44 results about "Triazole derivatives" patented technology

The invention provides a benzotriazole derivative and a resin composition containing the benzotriazole derivative. The benzotriazole derivative is of a 1H-site substitution type, and compared with a traditional 2H-site substitution type benzotriazole derivative light conversion material compound, the 1H-site substitution benzotriazole compound can remarkably improve the light conversion efficiency of a solar cell, especially the light conversion efficiency of the solar cell with a TOPCon photovoltaic module.

The application discloses a thiazole / oxazole group-containing 1,2,4-triazole derivative, a preparation method and application thereof, and relates to the technical field of medicinal chemistry.The thiazole / oxazole group-containing 1,2,4-triazole derivative has excellent broad-spectrum antifungal effect and the advantage of a simple synthesis method, and has important reference significance for developing a novel high-efficiency antiplant pathogenic fungus agent.

The invention discloses a preparation method and application of a triazole phosphate type corrosion and scale inhibitor, and relates to the technical field of industrial water treatment chemicals. The compound is prepared by a three-step synthesis method which comprises the following steps: firstly, preparing an amino methylene phosphonic acid compound with one-NH reaction site from n ethylene (n + 1) amine, phosphorous acid and formaldehyde; secondly, preparing a triazole derivative from ethylene glycol glycidyl ether and triazole; and reacting the two products with sodium bicarbonate to obtain a target product. The target molecule contains a sodium phosphate group and a triazole group at the same time, through the synergistic effect of functional groups, intramolecular synergy of scale inhibition and corrosion inhibition functions is achieved, and the corrosion inhibition performance higher than that of a DETPMP scale and corrosion inhibitor used commercially is shown. The triazole phosphate type corrosion and scale inhibitor has good catalytic activity on photocatalytic carbon dioxide reduction under the conditions of room temperature and high temperature, the TON (carbon monoxide conversion number) can reach 1206, and the selectivity is 100%.

The application discloses a kind of pyrimidine-substituted 1,2,4-triazole derivatives, it is characterized in that, with the structure expressed in general formula I or II:Wherein, R1 is hydrogen, methyl, ethyl, methoxy, ethoxy, thiomethyl, chlorine, fluorine, bromine, iodine, cyano, amine group, morpholine, triazole, pyrazole, trifluoromethyl, difluoromethyl, ethyl formate;R2 is hydrogen, methyl, ethyl, methoxy, chlorine, fluorine, bromine, iodine, cyano, amine group, trifluoromethyl, ethyl formate;R3 is hydrogen, methyl, ethyl, methoxy, ethoxy, thiomethyl, chlorine, fluorine, bromine, cyano, amine group, morpholine, triazole, pyrazole, trifluoromethyl, difluoromethyl.The compound of the application shows excellent activity against plant pathogens, such as rice sheath blight fungus, cucumber botrytis, blueberry botrytis, strawberry botrytis, tobacco botrytis, and sclerotinia sclerotiorum.

The present invention provides e / zz'-pleuromutilin triazole derivatives and e / zz'-tiamulin triazole derivatives with antibacterial activity.

The lubricant composition may provide corrosion resistance, oxidation resistance, and reduced wear to the hydraulic system. A lubricant composition can include an ashless dithiophosphate ester in an amount sufficient to provide the lubricant composition with a phosphorus concentration in the range of from 10 ppm to 250 ppm, a metal dialkyldithiophosphate salt, such as zinc dialkyldithiophosphate (ZDDP), in an amount sufficient to provide the lubricant composition with a phosphorus concentration in the range of from 50 ppm to 1000 ppm, a corrosion inhibitor comprising an alkyl triazole derivative in an amount sufficient to provide the lubricant composition with a nitrogen concentration in the range of from 0.75 ppm to 100 ppm; and a major amount of a base oil.

The present application provides a series of substituted 1,2,4-triazole derivatives and their applications, and specifically provides a compound shown in formula (I) and a pharmaceutically acceptable salt thereof.

The application discloses a class of podophyllotoxin triazole ether derivatives, a preparation method and application thereof, belongs to the technical field of chemical pharmacy, and particularly relates to a class of podophyllotoxin triazole derivatives and application thereof in preparation of antitumor drugs. The application combines a triazole structure with a podophyllotoxin parent body by using a click chemistry reaction, designs and synthesizes a series of novel 1,2,3-triazole podophyllotoxin derivatives, optimizes the kinetic characteristics of the podophyllotoxin by introducing the triazole structure, and improves the anticancer effect and drug property. Molecular docking shows that the series of compounds have strong binding energy on AKT1 and tubulin, can target inhibit tubulin / AKT1, and in-vitro antitumor activity research shows that the molecules have strong inhibitory activity on the proliferation of human colon cancer cell strains, and can provide a new strategy for structural derivatization of podophyllotoxin.

This invention provides an ultraviolet absorber that efficiently absorbs harmful light in the wavelength range of 380-400 nm and suppresses the absorption of light with wavelengths above 400 nm, which is a cause of initial yellowing, thereby providing a component with less influence from harmful light and a superior appearance, as well as excellent light resistance and heat resistance, and furthermore, excellent light resistance and heat resistance, i.e., durability. [Solution] The highly light-resistant ultraviolet absorber of the present invention consists of a 2-phenylbenzotriazole derivative having a thioaryl ring group, such as the following formula (3). [Formula 1] TIFF2026137696000066.tif9132 (in the formula, PhBzT 1c and PhBzT 2c Each of these may independently have a substituent, a thioaryl ring group (-SA 1c It exhibits a 2-phenylbenzotriazole skeleton with -S-) attached, A 1c It contains residues of a phenyl ring or naphthyl ring.

The invention discloses a preparation method and application of a urea triazole derivative which is simple and easy to operate, cheap and easily available in raw materials, high in reaction efficiency and good in inhibition effect on human liver cancer cells Huh-7, and belongs to the technical field of medicine synthesis. According to the key points of the technical scheme, the urea triazole derivative molecule has a structure, or R1 is hydrogen atom, fluorine, chlorine, bromine, iodine, nitryl, alkyl (such as methyl, ethyl or alkynyl) or alkoxy (such as methoxyl) and various substituent groups, R2 is phenyl derivative or benzyl derivative, and X is oxygen atom or sulfur atom. The invention designs and synthesizes a urea triazole derivative with a novel structure, and the compound has a good inhibition effect on human liver cancer cells Huh-7.

The invention discloses a polynitrogen heterocyclic chemical 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole and a synthesis method thereof.The synthesis method comprises the steps that 4-pyrazolecarboxylic acid and hydrazine hydrate serve as starting raw materials, the 4-pyrazolecarboxylic acid and the hydrazine hydrate are added into a high-pressure-resistant reaction kettle according to the molar ratio of 1: 1-1: 5 and react for 1-5 days at the temperature of 100-220 DEG C, and the 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole is synthesized through a ring formation reaction; the catalyst is 1, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole. The 4-amino-1, 2, 4-triazole derivative 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole with 3, 5-position symmetrical substituted pyrazolyl is synthesized for the first time, a multi-nitrogen heterocyclic compound library is enriched, and the synthesis method has the advantages of cheap and easily available initial raw materials, mild reaction conditions, high product yield and simple post-treatment, and is suitable for large-scale production.

The invention discloses high-extreme-pressure and corrosion-resistant vehicle gear oil and a preparation method thereof, and belongs to the technical field of engine gear oil. Comprising the following raw materials in parts by weight: 70-90 parts of base oil, 2-8 parts of an extreme pressure anti-wear agent, 1-5 parts of a corrosion inhibitor, 0.5-3 parts of an anti-rust agent, 3-10 parts of a viscosity index improver, 1-5 parts of a purification dispersant, 0.5-3 parts of an antioxidant, 0.1-1 part of a pour point depressant and 0.01-0.5 part of an anti-foaming agent. Wherein the anti-wear reagent at extreme pressure contains S-P-N elements, can react with a metal surface to form a high-strength chemical reaction film, remarkably improves the bearing capacity of the gear oil and reduces abrasion and scratch of a tooth surface, and has a synergistic effect with a benzotriazole derivative in the corrosion inhibitor, so that the problem of corrosion to non-ferrous metals is solved, and the service life is prolonged; the viscosity index improver ensures that the oil product can maintain good fluidity at low temperature, can maintain stable oil film strength at high temperature, and adapts to extreme climate and harsh working conditions.

Provided is a compound having the structure of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate or isotope thereof, wherein A, B, R1, R2, R3, R4, R5, R6, R7, m, n, p, and y are as defined herein, for use in methods for modulating MRGPRD or for treating a MRGPRD dependent condition. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.

The invention discloses a synthesis method of a C-13 labeled mercapto triazole derivative. The synthesis method comprises the following steps: (1) carrying out a reaction on C-13 potassium cyanide and S8 to prepare C-13 potassium thiocyanate; (2) carrying out nucleophilic substitution reaction on C-13 potassium thiocyanate and a benzyl bromide compound to obtain a compound 1; (3) carrying out nucleophilic addition reaction on the compound 1 and formylhydrazine to obtain a compound 2; (4) further cyclizing the compound 2 under an alkaline condition to obtain a compound 3; and (5) carrying out derivative reaction on the compound 3 to obtain a C-13 labeled target compound. According to the synthesis method, multi-step continuous reaction is adopted, operation is easy and convenient, the yield is high, and the utilization rate of the C-13 marker is greatly increased.

A porous coordination network is represented by the following formulas (I) to (VIII), in which M2+ is a divalent metal ion, M3+ is a trivalent metal ion, L1a and L1b are tridentate ligands having hexaazaphenalenyl, L2a and L2b are bidentate or tridentate ligands containing a carboxy group, L3− is a tertiary ligand ion that is an anion of triazole or a triazole derivative, and Y is a cation.

The invention discloses a synthesis method of a benzomorpholone derivative, and belongs to the technical field of organic chemistry. According to the method, a 3-hydroxy-2-indolone derivative and a triazole derivative react in an organic solvent at the temperature of 20-30 DEG C by taking commercialized cheap iodobenzene as a catalyst and selecting a fluorine reagent as an oxidizing agent, so that the benzomorpholone derivative can be obtained. The method is simple to operate, the raw materials are easy to obtain, the reaction steps are short and efficient, and the reaction yield is as high as 96%.

Disclosed is a fluorinated UV absorber compound which is a trimeric hydroxyphenyl benzotriazole derivative in which a plurality of hydroxyphenyl benzotriazole groups are bonded to one benzene substituted with fluorine. The fluorinated UV absorber compound according to the present invention exhibits improved solvent solubility, thermal stability and heat resistance at high temperatures, and excellent optical transparency. A transparent polyimide film prepared from the fluorinated UV absorber compound exhibits excellent ultraviolet absorption ability and light resistance.

The application discloses a WRN degrading agent, a preparation method and application thereof. The application provides triazole derivatives with structures of formula (I), (II) and (III), a pharmaceutical composition containing the compounds and pharmaceutically acceptable salts thereof. The application evaluates the effect of the triazole derivatives by improving the inhibition and degradation ability of the drugs on WRN and the growth inhibition effect on MSI cells, and the application can degrade WRN protein while inhibiting the activity of WRN, has good in-vitro activity and stability, and has the feasibility of further developing drugs for treating MSI cancer patients.

The invention relates to chemistry and agriculture, namely to the use of a 1,2,4-triazole derivative as an active compound againstFusarium lateritium.According to the invention, claimed is the use of (Z)-1-(2,4-dichlorophenyl)-3-(2-hydroxyphenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one as an active compound against the phytopathogenic fungus of the speciesF. lateritium- one of the causative agents of root rot.The technical result consists in increasing the fungitoxic activity of the compound of the invention in relation to the closest solution by 6.5…21.6% for strain 17 of the fungusFusarium lateritiumon the last day of cultivation, in the concentration range of 0.02…0.01%, respectively.

The invention discloses a benzenesulfonamide triazole derivative as well as a preparation method and application thereof, and is characterized in that the benzenesulfonamide triazole derivative has a structural formula shown as a formula I and a formula II or pharmaceutically acceptable salt, ester or solvate of the benzenesulfonamide triazole derivative with the structural formula shown as the formula I and the formula II, x is a carbonyl group, a sulfonyl group or a sulfuryl group; r1 is o-fluorophenyl, p-trifluoromethoxyphenyl, o-methoxyphenyl, o-methoxyanilino, p-methoxyphenyl, pyrimidine, thiazole, oxazole, methylthiophene, amino and methylamino, and the compound has the advantages that the compound can effectively inhibit CDK, the selectivity to CDK1 is higher than that of other subtype and / or eukaryotic tumor cell proliferation, and tumors are prevented and / or treated.

This invention discloses a triazole derivative, its preparation method, and its application, belonging to the field of pharmaceutical technology. The structure of the triazole derivative is shown in Formula I. The triazole derivative of this invention can be used as a CRM1 inhibitor for the preparation of therapeutic drugs for diseases related to CRM1 activity.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to phenyl sulfanilamide para-triazole derivatives, a preparation method and application of the phenyl sulfanilamide para-triazole derivatives in resisting carbonic anhydrase. The structural general formula of the derivative is as shown in formula I, the invention provides a brand-new phenyl sulfanilamide para-triazole derivative and pharmaceutically acceptable salt, the inhibition activity of the derivative on human carbonic anhydrase is obviously superior to that of traditional inhibitors acetazolamide and methazolamide, and the derivative has selective binding capacity on different human carbonic anhydrase subtypes and has the potential to be developed into a novel carbonic anhydrase inhibition drug.

This invention relates to a class of 1,2,4-triazole derivatives, characterized in that the derivative is a 1,2,4-triazole thioether amide derivative (I) or a pharmaceutically acceptable salt thereof: wherein, in formula I, R1 is -(CH3)2CH-,2-methylphenyl,4-isopropylphenyl. This invention relates to the field of tumor treatment, specifically to a class of novel 1,2,4-triazole derivatives with advantages such as structural stability and ease of preparation. These compounds can be used to treat diseases such as tumors and condyloma acuminata.

The present invention relates to a pharmaceutical composition or a functional food composition for preventing or treating a liver disease selected from the group consisting of fatty hepatitis, liver fibrosis, and liver cirrhosis. The triazole derivative compound according to the present invention can reduce the accumulation of collagen in liver tissue and significantly inhibit the expression of inflammatory factors. Therefore, unlike conventional drugs that have only a simple lipid-lowering effect, the triazole derivative compound effectively prevents the progression of a series of serious liver diseases, from excessive fibrosis of liver tissue to tissue cirrhosis, resulting in a decrease in the number of hepatocytes and liver failure, thereby effectively serving as a composition for fundamentally treating liver fibrosis and liver cirrhosis.

Provided is an ultraviolet absorber capable of efficiently absorbing harmful lights in a wavelength region of 380 to 400 nm; and suppressing the absorption of lights having a wavelength of not shorter than 400 nm, which constitutes the cause of yellowing at early stages. The ultraviolet absorber can thus be used to produce a member superior in appearance as being less affected by harmful lights, and has an excellent light resistance, heat resistance and durability accordingly. The highly light-resistant ultraviolet absorber of the present invention is comprised of a 2-phenylbenzotriazole derivative that contains a thioaryl ring group or the like and is represented by, for example, the following formula (1):wherein PhBzT1a represents a substituted or unsubstituted 2-phenylbenzotriazole skeleton bonded to a thioaryl ring group (—S—X1a— . . . ), X1a represents a residue of a phenyl ring or the like, each of l R1as independently represents, for example, a hydrocarbon group having 1 to 18 carbon atoms, l represents an integer of 0 to 5.

This invention provides a naphthobistriazole derivative chromophore, a light-converting material, and a method for preparing the same. The naphthobistriazole derivative chromophore is characterized by having the structural formula shown in Formula I: In Formula I, X is selected from -N(A0)-, and A0 is independently selected from any one of hydrogen, alkyl, cycloalkyl, alkenyl, alkoxy, aryloxy, acyloxy, aryl, heteroaryl, and amino. This invention develops a naphthobistriazole light-converting agent material system. These compounds can be used as chromophores to provide the desired optical properties and good photostability. These chromophores can be used as light-converting agents in various luminescent material applications, including in light-converting films.

The invention belongs to the field of gas separation technology and carbon dioxide capture, and particularly relates to an antioxidant compound amine solvent as well as a preparation method and application thereof. The invention provides an antioxidant compound amine solvent. The antioxidant compound amine solvent comprises a main absorption component, an auxiliary absorption component, a compound antioxidant, a corrosion inhibitor and a mixed solvent, the composite antioxidant comprises a benzotriazole derivative, sodium sulfite and an organic selenium compound; the corrosion inhibitor is a compound system of sodium molybdate and alkynol compounds. The components in the composite antioxidant generate a synergistic effect, the benzotriazole derivative captures free radicals, the sodium sulfite consumes oxygen, and the organic selenium compound decomposes peroxide, so that the stability and durability of the amine solvent in long-term operation are remarkably improved; the oxidative degradation rate of the compound amine solvent provided by the invention is reduced by 60% or above, the solvent consumption and the operation cost caused by oxidative degradation are reduced, the regeneration energy consumption is reduced by 30% or above, and the solvent loss is reduced by 40% or above.

The application discloses a method for constructing iminothiazole derivatives by alkali-promoted denitrogenation of 1,2,3-triazole, which uses 1,4-disubstituted-1,2,3-triazole derivatives and isothiocyanate as raw materials, and reacts under the presence of alkali and solvent at 10-120 DEG C. The reaction product is extracted, concentrated, and separated and purified by column chromatography to obtain iminothiazole derivatives. The method is easy to operate, and can provide a convenient and efficient new method for the synthesis of thiazole drugs, pesticides and organic materials.

The invention discloses a concentration detection system and a concentration detection method for PCB chemical reagent preparation. The system comprises a multiband spectrum emission unit; a dynamic environment noise elimination unit; a dual-optical-path reference detection unit; a new material feature analysis module; according to the invention, through a three-level innovative architecture of characteristic spectrum dynamic capture, environmental noise collaborative suppression and intelligent algorithm decision closed loop, technical faults of a traditional method in new material adaptability and complex working condition stability are systematically solved. On one hand, novel environment-friendly reagents such as a gold thiosulfate complex and a benzotriazole derivative realize full-fingerprint concentration inversion, and a detection blind area is reduced by 80%; and on the other hand, the submicron detection precision is still maintained in a high-temperature and high-pollution harsh production line environment. And finally, the PCB chemical reagent detection is promoted to be upgraded from a single-point calibration-manual correction extensive mode to a multi-dimensional perception-autonomous evolution intelligent system, and a concentration reference guarantee is provided for high-end electronic manufacturing such as an IC (Integrated Circuit) carrier plate and a Mini LED (Light Emitting Diode).

The invention discloses a triazole derivative-prothioconazole doped perovskite active layer, a preparation method of the triazole derivative-prothioconazole doped perovskite active layer and application of the triazole derivative-prothioconazole doped perovskite active layer in a trans-perovskite solar cell. The doped perovskite active layer is prepared from a precursor solution containing cesium iodide (CsI), formamidine hydroiodate (FAI), lead iodide (PbI2), methyl ammonium chloride (MACl) and prothioconazole. The trans-perovskite solar cell sequentially comprises a conductive glass substrate, a hole transport layer, a triazole derivative-prothioconazole doped perovskite active layer, an electron transport layer, a hole barrier layer and a metal electrode from bottom to top. The triazole derivative-prothioconazole is used for doping the perovskite active layer, so that the surface appearance of the perovskite thin film can be effectively improved, bulk phase defects can be passivated, component distribution can be optimized, the surface uniformity of the thin film can be improved, and meanwhile, a long-term effective passivation effect can be ensured by firmer passivation molecules; therefore, the efficiency and the operation stability of the perovskite solar cell are improved.