707 results about "Capillary channel" patented technology

The present disclosure relates to a microfluidic vaporizer, an aerosol delivery device that may include such vaporizer, and methods for forming an aerosol. A microfluidic vaporizer can comprise a substrate that defines: a reservoir configured to hold a liquid; a heater adapted to vaporize the liquid; and a capillary channel configured for movement of the liquid from the reservoir to the heater. An aerosol delivery device can comprise a shell and a microfluidic vaporizer. The microfluidic vaporizer and aerosol delivery device can be used for forming aerosols with precise and reproducible compositions.

The invention concerns an analytical test element for the determination of an analyte in a liquid containing an inert carrier, a detection element and a channel capable of capillary liquid transport which has a sample application opening at one end and a vent opening at the other end of the channel capable of capillary liquid transport, wherein the channel capable of capillary liquid transport is formed at least partially by the carrier and the detection element and extends in the direction of capillary transport from the sample application opening at least to the edge of the detection test element that is nearest to the vent opening and wherein a notch is located in one of the surfaces forming the channel capable of capillary liquid transport at the edge of the test element forming the sample application opening so that one side of the edge of the test element forming the sample application opening is at least partially discontinuous and the surface opposite to the notch is exposed. It also concerns the use of the said analytical test element for the determination of an analyte in a liquid as well as a method for the determination of an analyte in a liquid sample with the aid of the said analytical test element.

A test sensor having a pair of electrodes and a reagent for electrochemically measuring the concentration of the analyte in a liquid sample. The test sensor comprises a capillary channel for collecting the liquid sample and a conductor disposed outside the capillary channel. The conductor is in fluid communication with the capillary channel. The liquid test sample is collected and moved through the capillary channel. The liquid test sample contacts the conductor when the capillary channel is substantially full to signal a full condition.

A test strip for use of the determination of an analyte in a fluid sample according to one embodiment of the present invention is disclosed. The test strip comprises a base having a top and a bottom, a collection chamber that extends between the top and the bottom of the base, a containing ring that is disposed on the bottom of the base and surrounds the collection chamber, and a capillary channel formed in top of the base that has an inlet fluidly coupled to the collection chamber, a test element disposed within the capillary channel. A lid is attached to the top of the base and covers the collection chamber, the test membrane, and at least a portion of the capillary channel.

The invention relates to a multichannel micro-fluidic chip specially used for AIDS diagnosis and comprising quasi-one-dimensional sensitive electrodes, belonging to the field of test. One of the hopes in the progress of medical techniques is to quickly diagnose AIDS at low cost. The invention provides a micro-fluidic chip that uses a plurality of AIDS characteristic antibodies to simultaneously detect and quickly diagnose AIDS. The chip is provided with three micro liquid storage tanks. The key points of the proposal lie in that the inner of the chip contains capillary channels of parallel structure, the parallel structure contains four micro-channels mutually connected in parallel, four working electrodes of bead string structure in total are respectively arranged in the four micro-channels, the substances on the superficial coats of the four working electrodes of bead string structure are respectively four antibody substances, namely, AIDS antibodies p24, gp41, gp120 and gp36. The application of the chip is conducive to increasing the diagnosis efficiency of AIDS as shown by the structural characteristics.

The invention relates to a special micro-fluidic chip for cholera diagnosis with one-dimensional self-assembly magnetic bead chain electrodes, belonging to the field of testing. Rapid diagnosis of fulminating infectious disease cholera with low cost is one of many expectations in the development of medical technology, and the invention provides a micro-fluidic chip for simultaneously detecting and rapidly diagnosing cholera by using multiple characteristic antibodies of cholera. The chip is provided with three micro liquid storage tanks, and the invention is characterized in that capillary passages in parallel configuration contain in the chip, the parallel configuration contains four micro-passages that are mutually in parallel, four magnetic bead chain working electrodes are respectively installed inside the four micro-passages, the surface substances of the four magnetic bead chain working electrodes are respectively four antibody substances that are cholera TP0821 antibody, cholera TP0319 antibody, cholera TP0624 antibody and cholera O139 mycoprotein antibody. The integrated structure and the appearances of specific magnetic bead chain working electrodes facilitate to improve the diagnosis efficiency of cholera diseases.

A capillary biosensor analysis system is provided for analyzing a liquid sample, comprising a plurality of longitudinally arranged and consecutively provided and aligned capillary biosensors having a capillary channel enclosed by at least two wall parts and containing one or more reagents, and an evaluation instrument which has a holder to position a forward-most capillary biosensor in a measurement position for performing an analysis. The plurality of capillary biosensors are implemented as a multiple capillary-biosensor strip. A multiple capillary-biosensor strip is guided and held in the holder in such a manner that one capillary biosensor of the strip at a time is located in the measurement position. The multiple capillary-biosensor strip is movable in the evaluation instrument in such a manner that consecutive capillary biosensors of the multiple capillary-biosensor strip are transported one after the other into the measurement position.

A container assembly is disclosed including an outer container, a hollow inner member, and a closure. The outer container has a closed bottom, an open top, and a sidewall extending therebetween. The hollow inner member is disposed within the outer container and has an inner surface defining at least one capillary channel. The inner member includes a first end adjacent to the open top of the outer container and has an outer periphery seated against the sidewall of the outer container. The closure has a proximal end and a distal end. The closure proximal end is seated at least partially within the first end of the inner member to seal the outer container and inner member and define a fluid collection chamber. The closure distal end defines a recessed area shaped to direct fluid under capillary action to the at least one capillary channel in the inner member.

The invention relates to a multi-channel chip for cholera diagnosis based on a structural conductive macromolecular material technology, belonging to the test field. The invention aims to aid rapid and low-cost fulminating infectious disease cholera diagnosis which is one of medical technical progress expectations. The chip is provided with three micro liquid storage tanks and is characterized bycomprising capillary channels in parallel construction containing four micro channels mutually connected in parallel; four fibrous working electrodes are respectively mounted in the four micro channels; and four antibody substances, i.e. a cholera TP0821 antibody, a cholera TP0319 antibody, a cholera TP 0624 antibody and a cholera TP0139 antibody are respectively arranged on the surfaces of the four fibrous working electrodes which are originally made of a thermal-decomposition conductive macromolecular material. The chip has low cost and multiple channels.

A scanning probe microscope probe is disclosed. The scanning probe microscope probe includes a handle and a cantilever shank connected with the handle. The cantilever shank has at one end a base connected with the handle and at an opposing end a tip. The cantilever shank forms a capillary channel between the base to the tip of the cantilever shank.

The present invention relates to a method for the displacement of an analyte fluid within a capillary microchannel and to a microfluidic system. In particular, it relates to the field of microfluidics, and especially to microfluidic systems. The method comprises steps which consist in introducing at least one ferrofluid train (3) into the said capillary channel (1), the said ferrofluid train (3) comprising a slug of ferrofluid (5) and, placed against at least one of the two ends of the slug of ferrofluid and in contact with it, a slug of liquid (7) immiscible with both the ferrofluid and the analyte fluid; in introducing the said analyte fluid (9) into the said capillary channel, in proximity to the ferrofluid train and on the side having the slug of liquid (7) immiscible with both the ferrofluid and the analyte fluid; and in controlling the analyte fluid displacement within the said capillary channel by the action of a magnetic field on the ferrofluid train, which field is generated by a magnet system placed on the outside of the said capillary channel.

A test strip to assist in determining the concentration of an analyte in a fluid sample comprises a base, at least one tab and a break line. The base includes a capillary channel and a test element. The capillary channel is in fluid communication with the test element. The test element is adapted to receive the fluid sample. The at least one tab is removably attached to the base. The capillary channel extends from the base into a portion of the tab. The break line intersects the capillary channel in which an inlet to the capillary channel is exposed along the break line when the tab is separated from the base.

An improved spark ignition system for an internal combustion engine that includes a pair of electrodes disposed to extend from opposite sides and into a combustion chamber to form a spark gap between them that is central to the combustion chamber. Each electrode is integral with a conductive fuel delivery tube that contains a capillary passage and fuel outlet ports adjacent the electrode. The heat from combustion conducted into the electrodes and fuel delivery tubes is used to vaporize the fuel within the capillary passages before it exits the outlet ports as an atomized fog into the combustion chamber adjacent the spark gap. The vaporization of the fuel flowing in the capillary passages absorbs energy from the electrodes and thus performs a cooling effect on the electrodes. The spacing of the electrodes from opposite sides of the cylinder also allows a design that can utilize and increased spark gap to produce a larger spark across the gap.

Monolithic cartridges including a plurality of nominally aligned polymer fibers can be used as stationary phase materials for liquid chromatography separations. Bundles of fibers are packed together so as to form capillary channels between the fibers. Different polymer compositions permit the “chemical tuning” of the separation process. The fibers can be physically or chemically bonded at spaced locations throughout the cartridge or can be packed together under pressure by use of an encasing wrap to form the capillary channels. Use of fibers allows a wide range of liquid flow rates with very low backpressures. Applications in HPLC, cap-LC, prep-scale separations, analytical separations, waste remediation / immobilization, extraction of selected organic molecules / ions from solution, purification of liquid streams (process waste, drinking water, pure solvents), selective extraction of cell matter and bacteria from growth media, and immobilization of cell matter and bacteria are envisioned.

A replacement reservoir assembly (30) for an atomizing device (20), which uses a vibratable orifice plate (37) for atomizing liquid, includes a container (31), which contains a liquid to be atomized, and an elongated wick (56) having a lower end which is immersed in the liquid within the container (31) and an upper end located above the container (31). The wick (56) includes a dimensionally stable material having capillary passages for drawing liquid out of the container (31) to the upper end of the wick (56), which is outside the container (31). The upper end of the wick (56) has at least one surface that is configured to provide an unobstructed passage to the atmosphere from a region between a top surface of the wick (56) and a facing surface of the vibratable orifice plate (37) when the replacement reservoir is positioned in the atomizing device (20). A wick (56) for use in a replaceable reservoir assembly (30) that contains liquid to be atomized by a vibratory orifice plate (37) and a method of positioning an upper end of a solid, dimensionally stable wick (56) are also disclosed.

The present invention relates to a device and a method for quantitative detecting of the presence or absence of a target analyte in a liquid sample having a volume of less than 200 μl, the device comprising a reaction chamber in the form of a capillary channel, a first part comprising a sample inlet for the introduction of a sample containing an analyte, and a discharge outlet for the discharge of waste products; a second part comprising means for detection of the target analyte, and a solution inlet for introduction of washing solutions and reaction mixtures; and means for transferring an immobilized analyte from the first part to the second part of the chamber and vice versa, where the first and second parts are separated such that other liquid sample material may not enter the second part of the chamber and such that light may not be transferred from the first part of the chamber to the detector part of the second part of the chamber.

The present invention is directed to a system and method for cross-talk cancellation for multi-lane fluorescence detectors. The invention may be implemented in accordance with a variety of systems, including systems for multi-capillary electrophoresis. The present invention is based on a special calibration procedure for determination of a channel cross-talk matrix and enables an accurate separation of the fluorescence emitted from individual capillary lanes. The proposed method for cross-talk calibration and removal is very useful for design and development of multi-lane single photon counting detection systems.

A simple easy to manufacture analytical device capable of performing membrane based immunoassays on batch of samples within 3 to 10 minutes wherein the method permits focused application of samples, costly labeled immunoassay and signal amplification reagents, said device includes an antibody-immobilized micro porous membrane, breadth corner layer of which is directly attached to a semi-rigid liquid-impervious body with water insoluble adhesive; absorbent body is provided separately and is not attached to analytical device during manufacture, absorbent body is wetted and is placed proximal to the lower surface of the membrane thereby forming networks of capillary channels with the absorbent body; flow of samples or reagents is always kept downwards and focused without application of any force to the absorbent body and the use of disposable adsorbent body permits stepwise addition of signal amplification reagents for ultra sensitive detection of diagnostically important molecules by visual examination of the membrane surface.

This invention provides lateral flow filters with pore size gradients and with features to prevent peripheral flows around the filter. The filters can be laminated composites of two or more planar filter layers. Cartridges employing the filters can include a filtration chamber configured to retain the lateral flow filters including a port for sample application and a capillary channel for filtrate egress. The fluid egress port can be positioned to receive filtrate from one filter layer but not another.

Prosthetic joints, intervertebral prosthetic implants and methods of replacing intervertebral discs are provided. In an exemplary embodiment, a intervertebral prosthetic implant can include a pair of substantially rigid members and an articulation member having an articulation surface and configured to facilitate motion between the first and second members. The first member can be provided with at least one capillary channel configured to transport lubricious fluid proximate the articulation surface of the articulation member.

A process pressure measuring system includes a transmitter having a first sealed system in which a first outlet couples to a pressure sensor, a first isolator diaphragm assembly, a first capillary passage, and a first isolation fluid. The first isolation fluid couples a first pressure from the first isolator diaphragm to the first outlet and the pressure sensor. A second sealed system includes a second pressure outlet that is coupled to the first isolator diaphragm assembly, a second isolator diaphragm assembly, a second capillary passage and a second isolation fluid. The second isolation fluid is adapted for use in a first temperature range and couples a pressure from the second isolator diaphragm assembly to the second pressure outlet. A third sealed system includes a third pressure outlet that is coupled to the second isolator diaphragm assembly, a third isolator diaphragm assembly, a third capillary passage and a third isolation fluid. The third isolator fluid is adapted for use in a second temperature range and couples a process pressure to the third pressure outlet.

A device for studying individual cells including a picowell array (such as an array of microwells, dimples, depressions, tubes or enclosures) and a fluid reservoir in fluid communication with the picowells through channels is disclosed. Preferably, the device has a moveable lid that in one rest location allows loading of cells in the picowell array. Preferably the channels of the device are capillary channels.Also disclosed is a device for the automated study of cells including a picowell-bearing device having a picowell array with a moveable lid, a lid-moving component, at least one solution dispensing component and a control system functionally associated with the lid-moving component as well as with the solution dispensing component.

A microfluidic network having at least one channel which is open on the top side and in which one end of at least one hollow fiber is inserted and a process for making it. For this it is provided that the outside dimensions of the hollow fiber are matched to the inside dimensions of the channel, capillary channels being formed between the hollow fiber and the walls of the channel. The network is covered with a cover film or plate which closes the channel and preferably fixes the hollow fiber temporarily in the channel, and the capillary channels are filled with a fluidically sealing cement. In the area of the inserted end of the hollow fiber, a capillary stop structure is formed so that the cement as it is added it cannot seal the inserted open end of the hollow fiber.

Micro neutron detectors include relatively small pockets of gas including a neutron reactive material. During use, under a voltage bias in a neutron environment, neutron interactions in the neutron reactive material are seen to occur. Ultimately, electron-ion pairs form and positive ions drift to a cathode and electrons to the anode. The motion of charges then produces an induced current that is sensed and measurable, thereby indicating the presence of neutrons. Preferred pocket volumes range from a few cubic microns to about 1200 mm3; neutron reactive materials include fissionable, fertile or fissile material (or combinations), such as 235U, 238U, 233U, 232Th, 239Pu, 10B, 6Li and 6LiF; gasses include one or more of argon, P-10, 3He, BF3, BF3, CO2, Xe, C4H10, CH4, C2H6, CF4, C3H8, dimethyl ether, C3H6 and C3H8. Arrangements include two- and three-piece sections, arrays (including or not triads capable of performing multiple detecting functions) and / or capillary channels.

Solid phase extraction devices including a plurality of packed nominally aligned capillary-channeled polymeric fibers for use as stationary phase materials are disclosed. A plurality of fibers are packed together in a casing so as to provide good flow characteristics through the fibers and high surface area contact between a sample and the fibers. Different polymer compositions of the fibers permit the “chemical tuning” of the extraction process. The fibers can be physically or chemically derivatized to target specific analytes for separation from a test sample. Use of the fibers allows a wide range of liquid flow rates with very low backpressures. The fibers are easily packed into a micropipette tip or a conduit for use with a fluid flow device such as an aspirator or a pump. The devices can be used for isolation and pre-concentration of analytes from samples, for instance for proteins from buffer solutions or extraction of pollutants from remote locations.