42 results about "Thiazolidine" patented technology

The invention relates to the technical field of organic photoelectric materials, and particularly discloses a non-condensed ring small molecule acceptor material based on a quinonoid structure as well as a preparation method and application of the non-condensed ring small molecule acceptor material. According to the invention, easily available 1, 4-diacetyl piperazine-2, 5-diketone is used as a center, an alkyl chain and Ar are used for modification, EG is used as an end group, the non-condensed ring A-D-A '-D-A type structure acceptor material based on a quinone structure is constructed, and the general formula is shown in the specification. Wherein the PCE of the acceptor material which is modified by bithiophene and takes 2-(3-ethyl-4-oxothiazolidine-2-subunit) malononitrile as a terminal group reaches 15%. The non-condensed ring small molecule acceptor material based on the quinonoid structure is simple in synthesis process, and an effective strategy is provided for solving the problem of the overall performance of an organic solar cell.

The invention discloses a chiral amino acid CPL probe based on an aldehyde group functionalized luminescent rare earth spirochete complex as well as a preparation method and application thereof, and belongs to the technical field of biosensing materials. The invention aims to solve the problem that the existing probe has poor selectivity in recognition of sulfydryl amino acid. The chiral amino acid CPL probe is an aldehyde group functionalized water-soluble lanthanide helical complex, side chain aldehyde groups can enhance the water solubility of the helical complex by forming hemiacetal and can also be used as specific recognition sites, the aldehyde groups react with sulfydryl-containing amino acids such as D-penicillamine and L-cysteine to form thiazolidine rings, and the chiral amino acid CPL probe can be used as a specific recognition site. Furthermore, the chirality of D-PA and L-Cys is triggered to be transmitted to a metal center, and the chirality is amplified into a detectable CPL signal. Thiazolidine rings formed by condensation of different amino acids have steric hindrance differences, and the steric hindrance differences can influence spiral chirality, so that the probe still shows excellent selectivity even in a complex system in which a plurality of interfering substances coexist.

The present application relates to the technical field of agricultural chemistry, in particular to butenolide compounds containing a thiazolidinone structure as well as a preparation method therefor and the use thereof. The butenolide compounds containing a thiazolidinone structure are characterized by having the following structural general formula (I). The compounds disclosed by the present application have excellent fungicidal activity on various pathogens in agriculture or other fields, and can favorably protect important crops and domestic animals in agriculture and horticulture industry, and the environment that the human beings rely on from invasion of pathogens.

The invention relates to a method of producing a food composition comprising microalgal biomass with reduced off-flavour, said method comprising adding at least 0.001 wt.%, calculated by weight of the food product, of an aldehyde scavenger, said aldehyde scavenger containing at least 5 wt.%, calculated by weight of the aldehyde scavenger of cysteine. The invention also relates to Food composition comprising microalgal biomass material, said material comprising at least 5 wt% of microalgal protein by weight of dry matter of the microalgal biomass, and 2-pentyl-1,3-thiazolidine-4-carboxylic acid and / or salts thereof, and optionally, water. The invention also relates to a food composition comprising microalgal biomass material, comprising at least 5 wt% of microalgal protein by weight of dry matter of the microalgal biomass; hexanal or a source of hexanal; and at least 0.001 wt.%, calculated by weight of the food product, of an aldehyde scavenger, said aldehyde scavenger containing at least 5 wt.%, calculated by weight of the aldehyde scavenger of cysteine.

The present disclosure provides thiazolidine (Tz) linkers for protein-drug conjugates. In addition, the disclosure also encompasses compounds useful for producing such protein-drug conjugates, as well as methods for production of such protein-drug conjugates. The disclosure also encompasses methods of using the protein-drug conjugates for the treatment of a disease or disorder in a subject.

The application discloses a FAPI derivative containing 4-cyano thiazolidine modification and application thereof, relates to the field of drug compounds for diagnosing tumors, and provides a FAPI derivative containing 4-cyano thiazolidine modification, a chemical structural formula of which is shown as formula I. The FAPI derivative has good stability, is simple to prepare, has high radiochemical purity and good biological performance, and can be further used for clinical PET / CT tumor imaging, effectively solving the problems of low tumor uptake rate, short retention time and inability to further delay imaging of F-labeled FAPI probes. 18 The FAPI derivative containing 4-cyano thiazolidine modification can solve the problems of low tumor uptake rate, short retention time and inability to further delay imaging of F-labeled FAPI probes, and make up for the defects of the prior art.

Compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5, and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

The application discloses an epoxy thermosetting resin containing a thiazolidine dynamic co-curing component and a preparation and recovery method thereof, and belongs to the technical field of polymer materials and thermosetting resins. The thiazolidine dynamic co-curing component is a compound containing a thiazolidine structure, at least one thiazolidine ring and at least two carboxyl groups capable of participating in an epoxy curing reaction. The application introduces the dynamic co-curing unit containing the thiazolidine structure by partially replacing the curing component, realizes low-disturbance dynamic modification without completely reconstructing a traditional epoxy system, has little influence on the compatibility of an original formula and the comprehensive performance of a material. The double-response characteristics of the thiazolidine structure embedded in the network can trigger network topology rearrangement at high temperature, endow the material with stress relaxation, self-repairing, hot welding and hot pressing reprocessing capacity, and can also cause selective cleavage under acidic conditions, realize chemical deconstruction of the crosslinking network, and have good application prospect.

Compounds having the structure of formula (I) and their pharmaceutically acceptable salts are disclosed, wherein X 1 R 1 R 2 R 3 R 4 R 5 and R 6 This refers to: pharmaceutical compositions comprising such compounds and salts as defined in the specification; the use of such compounds and salts for the treatment or prevention of prolyl endopeptidase fibroblast activation protein (FAP)-mediated diseases; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts. Formula (I):

In some aspects, this disclosure relates to methods for preparing cysteine ​​source solutions containing thiazolidinediones. In some other aspects, this disclosure relates to methods for using these cysteine ​​source solutions (such as in the preparation of cell culture media, cell culture, and / or peptide production), and systems and kits comprising these cysteine ​​source solutions.

The invention discloses a thiazolidinone compound and a preparation method and application thereof.The structural formula of the thiazolidinone compound is shown in the formula (II), and the preparation method of the thiazolidinone compound comprises the steps that 4-bromobenzene isothiocyanate and pyridine-4-formyl hydrazine serve as raw materials to react to obtain a product (I); and preparing the thiazolidinone compound (II) by taking the product (I) and chloroacetic acid as raw materials. The thiazolidinone compound disclosed by the invention shows antibacterial activity, particularly has good antibacterial activity on haemophilus influenzae, and can be used as an antibacterial agent.

The present invention relates to pharmaceutical compositions comprising 5-(4-(2-((6-(4-methoxyphenoxy)pyrimidin-4-yl)(methyl)amino)ethoxy)benzyl)thiazolidine-2,4-dione, and salts and co-crystal forms thereof, for the treatment of diseases, processes for the preparation of such formulations, and pharmacokinetic parameters controlled by the formulations.

Disclosed herein are compositions comprising A) compound of Formula One (F1) or Formula Two (F2); and B) biological agent selected from the group consisting of Bacillus species, Baclovirus species, Pseudomonas species, Beauveria species, Mycobacterium species, Mycorrhizal fungi, Trichoderma species, and Metarhizium species.

This invention discloses a benzylpiperidine-containing thiazoline-2,4-dione derivative, its preparation method, and its application, belonging to the field of pesticide synthesis and application technology. This invention synthesizes a series of benzylpiperidine-containing thiazoline-2,4-dione derivatives by combining the highly active benzylpiperidine group with a thiazoline-2,4-dione structure via flexible bonds. Through tests on the inhibitory activity of the synthesized benzylpiperidine-containing thiazoline-2,4-dione derivatives against plant pathogenic fungi, it was found that the benzylpiperidine-containing thiazoline-2,4-dione derivatives synthesized in this invention can effectively inhibit plant pathogenic fungi, especially rice sheath blight pathogen.

The present invention relates to the use of a thiazolidine compound of the formula (I) for reducing or inhibiting surfaces corrosion, for example in applications such as water treatment, industrial cleaning and especially in automatic dishwashing (ADW). Moreover, the present invention also relates to a method for reducing or inhibiting surfaces corrosion using said thiazolidine compound. Furthermore, the present invention relates to specific thiazolidine compounds and to a process for producing these compounds. (I) wherein R1 is selected from the group consisting of hydrogen and C1-4-alkyl; R2 is selected from the group consisting of hydrogen, carboxyl, C1-10- alkoxycarbonyl, C1-20-alkyl, C2-10-alkenyl, where C1-20-alkyl and C2-10-alkenyl are unsubstituted or substituted by 1 or 2 of the groups Ra, etc.; R3 is selected from the group consisting of hydrogen and C1-4-alkyl; R4 is selected from the group consisting of hydrogen, NH-C(=O)-NH2 and C1-4- alkyl; X is selected from the group consisting of hydrogen, alkali metal ions, C1-20- alkyl, C2-10-alkenyl and C6-12-aryl-C1-4-alkyl, where C6-12-aryl is unsubstituted or substituted by 1, 2 or 3 substituents Rc; Ra is selected from the group consisting of COOH, OH, C1-10-alkoxycarbonyl, C1-10-alkylcarbonyl, C2-10-alkenyl, NHC(=O)Rd, C3-10-cycloalkyl, C6-10-bicyclo- alkyl, C5-10-cycloalkenyl, 5-or 6-membered heterocyclyl bearing 1 or 2 heteroatoms selected from O, S and N, where C3-10-cycloalkyl, C6-10-bicycloalkyl, C5-10-cycloalkenyl and heterocyclyl are unsubstituted or substituted by 1, 2 or 3 substituents Rb, C6-12-aryl, such as phenyl, and 5- or 6-membered hetaryl, such as furyl and pyridyl, where C6-12-aryl and hetaryl are unsubstituted or substituted by 1, 2 or 3 substituents Rc; Rb is C1-4-alkyl, OH or two groups Rb bound to the same carbon atom are =O; Rc is selected from the group consisting of OH, C1-4-alkyl and O-C1-4-alkyl; and Rd is selected from the group consisting of H and C1-4-alkyl.

A rubber composition includes a chloroprene-based rubber, 5 to 80 parts by mass of silica, 0.5 to 15 parts by mass a silane coupling agent, and 0.5 to less than 20 parts by mass of a hydrate. The rubber composition satisfies at least one of (i) and (ii): (i) the rubber composition includes 0.1 to 3.0 parts by mass of 3-methyl-thiazolidine-2-thione; (ii) the rubber composition includes 0.1 to 3.0 parts by mass of compound A that is at least one of a thiourea-based compound, 3-methyl-thiazolidine-2-thione, and di(5-mercapto-1,3,4-thiadiazol-2-yl) disulfide; and 0.01 to 3.0 parts by mass of compound B that is at least one of a thiuram-based compound, a sulfenamide-based compound, a thiazole-based compound, a guanidine-based compound, a benzimidazole-based compound, N-phenyl-N-(trichloromethylthio)benzenesulfonamide, and a diazabicycloundecene-based compound.

The present invention relates to the use of iminooxothiazolidine derivatives for the prevention or treatment of hair growth disorders. The iminooxothiazolidine derivatives can be formulated as compositions suitable for either systemic administration or topical application to the scalp.

The invention relates to a composition containing thiazolidinone acaricides and application thereof, the composition comprises a compound shown as a formula (I) and an active compound shown as a group (II), the active compound shown as the group (II) is selected from (3), (6), (10), (12), (13), (20), (21), (23) or (25) of an insecticide group (IRAC classification group), and the weight part ratio of the compound shown as the formula (I) to the active compound shown as the group (II) is 1: 99-99: 1. The composition disclosed by the invention has a remarkable synergistic effect, can effectively improve the prevention and control effects on agricultural pests, urban health pests and pest mites, reduces the dosage and cost, delays the generation of pest resistance to drugs, can be prepared into various dosage forms, and is widely applied to pest prevention and control in the fields of agriculture, forestry and urban health.

The application belongs to the technical field of reproductive health, and particularly relates to a new application of a testicular metabolite 2-n-propylthiazolidine-4-carboxylic acid (PTCA), and the 2-n-propylthiazolidine-4-carboxylic acid is used for preparing a drug for treating testicular spermatogenic disorder induced by AFB1. The PTCA can promote the secretion of testosterone of testicular interstitial cells, activate the PI3K / AKT / NRF2 antioxidant signaling pathway in testicular tissue, relieve testicular injury induced by AFB1, and reduce the ROS level in testicular tissue. The application discloses, for the first time, the important role of the PTCA as a new testicular metabolic marker and protective agent in the male reproductive system, provides a new insight into the reproductive toxicity mechanism of AFB1, and lays an experimental foundation for the application of metabolites to the intervention strategy of male spermatogenic disorder.

The application discloses a preparation method of levamisole hydrochloride and belongs to the technical field of medical intermediates. (R)-epoxyphenylalkane is used as raw material, and is subjected to ring opening with 2-chloroethylamine hydrochloride in water to obtain (R)-1-phenyl-2-aminoethanol; then, ring closure is carried out with thiourea to obtain (R)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidine imine; finally, intramolecular Mitsunobu ring closure reaction is carried out, and after treatment, levamisole hydrochloride is obtained. The preparation method has the advantages of short reaction steps, simple and coherent operation, easy control, low corrosion to equipment, and the like, and simultaneously improves the yield and quality of the product.

This disclosure relates to 1,4-oxazepane and 1,4-thiazepane derivatives and their use to treat disorders and diseases associated with ryanodine receptor (RyR) that modulate calcium channel signaling in cells. This disclosure also discloses pharmaceutical compositions comprising these compounds and their use to treat diseases and conditions associated with RyR dysfunction, particularly cardiac, musculoskeletal, and central nervous system (CNS) disorders.

The invention relates to the field of thioester peptide synthesis, in particular to a method for preparing thioester peptide with L-thiazolidine-4-carboxylic acid at the N end, which comprises the following steps: S1, dissolving polypeptide hydrazide in a mixed solvent consisting of hydrochloric acid, guanidine hydrochloride and sodium dihydrogen phosphate, and reacting with excessive sodium nitrite and L-thiazolidine-4-carboxylic acid at the temperature of 15 DEG C below zero to 5 DEG C below zero to obtain polypeptide hydrazide; generating an acyl-containing azide peptide system; s2, adding excessive methyl thioglycolate into the acyl-containing azide peptide system, then adding an ammonium bicarbonate solution to adjust the pH value to 5.5, and carrying out oscillation reaction at normal temperature to generate a sulfur-containing ester peptide system; and S3, adding diethyl ether which is precooled to 0 DEG C into the thioester peptide-containing system for washing, and removing an upper-layer solution to prepare the thioester peptide of which the N end is L-thiazolidine-4-carboxylic acid. According to the method, the L-thiazolidine-4-carboxylic acid is added in the sodium nitrite treatment process, conversion from the hydrazide peptide with the N end being the L-thiazolidine-4-carboxylic acid to the hydrazide peptide with the N end being the L-thiazolidine-4-carboxylic acid thioester peptide is achieved, the synthesis process is simple, and the synthesis efficiency is high.

In particular, the present invention provides a resist underlayer film having a high dry etching rate, a resist underlayer film forming composition, a resist pattern forming method, and a semiconductor device manufacturing method. [Solution] A resist underlayer film forming composition comprising a reaction product of an epoxy group-containing compound and a heterocyclic compound containing one moiety reactive with an epoxy group, and a solvent. Preferably, the heterocyclic compound is selected from furan, pyrrole, pyran, imidazole, pyrazole, oxazole, thiophene, thiazole, thiadiazole, imidazolidine, thiazolidine, imidazoline, dioxane, morpholine, diazine, thiaidine, triazole, tetrazole, dioxolane, pyridazine, pyrimidine, pyrazine, piperidine, piperazine, indole, purine, quinoline, isoquinoline, quinuclidine, chromene, thianthlene, phenothiazine, phenoxazine, xanthene, acridine, phenazine, and carbazole.

The application discloses application of a quinoline compound in preventing and treating Ralstonia solanacearum, and belongs to the technical field of plant bacterial wilt prevention and treatment; the quinoline compound is 1-ethyl-6-fluoro-7-morpholino-3-(3-(p-tolyl)-1,2,4-oxadiazol-5-yl) quinolin-4(1H)-one; it is found for the first time that 1-ethyl-6-fluoro-7-morpholino-3-(3-(p-tolyl)-1,2,4-oxadiazol-5-yl) quinolin-4(1H)-one has strong inhibitory activity on Ralstonia solanacearum; experiments show that the MIC of 1-ethyl-6-fluoro-7-morpholino-3-(3-(p-tolyl)-1,2,4-oxadiazol-5-yl) quinolin-4(1H)-one on Ralstonia solanacearum is 5 mu g / mL at 24 h, which is equivalent to that of thiazolidine ketone, and the compound can be used for preventing and treating plant bacterial wilt and provides a new candidate compound for development of a bactericide for Ralstonia solanacearum.

The present application relates to a composition containing a thiazolidine acaricide and its application, the composition comprising a compound of formula (I) and a group (II) active compound selected from the insecticides of groups (IRAC classification groups) (3), (6), (10), (12), (13), (20), (21), (23) or (25), the weight ratio of the compound of formula (I) to the group (II) active compound being 1:99-99:1. The composition of the present application has a significant synergistic effect, can effectively improve the control effect on agricultural pests, urban health pests and mites, reduce the dosage and cost, delay the development of pest resistance, and can be made into various dosage forms and widely applied in the control of pests in the fields of agriculture, forestry and urban health.

The present invention relates to a pharmaceutical compound or a pharmaceutically acceptable salt thereof for use in the prevention or treatment of the following conditions, wherein the pharmaceutical compound or a pharmaceutically acceptable salt thereof is characterized in that it simultaneously inhibits autotaxin (ATX) and agonizes PPARγ, and has a chemical formula selected from the group consisting of formulas (A), (B), (C), (D), (E), (F), (G), and (H): a) fibroproliferative diseases, in particular interstitial lung diseases (ILD) and / or liver diseases such as all types of hepatitis and / or non-alcoholic fatty liver disease (NAFLD) and / or non-alcoholic steatohepatitis (NASH) and / or cirrhosis, where the ILD is a primary disease, preferably idiopathic pulmonary fibrosis and / or sarcoidosis and / or interstitial pneumonia, or where the ILD is associated with an autoimmune and / or inflammatory and / or metabolic disease, preferably rheumatoid arthritis-ILD ​​and / or scleroderma-ILD and / or myositis-ILD ​​and / or diabetes-ILD ​​and / or cardiovascular disease-ILD combination, and / or b) an inflammatory and / or autoimmune disease, preferably rheumatoid arthritis and / or scleroderma, and / or c) cancer, in particular lung cancer and / or hepatocellular carcinoma and / or pancreatic cancer and / or glioblastoma and / or neuroblastoma, and / or d) metabolic diseases, in particular type 1 diabetes and / or type 2 diabetes and / or obesity [Formula 1] TIFF2026503883000014.tif94126

To provide compositions useful in the treatment of disorders such as preterm labor in early pregnancy.SOLUTION: Pharmaceutical compositions comprising a compound of Formula (I) or (II) and an additional therapeutic agent are provided. Also provided are HCl salts and crystalline forms of the compound of formula (I). The compounds inhibit the prostaglandin F receptor (PGF2 alpha).SELECTED DRAWING: Figure 1

Laboratory Apparatus for the Synthesis of Spiro Heterocyclic Derivatives of Isothiazolidine

The invention discloses a 4-cyano thiazolidine modified FAPI derivative and application thereof, relates to the field of medicine compounds for diagnosing tumors, and provides the 4-cyano thiazolidine modified FAPI derivative which has a chemical structural formula as shown in a formula I. The invention further discloses a preparation method of the 4-cyano thiazolidine modified FAPI derivative and application of the 4-cyano thiazolidine modified FAPI derivative. The FAPI derivative is good in stability, simple to prepare, high in radiochemical purity and good in biological performance, can be further used for clinical PET / CT tumor imaging, effectively solves the problems that an existing clinical imaging 18F-labeled FAPI probe is low in tumor uptake rate, short in residence time, incapable of further delaying imaging and the like, and makes up for the defects in the prior art.