23results about How to "Prolong the action time" patented technology

The present application relates to the technical field of feed additive, and discloses a lactation-promoting functional feed for lactating sows containing high-efficiency plant lactogenic factors, which is made of the following raw materials: sodium-based montmorillonite, fenugreek extract, motherwort extract, ion intensity regulator, lysophosphatidylcholine, tributyl citrate and high-purity silicon dioxide, and is prepared through the following steps: mixing and drying sodium-based montmorillonite with the ion intensity regulator to prepare a regulation carrier; adding fenugreek and motherwort extract and mixing them by strong shearing to form an active core; atomizing and spraying a mixture of lysophosphatidylcholine and tributyl citrate on the surface of the core to form a functional layer; and finally adding high-purity silicon dioxide and mixing uniformly to obtain the feed. Through the construction of the structure with ion-pretreated montmorillonite as the core and the functional layer as the shell, the present application realizes the protection, sustained release and efficient absorption of the active ingredients, and improves the bioavailability.

A cultivation method for improving the quality and yield of black fungus using hydrogen-rich water involves spraying a hydrogen-rich water composition three times during mycelial culture, spraying it every two days during primordium differentiation, and spraying it daily during fruiting body enlargement. The hydrogen-rich water composition comprises hydrogen-rich water, xylose, humic acid, gelatin, hydroxypropyl cellulose, and deionized water. This invention effectively solves the problems of poor hydrogen concentration stability and hydrogen volatilization in hydrogen-rich water by adding functional components such as gelatin, hydroxypropyl cellulose, xylose, and humic acid to the hydrogen-rich water, thus extending the time of hydrogen concentration stability and its effect. By using the above-mentioned hydrogen-rich water composition during the mycelial growth and primordium differentiation stages of black fungus, the microenvironment for black fungus growth is comprehensively optimized, resulting in increased yield, improved quality, and enhanced marketability. This provides an effective way to cultivate superior black fungus varieties.

The application belongs to the field of biomedical materials and biomedical engineering technology, and discloses a natural hydrogel nanoparticle with mecobalamin sustained release and a preparation method and application thereof. The preparation method is as follows: calcium carbonate nanoparticles are dispersed in water, loaded with mecobalamin to obtain drug-loaded nanoparticles; boric acid is modified on silk fibroin to obtain boric acid-modified silk fibroin; purified peach gum is reacted with sodium periodate under light-proof conditions to obtain aldehyde-modified peach gum; the drug-loaded nanoparticle suspension is mixed with the aldehyde-modified peach gum, and then the boric acid-modified silk fibroin is added to obtain the natural hydrogel nanoparticle with mecobalamin sustained release. The hydrogel has excellent biocompatibility, drug sustained release, self-repair and other functions, and can be applied to nerve injury repair.

This invention relates to a pharmaceutical composition and its application for treating acute ischemic stroke. The pharmaceutical composition for treating acute ischemic stroke comprises separately packaged tissue-type plasminogen activator citPA5 and a platelet aggregation inhibitor. Its beneficial effects include significantly improving cerebral blood flow recovery, shortening thrombolysis time, reducing infarct volume, and improving neurological function without increasing the risk of bleeding, demonstrating a good synergistic thrombolytic effect.

This invention discloses a nutritional composition and preparation method for improving joint health in senior pets. The nutritional composition comprises: N-acetylglucosamine, chondroitin sulfate, methanesulfonylmethane, unsaponifiable avocado and soybean extract, hyaluronic acid, curcumin microcapsule powder, and high-concentration fish oil. This invention uses a lipid / polysaccharide bilayer microcapsule structure to encapsulate curcumin and fish oil, and prepares the product through low-temperature homogenization, spray drying, and granulation processes. The composition of this invention works synergistically through multiple pathways, simultaneously exerting effects on three key levels: anti-inflammation, lubrication, and cartilage repair. It can significantly inhibit joint inflammation, improve joint lubrication, and promote cartilage repair. This invention solves the problems of existing pet joint products, such as single pathways of action, low stability and bioavailability of lipid-soluble active ingredients, and lack of overall formulation optimization tailored to the characteristics of aging pets. It is suitable for daily joint health maintenance or adjunctive treatment in middle-aged and senior dogs and cats.

This invention discloses a cockroach attractant and its application. The attractant is characterized by the following raw materials: 5-hydroxyfurfural. The cockroach attractant of this invention solves the problem of poor effectiveness of existing cockroach attractants. It utilizes the synergy of the components to form an enhanced cockroach attraction system, which greatly improves the attraction effect of cockroaches.

The utility model discloses an efficient heat exchange fin, which belongs to the technical field of heat exchangers and comprises a fin body and connecting pipes connected to the fin body, the fin body is of a wave-shaped structure and is provided with a wave crest part and a wave trough part, and the wave crest part and the wave trough part are fixedly connected with a plurality of connecting pipes in a penetrating manner. Auxiliary pipes are fixedly installed at the two opposite ends of the connecting pipe, the two ends of each auxiliary pipe are through and communicate with the connecting pipe, the auxiliary pipes and the connecting pipe are used for allowing a copper pipe to pass through, protruding parts are arranged on the outer walls of the auxiliary pipes and are of a threaded structure, and blade angles are arranged on the sides, away from the auxiliary pipes, of the protruding parts. According to the efficient heat exchange fin, the heat conduction effect of the connecting pipe is enhanced, and more heat around the connecting pipe can be taken away. The utility model further provides a heat exchanger with the efficient heat exchange fin.

The present application relates to plaster preparation technical field, disclose a kind of traditional Chinese medicine combination formula of dissolving blood stasis and reducing swelling and preparation process thereof, including dragon's blood 60 parts, xiaoshang 60 parts, chuanqiong 60 parts, red shao 60 parts, baizhi 60 parts, sea scallop 60 parts, raw dahuang 60 parts, purple jingpi 60 parts, gusuibu 60 parts, safflower 30 parts, xiaocin 30 parts, angelica 90 parts, prepared frankincense 90 parts, prepared myrrh 90 parts, mulberry bark 120 parts, artificial musk 10 parts, sesame oil 1200 parts, yellow wax 300 parts.The plaster provided by the present application can promote blood circulation to remove blood stasis and relieve pain, is suitable for long-term use for joint sprain without open wound and purplish swelling and pain, and the action time is up to 48 hours, can kill bacteria and relieve itching when being pasted on the skin of patient, prevent allergic reaction and bacterial infection caused by too long pasting time.

The application discloses a long-acting hydrogen-releasing microsphere in the stomach and use of the microsphere as a drug in treatment of gastritis, and belongs to the field of pharmaceutical preparations and hydrogen treatment. The composition provided by the application is composed of a hydrogen production micro-particle as a core and a sustained-release agent composed of hydroxypropyl methyl cellulose and ethyl cellulose. By selecting specific components and processes, the microsphere has good floatability and long-acting hydrogen-releasing capacity. The microsphere can float in the gastric juice environment and gradually release hydrogen, so that the sustained anti-oxidation and anti-inflammatory effects are realized, and the microsphere is suitable for treatment of gastric inflammation.

This invention relates to a degumming composition, its preparation method, and the degumming method thereof. The degumming composition comprises the following components in weight percentages: 84%–93.5% degumming solvent, 3%–5% solvent oil, 0.5%–3% solid wax, 1%–3% organobentonite, and 2%–5% polar activator; wherein the degumming solvent includes one or more of dichloromethane, N-methylpyrrolidone, and ethylene glycol monobutyl ether. This invention combines the degumming solvent, solid wax, solvent oil, organobentonite, and polar activator in a specific ratio, achieving synergistic effects among the components to obtain a degumming composition with slow evaporation and short degumming time.

This invention relates to the field of traditional Chinese medicine compound preparations, specifically to a traditional Chinese medicine compound nasal spray with both rapid-release and sustained-release effects, its preparation method, and its application. The preparation method of the traditional Chinese medicine compound nasal spray with both rapid-release and sustained-release effects includes the following steps: Step S1: Preparing the traditional Chinese medicine compound composition into a microemulsion solution; the traditional Chinese medicine compound composition contains volatile oils; Step S2: Making the microemulsion solution to volume with distilled water, then adjusting the osmotic pressure with sodium chloride solution, and adjusting the pH with hydrochloric acid solution. This invention combines rapid and long-lasting effects. One-fifth of the traditional Chinese medicine compound composition in the nasal spray has a rapid-release effect, and its rapid-release mechanism can produce a protective effect the moment the virus invades the nasal cavity; while the four-fifths of the drug sustained-release microspheres in the spray have a long-lasting mechanism, which can prolong the drug's action time, fully adapting to the "time-limited characteristic" of influenza virus transmission up to 48 hours, filling the gap in current similar nasal sprays that lack sustained-release effects.

This invention relates to an enzyme-responsive brain-targeting sustained-release formulation based on dialkylimidazolium biomimetic lipids, its preparation method, and its application, belonging to the field of drug delivery. First, dialkylimidazolium biomimetic lipids are covalently coupled with natural phospholipids to form a dialkylimidazolium conjugate. Then, this dialkylimidazolium conjugate is self-assembled with dialkylimidazolium biomimetic lipids, natural phospholipids, cholesterol, and a therapeutic drug to form a drug-loaded lipid nanoparticle delivery system. This drug delivery system can effectively cross the blood-brain barrier to achieve brain-targeted delivery of the loaded drug. In the glioma microenvironment, this drug delivery system can gradually hydrolyze the dialkylimidazolium conjugate through an enzyme-responsive mechanism to achieve sustained release of the loaded drug, providing a new strategy for improving the brain targeting and efficacy of different types of anti-glioma drugs, such as small nucleic acid drugs, peptide drugs, and small molecule drugs.

This invention discloses a nystatin microsphere with targeted enhanced antifungal function, its preparation method, and its application. The microsphere uses sodium alginate as a carrier, internally encapsulating the antifungal drug nystatin. The surface is covalently modified with the β-glucan binding domain of the Dectin-1 protein, constructing a smart drug delivery system with fungal targeting function. The microsphere preparation process is simple and reproducible, and can be scalable using an emulsion-ionic crosslinking method combined with protein coupling technology. In vitro characterization shows that the microspheres have uniform particle size and stable dispersion, and Dectin-1 modification significantly enhances their specific binding ability against Candida albicans. This targeted delivery system, while successfully preserving drug activity, significantly improves the antifungal efficiency of nystatin through Dectin-1-mediated targeting, achieving efficacy close to that of free drug, and providing a new strategy for constructing highly efficient and long-acting antifungal agents.

The application relates to a formic acid tin paste with ultra-low porosity, a preparation method and application thereof, the tin paste is prepared from the following raw materials in percentage by mass: 85-90% of alloy welding powder and 10-15% of a fluxing agent; the fluxing agent comprises the following raw materials in parts by weight: 5-10 parts of an activator, 1-5 parts of a rheological agent, 30-40 parts of an organic solvent, 20-30 parts of a paste forming agent, 3-5 parts of a surfactant and 0.1-0.5 parts of a corrosion inhibitor, the surfactant is a composition of lauryl amphoteric imidazoline surfactant, isomeric tridecanol polyoxyethylene ether and N-vinyl caprolactam, and the activator is a composition of castor oil acid, ethylenediaminetetraacetic acid and succinic acid amine salt. The surfactant and the activator in the fluxing agent of the application synergistically act, ensure the welding surface and the solder cleanliness, improve the wettability and the flowability, reduce the porosity, make the solder uniformly spread and fill, form a high-quality welding spot, and significantly reduce the tin paste porosity.

This invention discloses an siRNA that inhibits IL-25 gene expression and its application. The siRNA sequence provided by this invention can specifically knock down IL-25 expression levels. Furthermore, by modifying the sense strand with thiocyanate, this invention enhances the ability of siRNA to resist enzymatic hydrolysis in serum and prolongs its duration of action without significantly increasing cytotoxicity, thus bringing important application value to the treatment of autoimmune diseases.

The application discloses a programmable drug release anti-infection and bone formation promoting multifunctional orthopedic internal implant device and a preparation method thereof. The implant is prepared according to the following steps: 1) introducing a titanium nanotube (TNT) structure on the surface of a titanium alloy base by using an anodic oxidation method; 2) sequentially loading an anti-infection component, a bone formation promoting factor and a blood vessel formation promoting factor into the TNT tube by using a vacuum sequential loading process; and 3) finally, coating a poly-tannic acid (PTA) coating on the surface of the material base by using a tannic acid (TA) in-situ self-polymerization technology. The multifunctional bone implant device can sequentially release the anti-infection drug, the blood vessel formation promoting factor and the bone formation promoting factor in the order of the vacuum drug loading, and the modified surface of the device has good drug release and oxidation resistance, so that the bone infection can be efficiently prevented and treated, and the bone repair efficiency is improved.

This invention provides a method for preparing hydromorphone and dihydromorphine-like drugs via polyethylene glycol modification and their applications, which have the compound structure shown in general formula (I). The compounds provided by this invention reduce lipid solubility through polyethylene glycol modification, thereby slowing the rate of crossing the blood-brain barrier, slowing the release rate, prolonging the duration of action, and reducing the possibility of abuse. At high doses, they exhibit analgesic effects comparable to opioids, without producing side effects such as respiratory depression or addiction, demonstrating good safety.

This invention belongs to the field of mineral resource recycling technology, specifically disclosing a beneficiation method for recovering ultra-low-grade scheelite from molybdenum tailings. For refractory scheelite with severe alteration and mudding, the method employs pre-slurry conditioning, enhanced pretreatment with reagents moved forward, followed by grinding and classification of the raw ore. By combining collectors, the refractory scheelite is synergistically recovered, ultimately obtaining a tungsten concentrate with a grade >26%, achieving a comprehensive actual recovery rate of 77%. This invention's process achieves full recovery and utilization of refractory scheelite resources in tailings, while reducing the operating costs of refractory ore recovery, creating considerable economic and social benefits.

This invention belongs to the field of cleaning technology, specifically providing a vehicle wheel cleaning device for construction sites. It includes a soaking cleaning unit and a spray cleaning unit. The soaking tank in the soaking cleaning unit stores a certain level of cleaning fluid, sufficient to submerge the bottom of the wheel. A turbulence-inducing component is installed inside the first channel. When the impeller of the turbulence-inducing component rotates, it creates a swirling flow of cleaning fluid, flushing away the mud on the wheel, forming a simultaneous soaking and cleaning mode, which helps soften and remove hardened mud. The liquid level in the soaking tank is lower than the wheel axle height to avoid insufficient swirling force caused by excessive soaking fluid. After soaking, the vehicle enters the subsequent spray cleaning unit, where high-pressure water is used to rinse and clean the wheel surface. The combined action of the soaking and spray cleaning units solves the problems of short contact time and incomplete cleaning associated with manual washing.

This invention discloses a cockroach attractant and its application. The attractant is characterized by the following raw materials: difurfuryl disulfide. The cockroach attractant of this invention solves the problem of poor effectiveness of existing cockroach attractants. It utilizes the synergy of the components to form an enhanced cockroach attraction system, which greatly improves the attraction effect of cockroaches.

This invention belongs to the field of pharmaceutical formulation technology, and specifically relates to a sulfonamide derivative sustained-release granule and its preparation method. The sulfonamide derivative sustained-release granule includes a drug-loaded layer, a sustained-release layer I, and a sustained-release layer II. The drug-loaded layer includes a blank pellet core and an active ingredient layer, wherein the active ingredient is a compound of formula I. This invention prepares the drug into sustained-release granules with uniform particle size, precisely controls the particle size distribution of the blank pellet core and the sustained-release granules, and sequentially performs two sustained-release layer coatings on the drug-loaded layer, adjusting the type and amount of excipients in each layer to obtain sustained-release granules that are gritty, palatable, and easy to swallow. These sustained-release granules can be flexibly dosed according to clinical needs; by measuring different volumes, the dosage requirements of patients of different weights or ages can be met. Only one dose is required daily, achieving precise and convenient oral administration for children, while obtaining suitable sustained-release characteristics with a stable release rate and no burst release.

This invention discloses a black hot spring bath concentrate, its preparation method, and its application, relating to the field of personal care products technology. It comprises component A, an active black hot spring concentrate, and component C, a sulfide and humic acid composite stabilization system. Component A must contain humic acid with a content of ≥500 mg / L metasilicic acid, 5-15 mg / L fluoride ions, ≥10 mg / L total hydrogen sulfide, ≥20 mg / L metaboric acid, and ≥100 mg / L total organic carbon. Component C consists of selenite, polyphenolic antioxidants, and metal ion chelating agents. This invention utilizes a low-temperature membrane enrichment-bioenzymatic hydrolysis coupling-nano-stabilization integrated technology to fully preserve the quaternary characteristic component spectrum of black hot springs ("metasilicic acid-fluoride-sulfide-humic acid"), and uniquely employs a composite stabilization technology targeting the dual-active system of "sulfide-humic acid." It can be stored for a long time at room temperature and pressure, exhibiting excellent physical stability and long-lasting efficacy, and demonstrating a clearly targeted therapeutic effect of black hot springs.

The utility model discloses a kind of electric power cable with anti-insect bite structure, it is related to electric power cable technical field.The utility model includes outer sheath, the inner wall of outer sheath is fixedly connected with protective layer, the inner wall of protective layer is fixedly connected with wire core layer, the surface of outer sheath one side is equipped with anti-insect component, and the anti-insect component includes protective sleeve.The utility model fills anti-insect agent between the cavity between protective sleeve in anti-insect component and inner lining layer, can continuously release insect repellent component, effectively drives the insect approaching cable, simultaneously, the sawtooth strip on the surface of protective sleeve changes the physical structure of cable surface, so that insect is difficult to climb and adhere, further enhances the anti-insect effect, polyethylene agent layer in protective layer contains insect repellent component, can provide anti-insect protection from inner layer, and diatomite adsorption layer can adsorb the agent volatilized by polyethylene agent layer, prolongs agent action time, enhances the durability of anti-insect.