309results about "Raman/scattering spectroscopy" patented technology

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω. The system further includes a photonic integrated circuit (PIC) that includes multiple optical waveguides configured to: direct the pump and Stokes beams of light to a sample; receive a Raman signal produced by coherent Raman scattering of the pump and Stokes beams of light at the sample; and direct the Raman signal to an optical receiver. The optical receiver is configured to detect the Raman signal. The optical receiver includes a probe light source configured to produce a probe beam of light at a probe frequency, an optical detector, and an electronic circuit.

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency, and a Stokes light source configured to produce: (i) a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω and (ii) a Stokes reference beam of light. The system also includes one or more optical elements configured to: direct the pump and Stokes beams of light to a sample, and collect (i) a Raman signal produced by the sample in response to the pump and Stokes beams of light and (ii) residual light from the Stokes beam of light after the Stokes beam of light has interacted with the sample. The system further includes an optical receiver configured to detect the Raman signal, where the optical receiver includes a probe light source.

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω. The system also includes one or more optical elements configured to: direct the pump and Stokes beams of light to a sample, and collect a Raman signal produced by coherent Raman scattering of the pump and Stokes beams of light at the sample. The system further includes an optical receiver configured to detect the Raman signal. The optical receiver includes a probe light source configured to produce a probe beam of light at a probe frequency, where the probe light source includes a wavelength-tunable laser.

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency. The pump and Stokes frequencies are offset by a frequency offset Ω, and the pump and Stokes beams are directed to an object. The system further includes one or more optical elements configured to collect a Raman signal produced by coherent Raman scattering of the pump and Stokes beams of light at the object. The system also includes an optical receiver configured to detect the Raman signal. The optical receiver includes a probe light source configured to produce a probe beam of light at a probe frequency and an optical detector configured to coherently mix the Raman signal with the probe beam of light to produce a corresponding photocurrent signal.

In one embodiment, a system includes a first light source configured to produce a first beam of light at a first frequency and a second light source configured to produce a second beam of light at a second frequency, where the first and second frequencies are offset by a frequency offset Ω. The system also includes one or more optical elements configured to: direct the first and second beams of light to a sample, and collect a Raman signal produced by coherent Raman scattering of the first and second beams of light within the sample. The system further includes an optical receiver configured to detect the Raman signal. The optical receiver includes a third light source configured to produce a third beam of light at a third frequency, and an optical detector configured to coherently mix a portion of the Raman signal with the third beam of light.

In one embodiment, a Raman spectroscopy system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω. The system further includes one or more optical fibers configured to (i) direct the pump and Stokes beams to a sample located external to the system and (ii) direct a Raman signal to the system, where the Raman signal is produced by coherent Raman scattering of the pump and Stokes beams of light at the sample. The system also includes an optical receiver configured to detect the Raman signal. The optical receiver includes a probe light source and an optical detector configured to coherently mix the Raman signal with a probe beam of light.

In one embodiment, a system includes a first light source configured to produce a first beam of light at a first frequency and a second light source configured to produce a second beam of light at a second frequency, where the first and second frequencies are offset by a frequency offset Ω. The system also includes one or more optical elements configured to: direct the first and second beams of light to a sample, and collect a Raman signal produced by the sample in response to the first and second beams of light. The system further includes an optical receiver configured to detect the Raman signal. The optical receiver includes a third light source configured to produce a third beam of light at a third frequency, and one or more optical detectors configured to coherently mix a portion of the Raman with a portion of the third beam of light.

A sensor module for Raman spectroscopy includes a sensor package which encloses an application specific integrated circuit (ASIC), a light emitter arrangement, a light detector arrangement and a filter arrangement. The light emitter arrangement is electrically connected to the ASIC and operable to emit light with multiple excitation wavelengths to excite Raman scattering in an external probe to be placed outside of the sensor module. The light detector arrangement is operable to generate sensor signals from incident light emitted back from the external probe due to the Raman scattering. The filter arrangement is operable to filter the incident light according to a target passband. The ASIC is operable to drive the light emitter arrangement at the excitation wavelengths to shift a Raman spectral band of the external probe into the passband of the filter arrangement.

A composite optical filter may include a substrate, a communal optical filter, one or more first optical filters, and one or more second optical filters. The communal optical filter may be formed on a first surface of the substrate. The one or more first optical filters may be formed on one or more first portions of a second surface of the substrate and may be configured to pass light associated with a first wavelength. The one or more second optical filters may be formed on one or more second portions of the second surface of the substrate and may be configured to pass light associated with a second wavelength.

A cap having a closed end and one or more openings is attached to the tip of an optical Raman probe sensor. The cap serves to block stray light noise from entering the tip of the sensor. In this way, Raman spectra may be more accurate and consistent. Further, the cap may be permanently affixed or removably attached to the sensor. In some embodiments, a reflective surface may be included on the interior surface of the closed end of the cap. This reflective surface may reflect Raman scattering light toward the tip, enhancing the received signal by a factor of 2 to 100.

The present invention relates to a method and an apparatus for measuring surface-enhanced Raman scattering. The present invention provides an apparatus for measuring surface-enhanced Raman scattering, comprising: a Raman scattering measurement unit capable of detecting an optical signal resulting from incident light in a plurality of polarization states applied to a sample including nanoparticles enabling surface-enhanced Raman scattering measurement; a spectrometer for generating a spectral signal by spectroscopically analyzing the optical signal detected by a detector of the Raman scattering measurement unit; and a correction value calculation unit for calculating a correction value for the spectral signal, on the basis of the spectral signal resulting from irradiation with light in the plurality of polarization states.

A method and a system have been developed to calibrate the total spectral radiance factor (TSRF) obtained from different instruments. A broad-band light source covering the whole visible range as well as the fluorescence excitation wavelengths is used to measure the TSRF, and one or more narrow-band light sources outside of the fluorescent band is used to measure fluorescent spectral radiance factor (FSRF) separately. After that, the TSRF is adjusted by the FSRF, and a calibrated TSRF can be obtained. This can be applied to characterize Optical Brightening Agents (OBAs) as well as other fluorescent materials without requiring any moving part of the instrument to do the calibration.

A light source includes a mode-locked laser; a beam splitter that branches the femtosecond optical pulse train; a CW solid-state laser; a first beam combiner that outputs one side of the femtosecond optical pulse train on the same axis; a secondary nonlinear optical element that outputs a difference frequency generation and conversion optical pulse train from either a continuous wave or a femtosecond optical pulse train; an amplifier that amplifies the difference frequency generation and conversion optical pulse train; a polarization-maintaining all normal dispersion high nonlinear fiber that converts the other femtosecond optical pulse train into a supercontinuum optical pulse train; a first dispersion medium that converts the supercontinuum optical pulse train into a pulse width that is approximately the same as the difference frequency generation and conversion optical pulse train; and a second beam combiner that multiplexes and outputs the difference frequency generation and conversion optical pulse train and the supercontinuum optical pulse train.

A super-resolution microscopic imaging method and apparatus based on common-path parallel fluorescence emission difference microscopy. In the method, a liquid crystal spatial light modulator is used to modulate excitation light in fluorescence emission difference microscopy super-resolution microscopic imaging, and two parts of the spatial light modulator are respectively loaded into 0-2π vortex phase modulation and blazed grating, so that the common-path excitation light forms solid spot and doughnut-shaped spot with a certain distance on a sample surface at the same time, and parallel scanning is carried out, thereby ensuring that the imaging speed is doubled compared with that of ordinary fluorescence emission difference super-resolution microscopic imaging, and at the same time, the two excitation lights are not easily affected by noise, drift and other interferences due to the common path.

The disclosure regards a computer implemented method for estimating the reactivity of dissolved organic matter in a liquid comprising the steps of obtaining a first fluorescence measurement from the liquid, wherein the first fluorescence measurement comprises a first emission wavelength and a first excitation wavelength, obtaining a second fluorescence measurement from the liquid, wherein the second fluorescence measurement comprises a second emission wavelength and a second excitation wavelength, determining a sample photosensitivity index based on the first fluorescence measurement, the second fluorescence measurement and a conversion factor specific to said liquid, and estimating the reactivity of dissolved organic matter in the liquid based on the sample photosensitivity index, wherein the conversion factor is a correlation between a series of base photosensitivity indexes and a series of fluorescence measurement ratios, obtained from a liquid of a same type as the liquid. The present disclosure further relates to a computer implemented method for calibrating a fluorescence setup in relation to a liquid, and to an optical measurement system for estimating the reactivity of dissolved organic matter in a liquid.

The application provides an optical system and a monitoring method for monitoring stimulated Brillouin scattering effect. The optical system for monitoring stimulated Brillouin scattering effect firstly delivers a narrow linewidth seed source into a laser amplifier through a first optical device to amplify the narrow linewidth laser, and guides stimulated Brillouin scattering light generated by the laser amplifier to a back light monitoring module to detect the back light power and spectral components of the stimulated Brillouin scattering light in real time through the back light monitoring module, so as to realize the purpose of simultaneously and accurately measuring the stimulated Brillouin scattering light power and observing the laser components, and is more conducive to judging whether the stimulated Brillouin scattering effect occurs. Further, the optical system can adjust the light splitting ratio of the first optical device and the back light monitoring module to protect the narrow linewidth seed source and the spectrometer in the back light monitoring module from the damage of the back light to the greatest extent, and achieve the purpose of accurately judging the stimulated Brillouin scattering effect and protecting the system safety.

A portable device which detects a Raman signal from an analyte of interest contained in or suspected to contain in a sample. The portable device includes a laser source in optical communication with a dichroic mirror, an objective lens optically positioned to consolidate the laser from the laser source to the sample, (i) a pair of rotatable filters in optical communication with the dichroic mirror and an optical transmission module or (ii) a first band-pass filter in optical communication with the dichroic mirror and an optical transmission module, and a detector optically positioned to receive and detect a Raman signal produced from the laser incident on the analyte of interest. The dichroic mirror directs the laser from the laser source to the sample through the objective lens and transmits any Raman signal from the sample toward the detector. The detector is absent of a spectrometer and detects the Raman signal.

A light source according to the present disclosure comprises: a mode-locked laser; a beam splitter that splits a femtosecond optical pulse train having a center wavelength λs outputted from the mode-locked laser; a CW solid-state laser; a first combiner that coaxially outputs one femtosecond optical pulse train; a second-order nonlinear optical element that outputs a difference frequency generation / conversion optical pulse train having a center wavelength λc from continuous light and the one femtosecond optical pulse train; an amplifier that amplifies the difference frequency generation / conversion optical pulse train; a polarization-maintaining, all-normal-dispersion, highly nonlinear fiber that converts the other femtosecond optical pulse train into a supercontinuum optical pulse train; a first dispersion medium that converts the supercontinuum optical pulse train into substantially the same pulse width as that of the difference frequency generation / conversion optical pulse train; and a second combiner that combines and outputs the difference frequency generation / conversion optical pulse train and the supercontinuum optical pulse train. λs and λc are set so that a CARS measurement can be performed using the difference frequency generation / conversion optical pulse train and the supercontinuum optical pulse train.

The invention relates to a spectrum chip. The spectrum chip comprises a substrate, a medium optical waveguide, a photoluminescence structure and a photoelectric detector, wherein the dielectric optical waveguide is positioned on one side of the substrate; the photoluminescence structure is located on one side of the medium optical waveguide, and the photoluminescence structure and the medium optical waveguide are located on the same side of the substrate; the photoelectric detector, the medium optical waveguide and the photoluminescence structure are located on the same side of the substrate, and the photoelectric detector and the photoluminescence structure are located on different sides of the medium optical waveguide. Therefore, integration, small size, portability and multi-functionalization of the spectrum chip can be realized.

[Problem to be solved] An object of the present invention is to provide a microscopic Raman spectroscopy device that can achieve downsizing and cost reduction by simplifying a structure of a spectrometer and can always analyze samples with high accuracy. [Solution] A microscopic Raman spectroscopy device 1 includes laser oscillators (excitation light sources) 2 and 3 that emit excitation laser lights (excitation lights) L1 and L2 of different wavelengths, a spectrometer 10 that uses a diffraction grating 12 or 13 to disperse Raman scattering light R1 or R2 emitted from a sample S by irradiation with the excitation laser light L1 or L2 from the laser oscillator 2 or 3, and a CCD detector 20 that detects and photoelectrically converts the Raman scattering light R1 or R2 dispersed by the spectrometer 10. The spectrometer 10 includes incident apertures 11a and 11b, a plurality of (two) optical systems I and II that guide the Raman scattering light R1 or R2 incident from the incident aperture 11a or 11b to the diffraction grating 12 or 13, and a plurality of light beams dispersed by the diffraction grating 12 or 13 are incident on one imaging lens 14 in tandem.

The present disclosure provides apparatuses, systems, and methods for performing particle analysis through flow cytometry at comparatively high event rates and for gathering high resolution images of particles.

A time measurement apparatus 10 includes a TAC circuit 12, a measurement gate 11, a control unit 14 for setting a gate dead time, which is a time during which the measurement gate 11 is set to be in the second state, in the measurement gate 11, and the control unit 14 for deriving and outputting time information related to the detection signal based on a measurement signal output from the TAC circuit 12, and the control unit 14 functioning as a setting unit sets a time, which is an integral multiple of a repetition period of fluorescence detected by the detector 4 and is longer than a dead time of the TAC circuit 12 itself, in the measurement gate 11 as a gate dead time.

Dissolving activity analyzer including an integrating cavity comprising a reflective inner wall or walls, and configured to receive a cuvette containing liquid sample. The integrating cavity comprises a light inlet port and a light outlet port, the light inlet port being configured to receive light from a light source and the light outlet port being configured to deliver light to a spectrometer. The dissolving activity analyzer is configured to operate in a diffusely reflecting mode in which light from the light source follows a light path from the inlet port into the integrating cavity, is incident onto the reflective inner wall or walls and is diffusely reflected, such that the light from the light source irradiates the liquid sample before being transmitted through the light outlet port and received by the spectrometer to provide an absorbance spectrum of the liquid or liquid matrix contained in the liquid sample.

High-throughput hyperspectral imaging systems are provided. According to an aspect of the invention, a system includes an excitation light source; an objective that is configured to image excitation light onto the sample, such that the excitation light causes the sample to emit fluorescence light; a channel separator that is configured to separate the fluorescence light into a plurality of spatially dispersed spectral channels; and a sensor. The excitation light source includes a light source and a plurality of lenslet arrays. Each of the lenslet arrays is configured to receive light from the light source and to generate a pattern of light, and the patterns of light generated by the lenslet arrays are combined to form the excitation light. The objective is configured to simultaneously image each of the patterns of light to form a plurality of parallel lines or an array of circular spots at different depths of the sample.

The present disclosure relates to a novel liquid crystal assembly for use in multispectral imaging systems. In particular, the liquid crystal assembly includes an engineered polarizer and a liquid crystal. In various aspects, the liquid crystal assembly takes advantages of short-comings found in conventional polarizers and liquid crystals requiring complex temperature regulation.

There is set forth herein a light energy exciter that can include one or more light sources. A light energy exciter can emit excitation light directed toward a detector surface that can support biological or chemical samples.

A Fourier transform spectrometer including an interferometer is provided. In one embodiment, an FT spectrometer includes an excitation light source, a beam splitter adapted to separate a metrology signal from the excitation light source and direct the metrology signal through an interferometer to a metrology detector. The FT spectrometer is additionally adapted to receive a spectral signal from the sample and pass the spectral signal through the interferometer to the spectrometer detector. The invention provides a method for correcting the movement of an interferometer reflector. In addition, a total spectroscopic method is provided that includes a spectral signal that includes Raman scattering, fluorescence, and near-infrared absorption components.

The present application relates to a kind of based on micro-nano fiber and scattering medium substrate coding element and speckle spectrometer.The coding element includes sealed cavity, micro-nano fiber and scattering medium substrate;Including drawstring transition zone and waist zone in the body of micro-nano fiber, drawstring transition zone forms leaky mode, waist zone generates evanescent field, the body of micro-nano fiber penetrates sealed cavity, so that drawstring transition zone and waist zone are located in sealed cavity;Scattering medium substrate is fixed in sealed cavity, and the waist zone of micro-nano fiber is overlapped on scattering medium substrate, scattering medium substrate is used to receive evanescent field and is coupled leaky mode to obtain scattering pattern information;Wherein, in the direction parallel to waist zone, scattering medium substrate includes more than two scattering zones, and the light transmittance of each scattering zone is different, and the difference between maximum light transmittance and minimum light transmittance is 20%~80%.Speckle spectrometer using the coding element of the present application has the advantages of small size, low cost while high spectral resolution.

Provided is a portable biosensor that includes a sample filter cartridge, a filter collector, an optical sphere, an electromagnetic radiation emitter, a photo-detector, a processor, a signal display, a vacuum pump, and a power supply. The sample filter cartridge selectively removes small molecules to minimize spectral interference in the detection signal. The sample is concentrated onto the filter collector and subjected to illumination by the electromagnetic radiation emitter, producing Raman-scattering. The optical sphere collects and distributes the Raman-scattering shifts, which then pass through a spectral filter to produce spectral filtered scattering, which is then reflected by the concave holographic flat-field grating onto the photo-detector. The data is displayed graphically to provide the Raman-scattering shift data. The data is compared with a database for sample identification. The device is contained within a housing that is small enough to be easily transported for field use.

A fluorimeter reference cell which comprises a first material which emits an absorption spectrum when an excitation light is incident upon the first material. The absorption spectrum has a defined cha