396results about How to "Low critical micelle concentration" patented technology

The invention relates an amphiphilic polysaccharide-anti-tumor medicament conjugate capable of releasing medicines specifically at a lesion site of a living body, as well as a preparation method and application of a medicinal composition of the amphiphilic polysaccharide-anti-tumor medicament conjugate. In the conjugates, hydrophobic anti-tumor medicaments are introduced into a polysaccharide skeleton through a connecting arm which contains a disulfide bond, so that the polysaccharide-anti-tumor medicament conjugate has amphipathic characteristics and can be self-assembled into nano-micelles; the nano-micelles can load anti-tumor medicaments additionally and also can be directly used as conjugate pre-drug micelles. The amphiphilic polysaccharide-anti-tumor medicament conjugate is mainly characterized in that 1) after the nano-micelles reach the lesion site, the disulfide bond connecting arm of the conjugate can be specifically degraded by high-concentration reducing substances in lesion cells, so that the micelles are depolymerized and the medicament is released quickly, and therefore, the treatment effect is improved; 2) the anti-tumor medicament is chemically conjugated and physically coated to achieve a common treatment effect. The polysaccharide conjugate and the medicinal composition thereof can be used for injection, oral administration or external use administration; the anti-tumor activity can be improved remarkably; new ideas are provided for the development of anti-tumor medicaments.

The invention relates to a method of displacing oil by anionic-cationic composite surfactant and mainly solves the problems that the prior method of displacing oil by surfactant is low in oil displacement efficiency in tertiary oil recovery and an oil displacement system containing inorganic base is harmful to stratums and oil wells, corrosive to equipment and pipelines and difficult for demulsification. According to the technical scheme, crude oil is allowed to contact with oil-displacing agent, and the oil-displacing agent comprises, by weight percent, 0.01-5.0% of anionic-cationic composite surfactant, 0.01-3.0% of polymer, and 92.0-99.98% of injected water. The problems are solved well. The method is applicable to tertiary oil recovery for oil fields.

The present invention provides a preparation method for a novel dendritic oligomeric quaternary ammonium surfactant. The method comprises the following steps: (1) N, N-dimethyl-1,3 - propanediamine and an excess amount of methyl acrylate are subjected to a Michael addition reaction to generate a compound (I); (2) the compound (I) and an excess amount of N, N-dimethyl-1 ,3 - propanediamine are subjected to an amidation reaction to obtain a compound (II); and (3) the compound (II) and bromododecane are subjected to a quaternization reaction to obtain the final product of a compound (III). The surfactant prepared by using the method of the invention has excellent performances, and can be widely used in fields such as daily chemicals, water treatment, paper making and oilfield development.

The invention relates to a dual-sensitivity amphiphilic polysaccharide-doxorubicin conjugate.According to the conjugate, hydrophobic antitumor drug doxorubicin is introduced in a polysaccharide framework through a connecting arm containing a disulfide bond and a hydrazone bond, so that the polysaccharide-doxorubicin conjugate has an amphiphilic property, can be self-assembled into a nano-micelle in water and directly used for tumor treatment, and can also be physically loaded with an antitumor drug to be used for antitumor treatment.The conjugate is mainly characterized in that after the nano-micelle reaches a focus, the disulfide bond in the connecting arm can be degraded specifically by high-concentration reduction substances in focus cells, and meanwhile the hydrazone bond in the connecting arm can be degraded in a special pH environment of the focus, so that the micelle is degraded, the drug is quickly released, and the treatment effect is improved; the antitumor drug is loaded in two modes of chemical conjugation and physical package, and therefore the joint treatment effect is achieved.The polysaccharide conjugate and a pharmaceutical composition can be used for injection or oral administration or external administration, can remarkably improve antitumor activity, and provides a new thought for development of the antitumor drug.

The invention relates to a multifunctional polyethylene glycol-dual vitamin E succinate derivative and application thereof in drug delivery. An amphiphilic block copolymer utilizes polyethylene glycol as a hydrophyllic end to be combined with bimolecular hydrophobic vitamin E succinate under bridging of lysine, so that the AB2 type two-arm amphiphilic block copolymer is obtained. The polymer has potential antineoplastic activity and P-gp inhibitory action, and is capable of synergetically and effectively overcoming multidrug resistance to increase chemotherapeutic effect. Besides, the block copolymer can be self-assembled to form a micelle in aqueous medium, and can serve as a reservoir of poorly water-soluble drug, protein and gene-based drug, and the micelle is safe and high in stability and encapsulation, can be used for intravenous injection and oral ingestion, and has bright market application prospects.

The invention relates to an oil-displacing agent and an oil-displacing method for enhancing the recovery ratio of high-temperature, high-salinity and high-hardness reservoir crude oil. The oil-displacing agent is composed of the following components in percentage by mass: A, 0.05-0.07% of an amine oxide type amphoteric surfactant; B, 0.15-0.20% of alkylphenol ethoxylate carboxylate; and C, the balance of water. The oil-displacing method disclosed by the invention is implemented through injecting the oil-displacing agent into a natural core subjected to oil-displacing under the conditions that the oil reservoir temperature is 100-120 DEG C, the total salinity of formation water is (10-15)*10<4> mg/L, and the amount of calcium-magnesium divalent metal ions is 7000-10000 mg/L, so that residual oil is in contact with the oil-displacing agent, and then the residual oil is fully displaced. The oil-displacing agent provided by the invention reaches the magnitude order of 10<-3> mN/m under the condition of high-temperature, high-salinity and high-hardness salt reservoirs, and the interfacial tension still can be maintained in an ultra-low interfacial tension state after the oil-displacing agent is aged for a long time under the condition of oil reservoirs, therefore, the oil-displacing agent is applied to the tertiary oil recovery production of oil fields.

The invention relates to a sulfhydrylated amphipathic chitosan derivative carrier with biological adhesiveness. The derivatives are structured by respectively introducing hydrophilic groups, hydrophobic groups and groups containing sulfydryl. The derivative in an aqueous medium can be self-assembled to nano-micelle so as to load pharmaceutically active or pharmacologically active molecules. After the carrier reaches the mucosa of a living body, the sulfydryl groups can be bonded with surface protein of the mucosa through covalent bonds: disulfide bonds, so that the detaining and acting time of micelle on the surface of the mucosa is prolonged. In addition, the chitosan derivative further has the function of mutual effect in compact connection with cells and opening compact connection with cells of the mucosa. The auxiliary material can be used as the carrier of the pharmaceutically active or pharmacologically active molecules to be used for administration via oral administration, ocular administration, nasal mucosa administration and the like, so that medicine absorption is remarkably improved, and the bioavailability is improved. The carrier provided by the invention is simple in preparation method and manure in process, so that the carrier is suitable for large-scale continuous production.

The invention discloses an environment-friendly optical glass cleaning agent and a preparation method thereof. The environment-friendly optical glass cleaning agent is prepared from the following raw materials in percentage by mass: 2 to 6 percent of inorganic alkali, 0.5 to 0.8 percent of anionic surfactant, 0.2 to 0.4 percent of non-ionic surfactant, 15 to 35 percent of film-forming agent, 0.4 to 1.0 percent of corrosion inhibitor, 0.5 to 1 percent of chelating agent and the balance of deionized water, wherein the anionic surfactant is prepared from sodium lauryl sulfate and fatty acid methyl ester sulfonate in a mass ratio of (5:1) to (1:1); the non-ionic surfactant is prepared from dodecyl glycoside; the film-forming agent is prepared from ethanol and ethylene glycol in a mass ratio of 1:1; the corrosion inhibitor is prepared from sodium citrate and triethanolamine in a mass ratio of 1:1. The optical glass cleaning agent disclosed by the invention has the advantages of good cleaning effect, high cleanliness of cleaned glass, no corrosion to the glass, high biodegradability, freeness from pollution, and low skin irritation.

The invention relates to carboxylic acid betaine type gemini surfactant and a preparation method thereof. The surfactant is named as N,N'-dicarboxymethyl-N,N'-dimethyl-N,N'-dialkylethylenediammonium (DCMA for short). The surfactant has high surface activity and low critical micelle concentration, wherein CMC of DCMA-12 is 4.6*10mol.L, and gamma CMC is 27mN.m. The preparation method for the surfactant has the advantages of cheap and easily-obtained raw materials, mild reaction conditions and safe reaction.

The invention relates to the technical field of chemical products, in particular to ultrasonic water-based cleaning fluid for hardware products. The ultrasonic water-based cleaning fluid for hardware products comprises, by weight, 1-5 parts of dimeric surfactant, 10-20 parts of nonionic surfactant, 1-10 parts of alcohol ether compound, 1-5 parts of alkylol amine compound, 1-5 parts of a builder, 0.1-5 parts of auxiliaries and 60-80 parts of water. The water-based cleaning fluid is low in manufacturing cost, safe, environmentally friendly, efficient, convenient, fast, low in toxicity, and easy to biodegrade and wash away, the residual quantity of the fluid on the surface of metal is extremely low after the fluid is washed away, the metal cannot be corroded, the metal can keep good colour and luster, and the quality of metal products is improved.

The invention discloses a multi-stimuli responsive shell crosslinked polymeric micelle and a preparation method thereof. The polymeric micelle is prepared by: carrying out ATRP and click chemistry reaction to synthesize an amphiphilic diblock polymer with polydimethylaminoethyl methacrylate (PDMAEMA) as the hydrophilic chain and polymethacrylate ferrocenyl formyloxy ethyl ester (PMAFFEE) as the hydrophobic chain, subjecting the polymer to self-assembly in water to form core-shell micelles with uniform size, and then carrying out cross-linking reaction on the micelles and N, N'-di(bromoacetyl)cystamine. The core-shell crosslinked polymeric micelle provided by the invention is responsive to temperature, pH, light, oxidation and reduction stimuli, drugs can be released under single triggering of different stimuli in a controlled release process, and also can achieve controlled release through joint triggering of multiple stimuli. Therefore, the multi-stimuli responsive shell crosslinked polymeric micelle has broad application prospect in controlled release of anti-cancer drugs and other fields.

The invention relates to an active water oil displacement method used for low permeability reservoirs, in particular to a strengthened oil displacement method, and mainly solves the problem of low efficiency of oil displacement of the low permeability reservoirs in the prior art. According to the oil displacement method, a positive-negative system surfactant containing a 0.01-1.0wt% anionic-nonionic surfactant and a cationic surfactant in a molar ratio of 1:0.01-0.99 is injected into a water solution to form active water, dehydrated crude is enabled to be in contact with the active water under the condition of injected water at the oil displacement temperature of 40-100 DEG C with total mineralization (total dissolved solid) TDS more than 200mg/L, and crude in the core is displaced sufficiently. The problem is well solved, and the strengthened oil displacement method can be applied to tertiary recovery production of the low permeability reservoirs.

The invention relates to photo-responsive controlled-release nano-pesticide preparation and a preparation method and application thereof. A controlled-release effective constituent of the preparation is amphiphilic carboxymethyl chitosan derivative which is obtained through reaction between o-nitro benzyl hemisuccinate and carboxylmethyl chitosan. The preparation is prepared by the following steps: taking water solution of the carboxymethyl chitosan, adding organic solution of the o-nitro benzyl hemisuccinate activated by NHS and EDC.HCl according to the molar ration of sugar moiety of the carboxymethyl chitosan to the o-nitro benzyl hemisuccinate as 1 to (0.01 to 1), reacting for 6h in room temperature, then dialyzing and freeze drying to obtain photo-responsive carboxymethyl chitosan derivative, dispersing the derivative and pesticide into water at the same time and performing ultrasound at intervals to obtain photo-responsive controlled-release pesticide nanoparticle. The photo-responsive controlled-release nano-pesticide preparation can be selectively sprayed on the surfaces of or in target plants and pests under the condition free of illumination. Once the photo-responsive controlled-release nano-pesticide preparation is applied to the surfaces of or in the target plants and the pests, the photo-responsive controlled-release nano-pesticide preparation can respond external sunshine stimulation to release pesticide at any time.

The invention relates to a surfactant combination for enhancing oil recovery and a preparation method thereof, and mainly solves the problem of low oil displacement efficiency in the tertiary recovery process in the existing surfactants and the problem of damage to stratums and oil wells, corrosion of equipment and pipes and difficulty in demulsification because inorganic base is contained in oil displacement systems. The surfactant combination comprises a cationic surfactant and an anionic-nonionic surfactant, wherein the cationic surfactant is selected from any one of quaternary ammonium salt and quaternary ammonium alkali; the anionic-nonionic surfactant is a surfactant containing ethoxy nonionic groups and carboxyl or sulfo anionic groups; the mol ratio of the cationic surfactant to the anionic-nonionic surfactant is (1:0.01) to (1:100). The surfactant combination and the preparation method thereof preferably solve the problems, and can be applied to the tertiary recovery process of oil fields.

The invention discloses slick water applied to shale gas industrialized fracturing exploitation and a preparation method thereof, and solves the problems of long period of fracturing construction and high cost of the existing slick water due to long liquid preparation time and high liquid preparation requirements. The slick water provided by the invention includes 0.05%-0.1% of an emulsion resistance reducing agent, 0.1%-0.2% of a fungicide, 0.1%-0.2% of a clay stabilizer, 0.09%-0.11% of a cleanup agent and the balance of water. The formula of the invention is reasonable in design, the emulsion resistance reducing agent dissolves and glues rapidly and has strong salt resistance, so as to not only greatly shorten the cycle of fracturing construction but also reduce the construction cost to meet the requirements for shale gas industrialized fracturing exploitation. The invention has the advantages of simple process, wide source of raw materials, and high application value and promotion value.

The invention relates to a water-proof and medicinal-oil resistant watercraft dispersion liquid compound which comprises the following components according to weight percentage: 15-30 percent of fluorine-containing polymer, 1-5 percent of surface active agent, and 68-80 percent of watercraft medium, wherein, the fluorine-containing polymer is formed by the copolymerization of the following ingredients according to weight percentage: 30-70 percent of fluorine-containing monomer, 3-10 percent of polymerizable monomer containing confining polyisocyanate radical and 25-65 percent of polymerism monomer; the surface active agent consists of the following ingredients according to weight percentage; 10-50 percent of cation surface active agent containing two quaternary ammonium molecules, 20-70 percent of nonionics with the HLB value ranging from 3 to18, and 5-30 percent of response type emulsifier containing unsaturated vinyl and polyoxyethylene compound; and the watercraft medium is de-ionized water or the mixture of de-ionized water and hydrophilic organic solvent. The compound leads the processed textile not only to have good waterproof and oil resistance properties, but also to have high mechanical stability.

The invention relates to a novel fluoric block copolymer and a synthesis method thereof. The structure of the novel fluoric block copolymer comprises tow blocks or three blocks of AB or ABA: a. water soluble oxirane polyether or ethylene oxide and propylene oxide copolymer used as B segmer; b. hydrophobic and oleophobic perfluoro alkyl A segmer. The fluoric block copolymer can be used as surfactant, and the like, the synthesis method is simple, and is applicable to industrialized production. The fluoric block copolymer has sound surface activity in water solution, and can reduce the surface tension of the water solution to 12- 20mN/m. The surfactant can be used as emulsifier, dispersant, evaporation and volatilization inhibitor, penetrant, and the like.

The invention relates to an oil displacing method for reservoirs with high temperature and salinity, and mainly solves the problems that the oil displacing agent containing a surfactant in the prior art has poor displacement efficiency, high use concentration and corrosion and scale damage caused by bases in ASP (alkali surfactant polymer ) flooding to the formation and oil wells under the conditions of high temperature and salinity. Through the oil displacing method for reservoirs with high temperature and salinity provided by the invention, the crude oil in cores is fully displaced by contacting the underground dehydrated crude oil with a oil displacing composition under the formation water conditions of the oil displacing temperature greater than or equal to 85 DEG C, the total mineralization degree greater than or equal to 16000 mg/L and the total content of Ca<2+> and Mg<2+> greater than or equal to 450 mg/L, wherein the oil displacing composition comprises the following components in percentage by weight: (1) 0.01-5.0% of N,N-bisfatty acyl-diamine-dipropionate-dipolyoxyethylene ether dicarboxylate; (2) 0.01-3.0% a polymer; and (3) 92.0-99.98% of the formation water. The oil displacing method provided by the invention can solve the above problems in a better manner and can be used in tertiary oil recovery production of an oilfield.

The invention relates to a salt-resistant and high-temperature-resistant foam discharge agent and a method for preparing the same, and belongs to the technical field of oil and gas field development.The salt-resistant and high-temperature-resistant foam discharge agent comprises, by weight, 0.2-0.5% of anionic-nonionic surfactant composite systems, 0.02-0.08% of microbial fermentation liquor andthe balance water. The microbial fermentation liquor is glycolipid producing biological surfactant or lipopeptide producing biological surfactant microbial strain fermentation liquor. The salt-resistant and high-temperature-resistant foam discharge agent and the method have the advantages that the salt-resistant and high-temperature-resistant foam discharge agent has salt-resistant and high-temperature-resistant foaming, foam stabilizing and liquid carrying ability and is excellent in condensate oil resistance and methanol tolerance, and accordingly the salt-resistant and high-temperature-resistant foam discharge agent and the method are favorable for environmental protection and sustainable development of oil and gas fields.