23results about How to "Payload" patented technology

The invention discloses a one-step cell membrane bionic lipid nanoparticle as well as a preparation method, a device and application thereof, and belongs to the field of microfluidics preparation and bionic preparation. The one-step preparation chip is constructed by combining microfluidic and alternating current stimulation technologies, the preparation method is simple and convenient, and conditions are controllable. The fusion efficiency on cell membranes and lipid nanoparticles is better, the protection capability on protein components is better, and the clinical transformation possibility is good. The cell membrane bionic lipid nanoparticles can effectively carry various drugs, achieve accurate targeting of the recognition ability of pulmonary alveolar damaged pulmonary epithelial cells, achieve more efficient drug delivery ability, can achieve effective intervention in the early stage of pulmonary fibrosis, and have broad application prospects.

The invention discloses a preparation method of a multifunctional polyvinyl composite film and application of the multifunctional polyvinyl composite film in food preservation. The preparation method comprises the following steps: firstly, preparing Ag-coated MOF through a hydrothermal method, then uniformly dispersing the Ag-coated MOF and tannic acid into a carboxymethyl chitosan solution, and carrying out crosslinking modification on the Ag-coated MOF; and coating the prepared CMCS / TA / Ag (at) MOF mixed solution on a polyethylene film treated by oxygen plasma, and drying to form a film, so as to obtain the multifunctional polyethylene-based composite film. The CMCS and the TA are adopted to perform crosslinking modification on the Ag-coated MOF, so that the stability of the Ag-coated MOF can be further improved, and the release of silver ions is reduced. Compared with a common PE preservative film, the composite film prepared on the basis has better barrier capacity and mechanical property, and has antibacterial, anti-ultraviolet and anti-oxidation effects. The multifunctional preservative film is convenient to use and low in price, and has an important application prospect in the aspect of fresh-keeping packaging of meat products.

The invention relates to the field of traditional Chinese medicine active ingredient new dosage form pharmaceutical preparations, and discloses an ROS responsive bionic nano drug delivery system, a preparation method and application. The preparation method comprises the following steps: taking lipid components, namely soybean phospholipid (SPC), hydrogenated soybean phospholipid (HSPC), dipalmitoyl phosphatidylcholine (DPPC), pegylated distearoyl phosphatidyl ethanolamine (DSPE-PEG), dioleoyl lecithin (DOPC), (2, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate) and a surfactant, as well as an emulsifier, as well as a solvent; the ROS-responsive leonurine lipidosome is prepared by taking 1, 3-dioleoyl-propyl)-trimethylamine (DOTAP), cholesterol and the like as raw materials to prepare nano-lipidosome, taking the nano-lipidosome as an inner core and coating the leonurine serving as a traditional Chinese medicine effective component and catalase capable of catalyzing active oxygen to generate oxygen, so as to form the ROS-responsive leonurine lipidosome. And then realizing bionic fusion with an activated neutrophile granulocyte membrane on the outer layer through a pneumatic nano extruder co-extrusion technology, so as to prepare the activated neutrophile granulocyte membrane coated ROS responsive bionic nano-liposome drug delivery system. The invention can realize targeted therapy of rheumatoid arthritis and the like, and has the advantages of biological safety, slow release and the like.

The invention relates to a gearbox shell fatigue life detection device and method, and belongs to the technical field of gearbox shell fatigue tests.The gearbox shell fatigue life detection device comprises a supporting table which is provided with an installation base used for cantilever installation of a gearbox shell; the loading piece is arranged on the supporting table, a loading shaft of the loading piece is in threaded connection with a connecting frame used for being connected with a gearbox shell, and the loading shaft is provided with a limiting face facing the connecting frame; the pre-tightening pieces are arranged between the limiting face and the connecting frame and used for providing axial pre-tightening force to fasten the connecting frame, inclined faces are arranged on the pre-tightening pieces, the pre-tightening pieces are used in pairs, the inclined faces on the pre-tightening pieces are oppositely attached when the pre-tightening pieces are used, and the limiting face and the connecting frame are connected in an abutting mode by adjusting the relative positions of the inclined faces of the two pre-tightening pieces. The device can ensure the stable connection between the gearbox shell and the loading piece so as to effectively transmit the load, and achieves the fatigue strength examination of the gearbox shell.

A wind tunnel test model structure with a high slenderness ratio belongs to the field of wind tunnel test vehicle design technology. It solves the problems of large vibration amplitude and low data accuracy in existing technologies during testing. Key technical points: The rectifier cap, front cylinder, and front port flange are sequentially bonded together, with the front port flange connected to the front end of the central steel shell; the rear port flange, rear end cylinder, and rear end plate are sequentially bonded together, with the rear port flange connected to the rear end of the central steel shell; a balance sleeve is fitted onto the balance, the central steel shell is fitted onto the balance sleeve, the balance front cone tension plate is connected to the central steel shell, the front end of the balance is connected to the balance front cone tension plate, and the rear end of the balance is connected to the tail end of the balance sleeve. This invention significantly reduces the vibration amplitude of the model structure during testing, avoids damage to the model and equipment caused by resonance, and improves the safety and stability of the entire wind tunnel high angle-of-attack test process; it effectively suppresses the interference of model vibration on measurement results, ensuring accurate and reliable test data acquisition.

The utility model discloses a high-flatness PVC (polyvinyl chloride) film calendering device, which relates to the technical field of PVC calendered film production and comprises a calendering box. The compression roller assembly comprises an upper calendaring roller and a lower calendaring roller, and the inner side of the upper calendaring roller and the inner side of the lower calendaring roller are each provided with a rotating assembly, a heat dissipation assembly and an air inlet and outlet assembly; and the guide roller assembly comprises a guide roller, and a cooling assembly used for cooling is arranged on the inner side of the guide roller. According to the utility model, the upper calendering roller and the guide roller are arranged, and the first air outlet, the first air inlet and the second air inlet are respectively formed in the outer sides of the upper calendering roller and the guide roller, so that not only is the cooling work completed, but also the problem of hardening of a PVC film caused by direct blowing is avoided, the PVC film is effectively and quickly shaped, and the flatness of the PVC film is improved; not only can the upper calendering roller be effectively cooled, but also the PVC film can be shaped by redundant air flow, so that the utilization rate of resources is improved.

The invention relates to the technical field of polymer composite materials, in particular to a high-strength and high-toughness PHA plant fiber composite material and a preparation method thereof. The high-strength and high-toughness PHA plant fiber composite material comprises the following raw materials in parts by mass: 60-80 parts of polyhydroxyalkanoate, 20-30 parts of modified palm fibers, 1-5 parts of a plasticizer and 2-4 parts of a nucleating agent, and the modified palm fibers are long-chain fatty acid modified palm fibers. The PHA plant fiber composite material provided by the invention has excellent strength and toughness, also has excellent ultraviolet resistance, and also maintains excellent degradability of the PHA plant fiber composite material.

The present invention discloses a nucleic acid-based multi-channel Ca 2+ Nanomodulators and their preparation methods and applications belong to the field of biomedical technology. The present invention uses a coprecipitation method to load the calcium ion efflux inhibitor curcumin into amorphous calcium phosphate, and then adsorbs DNA aptamers on its surface. The resulting ACP@C‑D can be used to promote the dual pathway of cancer treatment mediated by mitochondrial dysfunction, and has been shown to have the following advantages: (1) ACP@C‑D can disintegrate at the TME and release CUR and Ca 2+ , thereby improving the accuracy of treatment. (2)Ca 2+ The sudden increase in Ca 2+ (3) The released CUR can not only prevent Ca 2+ efflux and can also promote Ca 2+ From the endoplasmic reticulum to the mitochondria, further amplifying Ca 2+ In conclusion, this nanomodulator is a promising nanomedicine that can provide a valuable reference for mitochondria-based tumor therapy.

This application provides a cylindrical battery heating device and system, relating to the field of cylindrical battery pack technology, for heating cylindrical batteries. It includes: two fixing seats, each with a mounting through-hole in its center, through which the fixing seats are fitted onto the ends of the cylindrical battery; a connecting nickel sheet disposed inside the fixing seats and electrically connected to an external power source; and two heating films with arc-shaped cross-sections, symmetrically covering the outer periphery of the cylindrical battery and extending along the axial direction of the battery. The two ends of each heating film are inserted into the mounting through-holes of the two fixing seats and connected to the connecting nickel sheet. This cylindrical battery heating device and system can heat and maintain the temperature of cylindrical batteries, providing uniform overall temperature distribution and effective contact between the heating films and the cylindrical battery, preventing the heating films from dry-burning.

The utility model discloses a multi -directional clamping formula plug -in folding paper meal tray belongs to environmental protection tableware technical field, in view of existing folding paper meal tray has the problem of poor fixed effect, side easy loose deformation, bottom easy breakage etc.

The utility model relates to the technical field of bridge traction, and particularly discloses a device for emergency opening and closing of a double-wing horizontal rotating steel bridge, which comprises a tractor positioned below the bridge and connected with one end of the bridge, a connecting mechanism for connecting the tractor and the bridge, and a counterweight component matched with the tractor and positioned below the bridge, the tractor moves in the transverse bridge direction. According to the utility model, the frame can be driven to lift through the lifting mechanism, so that the frame can effectively bear the weight of the counter weight, the traction force of the tractor is further increased, and effective traction of a large bridge is realized.

The application discloses a cross beam and processing equipment, which comprises an outer frame, an inner frame and a first reinforcing rib. The outer frame is provided with a containing cavity, and comprises a corner portion. The inner frame is located in the containing cavity. The first reinforcing rib is located between the inner circumferential surface of the outer frame and the outer circumferential surface of the inner frame. One end of the first reinforcing rib is connected with the outer frame, and the other end of the first reinforcing rib is connected with the inner frame. The first reinforcing rib is provided with two or more than two, and at least one end of the first reinforcing rib is connected with the corner portion. The cross beam can effectively improve the rigidity and strength of the cross beam.

This invention discloses nanoparticles for loading dihydroberberine, their preparation method, and applications. The nanoparticles comprise polydopamine (PDA) and polyethylene glycol modified with the PDA. The polyethylene glycol can be amino-NH2-terminated polyethylene glycol. In preparing the nanoparticles, dopamine hydrochloride is oxidatively self-polymerized under alkaline conditions to obtain PDA nanoparticles; the PDA nanoparticles are then modified with polyethylene glycol to obtain the nanoparticles. Utilizing the aromatic ring structure of the PDA in the nanoparticles, dihydroberberine can be stably loaded onto the nanoparticle surface through π–π stacking interactions and hydrogen bonding. These nanoparticles can effectively load and stably encapsulate dihydroberberine without complex chemical modifications to the dihydroberberine molecule, and are relatively safe and biocompatible.

The invention discloses a drug-loaded contact lens and a preparation method thereof, and the preparation method comprises the following steps: dissolving a drug in a mixed solution of a surfactant, a cosurfactant and deionized water to prepare a drug microemulsion; the preparation method comprises the following steps: uniformly mixing a silicon monomer, a hydrophilic monomer, a cross-linking agent and an initiator by ultrasonic waves, and carrying out compression molding, photopolymerization or thermal polymerization and demolding to obtain the contact lens, and soaking the contact lens in the drug microemulsion to obtain the drug-loaded contact lens. The maximum drug loading capacity of the contact lens is 215.17 to 217.47 [mu] g / lens. The drug microemulsion prepared by the method is uniform in particle size and stable in morphology. The contact lens can efficiently load the medicine, the bioavailability of the medicine is improved, the basic performance of the medicine-loaded contact lens is stable, and the wearing comfort is improved; the prepared drug microemulsion not only has uniform particle size and stable morphology, but also can effectively reduce the surface contact angle of contact lenses.

This application relates to the field of power distribution equipment technology and provides a high-voltage distribution box and electrical equipment. The high-voltage distribution box of this application includes a housing, and a power distribution circuit and a BMS component disposed within the housing for connection to external modules. The power distribution circuit includes a common node, an output circuit, a charging circuit, and a power supply circuit. At least one of the power supply circuit, output circuit, and charging circuit has multiple branches connected in parallel between the common node and the corresponding external module, and the BMS component is connected to the multiple branches via sampling harnesses. The high-voltage distribution box of this application, through the arrangement of multiple parallel branches in the power distribution circuit, ensures that when one branch fails, the other branches can still operate normally, maintaining the normal operation of the power distribution circuit for a short period. Simultaneously, the BMS component can monitor the operating status of each branch to facilitate subsequent maintenance work, thereby improving the reliability of the power distribution circuit.

The application discloses an oxygen-enhanced pH-responsive magnetic targeting photosensitizer delivery system, which is recorded as Fe3O4@mSiO2@MnO2@PS@PEG-b-PAsp, and the delivery system takes the superparamagnetic Fe3O4 core as a magnetic targeting matrix, is covered with mesoporous silica outside, and is crosslinked with polyethylene glycol-polyaspartic acid after being modified by amino on the surface of the mesoporous silica, so that the loading of the photosensitizer is realized. The oxygen-enhanced pH-responsive magnetic targeting photosensitizer delivery system provided by the application realizes the magnetic targeting property and the pH responsiveness, and realizes the effect of increasing the concentration of intracellular reactive oxygen species.

The utility model relates to a heat-resistant steel carrier for a vacuum industrial furnace, which comprises a bottom plate arranged in a hollowed-out manner, the bottom plate is hollowed to form a plurality of polygonal frames; the polygonal frames are arranged in parallel in the transverse direction and the radial direction of the bottom plate; the baffle is connected with the outer edge of the bottom plate; the baffle is vertically arranged around the circumferential direction of the bottom plate; wherein the bottom plate is also hollowed to form an elliptical frame; the polygonal frames are sequentially connected in the transverse direction of the bottom plate. Elliptical frames are arranged between the adjacent polygonal frames in the longitudinal direction of the bottom plate. Two ends of a short shaft of the elliptical frame are respectively connected with a polygonal frame. According to the hollow structure, the material consumption of the bottom plate is greatly reduced, the weight of the floor is reduced, and the production and transportation cost of the heat-resistant steel carrier of the vacuum industrial furnace is reduced. A polygonal frame and an oval frame are formed in the hollow-out position, by means of deformation of the polygonal frame and the oval frame, rigidity is supported, impact borne by the vacuum industrial furnace heat-resistant steel carrier is dispersed, the weight of the vacuum industrial furnace heat-resistant steel carrier is reduced, and the structural strength of the vacuum industrial furnace heat-resistant steel carrier is guaranteed.

This utility model relates to a prestressed reinforcement structure for concrete beam-column joints, comprising a split steel sleeve consisting of multiple arc-shaped steel plates temporarily fixed to the outside of the frame column by high-strength bolts, with butt joints welded together to form a closed ring structure; a lower connecting steel plate horizontally welded to the bottom of the sleeve; an upper connecting steel plate covering the top of the beam and welded to the sleeve; chemical anchor bolts penetrating the lower connecting steel plate and anchored to the side wall of the prestressed concrete beam; additional longitudinal reinforcement including: steel bars within the beam width fully welded to the steel plate through Φ25mm plug weld holes; longitudinal reinforcement extending to the floor slab outside the beam width and anchored thereto, tied to the stirrups to form a grid; and a grouting layer filling the space between the column and the sleeve. This utility model avoids cutting off the beam, fully preserving the performance of the prestressed tendons; the sleeve and anchor bolts work together to improve the joint's load-bearing capacity and seismic resistance; the modular design adapts to different beam and column sizes, offering strong versatility; construction requires no large equipment, reducing interruptions to building functions.

The invention discloses a high-strength and high-conductivity graphene / copper composite material and a preparation method thereof.According to the high-strength and high-conductivity graphene / copper composite material and the preparation method thereof, a small amount of graphite is added into copper powder, it is guaranteed that graphene is evenly dispersed in a matrix by means of chemical stripping combination and high-pressure bonding, strong interface combination with the matrix is achieved, and a three-dimensional communication graphene structure is formed; loads can be effectively borne under the action of tensile stress, and the overall mechanical property is enhanced; the charge transfer efficiency of a copper matrix is enhanced through a graphene three-dimensional structure, and the high conductivity effect of graphene is fully played, so that the prepared copper-graphene composite material has the advantages of high strength, high conductivity, shorter preparation process flow, higher preparation efficiency, lower industrial mass production cost, energy conservation and consumption reduction, and has multiple technical advantages at the same time.

The application belongs to the field of high-performance flexible sensing fiber, and discloses a UHMWPE-based intelligent rope and a preparation method and application thereof.The method comprises the following steps: controlling the tension of UHMWPE fiber tows in the range of 5N-7N, and uniformly coating a conductive dispersion liquid on the UHMWPE fiber tows at a rate of 1-5 m / min to obtain conductive fibers; uniformly coating an aqueous polyurethane dispersion liquid or a polyvinylidene fluoride solution on the conductive fibers to obtain sensing fibers with a protective layer; and winding the sensing fibers and the UHMWPE fiber tows according to a preset proportion around a core rod at a spiral angle of 45±5° in one of 2-16 spool weaving structures to obtain the UHMWPE-based intelligent rope.The application limits the mass fraction of the conductive dispersion liquid and the protective layer dispersion liquid and the coating rate window, improves the stability of the continuous coating process while taking into account the load capacity, flexibility and preparation efficiency, and is beneficial to large-scale production.The weaving method is used to weave the same into a rope with a proper length, and the rope can be used as an intelligent rope for real-time monitoring of stress, strain and other signals.

The invention discloses a preparation method of an in-situ CuO-loaded Si-based catalyst, which comprises the following steps: firstly, uniformly dissolving a copper-based precursor in a polar solvent, and adding a surfactant and silicon powder to form a uniform precursor dispersion liquid; the preparation method comprises the following steps: preparing Si powder, then sequentially carrying out atomization treatment, microwave treatment and heating drying treatment to effectively promote in-situ loading and highly uniform dispersion of a Cu element on the Si powder so as to obtain the Si-based catalyst, and by using the Si-based catalyst as a catalyst for synthesizing trichlorosilane, the reaction temperature and the dosage of the catalyst can be reduced, and the yield of trichlorosilane can be obviously improved. The preparation process disclosed by the invention is relatively low in energy consumption, relatively short in period and relatively low in preparation cost, and a new thought can be provided for preparation of the high-performance Si-based catalyst.

The invention discloses a full-load passenger car high-position supporting sequence turning device and method, and relates to the technical field of passenger car assembly.The full-load passenger car high-position supporting sequence turning device comprises a middle-section high-position supporting tool and two end high-position supporting tools, each end high-position supporting tool comprises a supporting base, and the supporting base is provided with a first moving assembly and a first limiting assembly; the upper side of the supporting base is connected with the first supporting cross beam through a double-linkage lifting mechanism, and the double-linkage lifting mechanism is used for adjusting the height of the first supporting cross beam so as to support a full-bearing vehicle body end supporting point. The middle-section high-position supporting tool is provided with a plurality of vehicle body supporting points and comprises a supporting frame, and the supporting frame is provided with a second moving assembly and a second limiting assembly; the first moving assembly and the second moving assembly are used for being matched with the mop plate chain track, and the first limiting assembly and the second limiting assembly are used for being matched with the mop plate chain. According to the device, it can be guaranteed that the vehicle body is kept balanced in the moving process, safety accidents caused by unstable supporting are effectively avoided, and the sequence turning efficiency can be improved.

The invention relates to a preparation method and application of a sodium alginate (SA) / PCN-225 / Eu (DBM) 3Bpy composite indicating film, PCN-225 powder is obtained through a hydrothermal method firstly, then the obtained PCN-225 powder is washed in ethyl alcohol and acetone to be activated to obtain PCN-225 fluorescent indicator powder with the pH sensitive characteristic, then the activated PCN-225 fluorescent indicator powder and organic europium Eu (DBM) 3Bpy (DBM: dibenzoylmethane) are subjected to a reaction, and the sodium alginate (SA) / PCN-225 / Eu (DBM) 3Bpy composite indicating film is obtained. The preparation method comprises the following steps: respectively and uniformly dispersing fluorescent powder (Bpy: bipyridine) in a sodium alginate (SA) solution, and finally preparing an SA / PCN-225 / Eu (DBM) 3Bpy composite indicating film by adopting a tape casting method. The SA film substrate has the advantages of no color, no toxicity, excellent transparency, degradability and the like; the ratio fluorescent probe constructed by the PCN-225 fluorescent indicator powder and the organic europium Eu (DBM) 3Bpy fluorescent powder has sensitive pH fluorescent color response; based on the SA / PCN-225 / Eu (DBM) 3Bpy fluorescence indication film, sensitive color development in the deterioration process of low-concentration ammonia water, milk and shrimp meat can be realized, so that real-time detection of the freshness of ammonia gas, milk and shrimp meat is realized, and the fluorescence indication film has important application prospects in the fields of ammonia gas detection and food freshness detection.