441results about "Raman/scattering spectroscopy" patented technology

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω. The system further includes a photonic integrated circuit (PIC) that includes multiple optical waveguides configured to: direct the pump and Stokes beams of light to a sample; receive a Raman signal produced by coherent Raman scattering of the pump and Stokes beams of light at the sample; and direct the Raman signal to an optical receiver. The optical receiver is configured to detect the Raman signal. The optical receiver includes a probe light source configured to produce a probe beam of light at a probe frequency, an optical detector, and an electronic circuit.

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency, and a Stokes light source configured to produce: (i) a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω and (ii) a Stokes reference beam of light. The system also includes one or more optical elements configured to: direct the pump and Stokes beams of light to a sample, and collect (i) a Raman signal produced by the sample in response to the pump and Stokes beams of light and (ii) residual light from the Stokes beam of light after the Stokes beam of light has interacted with the sample. The system further includes an optical receiver configured to detect the Raman signal, where the optical receiver includes a probe light source.

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω. The system also includes one or more optical elements configured to: direct the pump and Stokes beams of light to a sample, and collect a Raman signal produced by coherent Raman scattering of the pump and Stokes beams of light at the sample. The system further includes an optical receiver configured to detect the Raman signal. The optical receiver includes a probe light source configured to produce a probe beam of light at a probe frequency, where the probe light source includes a wavelength-tunable laser.

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency. The pump and Stokes frequencies are offset by a frequency offset Ω, and the pump and Stokes beams are directed to an object. The system further includes one or more optical elements configured to collect a Raman signal produced by coherent Raman scattering of the pump and Stokes beams of light at the object. The system also includes an optical receiver configured to detect the Raman signal. The optical receiver includes a probe light source configured to produce a probe beam of light at a probe frequency and an optical detector configured to coherently mix the Raman signal with the probe beam of light to produce a corresponding photocurrent signal.

In one embodiment, a system includes a first light source configured to produce a first beam of light at a first frequency and a second light source configured to produce a second beam of light at a second frequency, where the first and second frequencies are offset by a frequency offset Ω. The system also includes one or more optical elements configured to: direct the first and second beams of light to a sample, and collect a Raman signal produced by coherent Raman scattering of the first and second beams of light within the sample. The system further includes an optical receiver configured to detect the Raman signal. The optical receiver includes a third light source configured to produce a third beam of light at a third frequency, and an optical detector configured to coherently mix a portion of the Raman signal with the third beam of light.

In one embodiment, a Raman spectroscopy system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω. The system further includes one or more optical fibers configured to (i) direct the pump and Stokes beams to a sample located external to the system and (ii) direct a Raman signal to the system, where the Raman signal is produced by coherent Raman scattering of the pump and Stokes beams of light at the sample. The system also includes an optical receiver configured to detect the Raman signal. The optical receiver includes a probe light source and an optical detector configured to coherently mix the Raman signal with a probe beam of light.

Disclosed is a linear array scanning Brillouin scattering elastic imaging device. In the device, a signal generating system consists of a narrow linewidth continuous wave laser, a half-wave plate, a beam expander, a Y-direction scanning galvanometer, a microlens array, a pinhole array filter, a first plano-convex lens, a polarization beam splitter, a quarter-wave plate and a microscope objective. A signal receiving system consists of a microscope objective, a quarter-wave plate, a polarization beam splitter and an eight-channel optical collimator array. Each channel of an eight-channel spectrometer consists of an optical collimator, a convex lens, a scanning Fabry-Perot interferometer, a photomultiplier tube and an eight-channel photon collection card.

There is provided an optical measurement device including a spectral optical system that disperses fluorescence emitted from a biological specimen, and an image sensor that receives the fluorescence dispersed by the spectral optical system and generates fluorescence information. The image sensor is divided into a plurality of regions that receive different wavelength components of the fluorescence and generate fluorescence information for each of the wavelength components.

In one embodiment, a system includes a first light source configured to produce a first beam of light at a first frequency and a second light source configured to produce a second beam of light at a second frequency, where the first and second frequencies are offset by a frequency offset Ω. The system also includes one or more optical elements configured to: direct the first and second beams of light to a sample, and collect a Raman signal produced by the sample in response to the first and second beams of light. The system further includes an optical receiver configured to detect the Raman signal. The optical receiver includes a third light source configured to produce a third beam of light at a third frequency, and one or more optical detectors configured to coherently mix a portion of the Raman with a portion of the third beam of light.

Methods and systems for luminescence characterisation of semiconductor devices are provided herein In an embodiment, the method 300 for luminescence characterisation of a perovskite material 224 comprises a step 302 of exciting at least part of the perovskite material 224 with a modulated optical beam 210 to emit a modulated photoluminescence signal 226, the modulated optical beam 210 having a modulation frequency that is selected based on an estimated lifetime of the perovskite material 224 to be characterised; a step 304 of capturing the emitted modulated photoluminescence signal 226; and a step 306 of analysing a phase and / or modulation change between the modulated optical beam 210 and the modulated photoluminescence signal 226 for characterising the perovskite material 224.

An apparatus includes a spectrometer receiving an optical input signal that includes an input optical spectrum. The spectrometer includes a fiber laser cavity pumped by a first optical replica of the optical input signal that generates stimulated Brillouin scattering traveling in a direction opposite to a direction of the optical input signal. The first optical replica of the optical input signal excites at least one lasing mode in the fiber laser cavity. The at least one lasing mode respectively includes at least one lasing mode frequency. The at least one lasing mode frequency is offset by a respective Brillouin frequency shift from the respective at least one input frequency. The spectrometer also includes an optical heterodyne receiver. The optical heterodyne receiver generates the electrical output signal. The spectrometer outputs a measurement of the input optical spectrum based on the respective Brillouin frequency shift and the at least one input frequency.

An optical module for spatially offset Raman spectroscopy, the optical module comprising: a laser source mounted on a substrate and configured to emit electromagnetic radiation at a target; a plurality of sensors mounted on the substrate and configured to detect electromagnetic radiation scattered from a plurality of depths in the target; and a first plurality of filters, each disposed over one or more of the plurality of sensors, wherein, the plurality of sensors and filters are arranged on the substrate at spatially offset positions from the laser source; and wherein the first plurality of filters are substantially transparent to a first wavelength band corresponding to a Raman scattering wavelength of a first molecule of the target and substantially opaque to wavelengths outside the first wavelength band.

A sensor module for Raman spectroscopy includes a sensor package which encloses an application specific integrated circuit (ASIC), a light emitter arrangement, a light detector arrangement and a filter arrangement. The light emitter arrangement is electrically connected to the ASIC and operable to emit light with multiple excitation wavelengths to excite Raman scattering in an external probe to be placed outside of the sensor module. The light detector arrangement is operable to generate sensor signals from incident light emitted back from the external probe due to the Raman scattering. The filter arrangement is operable to filter the incident light according to a target passband. The ASIC is operable to drive the light emitter arrangement at the excitation wavelengths to shift a Raman spectral band of the external probe into the passband of the filter arrangement.

The invention provides an optical system and a monitoring method for monitoring a stimulated Brillouin scattering effect, and the optical system for monitoring the stimulated Brillouin scattering effect comprises the steps: firstly, conveying a narrow-linewidth seed source into a laser amplifier through a first optical device, and carrying out the narrow-linewidth laser amplification; and the stimulated Brillouin scattering light generated by the laser amplifier is guided out to the return light monitoring module, so that the return light power and the spectral component of the stimulated Brillouin scattering light are detected in real time through the return light monitoring module, and the purposes of simultaneously and accurately measuring the power of the stimulated Brillouin scattering light and observing the laser component are achieved. Whether the stimulated Brillouin scattering effect occurs or not can be judged more easily; furthermore, according to the optical system, the narrow-linewidth seed source and a spectrograph in the return light monitoring module can be protected from being damaged by return light to the maximum extent by adjusting the light splitting proportion of the first optical device and the return light monitoring module, and the purposes of accurately judging the stimulated Brillouin scattering effect and protecting system safety are achieved.

A composite optical filter may include a substrate, a communal optical filter, one or more first optical filters, and one or more second optical filters. The communal optical filter may be formed on a first surface of the substrate. The one or more first optical filters may be formed on one or more first portions of a second surface of the substrate and may be configured to pass light associated with a first wavelength. The one or more second optical filters may be formed on one or more second portions of the second surface of the substrate and may be configured to pass light associated with a second wavelength.

A cap having a closed end and one or more openings is attached to the tip of an optical Raman probe sensor. The cap serves to block stray light noise from entering the tip of the sensor. In this way, Raman spectra may be more accurate and consistent. Further, the cap may be permanently affixed or removably attached to the sensor. In some embodiments, a reflective surface may be included on the interior surface of the closed end of the cap. This reflective surface may reflect Raman scattering light toward the tip, enhancing the received signal by a factor of 2 to 100.

The present invention relates to a method and an apparatus for measuring surface-enhanced Raman scattering. The present invention provides an apparatus for measuring surface-enhanced Raman scattering, comprising: a Raman scattering measurement unit capable of detecting an optical signal resulting from incident light in a plurality of polarization states applied to a sample including nanoparticles enabling surface-enhanced Raman scattering measurement; a spectrometer for generating a spectral signal by spectroscopically analyzing the optical signal detected by a detector of the Raman scattering measurement unit; and a correction value calculation unit for calculating a correction value for the spectral signal, on the basis of the spectral signal resulting from irradiation with light in the plurality of polarization states.

A method of analyzing a mixed fluorescence response of a plurality of fluorophores in a microscopic sample includes reconstructing individual fluorescence responses from a mixed fluorescence response using spectral un-mixing based on reference emission spectra for fluorophores to be reconstructed, and a procedure for determining and validating reference emission spectra including providing a plurality of image acquisition settings for a sequence of images of the sample equal to, or greater than, the plurality of fluorophores and including an illumination setting for each image, acquiring the sequence of images using the plurality of image acquisition settings and storing each image together with the corresponding illumination setting, determining candidate reference emission spectra for the fluorophores to be reconstructed from the sequence of images of the sample using one or more reference emission spectra determination algorithms, and conditionally using the candidate reference emission spectra as the reference emission spectra in the spectral un-mixing.

The present disclosure relates to a system (1) for determining at least one of the character, composition and reactivity of dissolved organic matter, DOM in water comprising: an ultraviolet, UV light source (2) configured to excite a water under examination (3) with a light beam (2′) having an excitation wavelength in the range of 250-500 nm. Further, the system comprises a first detector device (4) and a second detector device (5), wherein the system (1) further comprises control circuitry (6) configured to predict at least one of the composition, character and reactivity of DOM in the water under examination (3) based on said first and second fluorescence intensity.

Systems and methods for spectroscopic analysis and particle identification using out-of-plane imaging of multimode-interferometer waveguide (MMI-WG) scattering are provided. A MMI-WG comprises an input end, a lateral surface, and an input port disposed on the input end, such that light in the MMI-WG propagates in a direction away from the input end. A sensor is configured to detect scattered light that scattered through the lateral surface of the MMI-WG, and to generate data based on the detected scattered light, wherein the data indicates an intensity of the scattered light. One or more processors are configured to determine, based on the intensity of the scattered light indicated by the data generated by the sensor, one or more wavelengths of the input light. The identity of one or more particles may be determined based on the one or more determined wavelengths.

Disclosed is a wearable device configured to perform standardised time domain diffuse optical spectroscopy, comprising an illumination system with a light source configured to illuminate a target region of the body, a photodetection system configured to detect scattered light exiting the target region and provide a measurement signal, and a processing circuit for time of flight (ToF) data acquisition. At least a portion of the beam is coupled to the photodetection system via a first reference optical path comprising a tissue mimicking phantom with one or more known optical properties to provide a first reference signal. The processing circuit measures a ToF distribution for photons detected from the target region and determines one or more optical properties of the target region from measured ToF distribution; measures a ToF distribution for photons detected from the phantom and determines one or more calibration factors for use in determining the one or more optical properties of the target region; and determines one or more optical biomarker values based, at least in part, on the one or more optical properties of the target region.

A method and a system have been developed to calibrate the total spectral radiance factor (TSRF) obtained from different instruments. A broad-band light source covering the whole visible range as well as the fluorescence excitation wavelengths is used to measure the TSRF, and one or more narrow-band light sources outside of the fluorescent band is used to measure fluorescent spectral radiance factor (FSRF) separately. After that, the TSRF is adjusted by the FSRF, and a calibrated TSRF can be obtained. This can be applied to characterize Optical Brightening Agents (OBAs) as well as other fluorescent materials without requiring any moving part of the instrument to do the calibration.

A light source includes a mode-locked laser; a beam splitter that branches the femtosecond optical pulse train; a CW solid-state laser; a first beam combiner that outputs one side of the femtosecond optical pulse train on the same axis; a secondary nonlinear optical element that outputs a difference frequency generation and conversion optical pulse train from either a continuous wave or a femtosecond optical pulse train; an amplifier that amplifies the difference frequency generation and conversion optical pulse train; a polarization-maintaining all normal dispersion high nonlinear fiber that converts the other femtosecond optical pulse train into a supercontinuum optical pulse train; a first dispersion medium that converts the supercontinuum optical pulse train into a pulse width that is approximately the same as the difference frequency generation and conversion optical pulse train; and a second beam combiner that multiplexes and outputs the difference frequency generation and conversion optical pulse train and the supercontinuum optical pulse train.

A super-resolution microscopic imaging method and apparatus based on common-path parallel fluorescence emission difference microscopy. In the method, a liquid crystal spatial light modulator is used to modulate excitation light in fluorescence emission difference microscopy super-resolution microscopic imaging, and two parts of the spatial light modulator are respectively loaded into 0-2π vortex phase modulation and blazed grating, so that the common-path excitation light forms solid spot and doughnut-shaped spot with a certain distance on a sample surface at the same time, and parallel scanning is carried out, thereby ensuring that the imaging speed is doubled compared with that of ordinary fluorescence emission difference super-resolution microscopic imaging, and at the same time, the two excitation lights are not easily affected by noise, drift and other interferences due to the common path.

The disclosure regards a computer implemented method for estimating the reactivity of dissolved organic matter in a liquid comprising the steps of obtaining a first fluorescence measurement from the liquid, wherein the first fluorescence measurement comprises a first emission wavelength and a first excitation wavelength, obtaining a second fluorescence measurement from the liquid, wherein the second fluorescence measurement comprises a second emission wavelength and a second excitation wavelength, determining a sample photosensitivity index based on the first fluorescence measurement, the second fluorescence measurement and a conversion factor specific to said liquid, and estimating the reactivity of dissolved organic matter in the liquid based on the sample photosensitivity index, wherein the conversion factor is a correlation between a series of base photosensitivity indexes and a series of fluorescence measurement ratios, obtained from a liquid of a same type as the liquid. The present disclosure further relates to a computer implemented method for calibrating a fluorescence setup in relation to a liquid, and to an optical measurement system for estimating the reactivity of dissolved organic matter in a liquid.

In general, in one aspect, the invention features a method of fluorescence spectroscopy including providing a high-performance sensor that combines imaging with high intrinsic time resolution and high

A method for non-invasively monitoring fluorescent tracers with background separation correction is disclosed, particularly a method for monitoring time-varying fluorescence emitted from a fluorescent agent within a diffusely reflecting medium having time-varying optical properties. The method comprises providing at least two measurements obtained from a patient before and after administration of the fluorescent agent, the measurements comprising a Flr adjacent to the medium detected by a filtered light detector during illumination of the medium with light of an excitation wavelength. meas signal, and at least one DR signal, the DR signal is selected from: #imgabs0#DR em and DR em,filtered The method further includes identifying a post-balanced portion of the measurement data set and assigning each Flr within the post-balanced portion of the measurement data set meas Signal conversion to IF agent signal, the IF agent The signal represents the intensity of the detected fluorescence emitted only by the fluorescent agent in the medium. The disclosed method includes eliminating the effects of leakage of excitation level light and meas Eliminate the influence of autofluorescence in the signal.

The application provides an optical system and a monitoring method for monitoring stimulated Brillouin scattering effect. The optical system for monitoring stimulated Brillouin scattering effect firstly delivers a narrow linewidth seed source into a laser amplifier through a first optical device to amplify the narrow linewidth laser, and guides stimulated Brillouin scattering light generated by the laser amplifier to a back light monitoring module to detect the back light power and spectral components of the stimulated Brillouin scattering light in real time through the back light monitoring module, so as to realize the purpose of simultaneously and accurately measuring the stimulated Brillouin scattering light power and observing the laser components, and is more conducive to judging whether the stimulated Brillouin scattering effect occurs. Further, the optical system can adjust the light splitting ratio of the first optical device and the back light monitoring module to protect the narrow linewidth seed source and the spectrometer in the back light monitoring module from the damage of the back light to the greatest extent, and achieve the purpose of accurately judging the stimulated Brillouin scattering effect and protecting the system safety.

A portable device which detects a Raman signal from an analyte of interest contained in or suspected to contain in a sample. The portable device includes a laser source in optical communication with a dichroic mirror, an objective lens optically positioned to consolidate the laser from the laser source to the sample, (i) a pair of rotatable filters in optical communication with the dichroic mirror and an optical transmission module or (ii) a first band-pass filter in optical communication with the dichroic mirror and an optical transmission module, and a detector optically positioned to receive and detect a Raman signal produced from the laser incident on the analyte of interest. The dichroic mirror directs the laser from the laser source to the sample through the objective lens and transmits any Raman signal from the sample toward the detector. The detector is absent of a spectrometer and detects the Raman signal.

A light source according to the present disclosure comprises: a mode-locked laser; a beam splitter that splits a femtosecond optical pulse train having a center wavelength λs outputted from the mode-locked laser; a CW solid-state laser; a first combiner that coaxially outputs one femtosecond optical pulse train; a second-order nonlinear optical element that outputs a difference frequency generation / conversion optical pulse train having a center wavelength λc from continuous light and the one femtosecond optical pulse train; an amplifier that amplifies the difference frequency generation / conversion optical pulse train; a polarization-maintaining, all-normal-dispersion, highly nonlinear fiber that converts the other femtosecond optical pulse train into a supercontinuum optical pulse train; a first dispersion medium that converts the supercontinuum optical pulse train into substantially the same pulse width as that of the difference frequency generation / conversion optical pulse train; and a second combiner that combines and outputs the difference frequency generation / conversion optical pulse train and the supercontinuum optical pulse train. λs and λc are set so that a CARS measurement can be performed using the difference frequency generation / conversion optical pulse train and the supercontinuum optical pulse train.