85 results about "Benzyl bromide" patented technology

The utility model provides a continuous photochemical reaction system for preparing 2, 4-disubstituted benzyl bromide by adopting 2, 4-disubstituted toluene. The continuous photochemical reaction system comprises a photocatalytic reaction device, a feeding device, a post-treatment device, a product receiving device and a heat exchange device. According to the system, 2, 4-disubstituted toluene and dibromohydantoin can be subjected to continuous bromination reaction to realize photochemical reaction, continuous feeding and continuous discharging are realized, and the reaction process is uninterrupted. The structure of the heat exchange device is improved, for example, the heat exchange device is controlled to be a corrugated pipe, the corrugation distance and the pipe diameter of the corrugated pipe are controlled, particularly, baffle plates are arranged on the inner wall of the corrugated pipe at intervals, and the size of the baffle plates and the distance between every two adjacent baffle plates are controlled to be within a certain range value; therefore, the heat transfer coefficient of the heat exchange device is high, the temperature control effect is better, and the efficiency of the continuous photochemical reaction and the purity of the 2, 4-disubstituted benzyl bromide product are improved.

The invention discloses a fullerene C60 tetra-addition derivative as well as a preparation method and application thereof. The structure of the fullerene C60 tetra-addition derivative is shown as a formula I. The specific preparation method comprises the following steps: under the protection of inert gas, taking fullerene C60, tetrabutyl ammonium hydroxide hydrate, benzyl bromide and a TBAOH methanol solution as raw materials, taking o-dichlorobenzene or methylbenzene as a solvent, and reacting at 60-80 DEG C to obtain the target fullerene C60 tetra-addition derivative. The preparation method of the fullerene C60 tetra-addition derivative has the advantages of simple operation steps, safety, easiness in control, high selectivity and the like. A photovoltaic device prepared by using the fullerene derivative as an acceptor material has high open-circuit voltage, and is a very potential photovoltaic material. # imgabs0 #

The invention discloses a breathable antibacterial fabric and a preparation process thereof. The preparation process comprises the following steps: S1, taking chinlon as warp yarns and keeping tension; s2, spandex serves as weft yarn, and the weft yarn and the warp yarn are interwoven into gray cloth; s3, the gray cloth is finished through a finishing agent, burrs are cut off, wrinkles are smoothed, a fabric is obtained, hexamethylene di (carbamate propionic acid) is obtained through a reaction of hexamethylene diisocyanate and 3-hydracrylic acid, the hexamethylene di (carbamate propionic acid) is subjected to acylating chlorination and reacts with N-methyl-2, 2-diaminodiethylamine and benzyl bromide, and the antibacterial finishing agent is obtained. The antibacterial agent contains a large number of quaternary ammonium salt antibacterial groups, has inhibiting and killing effects on escherichia coli and other bacteria, contains polyamide and carbamate structures, and has very high affinity and interfacial force with chinlon polyamide molecular chains in the blended fabric and the carbamate structure of spandex polyurethane. The firmness and antibacterial aging of the antibacterial finishing agent attached to the surface of the fabric are improved.

The invention provides a series of polybenzyl bromide or polybenzyl iodide-based monomolecular resin photoresists as well as a preparation method and application thereof. The monomolecular resin can be used as a main body material of the photoresists. The raw materials are cheap and easily available, and the synthesis process is simple. According to the compound disclosed by the invention, adamantane is taken as a core unit, a plurality of benzyl bromide or benzyl iodine groups, adamantane and a benzene ring are externally connected, and bromine atoms or iodine atoms are additionally introduced, so that the sensitivity and the etching resistance of the photoresist can be improved to the maximum extent.

The invention relates to the technical field of benzyl bromide preparation and discloses a benzyl bromide preparation device and method.The benzyl bromide preparation device comprises a stirring kettle, a heating box is fixedly connected to the outer wall of the stirring kettle, an isolation sleeve is fixedly connected to the inner wall of the stirring kettle, a water inlet pipe is fixedly connected to the upper surface of the heating box, and a water outlet pipe is fixedly connected to the lower surface of the heating box; one end of the water inlet pipe penetrates through the surface of the heating box and is fixedly connected with a water pump, a supporting plate is fixedly connected into the heating box, the water pump is installed on the surface of the supporting plate, and the middle of the heating box is connected with a heating assembly. The bottom of the isolation sleeve is connected with a temperature measuring assembly, and the inner wall of the isolation sleeve is connected with a scraping assembly. According to the preparation device and the preparation method of the benzyl bromide, reaction materials in the stirring kettle can be uniformly heated, so that the reaction uniformity is improved, and an overheating or supercooling phenomenon of a local area is avoided.

The application discloses a kind of breathable antibacterial fabric and its preparation process, S1, nylon is used as warp and tension is maintained;S2, spandex is used as weft, and weft and warp are interwoven into grey cloth;S3, the grey cloth is finished by finishing agent, the burr is cut, and the wrinkle is smoothed, to obtain fabric, using hexamethylene diisocyanate, 3-hydroxypropionic acid is reacted to obtain hexamethylene di (carbamate propionic acid), after acyl chloride, and with N-methyl-2,2-diamino diethylamine, benzyl bromide is reacted, to obtain antibacterial finishing agent.It contains a large number of quaternary ammonium salt antibacterial groups, and has inhibitory and killing effect on bacteria such as escherichia coli, and at the same time contains polyamide and urethane structure, and has high affinity and interfacial force between the polyamide molecular chain in the blended fabric and the urethane structure of spandex polyurethane, to improve the firmness of antibacterial finishing agent attached to the surface of fabric and antibacterial time effect.

The invention relates to the technical field of pesticide synthesis processes, in particular to a one-pot multi-component preparation method of a chiral Dufulin compound. The method comprises the following steps: mixing quinine, substituted benzyl bromide and a solvent, and refluxing to obtain a reaction solution; the preparation method comprises the following steps: mixing 2-amino-4-methylbenzothiazole, 2-fluorobenzaldehyde, a solvent and a catalyst, and then refluxing to obtain a reaction system; mixing the reaction system with diethyl phosphite, the reaction liquid and an alkali reagent, and stirring to react, so as to obtain a stirred reaction material; and extracting the stirred reaction material with an extraction liquid, separating the liquid to obtain an organic phase, washing the organic phase with water, and removing the solvent to obtain the chiral Dufulin compound. According to the invention, low-cost clean synthesis of chiral Dufulin is realized; the preparation method disclosed by the invention is reasonable in design, mild in reaction condition, easy to obtain raw materials, convenient to operate, high in product yield, suitable for large-scale production and good in industrial replicability.

The invention belongs to the technical field of chemical synthesis of spices, and particularly relates to a synthetic method of vanillin and ethyl vanillin. Carrying out substitution reaction on catechol and methyl iodide to generate o-dimethoxybenzene 3; 3 and 1, 2-dichloromethyl methyl ether are subjected to formylation reaction to generate 3, 4-dimethoxybenzaldehyde 4; carrying out demethylation reaction on the 3, 4-dihydroxy benzaldehyde 5 and pyridine hydrochloride to generate 3, 4-dihydroxy benzaldehyde 5; carrying out substitution reaction on the 4-benzyloxy-3-hydroxybenzaldehyde 5 and benzyl bromide to generate 4-benzyloxy-3-hydroxybenzaldehyde 6; carrying out substitution reaction on the 4-benzyloxy-3-methoxyl / ethyoxyl benzaldehyde 6 and iodomethane / iodoethane to generate 4-benzyloxy-3-methoxyl / ethyoxyl benzaldehyde 7; 7 is reduced by hydrogen under the catalysis of palladium on carbon to generate vanillin / ethyl vanillin. Cheap catechol is adopted as a raw material, reaction conditions are mild, equipment requirements are not high, energy consumption is low, the problems that raw materials are not suitable to obtain, the price is high, separation is difficult, and three wastes are seriously generated in a traditional vanillin synthesis method are solved, and a new method is provided for synthesis of vanillin.

This invention discloses a cellulose mixed ester and its preparation method, comprising the following steps: S1, dissolving cellulose in a solvent, adding an etherification protecting agent and reacting, then adding benzyl bromide and reacting to obtain a first intermediate product; S2, dissolving the first intermediate product in an organic mixed solution and reacting to obtain a second intermediate product, 3-o-benzyl cellulose; S3, reacting the second intermediate product with an acylation agent A under the action of a catalyst to obtain a third intermediate product; S4, removing the benzyl group from the third intermediate product to obtain a fourth intermediate product; S5, acylating the fourth intermediate product with an acylation agent B under the action of a catalyst to obtain the final product, 3-o-B-acyl-2,6-di-o-A-acyl cellulose. This invention successfully achieves the selective esterification preparation of cellulose mixed esters by constructing a solvent dissolution and etherification protecting system, an organic solution reaction system, and an acylation alkaline composite catalyst system in a synergistic manner. More importantly, it achieves a high product yield and a relatively fast reaction process.

This invention relates to the field of oilfield chemical additives technology, and discloses a method for preparing a 1-benzyl-10-phenylpyrrolo[1,2-a:3,4-b']dipyrazine-1-onium type quaternary ammonium salt high-temperature acidizing corrosion inhibitor. The method uses 2,2'-piperazine as the starting material, which undergoes a quaternization reaction with benzyl bromide to obtain a quaternary ammonium salt intermediate. The obtained intermediate undergoes an oxidative cyclization reaction with benzaldehyde and manganese dioxide in a dichloromethane system. After separation, drying, and purification, the target product is obtained. The preparation process of this invention is simple and easy to control, the product is easy to purify, and it is suitable for industrial production. It exhibits good synergistic effects with additives, excellent water solubility and compatibility, can stabilize and protect steel, reduce construction risks, and is suitable for various high-temperature acidizing operations.

The invention discloses an epoxy resin flame retardant as well as a preparation method and application thereof, and relates to the field of chemical synthesis. The chemical structural formula of the epoxy resin flame retardant is shown as a formula I and a formula II: # imgabs0. The preparation method of the epoxy resin flame retardant comprises the following steps: synthesizing a quaternary ammonium salt intermediate and synthesizing the flame retardant. N, N-dimethylethanolamine, benzyl bromide and phenylphosphonic dichloride are used as raw materials for two-step synthesis of the phosphate gemini quaternary ammonium salt type epoxy resin flame retardant, a quaternary ammonium salt structure is introduced to phosphate, the suffocation effect of phosphate in a gas phase is compensated, organic phosphorus-nitrogen free radicals can fully play a role in capturing free radicals during combustion, and the flame retardant property of the flame retardant is improved. Meanwhile, the phosphorus component takes epoxy resin as a carbon source to effectively form carbon, and the oxidation stability of Br <-> further improves the safety guarantee of the epoxy resin.

The invention provides a method for preparing an ester compound from a benzyl bromide compound under a photocatalysis condition. The method comprises the following steps: adding a benzyl bromide compound, an additive and a manganese oxide catalyst into an acetonitrile solvent, putting into a photoreactor, and reacting for 12-24 hours under the irradiation of blue light in an oxygen atmosphere, so as to oxidize and break a carbon-bromine bond into a corresponding ester compound. The system has the advantages that the catalyst activity is high, the method is wide in application range, reaction conditions are easy to control, the catalyst can be recycled, post-treatment is simple and the like, and the system has a good application prospect.

There is disclosed a method of preparing a compound of Formula (1), or a salt thereof (1) the method comprising: a) treating a compound of Formula (2) sequentially with o-tolylmagnesium chloride, N-methylpiperazine and iodine, under conditions sufficient to obtain a compound of Formula (3) b) treating the compound of Formula (3) from step a) with 3,5-bis(trifluoromethyl)benzyl bromide and a suitable base, under conditions sufficient to obtain a compound of Formula (1).

The invention discloses a method for modifying a C-21 site structure of fusidic acid, which comprises the following steps: adding fusidic acid as shown in a formula (I) and a substituted benzyl bromide reagent as shown in a formula (II) into a grinding tank, adding an alkaline reagent, adding a grinding aid and a cosolvent, adding stainless steel grinding balls with the diameter of 8mm, and grinding for 10-60 minutes at the grinding frequency of 10-30Hz. After grinding is finished, a reactant is scraped out, ethyl acetate is added to dissolve the reactant, the reactant is filtered and then washed with 10% hydrochloric acid, water and a saturated saline solution in sequence, an organic phase is dried with anhydrous sodium sulfate, concentration and column chromatography purification are conducted after filtering, and the fusidic acid C-21 esterified derivative shown in the formula (IV) is obtained. Compared with an existing chemical method, the method has the advantages that the operation is simple and convenient, the reaction condition is mild, the reaction time is short, the pollution is less, and the synthesis of the fusidic acid C-21 esterified derivative can be effectively realized.

The invention discloses a 5-hydroxypyrazole compound as well as a synthesis method and application thereof, and the structural formula of the 5-hydroxypyrazole compound is as follows: 3-phenoxyphenyl-3-oxo-methyl propionate derivative is used as a starting material, the starting material and benzyl bromide derivative are subjected to hydrocarbylation reaction firstly, then the starting material and hydrazine hydrate are subjected to Knorr reaction, and the 5-hydroxypyrazole compound is obtained. Finally, the 5-hydroxy-3-phenoxyphenyl pyrazole ring compound is prepared, and the prepared 5-hydroxypyrazole ring compound shows that the 5-hydroxypyrazole ring compound has a good inhibition effect on HepG2 cells and can be used for further preparing anti-cancer drugs.

The invention discloses a synthesis method and application of a pesticide and medical intermediate phenolic hydroxyl group-containing alkenyl oxime ether compound, and the synthesis method of the phenolic hydroxyl group-containing alkenyl oxime ether compound comprises the following steps: carrying out aldol condensation on p-hydroxy benzaldehyde and acetone under the action of alkali to obtain a phenolic hydroxyl group-containing alkenyl ketone compound 1; reacting the compound 1 with dimethyl tert-butyl chlorosilane (TBSCl) under the action of imidazole, so as to obtain a phenolic hydroxyl alkenyl ketone compound 2 protected by a silicon group; reacting the compound 2 with hydroxylamine hydrochloride under the action of alkali to obtain a silicon group protected alkenyl ketoxime compound 3; and carrying out nucleophilic substitution reaction on the compound 3 and a substituted benzyl bromide compound 4 under the action of alkali to prepare a phenolic hydroxyl group-containing alkenyl oxime ether compound 5. The phenolic hydroxyl-containing alkenyl oxime ether compound 5 or the preparation thereof can be used for preventing and treating diseases caused by common plant pathogenic fungi such as oomycetes, phycomycetes and ascomycetes on various crops.

The invention discloses hydroxyl-exposed urolithin A-8-O galactoside as well as a synthesis method and application thereof, and belongs to the technical field of organic synthesis. The synthesis method of urolithin A-8-O galactoside comprises the following steps: reacting 3-hydroxy-6-bromo-benzaldehyde with benzyl bromide, oxidizing the product by hydrogen peroxide, and coupling the oxidized product with resorcinol to obtain hydroxyl-exposed urolithin A; galactose is subjected to acetic anhydride substitution and hydrogen bromide substitution in sequence to obtain brominated galactose pentaacetate; and carrying out an oxygen glycosylation reaction on the urolithin A with the exposed hydroxyl and bromo-galactose pentaacetate, and removing a hydroxyl protecting group from a product to obtain the urolithin A-8-O galactoside with the exposed hydroxyl. The preparation method has the beneficial effects that the problem that the urolithin A is insoluble in water is solved, and the product has good blood sugar and blood fat reducing capacity; the process route is reasonable in design, convenient to operate, low in cost of used basic raw materials and suitable for industrial production.

The invention provides a method for preparing ester compounds by oxidizing and breaking carbon-bromine bonds (C-Br) of benzyl bromide compounds. The method comprises the following steps: adding a benzyl bromide compound, an additive and a cobalt-doped manganese oxide catalyst into an acetonitrile solvent, sealing in a pressure container, introducing 1.0 MPa oxygen source gas, and reacting at 120-170 DEG C for 4-12 hours, so as to oxidize and break a carbon-bromine bond into a corresponding ester compound. The system has the advantages that the catalyst activity is high, the method is wide in application range, reaction conditions are easy to control, the catalyst can be recycled, post-treatment is simple and the like, and the system has a good application prospect.

The present invention discloses a method for synthesizing aromatic sulfonyl fluoride compounds, belonging to the field of organic chemistry. In the method of the present invention, inexpensive and readily available Na2S2O4 is used as the sulfur dioxide source, and nickel acetate tetrahydrate is used as the nickel source. The substrate has a wide applicability, the raw materials are simple and readily available, and the economic cost is low. In addition, the method of the present invention only needs to react for 15 hours to obtain the target product in a good yield, which is more rapid and efficient. The synthesis method of the present invention converts simple and readily available β-arylvinyl bromide or benzyl bromide into aromatic sulfonyl fluoride under relatively simple conditions, and realizes the sulfofluorination of β-arylvinyl bromide or benzyl bromide in one pot. The target compound has wide applications in the fields of new drug development, new material synthesis, etc.

The application provides a series of monomolecular resin photoresists based on polybenzyl bromide or polybenzyl iodine and a preparation method and application thereof, and the monomolecular resin can be used as a main body material of the photoresist. Raw materials are cheap and easy to obtain, and the synthesis process is simple. The compound provided by the application takes adamantane as a core unit, is externally connected with multiple benzyl bromide or benzyl iodine groups, and the core structure of adamantane and benzene ring and the introduction of bromine atoms or iodine atoms can maximize the sensitivity and etching resistance of the photoresist.

The invention provides a synthesis method and application of a poly (N-heterocyclic carbene) copper material, and solves the defect that most poly (N-heterocyclic carbene) copper complexes prepared by the existing preparation method are irregular in morphology. Controllable construction of rod-shaped, sheet-shaped and spherical poly-N-heterocyclic carbene copper materials is achieved through a universal method; firstly, molecules with benzyl bromide groups are used as connectors, imidazolyl molecules are used as monomers, acetonitrile or 1, 4-dioxane is used as a solvent I, the growth speeds vx, vy and vz in three different directions of x, y and z are effectively regulated and controlled in the quaternization and self-assembly process of the connectors and the monomers through cooperation of different types of connectors, monomers and solvents I, and the growth rates vx, vy and vz in the three different directions of x, y and z are effectively regulated and controlled. The rod-shaped, sheet-shaped or spherical polyimidazole salt can be controllably prepared; and then, under the protection of an inert atmosphere, polyimidazolium salt is used as a framework, and deprotonation of the imidazolium salt is coordinated with copper salt under an alkaline condition, so that a rod-shaped, sheet-shaped or spherical poly-N-heterocyclic carbene copper material is controllably constructed.

The invention discloses a preparation method and application of a functional lithium battery positive electrode AT9 coating additive material. The method comprises the following steps: S1, carrying out preheating treatment on p-benzyl bromide and an alkylation reagent, then adding a catalyst, and carrying out Friedel-Crafts alkylation reaction to obtain a porous precursor; s2, dissolving the porous precursor and imidazole bromide in a solvent, and carrying out nucleophilic substitution reaction to obtain an imidazole modified porous precursor; and S3, placing the imidazole modified porous precursor in an alkali solution, and carrying out an ion exchange reaction to obtain the functional lithium battery positive electrode AT9 coating additive material. The material prepared by the method has the function of enriching carbon dioxide in battery swelling gas, relieves gas swelling pressure in the battery, and can overcome the defects of high cost, influence on battery performance and the like in the conventional battery swelling prevention technology.

The application belongs to the technical field of chemical industry and relates to a preparation method of a novel chiral bipyridine and application of the chiral bipyridine in catalytic reaction. Various benzyl bromides with 4,5-diazofluorene as a skeleton are reacted to generate a series of chiral bipyridine ligands, then under the participation of the ligands, indolines and quinoline nitrogen-containing heterocyclic compounds are reacted with pinacol diboronic acid under the catalysis of [IrOMe(COD)2] as a metal catalyst, and then a series of phenol compounds are obtained through oxidation of sodium perborate. The novel chiral bipyridine ligand developed by the method has the advantages of good site selectivity and excellent reaction yield without using strong acid and strong base in the process of C-H bond selective boronation.

This invention discloses a method for preparing high-purity quartz sand from quartz ore, relating to the field of high-purity quartz sand processing. First, a quaternized cation reagent is prepared using benzyl bromide and N,N-dimethyldodecylamine as raw materials. The adsorption of this self-made collector on the quartz surface is the result of the combined effects of electrostatic attraction and multiple forms of hydrogen bonding. The addition of quaternary ammonium and polyhydroxy groups allows for strong physical adsorption of quartz without the need for strong acids. Furthermore, a stable filler layer is formed on the quartz surface, thereby improving the collection effect of the quartz sand. Secondly, the preparation process of this invention is as follows: coarse washing – coarse crushing – direct high-temperature bursting water quenching – medium crushing – microwave heating – fine crushing – acid leaching – magnetic separation – flotation – drying. A segmented, step-by-step treatment is adopted, using different treatment methods for different particle sizes of quartz sand, which is beneficial for removing inclusions in the quartz and results in a larger surface area and better effect compared to acid leaching. The quartz sand prepared by this invention exhibits high purity.

The invention discloses a preparation method of a carptorelin intermediate based on catalytic oxidation of yeast alcohol dehydrogenase, which comprises the following operation steps of: generating an intermediate product 1 from N-Boc-4-piperidinol by adopting a method of catalytic oxidation of yeast alcohol dehydrogenase oxidase, purifying, adding semicarbazide, and reacting to obtain the carptorelin intermediate. The preparation method comprises the following steps: reacting at least one of tert-butyloxycarboryl hydrazine or methyl carbazate with alkali to generate an intermediate product 2, adding DMF-DMA to react with alkali to generate an intermediate product 3, adding benzyl bromide to react with basic salt to generate an intermediate product 4, and adding acid to react to generate the carprorelin intermediate. According to the method, a brand new synthesis route is used, the semicarbazide which is low in price and easy to obtain is adopted in the new process route, hydrazine hydrate which seriously pollutes a water body is prevented from being used, highly toxic methylhydrazine is prevented from being used, a shrinkage process and a micro-channel continuous flow process can be adopted in the synthesis steps, and the method is simple in process, high in yield, good in safety and high in product quality.

The invention provides an ultraviolet light grafting modified UHMWPE fiber, a fiber reinforced composite material and a preparation method and application of the UHMWPE fiber and the fiber reinforced composite material. The preparation method of the ultraviolet light grafting modified UHMWPE fiber comprises the following steps: (1) grafting Diazirine on the UHMWPE fiber: preparing absolute ethyl alcohol and 4-[3-(trifluoromethyl)-3H-bis (aziridin-3-yl) benzyl bromide (Diazirine) into a Diazirine ethanol solution; the UHMWPE fiber is immersed in a Diazirne ethanol solution, the surface of the fiber is fully wetted, the fiber is naturally aired, the two faces of the fiber are irradiated through an ultraviolet light source, and a UHMWPE-Dia fiber is obtained; (2) grafting the UHMWPE-Dia fiber with PEI: dissolving polyethyleneimine (PEI) in a solvent absolute ethyl alcohol to prepare a PEI solution, putting the UHMWPE-Dia fiber obtained in the step (1) and the PEI solution into a sealed container, and carrying out horizontal mechanical shaking for reaction; after the reaction is finished, the fiber is flatly laid and dried to remove the solvent absolute ethyl alcohol, and the UHMWPE-Dia-PEI fiber is obtained. The fiber reinforced composite material comprises epoxy resin, an amine curing agent and ultraviolet grafting modified UHMWPE (Ultra High Molecular Weight Polyethylene) fibers.

The invention discloses an antibacterial epoxy adhesive and a preparation method thereof. The antibacterial epoxy adhesive comprises the following components in parts by weight: 100 parts of epoxy resin, 5-50 parts of a curing agent, 0.1-3.0 parts of a coupling agent and 1-30 parts of antibacterial filler, wherein the antibacterial filler comprises an inner core and a shell, the inner core is aluminum oxide, and the shell is formed by polymerizing benzyl bromide, acrylic ester, glycidyl methacrylate, triethylene glycol dimethacrylate and acrylic acid. According to the invention, the epoxy resin, the curing agent, the coupling agent and the polymer-coated alumina antibacterial filler are compounded, so that the prepared epoxy adhesive has good mechanical properties and shows antibacterial ability, and the preparation method is simple and convenient to operate.

There is disclosed a method of preparing a compound of Formula (1), or a salt thereof (1) the method comprising: a) treating a compound of Formula (2) sequentially with o-tolylmagnesium chloride, N-methylpiperazine and iodine, under conditions sufficient to obtain a compound of Formula (3) b) treating the compound of Formula (3) from step a) with 3,5-bis(trifluoromethyl)benzyl bromide and a suitable base, under conditions sufficient to obtain a compound of Formula (1).

The invention discloses a cyclic quaternary ammonium salt N-hydronopyl tetrahydropyrrole compound as well as a synthesis method and antibacterial application thereof, and belongs to the technical field of plant antibiosis. Hydronopyl chloride and tetrahydropyrrole are taken as raw materials, an N-hydronopyl tetrahydropyrrole intermediate is prepared through reaction, and the cyclic quaternary ammonium salt N-hydronopyl tetrahydropyrrole compound is prepared through a one-step reaction. Then, the cyclic quaternary ammonium salt N-hydronopyl tetrahydropyrrole compound and an alpha-bromoacetophenone compound or a benzyl bromide compound are subjected to a quaternization reaction, and the cyclic quaternary ammonium salt N-hydronopyl tetrahydropyrrole compound can be synthesized; the cyclic quaternary ammonium salt N-hydronopyl tetrahydropyrrole compound has excellent broad-spectrum antibacterial activity, and especially has a remarkable inhibition effect on common phytopathogens such as rhizoctonia solani, oxysporum tomentosum, colletotrichum carpopogonum, fusarium oxysporum, tobacco black shank, Fusarium fulvum, coriolus versicolor, fusarium verticillium and the like.

The invention relates to a novel tetrahydro-beta-carboline derivative as well as a synthesis method and application thereof. The method comprises the following steps: by taking novel tetrahydro-beta-carboline as a substrate, firstly adding inorganic alkali NaH under the protection of nitrogen, then adding an anhydrous N, N-dimethylformamide solvent for dissolving, reacting with a series of benzyl bromide or similar compounds under the condition of ice bath, carrying out intermolecular nucleophilic substitution reaction, adding a quenching agent for quenching reaction, and extracting to remove redundant N, N-dimethyl formamide, so as to obtain the novel tetrahydro-beta-carboline derivative. A series of novel tetrahydro-beta-carboline derivatives are obtained through column chromatography analysis in an N, N-dimethylformamide solvent, and the compounds have the application of inhibiting phytopathogen. The phytopathogens comprise rhizoctonia solani, sclerotinia sclerotiorum, botrytis cinerea, fusarium graminearum, colletotrichum capsici and pyricularia oryzae. The synthesis process is simple, and the product purity is high.