105 results about "Dendrimer" patented technology

The invention relates to exosome-coated dendrimer nanogel co-loaded with gold nanoparticles and antibiotics as well as a preparation method and application of the exosome-coated dendrimer nanogel, the dendrimer nanogel is taken as a carrier, the gold nanoparticles and drugs are co-loaded in the carrier, and the surface of the carrier is coated with exosome. The operation condition is simple, purification is easy, the bioavailability of antibiotics can be improved, targeted delivery and responsive release of the medicine at the focus position are achieved, and the good application prospect in pulmonary tuberculosis treatment is achieved.

The invention relates to an exosome-coated phosphorus-containing dendrimer nano-composite as well as a preparation method and application thereof. The nano-composite is prepared from exosome derived from mesenchymal stem cells, a hydroxyl-terminal phosphorus-containing dendrimer and quercetin. The exosome derived from the mesenchymal stem cells is used as a carrier, so that not only are good biocompatibility and anti-inflammatory activity achieved, but also the bioavailability of the phosphorus-containing dendrimer and quercetin can be improved. The phosphorus-containing dendrimer and quercetin exert anti-inflammatory and anti-oxidation effects by promoting microglial cells to be polarized to M2 type and removing active oxygen, so that neuronal cells are protected from apoptosis. The preparation method has the advantages of being simple, easy to operate, good in biocompatibility and the like, and the provided strategy has good development prospects and application values in treatment of Parkinson's disease or other neurodegenerative diseases.

The application relates to the field of supramolecular chemistry and discloses a dendrimer supramolecular gel factor and application thereof. The molecular structure of the gel factor is a polybenzyl ether dendrimer modified by peripheral halogen atoms (chlorine, bromine or iodine). The gelation performance of the gel factor can be precisely controlled by changing the type, substitution number and position of the peripheral halogen, and the type and generation of the dendrimer. The dendrimer gel factor provided by the application has very excellent gelation performance. The dendrimer gel factor can effectively gelate in dozens of solvents such as polar solvents, non-polar solvents and mixed solvents containing water, and the minimum gelation concentration CGC is 1.5 mg / mL, belonging to a super gel factor. In addition, the gel factor has a simple preparation method and high yield, and is very suitable for being developed into a general and commercial supramolecular gel factor and applied to the preparation of various soft material functional materials.

The invention relates to hydroxylated polyamide-amine dendrimer integrated drug-loaded nanogel as well as a preparation method and application thereof. The drug-loaded nanogel comprises third-generation polyamide-amine dendrimer integrated nanogel modified by double bonds and high-density hydroxyl groups, MnO2 nanoparticles and quercetin, wherein the nanogel is loaded with MnO2 nanoparticles in situ, and quercetin is physically wrapped in the nanogel. The drug-loaded nanogel disclosed by the invention can enhance a blood-brain barrier penetrating effect, regulate microglial cells and neurons in a double-target manner and remodel a brain inflammation microenvironment, so that neuroinflammation and dyskinesia of a Parkinson's disease model mouse are relieved, and the curative effect of the Parkinson's disease is improved. The compound has good development prospect and application value in treatment of Parkinson's disease or other neurodegenerative diseases.

The application provides a kind of smart parent tree macromolecule based on DASA and a preparation method thereof.Hydrophilic alkoxy ether dendritic unit, combined with hydrophobic visible light responsive DASA, constructs a new type of smart parent tree macromolecule based on DASA.The parent tree macromolecule of the application can self-assemble in aqueous solution and its self-assembly behavior can be controlled by light and temperature.The unique topological structure of alkoxy ether dendritic unit, crowding synergistic effect and temperature-induced multi-stage dehydration collapse mechanism can construct a hydrophobic microenvironment, which can be regulated by changing the end group structure of alkoxy ether unit, alkoxy chain length and alkoxy ether arm number, so as to realize the regulation of the reversible isomerization behavior of DASA in aqueous solution.In addition, the raw materials are environmentally friendly, cheap, low toxicity and have good biocompatibility, which shows great application potential in the fields of biomedicine and photosensitive materials.

The invention relates to the technical field of oil exploitation, and relates to an alcohol-based fracturing fluid containing modified nanoparticles and a preparation method thereof, the alcohol-based fracturing fluid comprises the following components: an alcohol solvent, modified nanoparticles, an anti-swelling agent, a thickening agent, a polyamide-amine dendritic polymer, a pH regulator, an optional suspending agent and water; the modified nano-particles are prepared by modifying nano-particles with an alkenyl silane coupling agent, then copolymerizing the modified nano-particles with alkenyl-containing imidazolium salt, and grafting polyimidazolium salt on the surfaces of the nano-particles in situ. The preparation method comprises the following steps: modifying nanoparticles by using an alkenyl silane coupling agent, copolymerizing with alkenyl-containing imidazolium salt to form polyimidazolium salt, and grafting the polyimidazolium salt on the surfaces of the nanoparticles in situ to form modified nanoparticles; the anti-swelling property, the cross-linking property and the sand-carrying capacity of the alcohol-based fracturing fluid are remarkably improved through the combined action of the modified nanoparticles and the polyamide-amine dendritic polymer, and the gel forming and hanging time is 60-90 s, so that the alcohol-based fracturing fluid is particularly suitable for medium-high-temperature deep wells.

The invention belongs to the technical field of medical polymer materials, and discloses hydrogel as well as a preparation method and application thereof. The hydrogel comprises the following raw materials: a macromonomer, a polyamidoamine dendrimer, a photoinitiator, a delayed photosensitizer and a solvent, the mass ratio of the macromonomer to the polyamidoamine dendrimer is (1: 10)-(10: 1). The hydrogel has high transparency and excellent puncture resistance, and a needle passage left after the hydrogel is punctured can be quickly self-repaired, so that no trace is left after repeated puncture, and ultrasonic imaging is prevented from being interfered.

The application relates to the field of supramolecular chemistry, and discloses a peripheral trifluoromethyl functionalized polybenzyl ether dendrimer gelator, a preparation method and application thereof. The peripheral trifluoromethyl functionalized polybenzyl ether dendrimer gelator is shown in the following formula, can form stable supramolecular organic gels or supramolecular self-assembly systems in various organic solvents or mixed solvents through the synergistic effect of multiple pi-pi interactions between peripheral aromatic rings and F...H weak hydrogen bonds, has a minimum gelation concentration CGC of 3.2 mg / mL, and is easy to be functionally modified, for example, a gel with an aggregation-induced emission performance is prepared by introducing 1-pyrene or 9-anthracene functional groups. The preparation method of the gelator is efficient, high-yield and high-purity.

The present disclosure provides for a method of producing an amine from an alcohol that includes supplying a heterogeneous supported metal catalyst, where the heterogeneous supported metal catalyst comprises nanoparticles of an alloy encapsulated with a dendrimer on a solid support, where the alloy is of Formula I: where Pd is palladium; x is an integer of 20 to 30; y is an integer of 10 to 20, and M is selected from the group consisting of nickel (Ni), cobalt (Co), ruthenium (Ru) and rhodium (Rh), with the caveat that when y is 10, M is not Ni; mixing the heterogeneous supported metal catalyst with a first reagent containing an alcohol moiety and a second reagent containing an amine moiety to form a mixture; and heating the mixture to a predetermined temperature for a predetermined time to produce an amine compound.

The invention provides a dendrimer-modified phthalocyanine photosensitive compound and application thereof, the dendrimer-modified phthalocyanine photosensitive compound has any one structure as shown in formulas I-IV, and the photosensitive compound has the advantages of simple and controllable synthesis, clear structure, strong light killing ability and the like. The water solubility, tumor targeting and biocompatibility of the zinc phthalocyanine photosensitizer can be improved, the defects of a traditional nano photosensitizer delivery system can be overcome, and the zinc phthalocyanine photosensitizer has a good application prospect in the aspect of photodynamic therapy of tumors.

The invention relates to pH-ROS (potential of hydrogen) double-response type drug-loading dendrimer nanogel as well as a preparation method and application thereof. According to the pH-ROS double-response type drug-loading dendrimer nanogel, G3-PBA-OH is obtained after a G3 PAMAM (polyamidoamine) dendrimer is subjected to functional modification; cross-linking with polyethylene glycol PBA-PEG-PBA with two ends grafted with phenylboronic acid to obtain dendrimer nanogel DNG, and further loading hypoxia activated chemotherapeutic drugs and cytokines on the DNG to obtain the hypoxia activated chemotherapeutic drug-loaded dendrimer nanogel. The DNG prepared by the invention has the characteristics of good biocompatibility, high drug loading rate, pH-ROS dual response and blood brain barrier penetration, provides a new thought for constructing a brain drug delivery nano platform, and can significantly improve the bioavailability of TPZ and IFN-gamma.

The present invention discloses an electrochemical sensor based on dendrimer functionalized Ni-MOFs nanocomposite material, a preparation method and an application thereof. First, the dendrimer functionalized Ni-MOFs nanocomposite material is prepared by using polyamidoamine dendrimer PAMAM, HITP ligand and NiCl2. Then, the obtained dendrimer functionalized Ni-MOFs nanocomposite material is used to modify a glassy carbon electrode to obtain a functionalized electrode. The functionalized electrode is used as a working electrode, a platinum electrode is used as a counter electrode, and an Ag / AgCl electrode is used as a reference electrode to form a three-electrode system, i.e., an electrochemical sensor based on the dendrimer functionalized Ni-MOFs nanocomposite material. The present invention is a Pb 2+ 、Cu 2+ The simultaneous quantitative detection of β-catenin provides an analytical method that is simple, effective, low-cost and highly sensitive.

The present invention relates to the field of polymer compounds, relating to a water-dispersible copolymer, a preparation method therefor, and a use thereof. The water-dispersible copolymer provided by the present invention comprises repeat units generated from a monomer I, repeat units generated from a monomer II, and repeat units generated from a monomer III. Monomer I is a carbosiloxane dendrimer monomer, monomer II is a cationic monomer having a tertiary amine group, and monomer III is a hydrophilic monomer. The copolymer, or a composition containing said polymer, can be used for surface treatment of paper, and imparts strong water and oil repellent properties to the paper surface.

The invention discloses a borneol modified erythrocyte membrane coated dendritic macromolecule bionic nano drug delivery system and preparation and application thereof, the bionic nano drug delivery system comprises an erythrocyte membrane and a drug loaded dendritic macromolecule coated in the erythrocyte membrane, the surface of the erythrocyte membrane is modified with targeted molecule borneol, the drug is an anti-tumor drug, such as bufotalin. In combination with a nasal drop administration mode, not only can the brain targeting efficiency of the glioma treatment drug be improved, but also the glioma treatment drug has immune escape and tumor microenvironment response capabilities, the in-vivo circulation time of the drug is effectively prolonged, and the glioma treatment effect is further improved. The design that the dendritic macromolecules are coated with the modified erythrocyte membranes combines the biocompatibility of natural cell membranes and the multifunctionality of nanoparticles, and the dendritic macromolecules have huge application potential in the fields of drug delivery, immune regulation, detoxification, targeted therapy and the like.

The invention relates to ionizable amphiphilic Janus dendrimers with different linker lengths. In some embodiments, the different linkers enable delivery of the agent to a specific target of interest (e.g., kidney, heart, lung, liver, lymph nodes, spleen, or any combination thereof). In some embodiments, the invention relates to nanoparticles comprising said ionizable amphiphilic Janus dendrimers. In some embodiments, the invention relates to compositions comprising said ionizable amphiphilic Janus dendrimers. In some aspects, the present invention also relates to methods of inducing an adaptive immune response in a subject comprising administering to the subject an effective amount of said nanoparticle or said composition.

The present invention discloses a collagen matrix flap covalently bound to fibroblast growth factor and a preparation method thereof. The collagen matrix flap is prepared by cross-linking oxidized sodium alginate (OSA) and bovine type I collagen. Subsequently, polyamide-amine dendrimer (PAMAM) is used as a connection carrier to covalently graft basic fibroblast growth factor (bFGF), thereby constructing a scaffold system capable of long-term sustained release of growth factors. The scaffold has good biocompatibility. Experiments have shown that the scaffold of the present invention exhibits clinical operability, superior biological activity to other growth factor-loaded scaffolds, and a more sustained growth factor release effect.

The invention particularly relates to an endogenous and endogenous dual nano sensitizer, a preparation method of the endogenous and endogenous dual nano sensitizer and application of the endogenous and endogenous dual nano sensitizer in preparation of brain glioma drugs. The endogenous and exogenous dual nano sensitizer comprises a glycosylated dendrimer Gal-G5 modified compound norcantharidin (DMC) and nano particles internally wrapped with gold (Au). The preparation method and the application comprise the following steps: preparation of Gal-G5, preparation of Gal-G5-DMC, and preparation of the internal and external source dual nano sensitizer Gal-G5 (Au)-DMC. The preparation method is simple, the required raw materials are easy to obtain, the synthesis process is simple and convenient, separation and purification are easy, and the synthesized endogenous and endogenous dual nano sensitizer has the capability of crossing a blood brain barrier to reach brain glioma, can be used for dual sensitization of brain glioma radiotherapy, can also be combined with an immune checkpoint inhibitor (anti-PD-L1 antibody) for combined application of radiation-immunotherapy, and has broad application prospects. And potential application prospects are realized in the aspects of radiotherapy and immunotherapy.

The invention provides an application of a dendrimer modified perovskite nanocrystal probe in prediction of mammary gland lymph node metastasis. The probe is formed by coupling a biological material of a targeted EPN3 gene and a water-soluble perovskite nanocrystal through electrostatic interaction, the water-soluble perovskite nanocrystal is formed by packaging perovskite quantum dots and a dendritic macromolecular packaging material through the coordination bonding effect of chemical bonds. The EPN3 modified water-soluble perovskite nanocrystalline probe provided by the invention can be used for high-sensitivity rapid detection of tumor tissues or cells with breast cancer lymph node metastasis.

The present application relates to a kind of reduction response type polyamide-amine dendrimer nanogel and its preparation method, the nanogel with gold nanoparticles, tobramycin, third generation polyamide-amine dendrimer as component, preparation method includes: the preparation of G3-PEG-SAT, the preparation of G3NGs, the preparation of Au@G3NGs and the preparation of Au / Toy@G3NGs.The multifunctional nanogel Au / Toy@G3NGs constructed by the present application provides efficient diagnosis and treatment integrated platform for tumor treatment.

The peptide dendrimer is used for preparing the medicine for treating the breast cancer, the peptide dendrimer can promote tumor cells to start an autophagy procedure, the excellent performance in vitro and in vivo provides powerful support for wide application of the peptide dendrimer in the field of anti-tumor treatment, and the peptide dendrimer has good biocompatibility and biological safety and can be used for preparing the medicine for treating the breast cancer. Due to the unique structural design and excellent performance, a new thought is brought to the development of a nano-drug delivery system, and an important reference basis is provided for the research and development and clinical treatment of breast cancer drugs in the future.

Described herein are TIGIT binding peptides, nanoparticle systems such as dendrimer systems including the TIGIT binding peptides, pharmaceutical formulations, and methods of use. Also described are methods of identifying peptides that bind a target receptor, the method including phage display, chemical synthesis, determination of binding affinities, and computational modeling. Advantageously, adaptive evolution modeling can be used to optimize the peptides identified in the methods for improved binding affinities.

The present invention relates to compositions that can deliver therapeutic molecules such as nucleic acids to mammalian cells, and to the human and animal body and methods of preparing and using the same. The compositions comprise nanoparticles comprising a peptide dendrimer, a nucleic acid and a lipid. The compositions of the invention find utility in the field of medicine, such as for treating cancer and autoimmune diseases.

The invention provides a detection kit, application, a marker detection system and a marker detection method. The detection kit comprises carrier particles, a detection function substance, a peroxidase conjugate and a substrate solution, the carrier particles have magnetism, the surfaces of the carrier particles are coated with a capture function substance, the capture function substance can be specifically combined with a target substance, each carrier particle is provided with a fluorescent point, and the detection function substance is used for detecting the peroxidase conjugate. The fluorescent dots with the same color correspond to the same capture function substance, the substrate solution comprises a dendrimer, a plurality of fluoresceins are marked on the dendrimer, and the dendrimer is covalently coupled with a plurality of tyramine molecules. The detection kit disclosed by the invention can be used for detecting low-concentration markers, and is low in lower detection limit, simple to operate and relatively low in detection cost.

The present disclosure is directed, in some aspects, to oligonucleotide dendrimers comprising a molecular core covalently linked to one or more first oligonucleotide branches, wherein the molecular core is a polyethylene glycol (PEG) core, a polyester (PE) core, or a polyaminoamine (PAMAM) core. The disclosure also provides methods of making and / or using the oligonucleotide dendrimers for, e.g., treating a disease via inducing an immune response.

Provided herein is a dendrimer complex comprising a 2-deoxyglucose (2DG) dendrimer and a neuroactive agent conjugated to an outer surface of the dendrimer. The dendrimer complex may further include one or more imaging agents and / or radioligands conjugated to an outer surface of the dendrimer. Such complexes are useful in methods for detecting or treating neurological diseases or disorders.

Nanoparticles comprising at least one amphiphilic Janus dendrimer are described as well as methods of delivering an agent to a target of interest (e.g., lung, liver, lymph nodes, and spleen) using said nanoparticle and methods of inducing an adaptive immune response in a subject comprising administering to the subject an effective amount of a composition comprising at least one nucleoside-modified RNA encoding at least one antigen and at least one amphiphilic Janus dendrimer.

EMULSION COMPOSITIONS CONTAINING A CARBOSILOXANE DENDRIMER COMPOUND AND AN AQUEOUS-PHASE FILM-FORMING AGENT. The invention relates to water-in-oil (w / o) emulsion compositions, preferably for skin, comprising at least one colorant, at least one carbosiloxane dendrimer compound, and at least one aqueous-phase film-forming agent, as well as methods and kits for incorporating these emulsion compositions in one or more containers or for application. Figure for abstract: none

The invention discloses a dendritic macromolecular composition for gas channeling prevention and underground carbon sequestration, hydrogel as well as a preparation method and application of the dendritic macromolecular composition. The dendritic macromolecule composition is prepared from the following components in percentage by weight: 0.06 to 0.4 percent of dendritic macromolecules; 0.8-1.6 wt% of sodium carboxymethyl cellulose, and the balance of water. The dendritic macromolecules are at least one of second-generation and third-generation dendritic macromolecules prepared from ester monomers and amine monomers through iterative Michael addition reaction by taking amino-terminated dendritic macromolecules as cores; the ester monomer is methyl acrylate; the amine monomer is selected from one of tris (2-aminoethyl) amine, diethyltriamine and triethyltetramine. CO2 is introduced into the composition to form hydrogel with a three-dimensional network structure, the hydrogel has high-density active sites, and the reaction efficiency with CO2 can be remarkably improved, so that long-term channeling sealing and carbon sequestration performance is exerted in the CO2-EOR process, the problem of oil displacement efficiency reduction caused by gas channeling is relieved, and blocking-sealing integrated carbon sequestration is realized.

The invention discloses a rare earth tree-shaped probe and a preparation method thereof, and relates to the technical field of biological analysis and detection.The probe takes a polyamide-amine tree-shaped polymer as a framework, the surface of the polyamide-amine tree-shaped polymer is grafted with a 1, 4, 7, 10-tetraaza dodecane-1, 4, 7, 10-tetraacetic acid or diethylenetriaminepentaacetic acid polydentate ligand, the ligand is chelated with rare earth ions, and the rare earth ions are adsorbed on the surface of the polyamide-amine tree-shaped polymer. On the basis of a unique highly branched structure and a clear three-dimensional structure of the dendrimer skeleton, metal ion bearing sites are remarkably increased, the metal loading capacity is effectively improved, and meanwhile, the dendrimer skeleton has the advantages that the metal loading capacity is greatly improved; the rigid structure greatly reduces non-specific adsorption through the steric hindrance effect, the detection specificity is enhanced, the key problems of contradiction between metal loading capacity and steric hindrance, non-specific adsorption and the like of an existing probe are successfully solved, and a high-sensitivity and high-precision detection tool is provided for single cell mass spectrum flow analysis.