50 results about "Dendrimer" patented technology

The invention relates to hydroxylated polyamide-amine dendrimer integrated drug-loaded nanogel as well as a preparation method and application thereof. The drug-loaded nanogel comprises third-generation polyamide-amine dendrimer integrated nanogel modified by double bonds and high-density hydroxyl groups, MnO2 nanoparticles and quercetin, wherein the nanogel is loaded with MnO2 nanoparticles in situ, and quercetin is physically wrapped in the nanogel. The drug-loaded nanogel disclosed by the invention can enhance a blood-brain barrier penetrating effect, regulate microglial cells and neurons in a double-target manner and remodel a brain inflammation microenvironment, so that neuroinflammation and dyskinesia of a Parkinson's disease model mouse are relieved, and the curative effect of the Parkinson's disease is improved. The compound has good development prospect and application value in treatment of Parkinson's disease or other neurodegenerative diseases.

The application provides a kind of smart parent tree macromolecule based on DASA and a preparation method thereof.Hydrophilic alkoxy ether dendritic unit, combined with hydrophobic visible light responsive DASA, constructs a new type of smart parent tree macromolecule based on DASA.The parent tree macromolecule of the application can self-assemble in aqueous solution and its self-assembly behavior can be controlled by light and temperature.The unique topological structure of alkoxy ether dendritic unit, crowding synergistic effect and temperature-induced multi-stage dehydration collapse mechanism can construct a hydrophobic microenvironment, which can be regulated by changing the end group structure of alkoxy ether unit, alkoxy chain length and alkoxy ether arm number, so as to realize the regulation of the reversible isomerization behavior of DASA in aqueous solution.In addition, the raw materials are environmentally friendly, cheap, low toxicity and have good biocompatibility, which shows great application potential in the fields of biomedicine and photosensitive materials.

The invention belongs to the technical field of medical polymer materials, and discloses hydrogel as well as a preparation method and application thereof. The hydrogel comprises the following raw materials: a macromonomer, a polyamidoamine dendrimer, a photoinitiator, a delayed photosensitizer and a solvent, the mass ratio of the macromonomer to the polyamidoamine dendrimer is (1: 10)-(10: 1). The hydrogel has high transparency and excellent puncture resistance, and a needle passage left after the hydrogel is punctured can be quickly self-repaired, so that no trace is left after repeated puncture, and ultrasonic imaging is prevented from being interfered.

The application relates to the field of supramolecular chemistry, and discloses a peripheral trifluoromethyl functionalized polybenzyl ether dendrimer gelator, a preparation method and application thereof. The peripheral trifluoromethyl functionalized polybenzyl ether dendrimer gelator is shown in the following formula, can form stable supramolecular organic gels or supramolecular self-assembly systems in various organic solvents or mixed solvents through the synergistic effect of multiple pi-pi interactions between peripheral aromatic rings and F...H weak hydrogen bonds, has a minimum gelation concentration CGC of 3.2 mg / mL, and is easy to be functionally modified, for example, a gel with an aggregation-induced emission performance is prepared by introducing 1-pyrene or 9-anthracene functional groups. The preparation method of the gelator is efficient, high-yield and high-purity.

The invention provides a dendrimer-modified phthalocyanine photosensitive compound and application thereof, the dendrimer-modified phthalocyanine photosensitive compound has any one structure as shown in formulas I-IV, and the photosensitive compound has the advantages of simple and controllable synthesis, clear structure, strong light killing ability and the like. The water solubility, tumor targeting and biocompatibility of the zinc phthalocyanine photosensitizer can be improved, the defects of a traditional nano photosensitizer delivery system can be overcome, and the zinc phthalocyanine photosensitizer has a good application prospect in the aspect of photodynamic therapy of tumors.

The invention relates to ionizable amphiphilic Janus dendrimers with different linker lengths. In some embodiments, the different linkers enable delivery of the agent to a specific target of interest (e.g., kidney, heart, lung, liver, lymph nodes, spleen, or any combination thereof). In some embodiments, the invention relates to nanoparticles comprising said ionizable amphiphilic Janus dendrimers. In some embodiments, the invention relates to compositions comprising said ionizable amphiphilic Janus dendrimers. In some aspects, the present invention also relates to methods of inducing an adaptive immune response in a subject comprising administering to the subject an effective amount of said nanoparticle or said composition.

Described herein are TIGIT binding peptides, nanoparticle systems such as dendrimer systems including the TIGIT binding peptides, pharmaceutical formulations, and methods of use. Also described are methods of identifying peptides that bind a target receptor, the method including phage display, chemical synthesis, determination of binding affinities, and computational modeling. Advantageously, adaptive evolution modeling can be used to optimize the peptides identified in the methods for improved binding affinities.

The present invention relates to compositions that can deliver therapeutic molecules such as nucleic acids to mammalian cells, and to the human and animal body and methods of preparing and using the same. The compositions comprise nanoparticles comprising a peptide dendrimer, a nucleic acid and a lipid. The compositions of the invention find utility in the field of medicine, such as for treating cancer and autoimmune diseases.

Nanoparticles comprising at least one amphiphilic Janus dendrimer are described as well as methods of delivering an agent to a target of interest (e.g., lung, liver, lymph nodes, and spleen) using said nanoparticle and methods of inducing an adaptive immune response in a subject comprising administering to the subject an effective amount of a composition comprising at least one nucleoside-modified RNA encoding at least one antigen and at least one amphiphilic Janus dendrimer.

The invention discloses a dendritic macromolecular composition for gas channeling prevention and underground carbon sequestration, hydrogel as well as a preparation method and application of the dendritic macromolecular composition. The dendritic macromolecule composition is prepared from the following components in percentage by weight: 0.06 to 0.4 percent of dendritic macromolecules; 0.8-1.6 wt% of sodium carboxymethyl cellulose, and the balance of water. The dendritic macromolecules are at least one of second-generation and third-generation dendritic macromolecules prepared from ester monomers and amine monomers through iterative Michael addition reaction by taking amino-terminated dendritic macromolecules as cores; the ester monomer is methyl acrylate; the amine monomer is selected from one of tris (2-aminoethyl) amine, diethyltriamine and triethyltetramine. CO2 is introduced into the composition to form hydrogel with a three-dimensional network structure, the hydrogel has high-density active sites, and the reaction efficiency with CO2 can be remarkably improved, so that long-term channeling sealing and carbon sequestration performance is exerted in the CO2-EOR process, the problem of oil displacement efficiency reduction caused by gas channeling is relieved, and blocking-sealing integrated carbon sequestration is realized.

The application discloses a high-damping diaphragm, a preparation method thereof and a sound generating device, and relates to the technical field of loudspeaker diaphragms. The mass ratio of AEM rubber, modified polyamide-amine dendrimer and rubber compounding agent in the raw material composition is 100:0.1-10:90-150. The modified polyamide-amine dendrimer is a hydroxyl-terminated modified polyamide-amine dendrimer. The diaphragm has high damping, excellent tensile strength and fatigue resistance.

The application discloses star-shaped polyamino acid nanoparticles with long circulation properties and a preparation method and application thereof, and belongs to the technical field of biological medicines.The nanoparticles are of a star-shaped structure with polyamide-amine dendrimers as a core and copolyamino acids as arms;the nanoparticles are prepared through random copolymerization reaction of polyamide-amine as an initiator, first N -carboxylic acid cyclic anhydride and second N -carboxylic acid cyclic anhydride monomers, and the reaction is carried out in an organic solvent; wherein the organic solvent is a mixed solvent of low-polarity halogenated alkane and high-polarity amide or cyclic ether, and the volume ratio of the two is 9:1, and the preparation method is simple and efficient.The application proves that the star-shaped topological structure and glutamic acid / lysine side chains play a key role in realizing long circulation by regulating the types of amino acids, the charge and the topological structure of the nanoparticles, and the nanoparticles have wide application prospects in the field of preparing tumor treatment drugs.

Provided herein are dendrimers comprising a core unit, five generations of building units being a lysine residue or analogue thereof, a plurality of first terminal groups each comprising a residue of a nucleoside analogue, and a plurality of second terminal groups each comprising a hydrophilic polymeric group. Also provided herein are pharmaceutical compositions comprising the dendrimer, and methods and uses of the dendrimers in therapy of disorders such as cancer.

The application provides a dendrimer prodrug and a nano-assembly thereof, and belongs to the technical field of antitumor drugs. The application constructs a dendrimer prodrug Epi-DBP shown in formula I by bridging PEG and Epi dendrimer conjugate through a borate ester bond. An IDO inhibitor NLG919 is loaded in the hydrophobic cavity of the Epi-DBP to form a nano-assembly NLG919@Epi-DBP. The nano-assembly NLG919@Epi-DBP has a stable nano structure and can be enriched at a tumor tissue. In an acidic environment of a tumor cell, a hydrazone bond is broken to cause the release of Epi and NLG919. Experimental results show that the NLG919 in the NLG919@Epi-DBP has excellent synergistic antitumor effect with the Epi-DBP. The application constructs an IDO inhibition combined with chemotherapy nano platform based on a dendrimer, realizes the remodeling of a tumor immune microenvironment while synergistically performing chemotherapy to enhance the antitumor effect, and has a wide application prospect.

This invention provides a prodrug molecule, drug-loaded nanomicelles, and their preparation method and applications based on zwitterionic polyamide-amine dendritic macromolecules. The preparation method of the drug-loaded nanomicelles includes: modifying PAMAM with maleic anhydride, then grafting thiolated paclitaxel, c(RGDfC), and thiolated histidine onto PAMAM via a thioolefin reaction, utilizing its self-assembly properties to encapsulate hydrophobic anticancer drugs to form drug-loaded nanomicelles. These drug-loaded nanomicelles possess advantages such as high drug loading capacity, low toxicity, uniform particle size distribution, good stability, and enhanced bioavailability of hydrophobic drugs. Furthermore, they exhibit pH responsiveness, enabling targeted drug release at tumor sites, thereby enhancing tumor-suppressing effects.

A modified nanoparticle nanocarrier system for delivering one or more active ingredients into a skin that can slowly release the active ingredients is provided. The modified nanoparticle nanocarrier system comprises a dendrimer, a linker and a peptide, wherein the dendrimer is first coated with the linker to form a dendrimer-linker conjugate, and the dendrimer-linker conjugate is then coupled to a peptide to form a dendrimer-linker-peptide conjugate. Subsequently, the dendrimer-linker-peptide conjugate is loaded with one or more active ingredients and mixed with a topical base to form a homogenized product to be applied onto the skin.

A molecular scaffold having n consecutive generations is provided. The molecular scaffold has: a core having a plurality of arms (A1); (n-1) groups of branch portions each having a plurality of arms (A2, A3, A4); a functional group (FG1) capable of forming a bond with a second substance; and a plurality of identifier molecules (IM). Each branch portion of the first group, when present, is bonded to one of the arms (A1) of the core, and each branch portion of each subsequent group, when present, is bonded to the arms (A2, A3, A4) of the branch portions of the previous group. Wherein n = 1, each of the plurality of identifier molecules is bonded to an arm (A2, A3, A4) of a branch portion in the (n-1) group, or wherein n = 1, each of the plurality of identifier molecules is bonded to an arm (A1) of the core. One or more or all of the identifier molecules (IM) have the following general formula structure (1). The core has the following general formula structure (formula I). The molecular scaffolds can be used to label molecules, such as biomolecules, such as antibodies, which can be excited at the same or similar wavelengths, but emitted at different wavelengths. In particular, the molecular scaffold can be used as a labeling system for flow cytometry.

The invention provides a nano-enzyme synthesis method which comprises the following specific steps: sequentially heating, drying and grinding an aqueous solution containing 0-generation polyamide-amine dendritic macromolecules, potassium ferricyanide and urea, carrying out high-temperature pyrolysis twice, and grinding again to obtain the target nano-enzyme. The invention also provides a corresponding dichlorvos detection method, which comprises the following operation steps: mixing a sample solution, a buffer solution and a nano-enzyme solution for incubation, and then adding the mixed solution into a borate buffer solution containing hydrogen peroxide for reaction; and after the reaction is finished, sequentially adding a potassium iodide solution and a rhodamine 6G solution, and carrying out fluorescence detection after the reaction is finished. The nano-enzyme synthesized by the method has multiple enzymatic characteristics of oxidase-like, peroxidase-like, catalase-like and superoxide dismutase-like, has the advantages of excellent selectivity and high sensitivity in detection of dichlorvos, and is suitable for rapid detection of dichlorvos in actual samples.

The invention discloses chloride-free cation dispersed rosin size as well as a preparation method and application thereof, and belongs to the technical field of rosin size preparation, the rosin size is prepared from the following components: 50-200 parts of modified rosin, 10-20 parts of a compound emulsifier, 0.1-0.5 part of a defoaming agent and 100-200 parts of water, wherein the compound emulsifier consists of hyperbranched dendrimer and rigid gemini quaternary ammonium salt in a mass ratio of (1: 1)-(1: 2); the zeta potential of the rosin size is greater than or equal to + 50 mV, the average particle size is less than or equal to 0.3 mu m, and the content of chloropropanol is not detected. The cationic rosin size which is milky white in appearance, good in stability, good in dispersity in cold water, good in storage stability, low in viscosity, low in foam and free of chloropropanol content is obtained by using hyperbranched dendrimer and rigid gemini quaternary ammonium salt as a compound emulsifier and adopting continuous high-temperature pre-emulsification and high-pressure homogeneous emulsification processes.

The invention belongs to the technical field of biological medicine, and particularly relates to an oncolytic adenovirus and small interfering RNA co-delivery system for brain tumor immunotherapy, in particular to preparation of a functional nucleic acid molecule and oncolytic adenovirus co-delivery nano-system and application of the nano-system in brain tumor immunotherapy. The co-delivery system can be obtained through convenient and rapid self-assembly at room temperature, and the size is controllable and uniform. According to the co-delivery system, positive charge dendrimers serve as media, the oncolytic adenoviruses are wrapped, functional small interfering RNA molecules are carried, more adenoviruses are delivered into tumor cells, the utilization efficiency of the adenoviruses is improved, and the system can effectively improve the uptake of the oncolytic adenoviruses by glioma cell lines, so that the oncolytic adenoviruses in the glioma cell lines can be effectively improved. And the delivered functional small interfering RNA molecules can promote the replication of the oncolytic adenovirus, improve the effective titer of the oncolytic adenovirus and enhance the immunotherapy effect.

The invention discloses a nano multi-drug synergistic targeting delivery system based on bilirubin prodrugs and a preparation method of the nano multi-drug synergistic targeting delivery system. The system is formed by self-assembly of an amphiphilic conjugate, the conjugate takes a second-generation lysine dendrimer (G2K) as a hydrophilic skeleton, and the branched end of the conjugate is covalently modified with a hydrophobic antioxidant bilirubin (Br) through a reactive oxygen species (ROS)-sensitive thioketal bond (TK) and is further coupled with a targeting ligand serine (L-serine). The delivery system can specifically recognize damaged kidney tissue, and accurate enrichment of therapeutic drugs in acute kidney injury (AKI) focuses is achieved. After entering a focus, the carrier drives the explosive release of the medicine by utilizing a dual response mechanism of TK bond breakage and bilirubin polarity overturning, and meanwhile, the endogenous anti-oxidation effect of carrier components is exerted. The delivery system provided by the invention has the characteristics of high drug loading capacity, good biocompatibility, strong targeting property and multi-drug synergistic treatment, and has a wide application prospect in the field of kidney disease treatment.

The invention belongs to the technical field of photoetching patterning material preparation, and relates to an ultralow dielectric constant dendrimer with a regular branched structure and an internal cavity, a preparation method, a photoresist composition and application thereof. The preparation method comprises the following steps: firstly, respectively preparing an AB2 type monomer and a benzocyclobutene silane monomer containing Si-H bonds, then mixing the AB2 type monomer and the benzocyclobutene silane monomer, and adding a catalyst to carry out polymerization reaction to obtain the dendrimer. The electrons in the benzene ring in the polymer structure are distributed more uniformly due to the resonance effect; two atoms in the Si-C covalent bond are large in atomic radius, small in electronegativity difference and small in polarization effect. Therefore, the benzene ring and the Si-C bond are favorable for reducing the overall polarization degree of the material, so that the material has a relatively low dielectric constant. In addition, due to the branched structure and more C = C double bonds of the polymer, a cross-linking reaction between the polymer and an active initiator is facilitated, so that the polymer has good film-forming property and thermal stability.

The invention discloses an anti-collapse plugging agent for drilling fluid and a preparation method thereof. The preparation method comprises the following steps: preparing 2.0-generation dendrimers or 3.0-generation dendrimers; dispersing the unsaturated silane coupling agent modified nanoparticles in a first solvent to form a dispersion liquid; dissolving 2.0-generation dendrimers or 3.0-generation dendrimers in a first solvent, dropwise adding an unsaturated hydrophilic monomer solution and an unsaturated hydrophobic monomer solution, dropwise adding the dispersion liquid at the same time, heating, and after the reaction is finished, removing the solvent to obtain the anti-sloughing plugging agent for the drilling fluid. The preparation method is simple, and has the advantages that the plugging performance is improved, the temperature resistance and pressure resistance are improved, the environmental pollution is reduced, and the drilling efficiency is improved. The prepared anti-sloughing plugging agent is not only suitable for a conventional drilling operation environment, but also can play a good role in complex environments such as high temperature and high pressure.

The present invention relates to a composition for caring for and / or making up keratin materials in the form of an oil-in-water emulsion comprising: (i) at least one vinyl polymer grafted with a carbosiloxane dendrimer; (ii) at least one associative copolymer of (meth)acrylic acid and of at least one (C1-C6)alkyl ester thereof; (iii) at least one pigment coated with a gemini-type amphiphilic amino acid; (iv) at least one dispersant having an HLB value of less than 4 at a temperature of 25°C; and (v) at least one emollient. The present invention also relates to a non-therapeutic process for caring for and / or making up keratin materials comprising the application to the keratin materials of said composition.

This invention discloses a dendritic macromolecular nanogel, a nucleic acid-loaded dendritic macromolecular nanogel, its preparation method, and its applications, belonging to the biomedical field. The nanogel is a nanogel formed by cross-linking mannose and ferrocene-modified polyamide-amine dendritic macromolecules with a cross-linking agent, wherein the cross-linking agent is polyethylene glycol modified with cyclodextrins at both ends. The nucleic acid-loaded dendritic macromolecular nanogel is a dendritic macromolecular nanogel loaded with mRNA encoding a tumor antigen, wherein the tumor antigen is OVA. This nucleic acid-loaded dendritic macromolecular nanogel has application potential in tumor vaccines. The process of this invention is simple, easy to purify, and the raw materials used in its synthesis are all environmentally friendly materials, showing promise for industrialization.

The invention relates to a phosphorus-containing dendrimer co-loaded fibronectin / melatonin nano-drug as well as a preparation method and application thereof. The nano-drug comprises a phosphorus-containing dendrimer ZY-135 at a hydroxyl terminal, fibronectin FN and melatonin MT. The nano-drug provided by the invention can penetrate through a blood brain barrier, accurately target a diseased region, cooperatively regulate and control microglial cells, nerve cells and vascular endothelial cells, and can realize combined treatment of oxidative stress and inflammation level alleviation, neuroprotection and vascular regeneration of cerebral arterial thrombosis, so that nerve cell apoptosis is reduced, and cerebral arterial thrombosis is reduced. Good clinical transformation prospects and application values are realized.

This disclosure provides compositions, systems, and methods for delivering therapeutic oligonucleotides to the brain. The oligonucleotides are conjugated to a dendron comprising a hydrophilic end group, a phosphate group, and / or a hydrophobic chain.

The application relates to a sodium hypophosphite salt modified phosphorus-containing dendrimer with anti-inflammatory activity and a preparation method and application thereof, and a structural formula of the phosphorus-containing dendrimer is as follows: The phosphorus-containing dendrimer prepared by the application can realize intracellular delivery of various proteins, has the advantages of good biocompatibility and high cytoplasm delivery efficiency, and has potential application value in the field of developing protein drugs for intracellular disease targets.

The application provides a preparation method of an anti-fouling supramolecular material with nano structure, comprising the following steps: synthesizing a POSS-based dendrimer assembly structure unit; preparing an assembly micelle with a teardrop shape of Rupert; polymerizing the nanomicelle into an anti-fouling material; adding the assembly micelle with the teardrop shape of Rupert into bimimidazole, continuously freezing and thawing and degassing, and then stopping the reaction after in-situ deposition polymerization of the colloid under light, so that a surface-treated micelle with the teardrop shape of Rupert is obtained, which is the anti-fouling supramolecular material with nano structure. The application adopts non-covalent bond driving to form a highly ordered functional self-assembly material, and prepares a supramolecular material with special nano structure characteristics through in-situ polymerization, which has hydrophobic and oleophobic properties and is widely applied, and can be applied to metal surface anti-graffiti, anti-rust and anti-scratch, applied on glass and ceramic, and applied to anti-fouling self-cleaning, so that the substrate surface is long and bright like new.