116results about How to "Reduce stimulation" patented technology

The invention belongs to the technical field of chemistry, and particularly relates to a water-based stable transdermal preparation based on a structural nanoemulsion and a preparation method of the water-based stable transdermal preparation. 1% to 10% of a polyether block copolymer; 5%-20% of a co-emulsion; 0.1% to 15% of an active ingredient; and the balance of deionized water. Through a compounding system of an amino acid surfactant and a gemini surfactant and in combination with the synergistic effect of a specific polyether block copolymer, a nanoemulsion drug delivery system with a stable structure is constructed. Through a compound system of the amino acid surfactant and the gemini surfactant and by combining the synergistic effect of the polyether block copolymer, a nano-emulsion drug delivery system with a stable structure is constructed, and the nano-emulsion drug delivery system has good long-term storage stability and temperature adaptability, is not easy to layer and is uniform in particle size distribution.

The invention relates to the field of photocuring adhesives, and mainly relates to a UV adhesive for wig connection and a preparation method thereof. The UV adhesive for wig connection is prepared from the following components in parts by weight: 30 to 50 parts of urethane acrylate, 45 to 70 parts of first reactive diluent, 2 to 4 parts of photoinitiator and 2 to 4 parts of fumed silica, the first active diluent is prepared from two or a mixture of more than two of acryloyl morphine, 2-acrylic acid-2-(2-phenoxy ethyoxyl) ethyl ester, dicyclopentadiene acrylate and ethylene glycol dicyclopentenyl ether methacrylate. The preparation method comprises the following steps: mixing the components, heating in a water bath, and stirring to obtain the UV adhesive for wig connection. The UV adhesive for wig connection provided by the invention is low in odor, good in durability and good in matte effect.

The utility model discloses an anorectal drug delivery device which comprises a drug delivery tube and an injection tube connected with the drug delivery tube in an inserted mode, one end of the drug delivery tube is a closed end, a plurality of protruding rings are connected to the tube wall of the drug delivery tube at intervals in the length direction, a drug delivery hole is connected to the tube wall between every two adjacent protruding rings, and an isolation sleeve is arranged in the drug delivery tube. One end of the isolation sleeve is connected with the inner wall of the dosing tube through a connecting part, the other end of the isolation sleeve extends towards the closed end, and the dosing holes are formed between the closed end and the connecting part. By arranging the convex rings, when the dosing tube is inserted into the anorectum, the direct contact between the inner wall of the anorectum and the dosing hole can be reduced as much as possible through the convex rings; meanwhile, the isolation sleeve is arranged, so that the medicine flows through the inner wall of the closed end to be buffered, then flows into the gap between the isolation sleeve and the administration tube and then flows out of the administration hole in the administration process, the medicine pushing-out speed can be effectively reduced, stimulation to the anorectum is reduced, and the discomfort of a patient is further reduced.

The present application relates to mosquito liquid technical field, disclose a kind of environmental protection type mosquito repellent electric mosquito coil liquid with bio-based solvent and its preparation method, the electric mosquito coil liquid by mass percentage, including the following components: bio-based solvent 80%~85%, active ingredient 0.8%~1.9%, antioxidant 0.05%~0.2%, stabilizer 0.1%~0.5%, the rest is C1-C3 alcohol;Its preparation method includes: active ingredient and part bio-based solvent are dissolved to obtain active pre-solution;Remaining bio-based solvent is mixed with antioxidant, stabilizer to obtain main mixed solution;Active pre-solution is added to main mixed solution and homogenization treatment is carried out;Then in turn degassing treatment, standing ripening, filtration, filling, sealing, finished product is obtained.The present application uses bio-based solvent to replace traditional petroleum-based solvent, renewable, low irritation, and volatile uniform and stable, suitable for infant and the environment of sensitive population such as old people, and environmental protection is good.

The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans,-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and / or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.

The invention discloses an amino acid facial cleanser composition and application thereof, and aims to overcome the defects that the existing acne-removing facial cleanser is high in irritation, acne removal and mild cleaning are difficult to consider, and a single component only acts on a single target spot of acne. According to the composition, 5.0-25.0 wt% of sodium cocoyl glycinate, 0.1-2.0 wt% of capryloyl glycine, 0.2-5.0 wt% of nicotinamide and 0.01-0.5 wt% of a hydrolysis yeast extract are taken as core active components, the four components are specifically proportioned to form a synergistic effect, oil control and acne removal are realized through a closed-loop passage of pore cleaning, source oil control and targeted bacteriostasis, and the mild property is guaranteed by amino acid surface activity, and the skin barrier is not damaged. The composition disclosed by the invention can be prepared into facial cleanser and facial mousse, and is excellent in cleaning power and foamability, good in use experience and high in industrialization value.

This invention discloses a protective garment for epicondylitis of the humerus based on an antibacterial and thermally conductive composite material, belonging to the field of medical protective gear technology. It includes a forearm support and an upper arm support, which are rotatably connected by an adjusting mechanism. The upper arm and forearm sleeves are 3D printed using an antibacterial and thermally conductive composite material, which comprises a polylactic acid matrix, a graphene oxide-silver nanoparticle-carbon nanotube ternary composite filler, and phase change microcapsules, with a thermal conductivity of 1.5-4.0 W·m. ‑1 ·K ‑1 With an antibacterial rate of ≥95%, it solves the problems of poor thermal conductivity, lack of antibacterial properties, and uneven heat therapy in existing protective gear.

The utility model discloses a silica gel indwelling needle patch, and relates to an indwelling needle patch. Comprising a recording strip, release paper, a polyurethane film layer, a microporous silica gel layer, a silica gel adhesive tape strip and an embossed protective layer, the release paper is divided into a first part and a second part, the first part of the release paper is adhered to the polyurethane film layer, an opening is formed in the center of the first part, and the recording strip is arranged on the outer surface of the second part of the release paper; the polyurethane film layer is adhered to the microporous silica gel layer; one surface of the embossed protective layer is divided into a first area and a second area, and the microporous silica gel layer and the silica gel adhesive tape strip are respectively adhered to the first area and the second area of the embossed protective layer. Due to the adoption of the design of the microporous silica gel layer, the air permeability of the indwelling needle patch is improved, the risk of curling and falling off is reduced, the comfort and the fitting feeling of a product are improved, the irritation and the injury to the skin of a patient are reduced, the practicability is improved, and the indwelling needle patch has certain advantages.

This utility model discloses a tracheostomy nebulization and heating device, including a tracheostomy mask, an air delivery tube, a nebulizer, a fine-tuning infusion set, a constant-temperature heater, and an infusion tubing. Both ends of the infusion tubing are connected to the inlets of the fine-tuning infusion set and the nebulizer, respectively. Both ends of the air delivery tube are connected to the outlets of the tracheostomy mask and the nebulizer, respectively. The constant-temperature heater is located on the outside of the infusion tubing. By incorporating the fine-tuning infusion set and connecting it to the nebulizer, the input rate of the humidifying liquid can be controlled by adjusting the fine-tuning infusion set, avoiding the discontinuity of traditional manual water addition, ensuring a stable and sustained humidification process, and reducing airway mucosal irritation caused by humidity fluctuations. The constant-temperature heater on the outside of the infusion tubing heats the humidifying liquid, preheating it before nebulization, preventing cold mist from directly entering the airway and avoiding discomfort caused by inhaling cold air.

This utility model relates to the field of minimally invasive postoperative wound dressing technology, specifically a minimally invasive postoperative wound dressing with wound closure function. It includes an adhesive layer, release paper installed on both sides of the bottom of the adhesive layer, low-sensitivity adhesive tape evenly installed on both sides of the top of the adhesive layer, and a sterilization layer embedded in the middle of the adhesive layer. The improved minimally invasive postoperative wound dressing adds a first elastic band and a second elastic band. When the wound dressing is applied to the wound surface, the first and second elastic bands can be pulled to traction the sides of the adhesive layer, thereby effectively closing the wound, reducing the risk of wound dehiscence, and promoting rapid wound healing. An absorbent layer made of highly absorbent resin is also added, allowing the absorbent layer to quickly absorb tissue fluid exudated from the wound during the healing process, helping to reduce the risk of wound infection and thus promoting wound healing.

This application discloses a razor head assembly and a razor having the same. The razor head assembly includes a base, a razor head holder, and a floating mechanism. The base has an axis; the razor head holder is equipped with the razor assembly; the floating mechanism connects the base and the razor head holder, and allows the razor head holder to deflect relative to the axis under the action of an external force, and allows the razor head holder to return to its original position after the external force is removed. This application, through the floating mechanism, allows the razor head holder to deflect relative to the axis of the base during shaving, thereby maintaining a good fit between the razor assembly and the user's face; it also helps to tighten the facial skin, allowing the hair roots to be better exposed on the skin surface, improving shaving cleanliness, while also enhancing shaving comfort and experience, reducing pressure on the skin during shaving, and minimizing skin irritation; furthermore, the razor head holder can return to its initial position after the external force is removed for subsequent use.

The utility model provides a license plate recognition camera device with light supplement and glare prevention. The license plate recognition camera device comprises a shell, a camera module and a light supplement module, wherein the camera module and the light supplement module are arranged in the shell; the camera module is used for shooting a license plate image, and the light supplementing module is used for illuminating a license plate; the light supplementing module is arranged near the camera module; the light supplementing module area is provided with a first light transmitting piece, the first light transmitting piece is provided with a light shading area, and the light shading area is used for shading a light emitting area of the light supplementing module. The problems that the license plate recognition effect at the entrance and exit of the parking lot is poor, and a certain degree of glare is caused to pedestrians and riders are solved.

The invention relates to the field of herbal fragrant moxibustion, in particular to an edible and medicinal inhalation type atomized moxibustion material and a preparation method thereof. The invention relates to an edible and medicinal inhalation type moxibustion atomized material which comprises the following raw materials in parts by weight: 8-11 parts of astragalus membranaceus, 5-6 parts of pericarpium citri reticulatae, 6-10 parts of radix puerariae, 10-12 parts of agilawood, 8-12 parts of poria cocos, 7-9 parts of radix ophiopogonis, 20-25 parts of a carrier, 2-3 parts of an adhesive and the balance of water, wherein the total weight part is 100; the carrier comprises at least one of lotus leaves and loquat leaves; the adhesive comprises at least one of guar gum and pregelatinized starch. According to the application, the medicine taking astragalus membranaceus as a main medicine is prepared into the edible and medicinal inhalation type moxibustion atomized material, and the medicine can be absorbed in an aerosol inhalation mode during use. And after the moxibustion atomized material is prepared, the medicine medium has higher penetrability, can reach blood capillaries of a human body more easily, and has a stronger conditioning effect.

This invention belongs to the field of biomedicine, specifically relating to siRNA that inhibits AR gene expression, comprising a sense strand and an antisense strand, wherein the sense strand and the antisense strand are at least partially anticomplementary to form a double-stranded region, and the sense strand or antisense strand consists of 19-25 nucleotides with blunt ends of complementary nucleotide sequences; or the antisense strand consists of 27 nucleotide sequences with overhangs. The siRNA of this invention can maintain long-term efficacy with a single dose, exhibiting good compliance in patients with chronic diseases such as androgenetic alopecia. Furthermore, it has lower off-target toxicity and fewer side effects compared to small molecule chemical drugs and hormone drugs.

The application discloses a tobacco extract preparation method, which comprises the following steps: (1) one-time feeding: preparing a carbonated salt-amino acid mixed aqueous solution, uniformly applying the mixed aqueous solution to tobacco raw materials, and standing at room temperature; (2) drying: performing heating treatment on the tobacco raw materials after feeding, and drying; (3) secondary feeding: uniformly applying a polyol to the dried tobacco raw materials; (4) extrusion: performing extrusion and puffing treatment on the tobacco raw materials after feeding, and obtaining treated tobacco raw materials; and (5) extraction: performing extraction and separation on the treated tobacco raw materials, and obtaining a tobacco extract. The carbonated salt-amino acid solution can improve feeding uniformity, improve the pH of the system to reduce nicotine, drying is beneficial to subsequent reactions, the polyol improves material fluidity and prevents extrusion die blockage, extrusion and puffing high-temperature and high-pressure degrade macromolecules, and the tobacco aroma is improved. The extract can be used for heat cigarettes, the aroma is richer, and the odor and irritability are obviously reduced.

The utility model is suitable for liquid impurity detection technical field provides a kind of fluorine deoxy glucose injection's lamp detection device, including base;Through the pivot rotation installation in the adjusting plate of the base top;The illuminating lamp for emitting light to assist lamp detection is installed in the adjusting plate top;Through support rod fixed in the adjusting plate top and located the top plate of the illuminating lamp directly above, the top plate is fixed with the limiting piece for stabilizing fluorine deoxy glucose injection storage tube.This scheme provides fluorine deoxy glucose injection's lamp detection device by setting the observation board that can flexibly rotate, it is convenient to observe injection liquid light transmission shadow state from different angles, it is favorable to find impurity, while avoiding direct gaze light source by human eye, reduce the irritation to eye, make lamp detection process more comfortable.

The invention is suitable for the technical field of medical instruments, and provides a trephine tool bit type servo electric hair transplanting pen which comprises an electric hair transplanting pen body, an auxiliary hair transplanting mechanism is arranged on the outer side of the electric hair transplanting pen body, and a power supply mechanism is arranged at the top of the electric hair transplanting pen body; according to the electric hair transplanting pen, the auxiliary hair transplanting mechanism is arranged on the outer side of the electric hair transplanting pen body, so that the hair transplanting process depends on hand control of an operator, and the hair transplanting operation can be stably guided by means of an auxiliary supporting structure formed by the fixing rod, the connecting rod and the telescopic arm; the auxiliary hair transplanting mechanism is reliably locked in different position states, so that the influence of hand shaking on the operation precision is effectively reduced in the hair transplanting process, the stability of the hair transplanting posture can be kept especially in long-time continuous hair transplanting or high-density hair transplanting operation, the hair transplanting consistency and survival rate can be improved, and the overall hair transplanting effect is improved.

The utility model discloses a cup body for cupping, including the casing, be equipped with the mounting groove in the casing, be equipped with the heating component for heating the casing in the mounting groove, heating component heats the casing, after the casing is heated to the comfortable temperature, manual or mechanical cup body is buckled on the skin, and cupping operation is carried out, can avoid the cup body when the initial contact with the skin, the cup body is in the state of ice cold, reduces the stimulation to the user skin, optimizes the use experience of cup body.

The present application relates to gold mark implant technology field, disclose a pure gold gold mark implant with positioning features, including at least two markers, through gold mark injector to mark injection;Connecting line is collagen chain, fixed pattern, arranged on the marker, when the marker is located in the target tissue, the target tissue extrudes the fixed pattern, so that the marker can be fixed in the target tissue;The fixed pattern includes a fixed part opened on the marker;Wherein the left view of the marker is a circular structure, wherein two mutually perpendicular axis sections in the marker divide the plan view of the marker into four regions, wherein the fixed part is located in the above region, by setting the limiting groove in the pure gold gold mark, connecting line, mushroom-shaped third fixed part and the structure of multilayer groove, further make the human tissue can enter to cooperate with the barb to realize the fixation work of gold mark implant, avoid the displacement of implant position.

This utility model discloses a feeding tube with a flushing function, relating to the field of enteral feeding tube technology. It includes a silicone tube with a pin connector and a pagoda connector fixedly connected to its top and bottom ends, respectively. From top to bottom, the silicone tube is equipped with a drip bottle, a speed controller, and a medication inlet. The medication inlet is Y-shaped, and the silicone tube connects to one port at the top and one port at the bottom of the medication inlet. A flushing mechanism is connected to the other port at the top of the medication inlet. This utility model connects a flushing tube to the medication inlet of the flushing tube, and the flushing tube contains a storage chamber and a piston. The piston pushes saline solution from the storage chamber into the feeding tube, achieving flushing of the inside of the feeding tube. Through the cooperation of a ball screw and a ball nut, the saline solution is flushed at a pulsed frequency, reducing irritation to the intestines during saline injection.

The present application relates to a kind of antibacterial and anti-adhesion catheter based on intelligent response nanofiber membrane, which is composed of medical polymer catheter substrate, silane coupling agent transition layer grafted on the outer surface of the substrate and nanofunctional fiber membrane layer formed on the outer surface of the transition layer by electrospinning process, the nanofunctional fiber membrane layer is composed of polyvinyl alcohol loaded hyaluronic acid grafted copper-doped carbon dots (CCDH), CCDH takes copper-doped carbon dots as core, and forms core-shell structure by grafting hyaluronic acid on the surface. The present application solves the problem of easy peeling of catheter coating by chemical bonding, and the formed antibacterial and anti-adhesion catheter has very low water contact angle and friction coefficient, not only effectively blocks the initial adhesion of bacteria at the physical level by constructing hydration layer, but also releases copper ions and carbon dots by enzymatic hydrolysis of hyaluronic acid under bacterial infection microenvironment, induces the production of reactive oxygen species to kill bacteria efficiently, and has broad application prospect in reducing the risk of catheter-related urinary tract infection.

The utility model provides a depilation and skin polishing panel and depilation and skin polishing device, including panel body, be provided with the convex unit on panel body, and the convex unit includes outer convex and inner convex, and outer convex and inner convex are all closed line structure, and inner convex is located the inside of outer convex, and the number of inner convex is at least two, and at least two inner convexes are arranged in non - wrapped spacing between, and at least one inner convex has at least one angle. The depilation and skin polishing panel improves the depilation and skin polishing effect, and improves the user experience.

A cosmetic composition is provided, comprising: an oil phase in the form of an oil capsule; and an aqueous phase, the oil phase comprising: a lipid component containing ceramides or derivatives thereof, cholesterol and fatty acids; an alcohol having 16 to 20 carbon atoms; and an oil thickener, the oil capsule having a transparent appearance.

The utility model discloses a butterfly shape double mode oxygen uptake fixed face patch, include: butterfly shape face patch body, to be used to fit face profile, butterfly shape face patch body whole is butterfly wing spreading state, to cover the left and right cheek middle and lower part area of human face, oxygen uptake pipe fixed double channel, set up in butterfly shape face patch body left side inside, and whole is "L" shape, magic paste female fastener, sew up in the left and right two side edges of butterfly shape face patch body, be used to with the sub fastener cooperation of sunshade curtain and connect, it is the core connection structure of realizing sun protection function. Biological glue layer, cover in the back of butterfly shape face patch body, be used for with skin contact, sunshade curtain, with the upper half of human face matching, to cover eye, cheek upper part and nose bridge area, the left and right side edges of sunshade curtain sew up have magic paste sub fastener, magic paste sub fastener and magic paste female fastener cooperation is used. The utility model satisfies oxygen uptake fixed and ultraviolet protection demand, adapts to daytime outing scene.

The invention relates to the technical field of nursing materials, and discloses eye washing liquid for relieving eye fatigue and a preparation method thereof.The eye washing liquid is prepared from trehalose, taurine, sodium gualenate, sodium hyaluronate, ergothioneine, vitamin B12, vitamin B6, xanthophyll, mint, a humectant, a bacteriostatic agent, a chelating agent, a pH regulator and deionized water. Through the synergistic effect of the first synergistic composition and the second synergistic composition, retina cell injury induced by blue light can be effectively repaired, the repairing effect is superior to that of simple addition of a single component, blue light oxidative injury is repaired through a multi-target synergistic mechanism, a three-layer structure of a tear film lipid layer, a water layer and a mucoprotein layer can be reconstructed, and the repairing effect is good. According to the present invention, the tearable film stability is significantly improved, the excellent protection and repair effect is provided, the compatibility of the components is good, the product stability is high, and the multiple effects of ocular surface cleaning, asthenopia relieving, conjunctival congestion reducing and blue light oxidation damage preventing are provided.

This invention discloses an adjustable pressure dressing for drainage tube leakage, relating to the field of medical device technology. The dressing includes a main body with a central sponge channel and an adjustable pressure spiral plug structure. Through the steps of disinfecting the puncture site, covering and fixing the dressing, and adjusting the pressure according to the leakage situation, effective control of drainage tube leakage is achieved. This invention can provide personalized pressure support, reduce fluid leakage around the puncture site, lower the risk of infection, improve patient comfort, reduce nursing workload, and shorten the healing time of the puncture site, demonstrating significant clinical application value.

The present application relates to the technical field of pharmaceutical cocrystal, and specifically discloses a callylazine and quercetin pharmaceutical cocrystal, a preparation method and application thereof, wherein callylazine and quercetin are mixed in proportion, a good solvent n-propanol is added until complete dissolution, a poor solvent is added drop by drop into the mixed solvent until a supersaturated state, a mixed solution is obtained, solvent in the mixed solution is volatilized by using a solvent evaporation crystallization method, intermolecular hydrogen bonding of callylazine and quercetin is formed, and a callylazine and quercetin pharmaceutical cocrystal is obtained. The powder dissolution experiment result of the callylazine and quercetin cocrystal shows that the dissolution rate of callylazine decreases under neutral conditions compared with the release rate of free drug, and potential sustained release effect is shown, so that the callylazine and quercetin pharmaceutical cocrystal can be prepared into a muscle injection, and has potential for long-acting treatment of schizophrenia and reduction of muscle stimulation.

The invention discloses a limb fixing device for a critical patient, belongs to the technical field of limb fixing, and aims to solve the problems that the contact area between a bandage and the arm of the patient is small, the constraining force is concentrated, pressure injury is easily formed due to long-time constraining, the pain of the patient is increased, local infection is possibly caused, and the illness state is aggravated. The hospital bed comprises a hospital bed body and two supporting plates fixed to one side of the hospital bed body, restraint straps are arranged on one sides of the supporting plates, a plurality of first pressure air bags are installed on one sides of the restraint straps, a plurality of second pressure air bags are further installed on one sides of the restraint straps, and the second pressure air bags and the first pressure air bags are arranged in a staggered mode. Alternate inflation and deflation of the first pressure air bag and the second pressure air bag are achieved through the two-way air pump, so that the pressed parts of the limbs are continuously alternated, local skin and soft tissue are prevented from being in a pressed state for a long time, local blood circulation is effectively improved, the problems of skin redness, pressure sores, limb ischemia and the like are solved, and the completeness of the limb tissue of a patient is protected.

The invention relates to a multifunctional medicine release composition as well as a preparation method and application thereof. The multifunctional medicine release composition has a treatment effect on attention deficit and attention disorder of children. The invention also provides a dispersible sustained-release multi-unit pellet system which comprises an active pharmaceutical ingredient and pharmaceutically acceptable auxiliary materials, and the active pharmaceutical ingredient exists in the core pellet. The invention also relates to a method for preparing the sustained-release multi-unit pellet system by adopting a multi-seal coating technology. The dispersible slow-release multi-unit pellet system disclosed by the invention has a good release characteristic.

The invention discloses a sun-screening and repairing cosmetic composition as well as a preparation method and application thereof. The sun-screening and repairing cosmetic composition is prepared from the following components in parts by mass: 0.5 to 50 parts of a physical sun-screening agent, 0 to 30 parts of a chemical sun-screening agent, 0.5 to 20 parts of a humectant, 0.05 to 5 parts of an antioxidant, 1 to 5 parts of an emulsifier and 0.1 to 5 parts of other auxiliary components, the physical sun-screening agent comprises zinc oxide and / or titanium dioxide; the particle size of the zinc oxide and / or the titanium dioxide is greater than 100nm, and the radius-thickness ratio of the zinc oxide and / or the titanium dioxide is (30-40): 1. The sunscreen and repair cosmetic composition provided by the invention has the effects of efficient sunscreen, anti-oxidation repair, moisturizing and soothing, and can be widely applied to preparation of various sunscreen and repair cosmetics such as sunscreen cream, sunscreen emulsion, sunscreen spray and the like.