12 results about "Conjunctiva" patented technology

The present invention relates to an ophthalmic ultrasonic emulsification sleeve for confirming intraocular and extraocular penetration and perfusion, which allows determining whether aqueous humor communication between the inside and outside of the eye is smooth through a microtube implanted in the eye during glaucoma tube surgery. The sleeve is characterized by having a rigid branch tube made of a material harder than a sleeve made of a soft material, provided in a perfusion port that allows the injection of a balance salt solution into the eye, and with the branch tube connected to the perfusion port, the tip of the branch tube protrudes further than the tip of the Paco tip, and the end of the microtube inside the eye is connected to the tip of the branch tube, so that the establishment of aqueous humor communication of the microtube can be quickly and accurately and sensorially confirmed based on the pattern of pressure change in the conjunctival area and surrounding blood flow change that occurs when the balance salt solution leaks out of the eye.

This utility model relates to a conjunctival sac support sheet, comprising a light-transmitting support sheet body, the support sheet body having opposing outer and inner surfaces, and a plurality of first drainage holes provided on the support sheet body, the first drainage holes penetrating the support sheet body along the thickness direction and located in the edge region of the support sheet body. The first drainage holes not only have a stronger drainage function, but can also be used for suture fixation, allowing doctors to perform suture surgery to fix the support sheet in the conjunctival sac and prevent accidental dislodgement.

An intraocular lens (IOL) (100) specifically designed for posterior chamber sutureless scleral fixation comprises an optic plate (11) and two haptics (12) extending from opposite sides of the optic plate (11), each haptic (12) comprising at its extremity a pinhead-shaped anchoring element (13) for anchoring to the sclera. This eliminates the need for scleral flaps, thereby simplifying the surgical procedure and reducing operative time while enhancing postoperative outcomes.

Based on 3D printing technology and corneal topography assisted personalized ocular prosthesis manufacturing method, through the high polymer impression material to make the patient's eye side conjunctival sac impression, and obtain the three-dimensional data of the conjunctival sac impression of the affected eye, and establish a three-dimensional model, remove the front surface of the three-dimensional model with the pupil center as the center, and the corneal diameter data of the healthy eye as the diameter of the circular area, and integrate the pupil diameter and corneal anterior surface curvature data of the healthy eye in this area, and finally obtain the three-dimensional model of the ocular prosthesis, and the ocular prosthesis is made through 3D printing technology, because the data of the pupil diameter and corneal anterior surface curvature of the healthy eye are integrated on the front surface of the three-dimensional model of the affected eye, the ocular prosthesis is more realistic and more suitable for the affected eye.

This invention discloses a method and system for detecting pathogens in the conjunctival sac using fluorescence staining image analysis, belonging to the field of medical image processing technology. The method includes: acquiring multi-wavelength fluorescence images and performing inter-channel differential operations to construct a spectral response surface; identifying regions of abrupt curvature changes to determine candidate pathogen locations; extracting radial fluorescence intensity distribution curves; calculating attenuation gradients and transition band width matching rules to determine pathogen types; acquiring temporal fluorescence intensity; screening locations where the intensity change rate exceeds an activity threshold as active pathogen locations; identifying the diffusion axis based on spatial distribution; calculating the spatial density gradient based on statistical density changes; coupling the intensity change rate to calculate the diffusion rate and determine the warning region; identifying abnormal pixels within the warning region; verifying continuous growth characteristics through temporal tracking; confirming and marking early infection areas. This invention improves detection accuracy and timeliness, enabling early warning.

A stent implant for treating glaucoma by intraocular fluid drainage from the anterior chamber, for example into the suprachoroidal space. The stent implant is designed to change in shape after being inserted into the eye, during which change the width and / or thickness or the flow cross-section is increased by for example 20%, in another example more than 200%, and in a further example by more than 400%, at least one point of the stent implant. In the case of intraocular fluid drainage from the anterior chamber into the suprachoroidal space, a cyclodialysis cleft which may open can be largely or completely closed. With appropriate adjustments, the stent implant can also be applied in trabecular, uveoscleral, uveolymphatic and subconjunctival applications for intraocular fluid drainage from the anterior chamber. The implant can even be used for direct intraocular fluid discharge from the anterior chamber onto the surface of the eye.

The present disclosure provides an ophthalmic formulation comprising one or more pharmaceutically acceptable excipients; a pharmaceutically active compound that is capable of reducing the amount or deleterious actions of autoantibodies on the ocular surface, such as IgG; In particular, the present disclosure provides an ophthalmic formulation where the pharmaceutically active compound is capable of treating a clinical condition selected from the group consisting of inflammatory, infectious and immunological ocular surface or intraocular disease that can cause symptoms of ocular discomfort, keratitis, dry eye disease, symblepheron formation, fornix foreshortening, eyelid margin / conjunctival keratinization, subconjunctival fibrosis, retinal gliosis and glaucoma.

The application discloses a kind of based on dynamic softening polycarbonate composite ring's free suture biological amniotic membrane and preparation method thereof.The based on dynamic softening polycarbonate composite ring's free suture biological amniotic membrane includes the amniotic membrane tissue piece of decellularization processing and the modified polycarbonate composite ring for fixing the amniotic membrane tissue piece;The modified polycarbonate composite ring includes polycarbonate continuous phase and the dispersed phase of intelligent polymer in it, and the intelligent polymer is PLGA-PEG-PLGA tri-block copolymer.The application is by specially-made PLGA-PEG-PLGA intelligent polymer and gives modified PC composite ring dynamic modulus adjustable characteristics.After the composite ring is implanted in eye, under the action of body temperature and tear, its contact surface modulus can be reduced by 40%-68% within 24 hours, realize from "surgical rigidity" to "in situ soft" adaptive change.This fundamentally greatly reduces the mechanical friction with cornea / conjunctiva, relieves the strong foreign body sensation, pain and irritation symptom of patient after operation.

The invention consists of forceps with rounded gripping tips. These rounded tips are designed to prevent perforation of the amniotic membrane during its insertion onto the ocular surface for the treatment of dry eye and ocular inflammation, as well as to prevent injury to the conjunctiva during its removal. The forceps have gripping tips at their distal end, one of which has a notch on its inner surface. The dimensions of the notch allow the ophthalmologist to securely grasp the edge of the amniotic membrane to facilitate its insertion and removal from the ocular surface.

The present application relates to a kind of conjunctival transplantation device for pterygium excision surgery, including first holding unit, second holding unit, support unit, first angle adjusting unit, second angle adjusting unit, first pressing unit, first cutting unit and second cutting unit.Its advantages are that the angle of first cutting unit and second cutting unit is adjusted in proximal end using first holding unit and second holding unit;first angle adjusting unit and second angle adjusting unit are rotated using first pressing unit, and then first cutting unit and second cutting unit cut conjunctival flap on support unit, which integrates multiple dispersed steps into one medical instrument to complete continuously, reducing instrument replacement;the size of conjunctival flap is measured by support unit without damaging the flap, which not only ensures the accuracy of the size and shape of the flap, avoids the error of manual operation, improves the accuracy and efficiency of surgery, but also avoids tissue damage caused by traditional forceps directly holding.

This invention discloses the application of necrotizing 1 (Necrostatin-1) in the preparation of drugs for the prevention and / or treatment of dry eye, relating to the field of biomedical technology. The application of necrotizing 1 in the preparation of drugs for the prevention and / or treatment of dry eye is described. This invention is the first to discover the application of the programmed necrosis inhibitor Necrostatin-1 in the treatment of dry eye. Nec-1, by inhibiting programmed necrosis, can effectively protect corneal epithelial cells and reduce ocular surface inflammation and damage. In a scopolamine-induced dry eye model, subconjunctival injection of 0.3 μM Nec-1 significantly improved dry eye symptoms, including reduced corneal defects and increased tear secretion, without significant drug toxicity. Nec-1 provides a new targeting strategy for dry eye treatment and may become a potent and effective drug for the clinical treatment of dry eye in the future.