52results about How to "Prolong the action time" patented technology

The present application relates to the technical field of feed additive, and discloses a lactation-promoting functional feed for lactating sows containing high-efficiency plant lactogenic factors, which is made of the following raw materials: sodium-based montmorillonite, fenugreek extract, motherwort extract, ion intensity regulator, lysophosphatidylcholine, tributyl citrate and high-purity silicon dioxide, and is prepared through the following steps: mixing and drying sodium-based montmorillonite with the ion intensity regulator to prepare a regulation carrier; adding fenugreek and motherwort extract and mixing them by strong shearing to form an active core; atomizing and spraying a mixture of lysophosphatidylcholine and tributyl citrate on the surface of the core to form a functional layer; and finally adding high-purity silicon dioxide and mixing uniformly to obtain the feed. Through the construction of the structure with ion-pretreated montmorillonite as the core and the functional layer as the shell, the present application realizes the protection, sustained release and efficient absorption of the active ingredients, and improves the bioavailability.

A cultivation method for improving the quality and yield of black fungus using hydrogen-rich water involves spraying a hydrogen-rich water composition three times during mycelial culture, spraying it every two days during primordium differentiation, and spraying it daily during fruiting body enlargement. The hydrogen-rich water composition comprises hydrogen-rich water, xylose, humic acid, gelatin, hydroxypropyl cellulose, and deionized water. This invention effectively solves the problems of poor hydrogen concentration stability and hydrogen volatilization in hydrogen-rich water by adding functional components such as gelatin, hydroxypropyl cellulose, xylose, and humic acid to the hydrogen-rich water, thus extending the time of hydrogen concentration stability and its effect. By using the above-mentioned hydrogen-rich water composition during the mycelial growth and primordium differentiation stages of black fungus, the microenvironment for black fungus growth is comprehensively optimized, resulting in increased yield, improved quality, and enhanced marketability. This provides an effective way to cultivate superior black fungus varieties.

The application belongs to the field of biomedical materials and biomedical engineering technology, and discloses a natural hydrogel nanoparticle with mecobalamin sustained release and a preparation method and application thereof. The preparation method is as follows: calcium carbonate nanoparticles are dispersed in water, loaded with mecobalamin to obtain drug-loaded nanoparticles; boric acid is modified on silk fibroin to obtain boric acid-modified silk fibroin; purified peach gum is reacted with sodium periodate under light-proof conditions to obtain aldehyde-modified peach gum; the drug-loaded nanoparticle suspension is mixed with the aldehyde-modified peach gum, and then the boric acid-modified silk fibroin is added to obtain the natural hydrogel nanoparticle with mecobalamin sustained release. The hydrogel has excellent biocompatibility, drug sustained release, self-repair and other functions, and can be applied to nerve injury repair.

The present application relates to the technical field of pesticides, and discloses a phase change eutectic carrier embedded with a photothermal agent as well as a preparation method and application thereof.The phase change eutectic carrier embedded with the photothermal agent mainly comprises a photothermal agent, a fatty acid, an organic solvent and water.The preparation process of the preparation is simple, the conditions are mild, a large number of additives are not needed, and the preparation can be quantitatively prepared.The dispersion and utilization rate of the bactericide can be improved through eutectic, and the effectiveness of the bactericide can be improved.The preparation is suitable for various application modes such as seed coating and soil treatment, can play various synergistic functions such as temperature response release, prolonging drug retention time, enhancing adhesion and permeability on the surface of pathogenic bacteria, and is a kind of green and efficient bactericide dosage form, which has a wide application prospect in green and intelligent agriculture.

The invention provides an oral care composition for inhibiting helicobacter pylori and a preparation method of the oral care composition. The oral care composition comprises glycerin, xylitol, erythritol, thymol clathrate, garlic extract clathrate, propolis extract, lactoferrin, disodium ethylene diamine tetraacetate, menthol, potassium sorbate and purified water. The thymol clathrate compound is obtained by carrying out clathration on thymol through beta-cyclodextrin. The garlic extract clathrate compound is obtained by clathrating a garlic extract with beta-cyclodextrin. According to the oral care composition provided by the invention, the helicobacter pylori in the oral cavity can be effectively inhibited through reasonable proportioning of various components, so that the risks of ozostomia and stomach reinfection are reduced.

The invention discloses ultra-microporous synergistic powder for tank mixing of pesticides as well as a preparation method and application of the ultra-microporous synergistic powder, and belongs to the technical field of functional auxiliary agents of the pesticides. The powder takes a natural porous material as a raw material, is prepared through raw material pretreatment, inert atmosphere high-temperature calcination activation, superfine grinding and homogeneous compounding, and contains 85-98% of superfine porous powder, 1-10% of a dispersing agent and 1-5% of a wetting penetrant. The key of application is that the barrel mixing sequence of diluting the pesticide and then adding the powder is adopted, the adding amount is 1%-5% of the total weight of the pesticide liquid, the powder can efficiently adsorb effective components of the pesticide, and the light stability and the lasting period of the pesticide are remarkably improved through the ultraviolet shielding effect and the adsorption-desorption slow release effect of the ultra-micropore structure. The product and the using method are specially designed for terminal users, operation is easy and convenient, and efficiency is remarkable.

This invention relates to a pharmaceutical composition and its application for treating acute ischemic stroke. The pharmaceutical composition for treating acute ischemic stroke comprises separately packaged tissue-type plasminogen activator citPA5 and a platelet aggregation inhibitor. Its beneficial effects include significantly improving cerebral blood flow recovery, shortening thrombolysis time, reducing infarct volume, and improving neurological function without increasing the risk of bleeding, demonstrating a good synergistic thrombolytic effect.

The invention provides a personalized cancer vaccine based on apoptosis vesicles and a preparation method and application thereof, and belongs to the technical field of biological medicine, the personalized cancer vaccine comprises apoptosis vesicles, an immunologic stimulant and a biocompatibility carrier; the apoptosis vesicles are extracellular vesicles generated after tumor cells are subjected to apoptosis induction; the biocompatible carrier is a modified chitosan hydrogel, and the biocompatible carrier is a modified chitosan hydrogel; the immunologic stimulant is loaded in the apoptosis vesicle, and the apoptosis vesicle loaded with the immunologic stimulant is embedded into the modified chitosan hydrogel. According to the invention, apoptosis vesicles generated by induction of tumor cells of a patient are taken as a core, the apoptosis vesicles have a natural tumor antigen library and a strong immune activation capability, and personalized precise treatment can be realized; meanwhile, the invention provides a preparation method and application in postoperative tumor recurrence prevention and treatment, and provides technical support for clinical transformation.

This invention belongs to the field of solar cell technology, specifically relating to a top-down defect passivation perovskite solar cell. It includes, from bottom to top, a transparent conductive substrate, an electron transport layer, a first passivator layer, a perovskite layer, a second passivator layer, a hole transport layer, and a back electrode. The perovskite layer has an inverse opal structure, comprising perovskite and spherical pores. Several layers of spherical pores are arranged sequentially from top to bottom within the perovskite layer, with several pores per layer. This invention utilizes the three-dimensional continuous through-holes of the inverse opal perovskite structure to promote the penetration of the passivator to the buried interface, thereby achieving overall defect passivation of the perovskite bulk phase and the perovskite / carrier transport layer interface. Furthermore, the slow-light effect of the inverse opal structure helps to prolong the interaction time between incident light and the perovskite, enhancing light absorption performance. Ultimately, a perovskite solar cell with high photoelectric conversion efficiency and good long-term stability is obtained.

This invention discloses a nutritional composition and preparation method for improving joint health in senior pets. The nutritional composition comprises: N-acetylglucosamine, chondroitin sulfate, methanesulfonylmethane, unsaponifiable avocado and soybean extract, hyaluronic acid, curcumin microcapsule powder, and high-concentration fish oil. This invention uses a lipid / polysaccharide bilayer microcapsule structure to encapsulate curcumin and fish oil, and prepares the product through low-temperature homogenization, spray drying, and granulation processes. The composition of this invention works synergistically through multiple pathways, simultaneously exerting effects on three key levels: anti-inflammation, lubrication, and cartilage repair. It can significantly inhibit joint inflammation, improve joint lubrication, and promote cartilage repair. This invention solves the problems of existing pet joint products, such as single pathways of action, low stability and bioavailability of lipid-soluble active ingredients, and lack of overall formulation optimization tailored to the characteristics of aging pets. It is suitable for daily joint health maintenance or adjunctive treatment in middle-aged and senior dogs and cats.

The invention provides a dexmedetomidine transdermal patch which comprises a backing layer, a release film and a polymer matrix layer arranged between the backing layer and the release film, the polymer matrix layer comprises dexmedetomidine, povidone and a pressure-sensitive adhesive, based on the total mass of the polymer matrix layer, the dexmedetomidine accounts for 4-10%, the povidone accounts for 5-10%, and the pressure-sensitive adhesive accounts for 5-10%. The povidone accounts for 2-12%, and the pressure-sensitive adhesive accounts for 78-94%; the pressure-sensitive adhesive comprises at least one of polymers containing carboxyl or hydroxyl functionalization.

The present application relates to a kind of extracellular matrix-cell complex for inhibiting intervertebral disc degeneration and its preparation method and application, the extracellular matrix-cell complex for inhibiting intervertebral disc degeneration includes modified cell and the biomimetic extracellular matrix nanofiber constructed on the surface of modified cell.The present application is creatively modified to implant cell in cell therapy, constructs artificial extracellular matrix with nanofiber characteristics in situ on the surface of cell, the complex is implanted into nucleus pulposus by cell injection therapy, can induce cell rest, so that implanted cell is better adapted to the intracellular environment of nucleus pulposus anoxia.The artificial extracellular matrix can be long-term targeted to cell surface, significantly prolongs the action time, and different modified cells can be selected according to actual needs, so that intervertebral disc degeneration cell therapy can be better realized, with wide application prospect.

The invention belongs to the technical field of medicines, and particularly relates to a microneedle patch for disguising a macrophage cell membrane and a preparation method of the microneedle patch. Degradable high polymer material nano-particles camouflaged by the macrophage membrane are embedded in a microneedle array of the microneedle patch camouflaged by the macrophage membrane, and the degradable high polymer material nano-particles camouflaged by the macrophage membrane are wrapped with gambogic acid and oleic acid functionalized cerium dioxide nano-particles. Nanoparticles of the microneedle patch jointly load gambogic acid and oleic acid functionalized cerium dioxide, through microneedle transdermal drug delivery, active targeting of the drug to the liver is achieved by using natural inflammatory taxis of a macrophage membrane, the anti-inflammatory effect of gambogic acid and the anti-oxidation effect of cerium dioxide are synergistically exerted, polarization of macrophages is adjusted, and the anti-inflammatory effect of the drug on the liver is achieved. Therefore, the liver injury caused by the septic shock is treated.

The invention relates to a kitchen garbage treatment method which comprises the following steps: S1, collecting general kitchen garbage, and performing three-phase separation after pretreatment to obtain slurry residue a, sewage and waste oil; s2, soybean curb residue waste and bread waste are collected, after pretreatment, wheat skin worm larvae are added and cultured, then worm and material separation is conducted, and pulp residue b, wheat skin worm pupae and wheat skin worm adults are obtained; s3, blending the slurry residue a, the slurry residue b and modified diatomite, adding hermetia illucens larvae and dry animal waste, culturing, and then separating the larvae from the materials to obtain a fertilizer, hermetia illucens pupae and hermetia illucens adults; s4, blending the wheat skin worm pupae and the wheat skin worm adults with the hermetia illucens pupae and the hermetia illucens adults, adding soybean curb residue waste for filling, and drying to obtain the protein feed. The kitchen garbage treatment method provided by the invention can simplify the conventional treatment process, reduce the cost, obtain the fertilizer and the protein feed at the same time, and improve the economic benefits of enterprises.

This invention discloses a cockroach attractant and its application. The attractant is characterized by the following raw materials: 5-hydroxyfurfural. The cockroach attractant of this invention solves the problem of poor effectiveness of existing cockroach attractants. It utilizes the synergy of the components to form an enhanced cockroach attraction system, which greatly improves the attraction effect of cockroaches.

The invention relates to the technical field of heavy oil thermal recovery reagents, in particular to a strong emulsion system for assisting viscosity reduction and plug removal as well as a preparation method and application thereof. The strong emulsion system is prepared from the following raw materials in percentage by mass: 2%-10% of sorbitol dehydrated ester mixture, 5%-10% of 120 # solvent oil, 3%-6% of alcohol ether carboxylate, 0.5%-1.0% of ethylene glycol tert-butyl ether, 5%-10% of organic acid, 3%-6% of polybasic polycarboxylic acid, 3%-6% of villiaumite, 1%-2% of imidazoline corrosion inhibitor, 1.0%-3.0% of functional additive and 46%-76% of water. The strong emulsion system can perform deep plug removal on an underground reservoir and prevent organic acid of the strong emulsion system from being combined with heavy components in the thick oil so as to avoid formation of acid sludge, so that the plug removal effect of the strong emulsion system can be improved.

The utility model discloses an efficient heat exchange fin, which belongs to the technical field of heat exchangers and comprises a fin body and connecting pipes connected to the fin body, the fin body is of a wave-shaped structure and is provided with a wave crest part and a wave trough part, and the wave crest part and the wave trough part are fixedly connected with a plurality of connecting pipes in a penetrating manner. Auxiliary pipes are fixedly installed at the two opposite ends of the connecting pipe, the two ends of each auxiliary pipe are through and communicate with the connecting pipe, the auxiliary pipes and the connecting pipe are used for allowing a copper pipe to pass through, protruding parts are arranged on the outer walls of the auxiliary pipes and are of a threaded structure, and blade angles are arranged on the sides, away from the auxiliary pipes, of the protruding parts. According to the efficient heat exchange fin, the heat conduction effect of the connecting pipe is enhanced, and more heat around the connecting pipe can be taken away. The utility model further provides a heat exchanger with the efficient heat exchange fin.

The present application relates to plaster preparation technical field, disclose a kind of traditional Chinese medicine combination formula of dissolving blood stasis and reducing swelling and preparation process thereof, including dragon's blood 60 parts, xiaoshang 60 parts, chuanqiong 60 parts, red shao 60 parts, baizhi 60 parts, sea scallop 60 parts, raw dahuang 60 parts, purple jingpi 60 parts, gusuibu 60 parts, safflower 30 parts, xiaocin 30 parts, angelica 90 parts, prepared frankincense 90 parts, prepared myrrh 90 parts, mulberry bark 120 parts, artificial musk 10 parts, sesame oil 1200 parts, yellow wax 300 parts.The plaster provided by the present application can promote blood circulation to remove blood stasis and relieve pain, is suitable for long-term use for joint sprain without open wound and purplish swelling and pain, and the action time is up to 48 hours, can kill bacteria and relieve itching when being pasted on the skin of patient, prevent allergic reaction and bacterial infection caused by too long pasting time.

The application discloses an egg duck feed additive, a modified shellfish shell powder ferment, a preparation method and application, and relates to the technical field of feed additives. The modified shellfish shell powder ferment comprises a shellfish shell powder ferment base layer and a mineralization layer coated on the surface of the shellfish shell powder ferment base layer. The shellfish shell powder ferment base layer is prepared by solid-state fermentation of shellfish shell powder through directional biological enzyme preparation and a composite functional bacterial population. The mineralization layer is prepared by mineralization deposition of a mineralization solution on the surface of the shellfish shell powder ferment base layer. The directional biological enzyme preparation comprises neutral protease and polysaccharidase, the composite functional bacterial population comprises Bacillus subtilis and lactic acid bacteria, and the mineralization solution comprises soluble calcium salt, soluble magnesium salt, soluble phosphate and water. The shellfish shell powder is subjected to enzymatic fermentation and mineralization improvement, and can be compounded with probiotics to prepare the egg duck feed additive with high activity, high utilization rate, calcium supplement and intestinal protection functions.

Provided herein are compounds of formula (I) wherein Ra, Rb, Rc, A and p have the meanings given in the specification, as defined in formula (I), as well as pharmaceutically acceptable salts and solvates thereof, which are useful in the treatment of diseases in which pan-immune proteasome inhibition is desired or desired, and in particular in the treatment of cancer.

The application discloses a long-acting hydrogen-releasing microsphere in the stomach and use of the microsphere as a drug in treatment of gastritis, and belongs to the field of pharmaceutical preparations and hydrogen treatment. The composition provided by the application is composed of a hydrogen production micro-particle as a core and a sustained-release agent composed of hydroxypropyl methyl cellulose and ethyl cellulose. By selecting specific components and processes, the microsphere has good floatability and long-acting hydrogen-releasing capacity. The microsphere can float in the gastric juice environment and gradually release hydrogen, so that the sustained anti-oxidation and anti-inflammatory effects are realized, and the microsphere is suitable for treatment of gastric inflammation.

The utility model belongs to the technical field of blasting auxiliary devices, and particularly relates to a deep hole blasting explosive filling device which comprises an explosive filling pipe, an explosive filling device and a deep hole blasting device. The explosive filling pipe further comprises two half pipe bodies, the two half pipe bodies can be spliced to form the explosive filling pipe, and a splicing seam between the two half pipe bodies forms an explosion guiding groove. The positioning bulge is arranged in the inner wall of the half pipe body and is used for centrally fixing the emulsion explosive filled in the filling space; the connecting part comprises an extending groove part and an extending pipe part which are arranged at the two ends of the half pipe body respectively; aligning inserting grooves are formed in the inner walls of the extending groove parts, aligning inserting strips are arranged on the outer walls of the extending pipe parts, the aligning inserting grooves can be matched with the aligning inserting strips to align detonating grooves in the adjacent explosive filling pipes, and compared with the prior art, the phenomenon that blasting force is dispersed is reduced, and blasting uniformity is improved.

The invention relates to a targeted drug delivery device for improving coronary microcirculation disturbance. The targeted drug delivery device comprises a targeted drug carrying support and an implantation mechanism. One side of the far end of the implantation mechanism is provided with a targeted medicine carrying support installed in a blood vessel; the targeted drug-loading stent comprises a stent body, and micro grooves which are uniformly distributed are formed in the outer surface of the stent body; one side, facing the blood flow of the lumen, of the stent body is coated with a microcirculation improving coating; one side, facing the blood vessel wall, of each micro groove is coated with an anti-proliferation layer; the implantation mechanism comprises a catheter, a guide wire cavity and a drug delivery cavity are formed in the catheter, the guide wire cavity is used for passing of a guide wire, and the drug delivery cavity is used for targeted drug delivery; compared with the prior art, the invention has the following beneficial effects: by physically anchoring a focus through the targeted drug-loaded stent and intelligently responding to a microenvironment through the drug coating, "physical and chemical" dual precise positioning is realized, the local drug concentration is significantly improved, and the untoward effects of the whole body are reduced.

This invention relates to a degumming composition, its preparation method, and the degumming method thereof. The degumming composition comprises the following components in weight percentages: 84%–93.5% degumming solvent, 3%–5% solvent oil, 0.5%–3% solid wax, 1%–3% organobentonite, and 2%–5% polar activator; wherein the degumming solvent includes one or more of dichloromethane, N-methylpyrrolidone, and ethylene glycol monobutyl ether. This invention combines the degumming solvent, solid wax, solvent oil, organobentonite, and polar activator in a specific ratio, achieving synergistic effects among the components to obtain a degumming composition with slow evaporation and short degumming time.

This invention relates to the field of traditional Chinese medicine compound preparations, specifically to a traditional Chinese medicine compound nasal spray with both rapid-release and sustained-release effects, its preparation method, and its application. The preparation method of the traditional Chinese medicine compound nasal spray with both rapid-release and sustained-release effects includes the following steps: Step S1: Preparing the traditional Chinese medicine compound composition into a microemulsion solution; the traditional Chinese medicine compound composition contains volatile oils; Step S2: Making the microemulsion solution to volume with distilled water, then adjusting the osmotic pressure with sodium chloride solution, and adjusting the pH with hydrochloric acid solution. This invention combines rapid and long-lasting effects. One-fifth of the traditional Chinese medicine compound composition in the nasal spray has a rapid-release effect, and its rapid-release mechanism can produce a protective effect the moment the virus invades the nasal cavity; while the four-fifths of the drug sustained-release microspheres in the spray have a long-lasting mechanism, which can prolong the drug's action time, fully adapting to the "time-limited characteristic" of influenza virus transmission up to 48 hours, filling the gap in current similar nasal sprays that lack sustained-release effects.

The application discloses a multi-stage countercurrent absorption assembly for chlorine dioxide in tail gas of sodium chlorite process, and mainly relates to the technical field of tail gas treatment. The tail gas enters from a bottom gas inlet and is in contact with absorption liquid in a multi-stage countercurrent mode layer by layer upwards. A first type of atomizing nozzle continuously sprays downwards to form a stable main absorption liquid curtain covering the central region of the tower body, so that high-concentration chlorine dioxide in the tail gas is quickly captured. The absorption liquid flowing in the water ring jacket drives the synchronous rotation of the vortex fan blades. The liquid inlet of a second type of atomizing nozzle is periodically blocked by the blocking pieces distributed alternately with the blades, so that the second type of nozzle is intermittently sprayed upwards. The differential spraying mode and the self-driven metering mechanism of the water flow are combined to strengthen the gas-liquid mass transfer, and the partition pressure-temperature is cooperatively regulated to disperse the reaction heat, so that the technical problems of low-concentration chlorine dioxide in the traditional technology, such as low absorption efficiency, high alkali consumption and easy thermal decomposition, are effectively solved.

This invention relates to an enzyme-responsive brain-targeting sustained-release formulation based on dialkylimidazolium biomimetic lipids, its preparation method, and its application, belonging to the field of drug delivery. First, dialkylimidazolium biomimetic lipids are covalently coupled with natural phospholipids to form a dialkylimidazolium conjugate. Then, this dialkylimidazolium conjugate is self-assembled with dialkylimidazolium biomimetic lipids, natural phospholipids, cholesterol, and a therapeutic drug to form a drug-loaded lipid nanoparticle delivery system. This drug delivery system can effectively cross the blood-brain barrier to achieve brain-targeted delivery of the loaded drug. In the glioma microenvironment, this drug delivery system can gradually hydrolyze the dialkylimidazolium conjugate through an enzyme-responsive mechanism to achieve sustained release of the loaded drug, providing a new strategy for improving the brain targeting and efficacy of different types of anti-glioma drugs, such as small nucleic acid drugs, peptide drugs, and small molecule drugs.

This invention discloses a nystatin microsphere with targeted enhanced antifungal function, its preparation method, and its application. The microsphere uses sodium alginate as a carrier, internally encapsulating the antifungal drug nystatin. The surface is covalently modified with the β-glucan binding domain of the Dectin-1 protein, constructing a smart drug delivery system with fungal targeting function. The microsphere preparation process is simple and reproducible, and can be scalable using an emulsion-ionic crosslinking method combined with protein coupling technology. In vitro characterization shows that the microspheres have uniform particle size and stable dispersion, and Dectin-1 modification significantly enhances their specific binding ability against Candida albicans. This targeted delivery system, while successfully preserving drug activity, significantly improves the antifungal efficiency of nystatin through Dectin-1-mediated targeting, achieving efficacy close to that of free drug, and providing a new strategy for constructing highly efficient and long-acting antifungal agents.

The application relates to a formic acid tin paste with ultra-low porosity, a preparation method and application thereof, the tin paste is prepared from the following raw materials in percentage by mass: 85-90% of alloy welding powder and 10-15% of a fluxing agent; the fluxing agent comprises the following raw materials in parts by weight: 5-10 parts of an activator, 1-5 parts of a rheological agent, 30-40 parts of an organic solvent, 20-30 parts of a paste forming agent, 3-5 parts of a surfactant and 0.1-0.5 parts of a corrosion inhibitor, the surfactant is a composition of lauryl amphoteric imidazoline surfactant, isomeric tridecanol polyoxyethylene ether and N-vinyl caprolactam, and the activator is a composition of castor oil acid, ethylenediaminetetraacetic acid and succinic acid amine salt. The surfactant and the activator in the fluxing agent of the application synergistically act, ensure the welding surface and the solder cleanliness, improve the wettability and the flowability, reduce the porosity, make the solder uniformly spread and fill, form a high-quality welding spot, and significantly reduce the tin paste porosity.

The application provides an antifouling composite material and a preparation method and application thereof. The antifouling composite material is prepared from 100 parts by weight of a polymer matrix and 1-100 parts by weight of a slow-release filler, wherein the polymer matrix is a polyurethane with a main chain capable of being degraded into non-toxic small molecules, and the slow-release filler is halloysite nanotubes loaded with an antifouling agent. The polyurethane of the application can be continuously degraded into non-toxic small molecules, and the slow-release filler can release the antifouling agent for a long time, and the combination of the two guarantees the continuous dynamic updating of the surface of the composite material and excellent dynamic / static long-term antifouling performance. The antifouling composite material provided by the application can be coated on the surface of marine engineering equipment to form a long-term protection circle around the marine engineering equipment and prevent marine organisms from adhering or growing on the surface of the equipment.