyst, the oxygen-generating agent undergoes a catalytic reaction under the action of the catalyst to generate oxygen, and the oxygen provides singlet oxygen for PET detection. The solution provided in this application can improve the detection signal value of PET, thereby enhancing the stability, sensitivity, and precision of the detection.

The present invention relates to an improved method for determining the amount of FVIII inhibitors in a patient sample, comprising the provision of a patient plasma sample, a normal pool plasma samples, and a control plasma sample which is FVIII / VWF deficient, inactivating all clotting factors present in the samples, addition of recombinant FVIII (rFVIII) to the control plasma sample, combination of the patient plasma sample with the control plasma sample with rFVIII to obtain a test mixture, and of the normal plasma pool sample with the control plasma sample with rFVIII to obtain a control mixture, incubation of the test mixture and the control mixture for less than 30 minutes, and analyzing the mixtures for residual rFVIII activity in the absence of VWF.

The invention belongs to the technical field of acetonitrile detection, and particularly discloses an acetonitrile recognition method, device, medium and equipment, the method comprises the following steps: mixing a sample to be detected with a colorimetric detection reagent to obtain a mixture to be detected; carrying out image acquisition on the mixture to be detected; preprocessing the image, and extracting an ROI (Region of Interest) of the preprocessed image to obtain an ROI (Region of Interest) image; and inputting the ROI image into an acetonitrile recognition model to judge whether the sample to be detected is acetonitrile or not and output an acetonitrile concentration value. According to the invention, rapid, objective and accurate on-site qualitative and quantitative detection of acetonitrile can be realized.