The invention discloses oral medicament for treatment of oral leukoplakia. The oral medicament comprises 5%-30% of Chinese medical extract, 1%-5% of Western medicine ingredients and the balance adjuvant materials. The Chinese medical extract is prepared from bulbophyllum inconspicuum maxim, stems and leaves of hookedhairypod tickclover, nephelium chryseum, edible manna lichen, fragrant sarcococca herbs, fermented Chinese gall herb and tea leaves, dye yam, shaddock ped, asiatic cudweeds, white perilla leaves, seguin chinkapin cup bark or roots, elsholtzia blanda, caragana microphylla, fleshy-root gentian roots, ulmus parvifolia leaves, cucumber gourd seeds, artemisia japonica, averrhoa carambola L., humulus japonicus, feather cockscomb seeds, herbs of herba cirsii and desmodium triquetrum. The Western medicine ingredients include disodium succinate, vitamin A acetic ester, astaxanthin, sodium chloride, vitamin A palmitate, salicylic acid and urea. The oral medicament can achieve antisepsis and anti-inflammation, promote blood circulation and urinate with diuretics, promote production of body fluid and nourish the lung, reduce abscess and nurse the health from inside to outside. Thorough treatment can be achieved fundamentally, and the symptoms such as chapping, anabrosis or base hardening and surface thickening of a leukoplakia area are reduced obviously. The oral medicament can be taken conveniently, stimulation from local smearing is avoided, no toxic and side effects exist, favorable prognosis is realized, and relapse tends not to happen.