473 results about "IV Chemotherapy" patented technology

A pharmaceutical composition and formulations comprise preventative, prophylactic or therapeutic amounts of an oligo(s) anti-sense to a specific gene(s) or its corresponding mRNA(s), and a glucocorticoid and/or non-glucocorticoid steroid or a ubiquinone or their salts. The agents, composition and formulations are used for treatment of ailments associated with impaired respiration, bronchoconstriction, lung allergy(ies) or inflammation, and abnormal levels of adenosine, adenosine receptors, sensitivity to adenosine, lung surfactant and ubiquinone, such as pulmonary fibrosis, vasoconstriction, inflammation, allergies, allergic rhinitis, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction, COPD, RDS, ARDS, cancer, and others. The present treatment is effectively administered by itself for conditions without known therapies, as a substitute for therapies exhibiting undesirable side effects, or in combination with other treatments, e.g. before, during and after other respiratory system therapies, radiation, chemotherapy, antibody therapy and surgery, among others. Each of the agents of this invention may be administered directly into the respiratory system so that they gain direct access to the lungs, or by other effective routes of administration. A kit comprises a delivery device, the agents and instructions for its use.

The invention discloses culturing, freezing and recovering methods of an activated lymphocyte with CD3+CD8+as major, which can solve problems that a patient needs carrying out blood sampling for many times caused by continuously utilizing the activated lymphocyte with CD3+CD8+as major. The method comprises the following steps of: (1) contacting the extracted lymphocyte of the peripheral blood with IL-2, IL-15, an anti-CD3 antibody and an anti-CD28 antibody, so as to amplify the activated lymphocyte with CD3+CD8+as major; (2) freezing and storing the activated lymphocyte; and (3) recovering the activated lymphocyte. The activated lymphocyte cultured via the method disclosed by the invention has clear components, and comprises few CD4+CD25+Treg cells and more CD8+T lymphocyte; feedback time and frequency of the activated lymphocyte can be adjusted according to other treatments for a patient, such as a radiotherapy or a chemotherapy, so that diseases, such as tumor, infectious diseases and immunodeficiency can be treated well.

The invention provides a medicinal composition for treating digestive system dysfunction. The medicinal composition is characterized by comprising the following components in parts by weight: 10-25 parts of ginseng, 10-25 parts of bighead atractylodes rhizome, and 12-25 parts of poria. The medicinal composition is particularly suitable for treating gastrointestinal dysfunction after radiotherapy or chemotherapy, is good in curative effect, and does not have toxic or side effect; the patients have good tolerance and can easily accept the medicinal composition; the treatment cost is low. The medicinal composition can be used for treating gastrointestinal dysfunction after radiotherapy or chemotherapy independently, and also can be used for treating malignant tumor diseases by combining radiotherapy or chemotherapy.

A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the α subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside.

Provided herein are specific doses of, and dosing regimens for, using a HIF prolyl hydroxylase inhibitor in treating or preventing anemia, such as anemia secondary to or associated with chronic kidney disease, anemia associated with or resulting from chemotherapy, or anemia associated with AIDS.

This invention is for an improved method for making enhanced ginger capsules and for using these capsules for treating nausea and emesis in cancer patients.

Provided herein are specific doses of, and dosing regimens for, using a HIF prolyl hydroxylase inhibitor in treating or preventing anemia, such as anemia secondary to or associated with chronic kidney disease, anemia secondary to or associated with non-dialysis dependent chronic kidney disease anemia associated with or resulting from chemotherapy, or anemia associated with AIDS.

The invention discloses a minimally invasive intervention implantable drug-supplying device with a one-way valve. The drug-supplying device comprises a chemotherapy pump body, an extracorporeal marking part and an auxiliary accessory, wherein the extracorporeal marking part and the auxiliary accessory are matched with the chemotherapy pump body. The chemotherapy pump body comprises a pump body with the one-way valve, the pump body is connected with a matched catheter through a locking device, a locking inner sleeve baffle is arranged between the one-way valve and the catheter, and the catheter comprises through catheter bodies and catheter bodies with crack valves on the wall and at the front end; the pump body comprises a pump base, a matched puncture diaphragm is arranged at the upper end of the pump base, a pump cover matched with the pump base is arranged at the upper end of the puncture diaphragm, the one-way valve is connected with the side end of the pump base in a sealed mode, and a pump cavity is formed among the pump cover, the puncture diaphragm, the pump base and the one-way valve in a sealed mode. The implantable drug-supplying device has the advantages that drugs can directly enter a determined portion through a drug pump and the catheter, the drug concentration and the dosage of the focus portion are increased greatly, the lethality to lesion cells is increased, the curative effect on the lesion cells is improved, and the practicability of the device is effectively improved.

A method for classifying cancer patients as eligible to receive cancer therapy with a Bcl-2 inhibitor comprising determination of the presence or absence in a patient tissue sample of levels of pro-GRP, as a surrogate marker for the presence of chromosomal copy number gain at chromosomal locus 18q21-q22. The classification of cancer patients based upon pro-GRP levels as a surrogate for the presence or absence of 18q21-q22 gain allows selection of patients to receive chemotherapy with a Bcl-2 family inhibitor, either as monotherapy or as part of combination therapy, and to monitor patient response to such therapy using a peripheral blood sample.

The invention relates to an oral spray for controlling nausea and vomit of chemotherapy and radiation therapy, the formula of the oral spray is composed of ingredients with the following parts by weight: 5-50 parts of drug absorption enhancer, 2-20 parts of drug active ingredient and 30-90 parts of buffer, the drug absorption enhancer can be any one or the combination of more of the following ingredients: azone, propylene glycol, polysorbate (Tween), ethylene glycol deoxycholic acid sodium salt, brij, sodium decanoate, lauric acid, stearic acid, sodium lauryl sulphate, stearyl alcohol sodium sulfate, dioctyl succinate sodium sulfonate, oleic acid, GK2, menthol and borneol; the drug active ingredient can be any one combination of the following ingredients: palonosetron hydrochloride, granisetron, ondansetron, azasetron and tropisetron; and the ingredients of the buffer are sodium citrate buffer solution and phosphate buffer solution. The oral spray provides a formulation which is safer, painless and convenient for patients with advanced tumor, elderly and weak patients, children patients and the patients who suffer from the metal illness and do not obey the oral administration or the injection drug administration.

The invention relates to a silver cicada Chinese medicine preparation for treating liver cancer, esophagus cancer and gastric cancer and a preparation method thereof. The silver cicada Chinese medicine preparation for treating the liver cancer, the esophagus cancer and the gastric cancer is prepared from the following raw materials in the certain parts by weight: silver foil, full scorpion, cicada slough, red dates, dragon's blood, full toad, ancient lime, ledebouriella seseloides, lucid ganoderma, borneol and sugar. The silver cicada Chinese medicine preparation has the curative effects of eliminating cancers, relieving pain, clearing blood and clearing away toxic materials, and activating the blood circulation and benefiting qi, has the functions of eliminating cancer cells, releasing patient pain, and modifying organs of cancer patients, has unique curative effect on the cancers, the gastric cancer and the esophagus cancer, can be used for largely releasing pains of patients on a chemotherapy and an operation, and also reducing the economic burden of the patients; in addition, the raw materials utilized in the silver cicada Chinese medicine preparation disclosed by the invention are abundant, the preparation method is simple and convenient, the cost is low, and the silver cicada Chinese medicine preparation is economical and applicable.

The invention discloses a system for predicting prognosis of patients with lung adenocarcinoma and judging benefit of an adjuvant chemotherapy. The system comprises a system used for detecting expression quantities of six proteins, i.e., c-Src, Cyclin E1, TTF1, p65, CHK1 and JNK1, and a protein expression quantity data processing system. The system used for detecting the expression quantities of the six proteins can determine the expression quantities of the proteins by using an immunohistochemistry staining method; the protein expression quantity data processing system converts the expression quantities of the six proteins in lung adenocarcinoma tissues, separated from to-be-predicted patients with the lung adenocarcinoma, into a prognosis score, and predicting the prognosis of the to-be-predicted patients with the lung adenocarcinoma according to the prognosis score, and/or predicting whether the to-be-predicted patients with the lung adenocarcinoma are benefited from the adjuvant chemotherapy or not according to the prognosis score.

The present invention discloses and claims: (i) compositions, methods, and kits which lead to an increase in patient survival time in cancer patients receiving chemotherapy; (ii) compositions and methods which cause cytotoxic or apoptotic potentiation of the anti-cancer activity of chemotherapeutic agents; (iii) compositions and methods for maintaining or stimulating hematological function in patients in need thereof, including those patients suffering from cancer; (iv) compositions and methods for maintaining or stimulating erythropoietin function or synthesis in patients in need thereof, including those patients suffering from cancer; (v) compositions and methods for mitigating or preventing anemia in patients in need thereof, including those patients suffering from cancer; (vi) compositions and methods for maintaining or stimulating pluripotent, multipotent, and unipotent normal stem cell function or synthesis in patients in need thereof, including those patients suffering from cancer; (vii) compositions and methods which promote the arrest or retardation of tumor progression in those cancer patients receiving chemotherapy; (viii) compositions and methods for increasing patient survival and/or delaying tumor progression while maintaining or improving the quality of life in a cancer patient receiving chemotherapy; (ix) novel methods of the administration of taxane and/or platinum medicaments and a Formula (I) compound of the present invention to a cancer patient; and (x) kits to achieve one or more of the aforementioned physiological effects in a patient in need thereof, including those patients suffering from cancer.

Disclosed herein are methods and materials for prognosing survival of lung cancer patients, the methods comprising the detection of gains and losses of minimal common regions and/or genes associated with prognosis and benefit of chemotherapy.

The invention provides novel compositions, methods and uses, for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia and breast cancer. The invention further relates to genes that are differentially expressed in breast tissue of breast cancer patients versus those of normal “healthy” tissue. Differentially expressed genes for the identification of patients which are likely to respond to chemotherapy are also provided.

An improved autovaccination method designed to prevent or treat various neoplastic diseases by inducing a systemic immune response against a tumor and its remote metastases, consisting of the induction of an immunogenic cell death in one or more targeted tumor sites with local radiation therapy, cryotherapy, heat, chemotherapy or various other treatments, followed by intratumoral/peritumoral injection of dsRNAs (poly-ICLC in particular) in the same tumor site.

The invention discloses a method for modeling and analyzing protein fingerprinting of advanced colorectal cancer and a kit. The steps comprises: (1) respectively establishing serum protein fingerprinting for patient samples with advanced colorectal cancer, who suffer from a chemotherapy regimen; (2) extracting serum protein fingerprint characteristics in the serum protein fingerprinting of the obtained samples, and respectively establishing standard models based on the chemotherapy regimen; (3) establishing serum protein fingerprinting for patients with advanced colorectal cancer, who do not suffer from the chemotherapy regimen, and extracting the serum protein fingerprint characteristics; and (4) contrasting and analyzing the serum protein fingerprint characteristics of the patients who do not suffer from the chemotherapy regimen, with the standard models established in the step (2). The chemotherapy regimen may be FOLFOX or FOLFIRI. The method overcomes a blindness problem of a therapeutic regimen for advanced colorectal cancer. Before chemotherapy, the serum protein fingerprinting of the patients with advanced colorectal cancer is detected, to analyze the patient is a beneficiary of the FOLFOX regimen or the FOLFIRI regimen.

The invention relates to the technical field of medical supplies, specifically to a liquid adhesive bandage and a preparation technology thereof. The liquid adhesive bandage is prepared by free radical polymerization of an acrylate soft monomer, an acrylate hard monomer, a functional monomer, an initiator and a solvent for the preparation of a film-forming main body and with the assistance of a functional auxiliary agent. The liquid adhesive bandage can be applied on a wounded part, and then a layer of soft, non-toxic and non-irritating skin protection film which is not easy to peel off is rapidly formed on the wound surface. The film has good water resistance, air permeability and adhesiveness, prevents outside foreign matter and microorganisms from invading and infecting wounds, and hasthe effect of protecting the wound surface and promoting wound healing. The liquid adhesive bandage is direct and simple to use, is beautiful, comfortable and effective, is suitable for wounds of burn, scald, bruise, scratch, dactylotome cracking, chapped skin, chilblain, etc. and small wounds caused by other trauma, has hemostasis and wound protection effects, and is also suitable for superficialwounds caused after face-lifting, skin ulcer of patients with diabetes or chemotherapy, etc.