107 results about "Thiazolidine" patented technology

The invention provides a thiazolidinone compound and application thereof in preparation of drugs for resisting staphylococcus aureus infection. The molecular structural formula of the thiazolidinone compound is shown as a formula (1), a formula (2), a formula (3) or a formula (4). The technical scheme of the invention discloses several thiazolidinone compounds, which not only have an excellent bactericidal effect on staphylococcus aureus and can significantly inhibit the formation of a biofilm of staphylococcus aureus, but also have low cytotoxicity and hemolytic activity. According to the technical scheme, a certain foundation is laid for research and development of novel staphylococcus aureus biofilm infection resisting drugs, and the potential of thiazolidone derivatives for developing novel antibacterial agents for staphylococcus aureus related infection can be deeply known possibly.

The invention relates to the technical field of organic photoelectric materials, and particularly discloses a non-condensed ring small molecule acceptor material based on a quinonoid structure as well as a preparation method and application of the non-condensed ring small molecule acceptor material. According to the invention, easily available 1, 4-diacetyl piperazine-2, 5-diketone is used as a center, an alkyl chain and Ar are used for modification, EG is used as an end group, the non-condensed ring A-D-A '-D-A type structure acceptor material based on a quinone structure is constructed, and the general formula is shown in the specification. Wherein the PCE of the acceptor material which is modified by bithiophene and takes 2-(3-ethyl-4-oxothiazolidine-2-subunit) malononitrile as a terminal group reaches 15%. The non-condensed ring small molecule acceptor material based on the quinonoid structure is simple in synthesis process, and an effective strategy is provided for solving the problem of the overall performance of an organic solar cell.

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, and processes of using such pesticidal compositions against such pests. The pesticidal compositions comprise (A) an oxathiazolidine derivative of formula one and (B) a mixing partner and may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides.

Provided is a rubber composition with which it is possible to obtain a vulcanized product and a vulcanized molded product having excellent wear resistance. According to the present invention, there is provided a rubber composition containing a chloroprene rubber, silica, a silane coupling agent, and a hydrate, the rubber composition containing 5-80 parts by mass of silica and 0.5-20 parts by mass or more of hydrate per 100 parts by mass of the chloroprene rubber, and the rubber composition containing 5-80 parts by mass of silica and 0.5-20 parts by mass of hydrate per 100 parts by mass of the chloroprene rubber. The content of a silane coupling agent is 0.5-15 parts by mass per 100 parts by mass of the silica, and the rubber composition satisfies at least one of the following conditions i) and ii): condition i) the rubber composition contains 3-methyl-thiazolidine-2-thione, and in the rubber composition, the content of 3-methyl-thiazolidine-2-thione is 0.5-15 parts by mass per 100 parts by mass of the chloroprene-based rubber, and the content of 3-methyl-thiazolidine-2-thione is 0.5-15 parts by mass per 100 parts by mass of the chloroprene-based rubber. The composition contains 0.1 to 3.0 parts by mass of 3-methyl-thiazolidine-2-thioketone; condition ii) the rubber composition contains a compound A and a compound B. The compound A is at least one compound selected from the group consisting of thiourea compounds, 3-methyl-thiazolidine-2-thione, and bis (5-mercapto-1, 3, 4-thiadiazol-2-yl) disulfides, and the compound B is at least one compound selected from the group consisting of thiourea compounds, 3-methyl-thiazolidine-2-thione, and bis (5-mercapto-1, 3, 4-thiadiazol-2-yl) disulfides. The compound B is at least one compound selected from the group consisting of thiuram-based compounds, sulfinamide-based compounds, thiazole-based compounds, guanidine-based compounds, benzimidazole-based compounds, N-phenyl-N-(trichloromethylthio) benzsulfonamide, and diazabicyclo-undecene-based compounds, and the content of the compound B is 100 parts by mass per 100 parts by mass of the chloroprene rubber. The rubber composition contains 0.1 to 3.0 parts by mass of a compound A and 0.01 to 3.0 parts by mass of a compound B.

The invention relates to a substituted arylthio thiazolidone derivative as well as preparation and application thereof. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope-labeled compound, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture, or an acceptable salt of the compound, which is used as a substituted arylthio thiazolidone derivative, and application of the compound in preparation of insecticides for pest control, the compound can achieve a better pest control effect at a lower dosage, especially for pests such as tetranychidae, microcosaridae, acaridae, tarsonidae, aleuridae and root-knot nematode, and can be used for controlling pests such as tetranychidae, microcosaridae, gall mite, tarsonidae, aleuridae and the like.

The invention discloses a chiral amino acid CPL probe based on an aldehyde group functionalized luminescent rare earth spirochete complex as well as a preparation method and application thereof, and belongs to the technical field of biosensing materials. The invention aims to solve the problem that the existing probe has poor selectivity in recognition of sulfydryl amino acid. The chiral amino acid CPL probe is an aldehyde group functionalized water-soluble lanthanide helical complex, side chain aldehyde groups can enhance the water solubility of the helical complex by forming hemiacetal and can also be used as specific recognition sites, the aldehyde groups react with sulfydryl-containing amino acids such as D-penicillamine and L-cysteine to form thiazolidine rings, and the chiral amino acid CPL probe can be used as a specific recognition site. Furthermore, the chirality of D-PA and L-Cys is triggered to be transmitted to a metal center, and the chirality is amplified into a detectable CPL signal. Thiazolidine rings formed by condensation of different amino acids have steric hindrance differences, and the steric hindrance differences can influence spiral chirality, so that the probe still shows excellent selectivity even in a complex system in which a plurality of interfering substances coexist.

The present application relates to the technical field of agricultural chemistry, in particular to butenolide compounds containing a thiazolidinone structure as well as a preparation method therefor and the use thereof. The butenolide compounds containing a thiazolidinone structure are characterized by having the following structural general formula (I). The compounds disclosed by the present application have excellent fungicidal activity on various pathogens in agriculture or other fields, and can favorably protect important crops and domestic animals in agriculture and horticulture industry, and the environment that the human beings rely on from invasion of pathogens.

The invention relates to the technical field of suspending agents, in particular to a suspending agent containing oxine-copper and benziothiazolinone as well as a preparation method and application of the suspending agent. The invention relates to a suspending agent containing oxine-copper and benziothiazolinone, which is prepared from the following raw materials in percentage by mass: 28 to 32 percent of oxine-copper, 4 to 8 percent of benziothiazolinone, 1 to 6 percent of dispersing agent, 1 to 6 percent of wetting dispersant, 1 to 1.5 percent of suspending thixotropic agent, 4 to 8 percent of antifreezing agent, 0.05 to 0.5 percent of preservative, 0.05 to 0.5 percent of thickening agent, 0.1 to 0.5 percent of defoaming agent and the balance of water. The dispersing agent comprises polycarboxylic acid ammonium salt; the invention provides the suspending agent containing oxine-copper and benziothiazolinone, which has the advantages of favorable dispersity, favorable stability and favorable control effect. The suspending agent containing oxine-copper and benziothiazolinone provided by the invention has a good control effect on citrus tree canker and cucumber bacterial angular leaf spot.

The invention relates to a method of producing a food composition comprising microalgal biomass with reduced off-flavour, said method comprising adding at least 0.001 wt.%, calculated by weight of the food product, of an aldehyde scavenger, said aldehyde scavenger containing at least 5 wt.%, calculated by weight of the aldehyde scavenger of cysteine. The invention also relates to Food composition comprising microalgal biomass material, said material comprising at least 5 wt% of microalgal protein by weight of dry matter of the microalgal biomass, and 2-pentyl-1,3-thiazolidine-4-carboxylic acid and / or salts thereof, and optionally, water. The invention also relates to a food composition comprising microalgal biomass material, comprising at least 5 wt% of microalgal protein by weight of dry matter of the microalgal biomass; hexanal or a source of hexanal; and at least 0.001 wt.%, calculated by weight of the food product, of an aldehyde scavenger, said aldehyde scavenger containing at least 5 wt.%, calculated by weight of the aldehyde scavenger of cysteine.

The present disclosure provides thiazolidine (Tz) linkers for protein-drug conjugates. In addition, the disclosure also encompasses compounds useful for producing such protein-drug conjugates, as well as methods for production of such protein-drug conjugates. The disclosure also encompasses methods of using the protein-drug conjugates for the treatment of a disease or disorder in a subject.

The present invention discloses a preparation method of thiazolidine-4-thione derivatives, which comprises the following steps: (1) mixing an isothiocyanate or its derivative, a sulfur ylide, an additive and an organic solvent, and reacting at 20-90 °C for 12-48 h under an air atmosphere; (2) diluting the material obtained in step (1) with ethyl acetate and washing with water, and separating to obtain an organic phase; (3) subjecting the above organic phase to drying, filtration, concentration and column chromatography or thin-layer chromatography in sequence to obtain thiazolidine-4-thione derivatives. The present invention can construct tetra-substituted thiazolidine-4-thione derivatives, can efficiently synthesize thiazolidine-4-thione derivatives containing trifluoromethyl, the raw materials used are easily available, the yield is high, the reaction conditions are mild, the reaction time is short, the substrate range is wide, the reaction specificity is strong, and the post-treatment is simple.

The invention discloses a preparation method and application of a low-field nuclear magnetic resonance sensor for detecting circulating tumor cells based on biological orthogonal chemistry and click chemistry. The preparation method is characterized by comprising the following steps: 1) preparing Fe3O4 (at) Apt; (2) preparing Cys-GO coated CuO; and (3) preparing the LF-NMR biosensor. The Apt specificity is used for identifying mucoprotein (MUC1), so that targeted capture and enrichment of CTC are realized; oxidizing cell membrane sialic acid through NaIO4 to generate an aldehyde group, and triggering a thiazolidine chemical bond to be covalently coupled with sulfydryl / amino of the Cys-GO-coated CuO nano probe; cu < + > released by acidolysis-reduction catalyzes azide and alkyne cycloaddition click reaction, and sol-gel phase transformation is driven. According to the method, the intensity of T2 under the condition of CTC with different concentrations is measured, and a quantitative relation between the CTC concentration and delta T2 is established, so that the CTC in an unknown sample is measured, and the method has the advantages of high selectivity and high sensitivity.

The present invention relates to topical formulations comprising a combination of antimicrobial peptides (AMP), in particular synthetic cyclic peptide compounds based on thiazolidine and # imgabs0 # oxazolidine components, and a skin soothing substance, such as menthoxypropanediol, a substance that enhances the skin barrier, such as omega-6 fatty acids, and / or a flavonoid, such as licochalcone, for example licochalcone, for example licochalcone, for example licochalcone, for example licochalcone, for example licochalcone, for example licochalcone, for example licochalcone, for example licochalcone, for example licochalcone, for example licochalcone, for example licochalcone. In particular, the present invention relates to compounds that synergistically and selectively fight against pathogenic bacteria, such as Staphylococcus aureus (S. aureus) and Propionibacterium acnes (C. acnes), but not fight against skin symbiotic bacteria, such as Staphylococcus epidermidis (S. epidermidis). The formulations can be advantageously used in the treatment of acne or atopic dermatitis, as well as in the care of skin that has been impaired by acne or atopic dermatitis.

The application discloses a kind of chiral PEG-Ag6D / LSP6 cluster-based nanoparticles, method and application, method includes: S1, the preparation of chiral nanocluster, in mixed solvent silver salt and thiazolidine thione ligand is added, and the crystal of chiral silver nanocluster is obtained by volatilization;S2, a certain amount of amphiphilic polymer DSPE-PEG2000 and chiral silver nanocluster are dissolved in organic solvent, then added to a certain volume of aqueous solution;S3, under the condition of violent stirring, reaction is carried out until organic solvent is completely removed, filtration is carried out, and the product is obtained;The chiral PEG-Ag6D / LSP6 cluster-based nanoparticles prepared in the application has good biocompatibility, rapid response to biological thiol, strong anti-interference ability and low detection limit, and is suitable for high-throughput equipment, can be used for biological thiol distinction, enantioselective chiral recognition and biological thiol quantitative detection in plasma, and as potential nanomedicine and exhibit chiral-dependent anti-tumor effect.

The invention relates to a meat analogue comprising 7-36 wt.% of plant protein and 40-88 wt.% of water, said meat analogue further comprising 2-pentyl-1,3-thiazolidine-4-carboxylic acid and / or salts thereof. The inventors have discovered that the off-flavour note in plant-based meat analogues that is caused by the presence of aldehydes, such as hexanal, can be reduced by adding cysteine during the production of these meat analogues. Cysteine is capable of reacting with off-flavour-generating aldehydes under the formation of a reaction product that does not adversely affect the flavour of the meat analogue. An important example of such a reaction product is 2-pentyl-1,3-thiazolidine-4-carboxylic acid, which is formed by the reaction between cysteine and hexanal. The invention also relates to a method of producing a plant-based meat analogue with reduced off-flavour, said method comprising adding at least 0.001 wt.%, calculated by weight of the meat analogue, of an aldehyde scavenger, said aldehyde scavenger containing at least 5 wt.%, calculated by weight of the aldehyde scavenger, of cysteine.

The application discloses a FAPI derivative containing 4-cyano thiazolidine modification and application thereof, relates to the field of drug compounds for diagnosing tumors, and provides a FAPI derivative containing 4-cyano thiazolidine modification, a chemical structural formula of which is shown as formula I. The FAPI derivative has good stability, is simple to prepare, has high radiochemical purity and good biological performance, and can be further used for clinical PET / CT tumor imaging, effectively solving the problems of low tumor uptake rate, short retention time and inability to further delay imaging of F-labeled FAPI probes. 18 The FAPI derivative containing 4-cyano thiazolidine modification can solve the problems of low tumor uptake rate, short retention time and inability to further delay imaging of F-labeled FAPI probes, and make up for the defects of the prior art.

The present invention belongs to the field of medicinal chemistry and relates to a triazine-thiazolidinone compound and its preparation method and application. Its structural formula is wherein R1 is any one of alkyl, pyranyl, indolyl, phenyl or thienyl. Its pharmaceutically acceptable salt is the acid salt of the compound, and the acid is any one of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, boric acid, methanesulfonic acid, p-toluenesulfonic acid, naphthalenesulfonic acid, benzenesulfonic acid, citric acid, lactic acid, pyruvic acid, tartaric acid, acetic acid, trifluoroacetic acid, maleic acid, succinic acid, mandelic acid, fumaric acid, salicylic acid or phenylacetic acid. The triazine-thiazolidinone compound skeleton provided by the present invention is novel, has a good inhibitory effect on glucose transporter 1 (GLUT1), and its inhibitory effect in HT29 cells is much better than that of positive control compound BAY-876, with good potential for further development as an anti-tumor drug.

Compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, wherein X1, R1, R2, R3, R4, R5, and R6 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts.

The invention discloses application of a quinoline compound to prevention and treatment of ralstonia solanacearum, and belongs to the technical field of prevention and treatment of plant bacterial wilt. The quinoline compound is 1-ethyl-6-fluoro-7-morpholinyl-3-(3-(p-tolyl)-1, 2, 4-oxadiazole-5-yl) quinoline-4 (1H)-ketone, and it is found for the first time that the 1-ethyl-6-fluoro-7-morpholinyl-3-(3-(p-tolyl)-1, 2, 4-oxadiazole-5-yl) quinoline-4 (1H)-ketone has very strong inhibitory activity on Ralstonia solanacearum, and the quinoline compound can be used for preparing a compound for inhibiting Ralstonia solanacearum. Experiments show that the MIC of the 1-ethyl-6-fluoro-7-morpholinyl-3-(3-(p-tolyl)-1, 2, 4-oxadiazole-5-yl) quinoline-4 (1H)-ketone to ralstonia solanacearum is 5 [mu] g / mL within 24 h, which is equivalent to that of benziothiazolinone, so that the 1-ethyl-6-fluoro-7-morpholinyl-3-(3-(p-tolyl)-1, 2, 4-oxadiazole-5-yl) quinoline-4 (1H)-ketone can be used for preventing and treating plant bacterial wilt, and a new candidate compound is provided for development of ralstonia solanacearum bactericides.

The invention relates to a novel N-(2-(4-cyano thiazolidine-3-yl)-2-oxyethyl) quinoline-4-formamide derivative and a preparation method of the N-(2-(4-cyano thiazolidine-3-yl)-2-oxyethyl) quinoline-4-formamide derivative. The structure of the compound or the pharmaceutically acceptable salt is C-A-B, A is a quinoline ring, B is an (R)-3-glycyl thiazolidine-4-nitrile side chain, and C is a side chain containing a sulfoximine structure. The compound or the pharmaceutically acceptable salt of the compound, and the pharmaceutical composition containing the compound or the pharmaceutically acceptable salt of the compound have obvious FAP enzyme inhibition activity, and can be used for preparing an FAP small-molecule inhibitor.

The present invention discloses a pleuromutilin derivative containing a 2-thio-4-thiazolidinone side chain, and its preparation method and application. The preparation method is as follows: first, pleuromutilin and p-toluenesulfonyl chloride are added to methyl tert-butyl ether, sodium hydroxide solution is added dropwise with stirring, and the reaction is refluxed to obtain intermediate 1; then, 2-thio-4-thiazolidinone is added to acetonitrile, anhydrous potassium carbonate is added and stirred at room temperature for 20 minutes, and then intermediate 1 is added, and the reaction is stirred at room temperature for a certain time to obtain intermediate 2; finally, intermediate 2 and an acyl chloride with different group donors are added to dichloromethane, and under the catalysis of triethylamine, stirred at room temperature for a certain time to obtain a pleuromutilin derivative containing a 2-thio-4-thiazolidinone side chain. The present invention synthesizes a pleuromutilin derivative containing a 2-thio-4-thiazolidinone side chain with good antibacterial activity through a simple preparation process, with high yield, good antibacterial activity against drug-resistant bacteria, and good application prospects.

The invention relates to the technical field of biological medicine, in particular to a synthesis method and application of pinenyl thiazolidone derivatives, and the synthesis method comprises the step of synthesizing thiosemicarbazide A at the yield of 90% under the promotion of hydrochloric acid through condensation reaction between myrtenal and 4-methyl-3-thiosemicarbazide. Cyclizing the compound A and chloroacetic acid to obtain a key intermediate thiazolidone B; then, the intermediate reacts with substituted benzaldehyde, and the target compound C1-C13 is obtained. The adopted substrate myrtenal has a better anti-proliferation effect on malignant cells, strong water solubility is enhanced by introducing thiazolidines, and remarkably enhanced anti-cancer activity can be shown by introducing the thiazolidine derivative modified by Schiff base. The series of products are novel in structure, high in yield, simple in separation and purification operation and suitable for mass production, and part of products such as C5 have good biological activity.

Compounds having the structure of formula (I) and pharmaceutically acceptable salts thereof, wherein X 1 , R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 is as defined herein, compounds and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts for treating or preventing prolyl endopeptidase fibroblast activation protein (FAP) mediated conditions; kits comprising such compounds and salts; and methods for preparing such compounds and salts. [Formula 1] JPEG2025525344000321.jpg56128

This invention discloses a novel thiazolidinone-based amphoteric Gemini surfactant, its preparation method, and its application. The surfactant's molecule contains two thiazolidinone groups and a long hydrophobic chain, represented by the following formula 1. This surfactant, when combined with an inorganic salt, can produce a clean fracturing fluid exhibiting excellent viscoelasticity, shear resistance, and rheological properties in low-temperature environments. This fracturing fluid complies with national petroleum and natural gas industry standards and exhibits excellent sand-carrying performance, no residue, and high temperature resistance. Furthermore, it is easy to prepare on-site and can effectively remove gel-breaking substances. This fluid causes minimal damage to formations and requires a low fracturing margin, making it suitable for natural gas hydrate extraction in low-temperature, high-pressure deep-sea areas. #imgabs0#

The present invention relates to novel cyclic compounds; a method for the solid phase synthesis of said novel cyclic compounds; novel thiazolidine and oxazolidine building blocks that can be directly incorporated into the solid phase synthesis of said novel cyclic compounds, and a novel method for the synthesis of said thiazolidine and oxazolidine building blocks; and cosmetic compositions containing said novel cyclic compounds.

The present invention relates to a solid state form of N-(2-(4-cyanothiazolidin-3-yl)-2-oxoethyl)-6-morpholinoquinoline-4-carboxamide, and to a method for preparing the same. Specifically, the invention discloses a solid state form of N-(2-(4-cyano thiazolidine-3-yl)-2-oxoethyl)-6-morpholinoquinoline-4-carboxamide, and a preparation method of the solid state form. A corresponding pharmaceutical composition; their use in the treatment or prevention of prolyl endopeptidase fibroblast activation protein (FAP) mediated conditions; a kit; and a preparation method thereof.

The application discloses an epoxy thermosetting resin containing a thiazolidine dynamic co-curing component and a preparation and recovery method thereof, and belongs to the technical field of polymer materials and thermosetting resins. The thiazolidine dynamic co-curing component is a compound containing a thiazolidine structure, at least one thiazolidine ring and at least two carboxyl groups capable of participating in an epoxy curing reaction. The application introduces the dynamic co-curing unit containing the thiazolidine structure by partially replacing the curing component, realizes low-disturbance dynamic modification without completely reconstructing a traditional epoxy system, has little influence on the compatibility of an original formula and the comprehensive performance of a material. The double-response characteristics of the thiazolidine structure embedded in the network can trigger network topology rearrangement at high temperature, endow the material with stress relaxation, self-repairing, hot welding and hot pressing reprocessing capacity, and can also cause selective cleavage under acidic conditions, realize chemical deconstruction of the crosslinking network, and have good application prospect.

The present invention relates to the technical field of materials, and particularly discloses a high refractive index polyimide optical material and a preparation method thereof, the high refractive index polyimide optical material comprises: a diamine component, the diamine component comprises 30-70 mol% of a sulfur-containing heterocyclic diamine selected from at least one of 4, 5-thiazolidine-2-thiol diamine, 1, 3, 4-thiazolidinedithiol diamine and 2-methylthiopyrimidine-4, 6-diamine, and the diamine component comprises at least one of 4, 5-thiazolidine-2-thiol diamine, 1, 3, 4-thiazolidinedithiol diamine, 1, 3, 4-thiazolidinedithiol diamine and 2-methylthiopyrimidine-4, 6-diamine; 5-40 mol% of a diamine monomer containing a tertiary amino group; 0 to 65 mol% of an aromatic or aliphatic diamine; the dianhydride component comprises at least one sulfur-containing dianhydride monomer, and the sulfur-containing dianhydride monomer contains a sulfur sulfuryl (-SO2-) or thioether bond (-S-) structural unit; according to the present invention, the synergistic combination of sulfur-containing heterocyclic diamine and tertiary amino-containing diamine is introduced, and the structural design of sulfur-containing dianhydride is matched, such that the electron cloud density and the molecular polarization are improved at the molecular level;

The invention discloses a modified polyester film for an automobile window and a preparation method of the modified polyester film, and relates to the technical field of polyester films. When the modified polyester film for the automobile window is prepared, firstly, methyl p-hydroxycinnamate reacts with [chlorine (ethyoxyl) phosphonyl] benzene to prepare a modified phosphorus-containing cinnamic acid diester compound; the preparation method comprises the following steps: reacting nano antimony tin oxide with a silane coupling agent to prepare pre-modified nano antimony tin oxide; the pre-modified nano tin antimony oxide is subjected to a reaction with thiazolidine acid, 6-maleimido-1-hexanal and ethyl isocyano acetate, and modified nano tin antimony oxide is prepared; carrying out copolycondensation on terephthalic acid, ethylene glycol, the modified phosphorus-containing cinnamic acid diester compound, 2, 2 '-difuran-5, 5'-dicarboxylic acid dimethyl ester and the modified nano tin antimony oxide to obtain modified polyester; and carrying out hot-pressing film formation on the modified polyester to obtain the modified polyester film for the automobile window. The prepared modified polyester film for the automobile window has the advantages of flame retardance, ultraviolet shielding, heat insulation, self-repairing and aging resistance.