77 results about "Triazole derivatives" patented technology

The invention provides a benzotriazole derivative and a resin composition containing the benzotriazole derivative. The benzotriazole derivative is of a 1H-site substitution type, and compared with a traditional 2H-site substitution type benzotriazole derivative light conversion material compound, the 1H-site substitution benzotriazole compound can remarkably improve the light conversion efficiency of a solar cell, especially the light conversion efficiency of the solar cell with a TOPCon photovoltaic module.

This disclosure provides processes for preparation of substituted triazole compounds of Formula X:

The application discloses a thiazole / oxazole group-containing 1,2,4-triazole derivative, a preparation method and application thereof, and relates to the technical field of medicinal chemistry.The thiazole / oxazole group-containing 1,2,4-triazole derivative has excellent broad-spectrum antifungal effect and the advantage of a simple synthesis method, and has important reference significance for developing a novel high-efficiency antiplant pathogenic fungus agent.

The invention discloses a preparation method and application of a triazole phosphate type corrosion and scale inhibitor, and relates to the technical field of industrial water treatment chemicals. The compound is prepared by a three-step synthesis method which comprises the following steps: firstly, preparing an amino methylene phosphonic acid compound with one-NH reaction site from n ethylene (n + 1) amine, phosphorous acid and formaldehyde; secondly, preparing a triazole derivative from ethylene glycol glycidyl ether and triazole; and reacting the two products with sodium bicarbonate to obtain a target product. The target molecule contains a sodium phosphate group and a triazole group at the same time, through the synergistic effect of functional groups, intramolecular synergy of scale inhibition and corrosion inhibition functions is achieved, and the corrosion inhibition performance higher than that of a DETPMP scale and corrosion inhibitor used commercially is shown. The triazole phosphate type corrosion and scale inhibitor has good catalytic activity on photocatalytic carbon dioxide reduction under the conditions of room temperature and high temperature, the TON (carbon monoxide conversion number) can reach 1206, and the selectivity is 100%.

The invention discloses an anti-ultraviolet hardened coating for a PC material and a preparation method of the anti-ultraviolet hardened coating, and relates to the technical field of coatings, the anti-ultraviolet hardened coating is composed of an internal connecting layer, a middle functional layer and an external protective layer, the internal connecting layer contains an epoxy group-containing siloxane coupling agent, and the internal connecting layer is covalently connected with hydroxyl after being subjected to surface plasma activation of the PC material to generate hydroxyl, so that the adhesive force of the coating is enhanced; the middle functional layer contains ZnO-S < 2 > nano particles, a benzotriazole derivative and modified polyurethane acrylate, the ZnO-S < 2 > nano particles are of a core-shell structure formed by coating ZnO with S < 2 >, the S < 2 > shell layer inhibits the photocatalytic activity of ZnO and improves the dispersity, and the benzotriazole derivative serves as an anti-ultraviolet functional component, so that the photocatalytic activity of ZnO is improved, and the photocatalytic activity of ZnO is improved. A disulfide bond and a Schiff base structure are introduced into modified polyurethane acrylate through modification preparation, the disulfide bond can inhibit free radical chain reaction and reversible fracture / recombination under mechanical stress, and the Schiff base structure can capture Fe < 3 + > / Cu < 2 + > generated by PC degradation and inhibit catalytic oxidation of metal ions, so that the anti-ultraviolet performance and mechanical performance of the material are enhanced.

The application discloses a kind of pyrimidine-substituted 1,2,4-triazole derivatives, it is characterized in that, with the structure expressed in general formula I or II:Wherein, R1 is hydrogen, methyl, ethyl, methoxy, ethoxy, thiomethyl, chlorine, fluorine, bromine, iodine, cyano, amine group, morpholine, triazole, pyrazole, trifluoromethyl, difluoromethyl, ethyl formate;R2 is hydrogen, methyl, ethyl, methoxy, chlorine, fluorine, bromine, iodine, cyano, amine group, trifluoromethyl, ethyl formate;R3 is hydrogen, methyl, ethyl, methoxy, ethoxy, thiomethyl, chlorine, fluorine, bromine, cyano, amine group, morpholine, triazole, pyrazole, trifluoromethyl, difluoromethyl.The compound of the application shows excellent activity against plant pathogens, such as rice sheath blight fungus, cucumber botrytis, blueberry botrytis, strawberry botrytis, tobacco botrytis, and sclerotinia sclerotiorum.

The present invention provides e / zz'-pleuromutilin triazole derivatives and e / zz'-tiamulin triazole derivatives with antibacterial activity.

The lubricant composition may provide corrosion resistance, oxidation resistance, and reduced wear to the hydraulic system. A lubricant composition can include an ashless dithiophosphate ester in an amount sufficient to provide the lubricant composition with a phosphorus concentration in the range of from 10 ppm to 250 ppm, a metal dialkyldithiophosphate salt, such as zinc dialkyldithiophosphate (ZDDP), in an amount sufficient to provide the lubricant composition with a phosphorus concentration in the range of from 50 ppm to 1000 ppm, a corrosion inhibitor comprising an alkyl triazole derivative in an amount sufficient to provide the lubricant composition with a nitrogen concentration in the range of from 0.75 ppm to 100 ppm; and a major amount of a base oil.

Disclosed are a substituted triazole derivative, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof; specifically, provided are a compound represented by general formula (I), cis-trans isomers thereof, enantiomers thereof, diastereoisomers thereof, racemates thereof, solvates thereof, hydrates thereof, or pharmaceutically acceptable salts or prodrugs thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and a use of the compound as an α5-GABAA receptor inverse modulator.

The present application provides a series of substituted 1,2,4-triazole derivatives and their applications, and specifically provides a compound shown in formula (I) and a pharmaceutically acceptable salt thereof.

The application discloses a class of podophyllotoxin triazole ether derivatives, a preparation method and application thereof, belongs to the technical field of chemical pharmacy, and particularly relates to a class of podophyllotoxin triazole derivatives and application thereof in preparation of antitumor drugs. The application combines a triazole structure with a podophyllotoxin parent body by using a click chemistry reaction, designs and synthesizes a series of novel 1,2,3-triazole podophyllotoxin derivatives, optimizes the kinetic characteristics of the podophyllotoxin by introducing the triazole structure, and improves the anticancer effect and drug property. Molecular docking shows that the series of compounds have strong binding energy on AKT1 and tubulin, can target inhibit tubulin / AKT1, and in-vitro antitumor activity research shows that the molecules have strong inhibitory activity on the proliferation of human colon cancer cell strains, and can provide a new strategy for structural derivatization of podophyllotoxin.

This invention provides an ultraviolet absorber that efficiently absorbs harmful light in the wavelength range of 380-400 nm and suppresses the absorption of light with wavelengths above 400 nm, which is a cause of initial yellowing, thereby providing a component with less influence from harmful light and a superior appearance, as well as excellent light resistance and heat resistance, and furthermore, excellent light resistance and heat resistance, i.e., durability. [Solution] The highly light-resistant ultraviolet absorber of the present invention consists of a 2-phenylbenzotriazole derivative having a thioaryl ring group, such as the following formula (3). [Formula 1] TIFF2026137696000066.tif9132 (in the formula, PhBzT 1c and PhBzT 2c Each of these may independently have a substituent, a thioaryl ring group (-SA 1c It exhibits a 2-phenylbenzotriazole skeleton with -S-) attached, A 1c It contains residues of a phenyl ring or naphthyl ring.

The application discloses a kind of high selectivity β-triazole (β-triazole trifluoromethyl, β-triazole ketone, β-triazole thio, β-triazole selenide) Derivative and its synthesis method and application, with triazole compound, alkyl compound / aldehyde / dithioether / diselenide and styrene as raw material, in oxidant, additive and organic solvent, through one step reaction can high selectivity, high yield product is obtained.The method of the application has the advantages of good selectivity, mild reaction condition, high yield, simple and safe operation and high efficiency etc.The β-triazole ketone derivative compound involved in the application is a kind of new structure, has good anti-osteosarcoma activity, biological activity analysis shows that part of compounds can reach 99% inhibition rate to osteosarcoma (OS) cell line 143B, MNG / HOS and SJSA-1 at 10 μM concentration.Therefore, the compound can be used as important pharmaceutical and chemical intermediates, and has wide application prospect in the field of medicine.

The application discloses a kind of 1,5-diaryl-1,2,4-triazole compounds or pharmaceutically acceptable salt represented by structural formula I, II or pharmaceutical composition containing such compounds.The application also discloses the application of the compound or pharmaceutically acceptable salt in the preparation of drugs for treating various malignant tumors and related diseases of tumor metastasis.The compound represented by formula I, II of the application can inhibit the proliferation, invasion and infiltration of tumor cells such as gastric cancer cells, breast cancer cells, prostate cancer cells, colon cancer cells, liver cancer cells, non-small cell lung cancer cells and bladder cancer cells in a concentration gradient-dependent manner, has the characteristics of high efficiency and low toxicity, and has a wide application prospect in the biological medicine industry.

The invention discloses a preparation method and application of a urea triazole derivative which is simple and easy to operate, cheap and easily available in raw materials, high in reaction efficiency and good in inhibition effect on human liver cancer cells Huh-7, and belongs to the technical field of medicine synthesis. According to the key points of the technical scheme, the urea triazole derivative molecule has a structure, or R1 is hydrogen atom, fluorine, chlorine, bromine, iodine, nitryl, alkyl (such as methyl, ethyl or alkynyl) or alkoxy (such as methoxyl) and various substituent groups, R2 is phenyl derivative or benzyl derivative, and X is oxygen atom or sulfur atom. The invention designs and synthesizes a urea triazole derivative with a novel structure, and the compound has a good inhibition effect on human liver cancer cells Huh-7.

The invention belongs to the technical field of organic chemistry, and particularly relates to a dehydroabietic acid 1, 2, 3-triazole derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: reacting dehydroabietic acid in a first organic solvent under the action of a reducing agent to obtain a compound 2 with reduced carboxyl; reacting the compound 2 with p-toluenesulfonyl chloride under the action of an alkali solution to obtain a hydroxyl-protected compound 3; in a second organic solvent, reacting the compound 3 with sodium azide under a high-temperature condition to obtain an azide compound 4; and reacting the compound 4 with a copper salt and an alkyne compound in a polar solvent of alkali to obtain a target compound. The dehydroabietic acid derivative with high biological activity is synthesized, raw materials are cheap and easy to obtain, reaction conditions are mild, aftertreatment is simple, the yield is high, a virulent solvent is not used in the synthesis process, the green chemical requirement is met, high pressure or a special catalyst is not needed, and large-scale production can be achieved in conventional equipment.

The invention discloses a polynitrogen heterocyclic chemical 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole and a synthesis method thereof.The synthesis method comprises the steps that 4-pyrazolecarboxylic acid and hydrazine hydrate serve as starting raw materials, the 4-pyrazolecarboxylic acid and the hydrazine hydrate are added into a high-pressure-resistant reaction kettle according to the molar ratio of 1: 1-1: 5 and react for 1-5 days at the temperature of 100-220 DEG C, and the 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole is synthesized through a ring formation reaction; the catalyst is 1, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole. The 4-amino-1, 2, 4-triazole derivative 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole with 3, 5-position symmetrical substituted pyrazolyl is synthesized for the first time, a multi-nitrogen heterocyclic compound library is enriched, and the synthesis method has the advantages of cheap and easily available initial raw materials, mild reaction conditions, high product yield and simple post-treatment, and is suitable for large-scale production.

Compounds which are thiazole and triazole derivatives are disclosed, including compounds of the following genus:The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.

The invention discloses high-extreme-pressure and corrosion-resistant vehicle gear oil and a preparation method thereof, and belongs to the technical field of engine gear oil. Comprising the following raw materials in parts by weight: 70-90 parts of base oil, 2-8 parts of an extreme pressure anti-wear agent, 1-5 parts of a corrosion inhibitor, 0.5-3 parts of an anti-rust agent, 3-10 parts of a viscosity index improver, 1-5 parts of a purification dispersant, 0.5-3 parts of an antioxidant, 0.1-1 part of a pour point depressant and 0.01-0.5 part of an anti-foaming agent. Wherein the anti-wear reagent at extreme pressure contains S-P-N elements, can react with a metal surface to form a high-strength chemical reaction film, remarkably improves the bearing capacity of the gear oil and reduces abrasion and scratch of a tooth surface, and has a synergistic effect with a benzotriazole derivative in the corrosion inhibitor, so that the problem of corrosion to non-ferrous metals is solved, and the service life is prolonged; the viscosity index improver ensures that the oil product can maintain good fluidity at low temperature, can maintain stable oil film strength at high temperature, and adapts to extreme climate and harsh working conditions.

Provided is a compound having the structure of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate or isotope thereof, wherein A, B, R1, R2, R3, R4, R5, R6, R7, m, n, p, and y are as defined herein, for use in methods for modulating MRGPRD or for treating a MRGPRD dependent condition. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.

The invention discloses a synthesis method of a C-13 labeled mercapto triazole derivative. The synthesis method comprises the following steps: (1) carrying out a reaction on C-13 potassium cyanide and S8 to prepare C-13 potassium thiocyanate; (2) carrying out nucleophilic substitution reaction on C-13 potassium thiocyanate and a benzyl bromide compound to obtain a compound 1; (3) carrying out nucleophilic addition reaction on the compound 1 and formylhydrazine to obtain a compound 2; (4) further cyclizing the compound 2 under an alkaline condition to obtain a compound 3; and (5) carrying out derivative reaction on the compound 3 to obtain a C-13 labeled target compound. According to the synthesis method, multi-step continuous reaction is adopted, operation is easy and convenient, the yield is high, and the utilization rate of the C-13 marker is greatly increased.

A porous coordination network is represented by the following formulas (I) to (VIII), in which M2+ is a divalent metal ion, M3+ is a trivalent metal ion, L1a and L1b are tridentate ligands having hexaazaphenalenyl, L2a and L2b are bidentate or tridentate ligands containing a carboxy group, L3− is a tertiary ligand ion that is an anion of triazole or a triazole derivative, and Y is a cation.

The invention discloses a passivation solution as well as a preparation method and application thereof. The passivation solution is composed of the following components: 4.0-10.0% of a film-forming agent, 2.0-6.0% of an auxiliary film-forming agent, 1.0-10.0% of an oxidizing agent, 2.0-6.0% of boron powder, and the balance of deionized water. The effective components of the film-forming agent are a benzotriazole derivative and decamethylcyclopentasiloxane, the effective components of the auxiliary film-forming agent are sodium molybdate and sodium tungstate, and the effective component of the oxidizing agent is hydrogen peroxide. The method for passivating B30 cupronickel by using the passivation solution comprises the following steps: (1) carrying out surface pretreatment on a cupronickel sample to remove pollutants and an oxide layer on the surface of the cupronickel sample; (2) the pretreated cupronickel sample is put into a passivation solution, the passivation temperature ranges from 25 DEG C to 60 DEG C, the pH value ranges from 4 to 10, and the passivation treatment time ranges from 5 min to 60 min; and (3) the cupronickel sample treated in the step (2) is dried under the condition of 60-100 DEG C, and passivation is completed. The method has the characteristics that chromium-salt-free environment-friendly passivation of the B30 cupronickel is realized, and meanwhile, the corrosion-resistant effect of a passivation film in a long-term corrosion-resistant environment is improved.

The invention relates to an iridium (III) or rhodium (III) complex of formula (formula) and stoichiometric formula [Cp'M(k2-N,N)Y]n+[A-]n, wherein: k2-(N,N) is a pyridyl-1,2,3-triazole derivative; Cp' is an η5-cyclopentadienyl ligand; R1 to R5 represent a hydrogen atom or an alkyl, aryl, silyl or perfluoroalkyl group; n is 1 or 2; Y is F, Cl, Br or I; or, when n=1, an OH or OTf group; or, when n=2, H2O; A is F, Cl, Br, I, OH, OTf, BF4, BAr4 or PF6; R6 to R9 represent a hydrogen atom; or a carbon or fluorocarbon chain, or an alkoxyalkane group and R10 is a CO2R11 group; wherein R11 is a hydrogen or an alkyl or aryl group. The invention also relates to the use thereof as a catalyst of a formic acid dehydrogenation and hydrogen production reaction.

The invention discloses a synthesis method of a benzomorpholone derivative, and belongs to the technical field of organic chemistry. According to the method, a 3-hydroxy-2-indolone derivative and a triazole derivative react in an organic solvent at the temperature of 20-30 DEG C by taking commercialized cheap iodobenzene as a catalyst and selecting a fluorine reagent as an oxidizing agent, so that the benzomorpholone derivative can be obtained. The method is simple to operate, the raw materials are easy to obtain, the reaction steps are short and efficient, and the reaction yield is as high as 96%.

The invention discloses a podophyllotoxin structure-based tubulin / EGFR (epidermal growth factor receptor) dual-targeting podophyllotoxin triazole derivative and application thereof in antitumor drugs, and belongs to the technical field of medicinal chemistry. A triazole group is introduced into a podophyllotoxin mother nucleus through click chemistry, and a series of novel derivatives are designed and synthesized. Molecular docking studies show that the compound can target tubulin and EGFR kinase structural domains at the same time, and tumor cell proliferation is inhibited through a double-target synergistic effect. In-vitro experiments prove that the derivative has significant inhibitory activity on non-small cell lung cancer cells and has low toxicity on normal pulmonary epithelial cells. The dual-targeting strategy can overcome the drug resistance problem of the EGFR inhibitor, optimizes the pharmacokinetic characteristics, has the advantages of high oral availability, good in-vivo stability and the like, and is suitable for treatment of solid tumors such as non-small cell lung cancer and the like.

Disclosed is a fluorinated UV absorber compound which is a trimeric hydroxyphenyl benzotriazole derivative in which a plurality of hydroxyphenyl benzotriazole groups are bonded to one benzene substituted with fluorine. The fluorinated UV absorber compound according to the present invention exhibits improved solvent solubility, thermal stability and heat resistance at high temperatures, and excellent optical transparency. A transparent polyimide film prepared from the fluorinated UV absorber compound exhibits excellent ultraviolet absorption ability and light resistance.

Provided is a negative photosensitive resin composition containing (A) a polyimide precursor or polyimide, (B) a photopolymerization initiator, (C) a radically polymerizable monomer having one photopolymerizable group, and (D) a nitrogen-containing heterocyclic compound, wherein the component (C) is a liquid at 25°C and 1 atm, the component (D) is a tetrazole derivative, a triazole derivative, a triazine derivative, or a purine derivative, and the purine derivative has an acyl group, an alkoxy group, an alkyl group, a hydroxyalkyl group, or a heteroaryl group.

The application discloses a WRN degrading agent, a preparation method and application thereof. The application provides triazole derivatives with structures of formula (I), (II) and (III), a pharmaceutical composition containing the compounds and pharmaceutically acceptable salts thereof. The application evaluates the effect of the triazole derivatives by improving the inhibition and degradation ability of the drugs on WRN and the growth inhibition effect on MSI cells, and the application can degrade WRN protein while inhibiting the activity of WRN, has good in-vitro activity and stability, and has the feasibility of further developing drugs for treating MSI cancer patients.