99 results about "Triazole derivatives" patented technology

The invention relates to a preparation method and application of a triazole derivative with an antidepressant effect, and belongs to the technical field of synthesis of drugs. Based on a 2-[3-nitrile group-4-(2-isobutoxy)-phenyl]-4-methylthiazole-5-formic acid structure, terminal alkyne is introduced into the structure, and the triazole derivative with the antidepressant effect is prepared. According to the present invention, the novel compounds are obtained through the reaction of the compounds and the azide compounds through the click reaction, and the test results prove that the obtained compounds have good anti-inflammatory activity on LPS-induced BV2 cells, are expected to be used for the treatment of depression, and have strong guiding effects on the research and development of anti-depression drugs.

The invention provides a benzotriazole derivative and a resin composition containing the benzotriazole derivative. The benzotriazole derivative is of a 1H-site substitution type, and compared with a traditional 2H-site substitution type benzotriazole derivative light conversion material compound, the 1H-site substitution benzotriazole compound can remarkably improve the light conversion efficiency of a solar cell, especially the light conversion efficiency of the solar cell with a TOPCon photovoltaic module.

This disclosure provides processes for preparation of substituted triazole compounds of Formula X:

The application discloses a thiazole / oxazole group-containing 1,2,4-triazole derivative, a preparation method and application thereof, and relates to the technical field of medicinal chemistry.The thiazole / oxazole group-containing 1,2,4-triazole derivative has excellent broad-spectrum antifungal effect and the advantage of a simple synthesis method, and has important reference significance for developing a novel high-efficiency antiplant pathogenic fungus agent.

The invention discloses a preparation method and application of a triazole phosphate type corrosion and scale inhibitor, and relates to the technical field of industrial water treatment chemicals. The compound is prepared by a three-step synthesis method which comprises the following steps: firstly, preparing an amino methylene phosphonic acid compound with one-NH reaction site from n ethylene (n + 1) amine, phosphorous acid and formaldehyde; secondly, preparing a triazole derivative from ethylene glycol glycidyl ether and triazole; and reacting the two products with sodium bicarbonate to obtain a target product. The target molecule contains a sodium phosphate group and a triazole group at the same time, through the synergistic effect of functional groups, intramolecular synergy of scale inhibition and corrosion inhibition functions is achieved, and the corrosion inhibition performance higher than that of a DETPMP scale and corrosion inhibitor used commercially is shown. The triazole phosphate type corrosion and scale inhibitor has good catalytic activity on photocatalytic carbon dioxide reduction under the conditions of room temperature and high temperature, the TON (carbon monoxide conversion number) can reach 1206, and the selectivity is 100%.

The invention discloses an anti-ultraviolet hardened coating for a PC material and a preparation method of the anti-ultraviolet hardened coating, and relates to the technical field of coatings, the anti-ultraviolet hardened coating is composed of an internal connecting layer, a middle functional layer and an external protective layer, the internal connecting layer contains an epoxy group-containing siloxane coupling agent, and the internal connecting layer is covalently connected with hydroxyl after being subjected to surface plasma activation of the PC material to generate hydroxyl, so that the adhesive force of the coating is enhanced; the middle functional layer contains ZnO-S < 2 > nano particles, a benzotriazole derivative and modified polyurethane acrylate, the ZnO-S < 2 > nano particles are of a core-shell structure formed by coating ZnO with S < 2 >, the S < 2 > shell layer inhibits the photocatalytic activity of ZnO and improves the dispersity, and the benzotriazole derivative serves as an anti-ultraviolet functional component, so that the photocatalytic activity of ZnO is improved, and the photocatalytic activity of ZnO is improved. A disulfide bond and a Schiff base structure are introduced into modified polyurethane acrylate through modification preparation, the disulfide bond can inhibit free radical chain reaction and reversible fracture / recombination under mechanical stress, and the Schiff base structure can capture Fe < 3 + > / Cu < 2 + > generated by PC degradation and inhibit catalytic oxidation of metal ions, so that the anti-ultraviolet performance and mechanical performance of the material are enhanced.

The application discloses a kind of pyrimidine-substituted 1,2,4-triazole derivatives, it is characterized in that, with the structure expressed in general formula I or II:Wherein, R1 is hydrogen, methyl, ethyl, methoxy, ethoxy, thiomethyl, chlorine, fluorine, bromine, iodine, cyano, amine group, morpholine, triazole, pyrazole, trifluoromethyl, difluoromethyl, ethyl formate;R2 is hydrogen, methyl, ethyl, methoxy, chlorine, fluorine, bromine, iodine, cyano, amine group, trifluoromethyl, ethyl formate;R3 is hydrogen, methyl, ethyl, methoxy, ethoxy, thiomethyl, chlorine, fluorine, bromine, cyano, amine group, morpholine, triazole, pyrazole, trifluoromethyl, difluoromethyl.The compound of the application shows excellent activity against plant pathogens, such as rice sheath blight fungus, cucumber botrytis, blueberry botrytis, strawberry botrytis, tobacco botrytis, and sclerotinia sclerotiorum.

The present invention provides e / zz'-pleuromutilin triazole derivatives and e / zz'-tiamulin triazole derivatives with antibacterial activity.

The lubricant composition may provide corrosion resistance, oxidation resistance, and reduced wear to the hydraulic system. A lubricant composition can include an ashless dithiophosphate ester in an amount sufficient to provide the lubricant composition with a phosphorus concentration in the range of from 10 ppm to 250 ppm, a metal dialkyldithiophosphate salt, such as zinc dialkyldithiophosphate (ZDDP), in an amount sufficient to provide the lubricant composition with a phosphorus concentration in the range of from 50 ppm to 1000 ppm, a corrosion inhibitor comprising an alkyl triazole derivative in an amount sufficient to provide the lubricant composition with a nitrogen concentration in the range of from 0.75 ppm to 100 ppm; and a major amount of a base oil.

Disclosed are a substituted triazole derivative, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof; specifically, provided are a compound represented by general formula (I), cis-trans isomers thereof, enantiomers thereof, diastereoisomers thereof, racemates thereof, solvates thereof, hydrates thereof, or pharmaceutically acceptable salts or prodrugs thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and a use of the compound as an α5-GABAA receptor inverse modulator.

The present invention relates to a novel compound, and a composition for preventing or treating eye diseases, comprising same, and, more specifically, to: a series of phenyl-triazole derivative compound or a pharmaceutically acceptable salt thereof; a pharmaceutical composition for preventing or treating eye disease, comprising the compound; a method for preventing or treating eye diseases, comprising administering the pharmaceutical composition; an autophagy activation composition comprising the compound or a pharmaceutically acceptable salt thereof; a food composition for preventing or alleviating eye diseases; and a feed composition.

The present application provides a series of substituted 1,2,4-triazole derivatives and their applications, and specifically provides a compound shown in formula (I) and a pharmaceutically acceptable salt thereof.

The invention belongs to the field of pesticides, and particularly relates to a novel glycosyl C-glycoside derivative as well as a preparation method and application thereof, and the structure of the novel glycosyl C-glycoside derivative is shown as a formula I or a formula II; the compound can be used as an insect chitin degrading enzyme, and has good target enzyme inhibition activity and insecticidal activity when being used for preventing diseases and insect pests caused by lepidoptera insects. # imgabs0 #

The application discloses a class of podophyllotoxin triazole ether derivatives, a preparation method and application thereof, belongs to the technical field of chemical pharmacy, and particularly relates to a class of podophyllotoxin triazole derivatives and application thereof in preparation of antitumor drugs. The application combines a triazole structure with a podophyllotoxin parent body by using a click chemistry reaction, designs and synthesizes a series of novel 1,2,3-triazole podophyllotoxin derivatives, optimizes the kinetic characteristics of the podophyllotoxin by introducing the triazole structure, and improves the anticancer effect and drug property. Molecular docking shows that the series of compounds have strong binding energy on AKT1 and tubulin, can target inhibit tubulin / AKT1, and in-vitro antitumor activity research shows that the molecules have strong inhibitory activity on the proliferation of human colon cancer cell strains, and can provide a new strategy for structural derivatization of podophyllotoxin.

The invention belongs to the technical field of copper surface treatment, and particularly provides a passivation solution and a preparation method and application thereof. The passivation solution is prepared from 4.5%-10.0% of a film agent, 3.0%-6.5% of an auxiliary film-forming agent, 0.5%-15.0% of an oxidizing agent, 2.5%-6.5% of boron powder and the balance deionized water. The effective components of the film-forming agent are a benzotriazole derivative and tolyl triazole, the effective components of the auxiliary film-forming agent are cerous nitrate and lanthanum nitrate, and the effective component of the oxidizing agent is sodium hypochlorite or hydrogen peroxide; the problems that an existing passivation solution is complex, the production cost is high, the time of the passivation solution is too long, the speed requirement of a production line cannot be met, the passivation technological process is complex, part of performance cannot meet the requirement, and industrial application is difficult to achieve are solved, the passivation solution is easy to prepare, the passivation process is simple, the passivation time is short, and the speed requirement of the technological generation process is met.

This invention provides an ultraviolet absorber that efficiently absorbs harmful light in the wavelength range of 380-400 nm and suppresses the absorption of light with wavelengths above 400 nm, which is a cause of initial yellowing, thereby providing a component with less influence from harmful light and a superior appearance, as well as excellent light resistance and heat resistance, and furthermore, excellent light resistance and heat resistance, i.e., durability. [Solution] The highly light-resistant ultraviolet absorber of the present invention consists of a 2-phenylbenzotriazole derivative having a thioaryl ring group, such as the following formula (3). [Formula 1] TIFF2026137696000066.tif9132 (in the formula, PhBzT 1c and PhBzT 2c Each of these may independently have a substituent, a thioaryl ring group (-SA 1c It exhibits a 2-phenylbenzotriazole skeleton with -S-) attached, A 1c It contains residues of a phenyl ring or naphthyl ring.

The invention relates to a triazole derivative and an application thereof in medicine, in particular to a compound shown in a general formula (I) or a stereoisomer, a tautomer, a deuterated compound, a solvate, a prodrug, a metabolite, pharmaceutically acceptable salt or eutectic crystal thereof, an intermediate and a preparation method thereof, and an application of the triazole derivative in preparation of medicines for treating kidney stone, recurrent kidney stone, renal calculus and the like. The invention also relates to application of the pharmaceutical composition in drugs for treating type I primary hyperoxaluria (PH). # imgabs0 #

The invention discloses an application of an indole triazole derivative in preparation of a drug for resisting drug-resistant candida albicans. The structure of the indole triazole compound contains an indole ring and a triazole ring, so that the indole triazole compound has a good inhibition effect on drug-resistant fungi, especially fluconazole-resistant candida albicans, and is expected to further solve the problem of infection of candida albicans drug-resistant strains.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to an oleanolic acid triazole derivative as well as a preparation method and application thereof. The oleanolic acid derivative with a brand new structure provided by the invention has good cell proliferation inhibition activity on tumor cell lines, the inhibition effect is greatly improved compared with that of oleanolic acid, and the oleanolic acid derivative has the potential to be developed into a new anti-cancer drug.

The invention discloses a pyrimido triazole derivative, the pyrimido triazole derivative is a pyrimido triazole derivative containing amino dithio ester, and the pyrimido triazole derivative has the following general formula I: # imgabs0 #. The reversion activity of the pyrimido triazole derivative containing amino dithio ester disclosed by the invention is obviously superior to that of an ABCB1 inhibitor Verapamil, and the reversion activity of the pyrimido triazole derivative containing amino dithio ester is obviously superior to that of the ABCB1 inhibitor Verapamil; the compound can be used as a candidate or lead compound for further development and is applied to preparation of a drug resistance reversal agent.

The application discloses a kind of high selectivity β-triazole (β-triazole trifluoromethyl, β-triazole ketone, β-triazole thio, β-triazole selenide) Derivative and its synthesis method and application, with triazole compound, alkyl compound / aldehyde / dithioether / diselenide and styrene as raw material, in oxidant, additive and organic solvent, through one step reaction can high selectivity, high yield product is obtained.The method of the application has the advantages of good selectivity, mild reaction condition, high yield, simple and safe operation and high efficiency etc.The β-triazole ketone derivative compound involved in the application is a kind of new structure, has good anti-osteosarcoma activity, biological activity analysis shows that part of compounds can reach 99% inhibition rate to osteosarcoma (OS) cell line 143B, MNG / HOS and SJSA-1 at 10 μM concentration.Therefore, the compound can be used as important pharmaceutical and chemical intermediates, and has wide application prospect in the field of medicine.

The application discloses a kind of 1,5-diaryl-1,2,4-triazole compounds or pharmaceutically acceptable salt represented by structural formula I, II or pharmaceutical composition containing such compounds.The application also discloses the application of the compound or pharmaceutically acceptable salt in the preparation of drugs for treating various malignant tumors and related diseases of tumor metastasis.The compound represented by formula I, II of the application can inhibit the proliferation, invasion and infiltration of tumor cells such as gastric cancer cells, breast cancer cells, prostate cancer cells, colon cancer cells, liver cancer cells, non-small cell lung cancer cells and bladder cancer cells in a concentration gradient-dependent manner, has the characteristics of high efficiency and low toxicity, and has a wide application prospect in the biological medicine industry.

The invention discloses a preparation method and application of a urea triazole derivative which is simple and easy to operate, cheap and easily available in raw materials, high in reaction efficiency and good in inhibition effect on human liver cancer cells Huh-7, and belongs to the technical field of medicine synthesis. According to the key points of the technical scheme, the urea triazole derivative molecule has a structure, or R1 is hydrogen atom, fluorine, chlorine, bromine, iodine, nitryl, alkyl (such as methyl, ethyl or alkynyl) or alkoxy (such as methoxyl) and various substituent groups, R2 is phenyl derivative or benzyl derivative, and X is oxygen atom or sulfur atom. The invention designs and synthesizes a urea triazole derivative with a novel structure, and the compound has a good inhibition effect on human liver cancer cells Huh-7.

The invention belongs to the technical field of organic chemistry, and particularly relates to a dehydroabietic acid 1, 2, 3-triazole derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: reacting dehydroabietic acid in a first organic solvent under the action of a reducing agent to obtain a compound 2 with reduced carboxyl; reacting the compound 2 with p-toluenesulfonyl chloride under the action of an alkali solution to obtain a hydroxyl-protected compound 3; in a second organic solvent, reacting the compound 3 with sodium azide under a high-temperature condition to obtain an azide compound 4; and reacting the compound 4 with a copper salt and an alkyne compound in a polar solvent of alkali to obtain a target compound. The dehydroabietic acid derivative with high biological activity is synthesized, raw materials are cheap and easy to obtain, reaction conditions are mild, aftertreatment is simple, the yield is high, a virulent solvent is not used in the synthesis process, the green chemical requirement is met, high pressure or a special catalyst is not needed, and large-scale production can be achieved in conventional equipment.

The invention discloses a polynitrogen heterocyclic chemical 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole and a synthesis method thereof.The synthesis method comprises the steps that 4-pyrazolecarboxylic acid and hydrazine hydrate serve as starting raw materials, the 4-pyrazolecarboxylic acid and the hydrazine hydrate are added into a high-pressure-resistant reaction kettle according to the molar ratio of 1: 1-1: 5 and react for 1-5 days at the temperature of 100-220 DEG C, and the 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole is synthesized through a ring formation reaction; the catalyst is 1, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole. The 4-amino-1, 2, 4-triazole derivative 3, 5-bis (4-pyrazolyl)-4-amino-1, 2, 4-triazole with 3, 5-position symmetrical substituted pyrazolyl is synthesized for the first time, a multi-nitrogen heterocyclic compound library is enriched, and the synthesis method has the advantages of cheap and easily available initial raw materials, mild reaction conditions, high product yield and simple post-treatment, and is suitable for large-scale production.

Compounds which are thiazole and triazole derivatives are disclosed, including compounds of the following genus:The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.

The invention discloses high-extreme-pressure and corrosion-resistant vehicle gear oil and a preparation method thereof, and belongs to the technical field of engine gear oil. Comprising the following raw materials in parts by weight: 70-90 parts of base oil, 2-8 parts of an extreme pressure anti-wear agent, 1-5 parts of a corrosion inhibitor, 0.5-3 parts of an anti-rust agent, 3-10 parts of a viscosity index improver, 1-5 parts of a purification dispersant, 0.5-3 parts of an antioxidant, 0.1-1 part of a pour point depressant and 0.01-0.5 part of an anti-foaming agent. Wherein the anti-wear reagent at extreme pressure contains S-P-N elements, can react with a metal surface to form a high-strength chemical reaction film, remarkably improves the bearing capacity of the gear oil and reduces abrasion and scratch of a tooth surface, and has a synergistic effect with a benzotriazole derivative in the corrosion inhibitor, so that the problem of corrosion to non-ferrous metals is solved, and the service life is prolonged; the viscosity index improver ensures that the oil product can maintain good fluidity at low temperature, can maintain stable oil film strength at high temperature, and adapts to extreme climate and harsh working conditions.

Disclosed are a substituted triazole derivative, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof, specifically, provided are a compound represented by general formula (I), cis-trans isomers thereof, enantiomers thereof, diastereoisomers thereof, racemates thereof, solvates thereof, hydrates thereof, or pharmaceutically acceptable salts or prodrugs thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and a use of the compound as an α5-GABAA receptor inverse modulator.

Provided is a compound having the structure of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate or isotope thereof, wherein A, B, R1, R2, R3, R4, R5, R6, R7, m, n, p, and y are as defined herein, for use in methods for modulating MRGPRD or for treating a MRGPRD dependent condition. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.

The invention discloses a synthesis method of a C-13 labeled mercapto triazole derivative. The synthesis method comprises the following steps: (1) carrying out a reaction on C-13 potassium cyanide and S8 to prepare C-13 potassium thiocyanate; (2) carrying out nucleophilic substitution reaction on C-13 potassium thiocyanate and a benzyl bromide compound to obtain a compound 1; (3) carrying out nucleophilic addition reaction on the compound 1 and formylhydrazine to obtain a compound 2; (4) further cyclizing the compound 2 under an alkaline condition to obtain a compound 3; and (5) carrying out derivative reaction on the compound 3 to obtain a C-13 labeled target compound. According to the synthesis method, multi-step continuous reaction is adopted, operation is easy and convenient, the yield is high, and the utilization rate of the C-13 marker is greatly increased.