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3199 results about "Microfluidic chip" patented technology

A microfluidic chip is a device that enables tiny amount of liquid to be processed or visualized. The chip is usually transparent and its length or width are from 1cm (0.5″) to 10cm (4″). The chip thickness ranges from about 0.5mm(1/64″) to 5mm (1/4″). Microfluidic chips have internal hair-thin microchannels...

Special micro-fluidic chip for cholera diagnosis with one-dimensional self-assembly magnetic bead chain electrodes

The invention relates to a special micro-fluidic chip for cholera diagnosis with one-dimensional self-assembly magnetic bead chain electrodes, belonging to the field of testing. Rapid diagnosis of fulminating infectious disease cholera with low cost is one of many expectations in the development of medical technology, and the invention provides a micro-fluidic chip for simultaneously detecting and rapidly diagnosing cholera by using multiple characteristic antibodies of cholera. The chip is provided with three micro liquid storage tanks, and the invention is characterized in that capillary passages in parallel configuration contain in the chip, the parallel configuration contains four micro-passages that are mutually in parallel, four magnetic bead chain working electrodes are respectively installed inside the four micro-passages, the surface substances of the four magnetic bead chain working electrodes are respectively four antibody substances that are cholera TP0821 antibody, cholera TP0319 antibody, cholera TP0624 antibody and cholera O139 mycoprotein antibody. The integrated structure and the appearances of specific magnetic bead chain working electrodes facilitate to improve the diagnosis efficiency of cholera diseases.

Micro-fluidic chip and micro-fluidic chip system for single cell analysis and single cell analyzing method

The invention relates to a micro-fluidic chip and a micro-fluidic chip system for single cell analysis and a single cell analyzing method. The micro-fluidic chip for single cell analysis comprises a transparent top cover, a microfluid channel, a substrate with a micropore array and a bottom plate with a cavity body, which are sequentially connected from top to bottom in a sealing manner, wherein the transparent top cover is provided with an inflow hole and an outflow hole which are used for communicating the outside and the microfluid channel, the micropore array of the substrate is arranged below the microfluid channel and is communicated with the microfluid channel, each micropore is internally provided with an electrode, each electrode is provided with a cathode and an anode, each micropore can contain a single cell only, the bottom of each micropore is provided with a channel which is communicated with the cavity body of the bottom plate, and the cross section of the channel is smaller than the size of each single cell. With the adoption of the micro-fluidic chip, the micro-fluidic chip system and the single cell analyzing method, the capturing, identifying and disruption processes of each single cell are integrated on one micro-fluidic chip; as a corresponding operation method is provided, the content of each single cell is rapidly acquired and accurately analyzed.

Microfluidic chip and manufacturing method thereof

InactiveCN102059161AIntelligent control of flow stateRapid reversible transitionLaboratory glasswaresChemical/physical/physico-chemical processesChemical compositionMicrometer
The invention relates to a microfluidic chip and a manufacturing method thereof. The microfluidic chip comprises an upper chip unit and a lower chip unit; the surfaces of the chip units are respectively provided with a liquid storing hole, a liquid channel communicated with the liquid storing holes and a microchannel communicated with the liquid channel; the upper chip unit and the lower chip unit are attached to each other and the microchannel is sealed between the two chip units; the microfluidic chip also comprises a micro valve, wherein the micro-valve main body is one of the following structures: a three-dimensional micrometer and three-dimensional nanometer hierarchical structure of polymers formed on the microchannel in array arrangement, a three-dimensional micrometer structure ofpolymers formed on the microchannel in array arrangement or a three-dimensional nanometer structure of polymers formed on the microchannel in array arrangement; the polymers can generate specific responses to an external field under the action of the external field; and the specific responses are reversibility transformation of one or more of surface chemical compositions of the polymers, the above structures and surface properties, thus realizing controllable operations for the flow state of a microfluid in the microchannel. The micro valve in the microfluidic chip is manufactured in situ and miniaturized on the microfluidic chip, thus realizing switch gradient control for the flow of the microfluid and fast switch reversibility transformation.

Cell sorter micro-fluidic chip based on immunomagnetic separation technology and application thereof in aspect of enrichment of rare cells

The invention discloses a cell sorter micro-fluidic chip based on the immunomagnetic separation technology and application thereof in the aspect of enrichment of rare cells, belonging to the technicalfield of micro-fluidic chips. The micro-fluidic chip, improved on the basis of the existing Y-type micro-fluidic chip, comprises a substrate and a cover-slip, wherein a Y-shaped micro-channel, a sample cell (1) and a buffer cell (2) respectively located at two end points of the upper part of the Y-shaped micro-channel, and an effluent cell (3) located at the end point of the lower part of the Y-shaped micro-channel are arranged on the substrate; and an antigen/antibody immunological reaction chamber (4) located on the micro-channel between the cross point (5) of the Y-shaped micro-channel andthe effluent cell (3) is further arranged on the substrate, wherein the width of the antigen/antibody immunological reaction chamber (4) is 2 to 5 times that of the micro-channel. The chip of the invention can effectively and rapidly fix the magnetic beads, increase the sample size of cells, improve the analysis flux, reduce the dead volume of sample introduction and reduce the retention and cross infection.

Method for preparing super-hydrophobic antireflex micron and nano composite structure surface

The invention belongs to the technical field of preparing the surface of a composite structure, and in particular relates to a method for preparing super-hydrophobic antireflective silicon surface with a micron and nanometer composite structure. The method comprises the following steps: cleaning a silicon chip; preparing a micron-level silicon island and a gridding structure on the surface of the silicon chip; carrying out catalytic etching taking silver or aurum nanoparticles as blockage; obtaining the surface of the micron and nanometer composite structure; and carrying out chemical modification of the surface of the composite structure. A static contact angle between the super-hydrophobic antireflective material surface prepared by the method and water is more than 150 degrees, and a static rolling angle of water is less than 3 degrees. The surface has superior antireflective performance, and in particular, the light reflectivity within the wavelength range between 800 and 1,100 nm is less than 3 percent. With application of the method, the super-hydrophobic antireflective silicon surface of the micron and nanometer composite structure can be produced on scale, can be widely applied to a solar cell, a microfluidic chip, a photoelectric device, and the like, and has good industrial application prospect.

Micro-fluidic chip structure for flow cytometer, and preparation method of micro-fluidic chip

The invention discloses a micro-fluidic chip structure for a flow cytometer, and a preparation method a micro-fluidic chip. The chip comprises a sample liquid inlet 1, a column array structure 6, a conical focusing structure 7, a micro-channel 8, a detection zone 4, a flow expanding channel 9 and a waste liquid outlet end 5, wherein the column array structure 6 can play a role of filtering agglomerate protein impurities and other large biological solids inside sample liquid; and the conical focusing structure 7 has a focusing effect which is similar to that of the traditional sheath liquid system, so that cell granules flow inside the micro-channel 8 one by one; and the micro-channel 8 restricts the cells through the channel, so that the cells pass through the detection zone 4 one by one. By adopting the chip structure disclosed by the invention, the focusing effect without sheath flow liquid can be achieved; and blockage is not generated, so as to reduce use of the sheath flow liquid; and meanwhile, the situation that the cell granules pass through the detection zone one by one is ensured. The processing method of the micro-fluidic chip is convenient; the used bonding method is a common bonding method, and is simple and convenient to operate; and the used material PDMS (polydimethylsiloxane) is easy to process and has good biocompatibility.

Full-automatic nucleic acid extraction and PCR amplification micro-fluidic chip and application method thereof

The invention provides a full-automatic nucleic acid extraction and PCR amplification micro-fluidic chip which comprises at least one main body, wherein the main body is distributed in equal distance around the chip; the main body comprises a nucleic acid extraction unit, a PCR amplification unit, a waste liquid unit and an exhaust unit, wherein the nucleic acid extraction unit is positioned on the main body and is used for extracting, washing and eluting nucleic acid in sequence under the driving of centrifugal force and capillary force; the PCR amplification unit is adopted for PCR reaction amplification; the waste liquid unit comprises a waste liquid cavity which is used for storing a waste liquid; the exhaust unit comprises exhaust holes and a plurality of exhaust channels; and the plurality of exhaust channels are communicated with the nucleic acid extraction unit, the PCR amplification unit and the waste liquid unit and are used for exhausting air. The invention discloses a micro-fluidic chip for achieving full-automatic nucleic acid extraction and PCR reaction through centrifugal force, capillary force and siphon phenomenon, the micro-fluidic chip has no integrated equipment such as pumps or valves, so that the manufacturing difficulty and cost of the chip are greatly reduced, and moreover the reliability of the chip is improved.

Integrated chip system for high-throughput sorting and counting detection of biological particles, and application

The invention discloses an integrated chip system for high-throughput sorting and counting detection of biological particles, and an application. The chip system comprises a main microfluidic chip, a micropipe, a sample liquid micropump, an exchange liquid micropump, a first waste liquid collecting device, a second waste liquid collecting device, a third waste liquid collecting device, laser emitters, photoelectric conversion devices, optical fibers and a computer, wherein the main microfluidic chip comprises an asymmetric curved flow path, a first branch channel, a second branch channel, a third branch channel, a main flow path, a branch flow path, aligning marks, etc. The system utilizes the asymmetric curved flow path to realize pre-focusing and sorting for the particles, utilizes a liquid changing flow channel to realize change of a carrier liquid of to-be-tested particles and particle cleaning, and utilizes a viscoelastic effect and an inertial effect of a viscoelastic fluid to realize focus of single equilibrium position of section centers of the particles. The system does not need a sheath liquid, complex pre-cleaning of the particles, and optical alignment, has advantages of high speed, high precision, integration, miniaturization, automation, low cost, simple production process, easy batch production, etc.

Method for preparing mono-disperse microemulsion, liposome and microsphere based on microfluidic technology

The invention discloses a method for preparing mono-disperse microemulsion, liposome and microspheres based on a microfluidic technology. The method comprises the following steps: taking aqueous solution (or oily solution) of a hydrophilic medicine (or a lipid-soluble medicine) as a disperse phase; taking an oil phase (or an aqueous phase) as a continuous phase; and respectively conveying the disperse phase and the continuous phase into corresponding micro-channels of a microfluidic chip device, shearing the phases into mono-disperse liquid drops of the encapsulated medicine, then curing the liquid drops by a certain curing method, and finally obtaining the medicine-carrying liposome, microspheres or the biodegradable microspheres with uniform size and dispersion stability. Under an optimum condition, the diameter distribution coefficients of the microemulsion and the microspheres can be less than 5%, and the diameter is 10-500microns. By utilizing the method, the problems such as uneven size, low embedding rate, poor dispersibility, poor targeting property, low bioavailability, low bioactivity of enzyme and cells, immune suppression and the like of the medicine-carrying microemulsion, the liposome and the microspheres prepared by the traditional ultrasonic method, agitation emulsification method and film hydration-dispersion method are solved.
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