2results about How to "Not easy to dissociate" patented technology

This invention belongs to the field of biotechnology and discloses a monoclonal antibody that recognizes a conformational epitope to neutralize porcine acute diarrhea syndrome coronavirus and its applications. Specifically, it discloses an antibody or its antigen-binding fragment. The antibody provided by this invention can neutralize 200 TCID at a concentration of 31.75 μg / mL. 50 The SADS-CoV virus particles were analyzed using the BLI assay, which showed that the antibody had a strong affinity for the S protein and was not easily dissociated after binding, providing important material for the development of SADS-CoV neutralizing antibody antiviral drugs.

This invention relates to a method for deep removal of heavy metals in a wet-process phosphoric acid process, comprising the following steps: (1) using a straight-chain or branched alcohol as a raw material, reacting it with phosphorus pentasulfide to obtain dialkyl dithiophosphate, and then reacting it with metal oxides, hydroxides or salts to synthesize dialkyl dithiophosphate (DDP); (2) reacting the DDP with one or more of the following: phosphoric acid slurry containing heavy metals, dilute phosphoric acid, concentrated phosphoric acid, and residual acid from phosphoric acid purification, to generate a heavy metal complex precipitate. After the reaction is complete, the purified phosphoric acid is separated to achieve the removal of heavy metals. This method has low raw material costs, and the cadmium content after heavy metal removal of phosphoric acid is ≤2ppm with a removal rate ≥96%; the copper content is ≤0.5ppm with a removal rate ≥99.5%; the arsenic content is ≤5ppm with a removal rate ≥70%; phosphorus loss is ≤0.5%; no reducing agent is required, thus avoiding hydrogen generation; it has little impact on the decrease in phosphoric acid concentration; and no H2S is generated. It is suitable for the removal of heavy metals from wet-process phosphoric acid slurry, dilute phosphoric acid, concentrated phosphoric acid, and other systems, and can be directly integrated into existing production lines.