580results about "Raman/scattering spectroscopy" patented technology

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω. The system further includes a photonic integrated circuit (PIC) that includes multiple optical waveguides configured to: direct the pump and Stokes beams of light to a sample; receive a Raman signal produced by coherent Raman scattering of the pump and Stokes beams of light at the sample; and direct the Raman signal to an optical receiver. The optical receiver is configured to detect the Raman signal. The optical receiver includes a probe light source configured to produce a probe beam of light at a probe frequency, an optical detector, and an electronic circuit.

In one embodiment, a system includes a first light source configured to produce a first beam of light at a first frequency and a second light source configured to produce a second beam of light at a second frequency, where the first and second frequencies are offset by a frequency offset Ω. The system also includes one or more optical elements configured to: direct the first and second beams of light to a sample, and collect a Raman signal produced by the sample in response to the first and second beams of light. The system further includes an optical receiver configured to detect the Raman signal. The optical receiver includes a third light source configured to produce a third beam of light at a third frequency, where the third light source includes a wavelength-tunable laser, where the third frequency is adjustable.

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency, and a Stokes light source configured to produce: (i) a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω and (ii) a Stokes reference beam of light. The system also includes one or more optical elements configured to: direct the pump and Stokes beams of light to a sample, and collect (i) a Raman signal produced by the sample in response to the pump and Stokes beams of light and (ii) residual light from the Stokes beam of light after the Stokes beam of light has interacted with the sample. The system further includes an optical receiver configured to detect the Raman signal, where the optical receiver includes a probe light source.

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω. The system also includes one or more optical elements configured to: direct the pump and Stokes beams of light to a sample, and collect a Raman signal produced by coherent Raman scattering of the pump and Stokes beams of light at the sample. The system further includes an optical receiver configured to detect the Raman signal. The optical receiver includes a probe light source configured to produce a probe beam of light at a probe frequency, where the probe light source includes a wavelength-tunable laser.

In one embodiment, a system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency. The pump and Stokes frequencies are offset by a frequency offset Ω, and the pump and Stokes beams are directed to an object. The system further includes one or more optical elements configured to collect a Raman signal produced by coherent Raman scattering of the pump and Stokes beams of light at the object. The system also includes an optical receiver configured to detect the Raman signal. The optical receiver includes a probe light source configured to produce a probe beam of light at a probe frequency and an optical detector configured to coherently mix the Raman signal with the probe beam of light to produce a corresponding photocurrent signal.

In one embodiment, a system includes a first light source configured to produce a first beam of light at a first frequency and a second light source configured to produce a second beam of light at a second frequency, where the first and second frequencies are offset by a frequency offset Ω. The system also includes one or more optical elements configured to: direct the first and second beams of light to a sample, and collect a Raman signal produced by coherent Raman scattering of the first and second beams of light within the sample. The system further includes an optical receiver configured to detect the Raman signal. The optical receiver includes a third light source configured to produce a third beam of light at a third frequency, and an optical detector configured to coherently mix a portion of the Raman signal with the third beam of light.

In one embodiment, a Raman spectroscopy system includes a pump light source configured to produce a pump beam of light at a pump frequency and a Stokes light source configured to produce a Stokes beam of light at a Stokes frequency, where the pump and Stokes frequencies are offset by a frequency offset Ω. The system further includes one or more optical fibers configured to (i) direct the pump and Stokes beams to a sample located external to the system and (ii) direct a Raman signal to the system, where the Raman signal is produced by coherent Raman scattering of the pump and Stokes beams of light at the sample. The system also includes an optical receiver configured to detect the Raman signal. The optical receiver includes a probe light source and an optical detector configured to coherently mix the Raman signal with a probe beam of light.

Systems and methods are provided for analyzing a biomechanical property of a medium using stimulated Brillouin scattering microscopy. The method can include a first step of applying a probe beam and pulsed pump beam to a target section of the medium, wherein the pump beam interacts with the probe beam to generate at least one acoustic wave in the medium and at least one Brillouin signal is produced as a result of the generated acoustic wave. The method can also include a second step of receiving the produced Brillouin signal and a third step of determining, using a processor and the Brillouin signal, information associated with at least one biomechanical property of the target section.

Disclosed is a linear array scanning Brillouin scattering elastic imaging device. In the device, a signal generating system consists of a narrow linewidth continuous wave laser, a half-wave plate, a beam expander, a Y-direction scanning galvanometer, a microlens array, a pinhole array filter, a first plano-convex lens, a polarization beam splitter, a quarter-wave plate and a microscope objective. A signal receiving system consists of a microscope objective, a quarter-wave plate, a polarization beam splitter and an eight-channel optical collimator array. Each channel of an eight-channel spectrometer consists of an optical collimator, a convex lens, a scanning Fabry-Perot interferometer, a photomultiplier tube and an eight-channel photon collection card.

Photonic particles and methods of using particles in biological samples are disclosed. The particles are configured to emit laser light when stimulated by, for example, pump source energy. The particles may include: a gain medium having an inorganic material, an optical cavity having a high refractive index, and a coating having an organic material. The particles may be less than 3 microns along their longest axis. The particles may be attached to each other to form, for example, doublets and triplets. The particles may be injection locked by coupling an injection beam into the particles during pumping, so that the injection seeds are amplified to develop into laser oscillations. The microscope system may include a pump source, a beam scanner, a spectrometer having a resolution of less than 1 nanometer and an acquisition rate of greater than 1 kilohertz, and a spectrum analyzer configured to distinguish the spectral peaks output by the laser from a broadband background.

Provided herein are systems and methods for tissue characterization that may be utilized for intraoperative cancer margin assessment. A tissue sample is resected from a patient and then placed in a system where it is imaged for autofluorescence characteristics to help identify regions of interest such as cancerous tissue margins. Based on the imaging results and tissue characterization, the resection of tissue in the subject can be adjusted.

Various embodiments of a laser illumination system are disclosed. In some examples, a system includes one or more lasers and a beam combiner configured to direct a combined light beam along a path. The system can include a polychroic optical assembly that receives the combined light beam and to output a first beam of the first light of the first wavelength and a second beam of the second light of the second wavelength. The second beam can be offset from the first beam. The polychroic optical assembly can be a prism assembly. The system can include one or more optical elements configured alter a distribution of light of the first beam to output a first output line at a sample plane, and to alter a distribution of light of the second beam to output a second output line at the sample plane.

The invention provides detection equipment which is applied to the field of detection, such as the field of spectrum detection. The detection equipment comprises an optical coupler, a scattering assembly, a detector and a processor. The optical coupler is used for receiving a to-be-detected light beam and coupling the to-be-detected light beam to the scattering assembly. The scattering assembly is used for scattering the to-be-detected light beams and outputting a plurality of scattered to-be-detected light beams to the detector at different angles in a time division manner. The plurality of scattered light beams to be detected are in one-to-one correspondence with the plurality of angles. The detector is used for detecting a plurality of different areas in the plurality of scattered light beams to be detected to obtain a plurality of paths of electric signals. The detector is further used for transmitting multiple paths of electric signals to the processor. And the processor is used for calculating the multiple paths of electric signals to obtain related information of the light beam to be detected. In the technical scheme provided by the invention, by adjusting the output direction of the to-be-detected light beam, the related information of the to-be-detected light beam can be obtained through the detector in a time division manner, so that the cost of the detection equipment is reduced.

There is provided an optical measurement device including a spectral optical system that disperses fluorescence emitted from a biological specimen, and an image sensor that receives the fluorescence dispersed by the spectral optical system and generates fluorescence information. The image sensor is divided into a plurality of regions that receive different wavelength components of the fluorescence and generate fluorescence information for each of the wavelength components.

In one embodiment, a system includes a first light source configured to produce a first beam of light at a first frequency and a second light source configured to produce a second beam of light at a second frequency, where the first and second frequencies are offset by a frequency offset Ω. The system also includes one or more optical elements configured to: direct the first and second beams of light to a sample, and collect a Raman signal produced by the sample in response to the first and second beams of light. The system further includes an optical receiver configured to detect the Raman signal. The optical receiver includes a third light source configured to produce a third beam of light at a third frequency, and one or more optical detectors configured to coherently mix a portion of the Raman with a portion of the third beam of light.

Methods and systems for luminescence characterisation of semiconductor devices are provided herein In an embodiment, the method 300 for luminescence characterisation of a perovskite material 224 comprises a step 302 of exciting at least part of the perovskite material 224 with a modulated optical beam 210 to emit a modulated photoluminescence signal 226, the modulated optical beam 210 having a modulation frequency that is selected based on an estimated lifetime of the perovskite material 224 to be characterised; a step 304 of capturing the emitted modulated photoluminescence signal 226; and a step 306 of analysing a phase and / or modulation change between the modulated optical beam 210 and the modulated photoluminescence signal 226 for characterising the perovskite material 224.

An apparatus includes a spectrometer receiving an optical input signal that includes an input optical spectrum. The spectrometer includes a fiber laser cavity pumped by a first optical replica of the optical input signal that generates stimulated Brillouin scattering traveling in a direction opposite to a direction of the optical input signal. The first optical replica of the optical input signal excites at least one lasing mode in the fiber laser cavity. The at least one lasing mode respectively includes at least one lasing mode frequency. The at least one lasing mode frequency is offset by a respective Brillouin frequency shift from the respective at least one input frequency. The spectrometer also includes an optical heterodyne receiver. The optical heterodyne receiver generates the electrical output signal. The spectrometer outputs a measurement of the input optical spectrum based on the respective Brillouin frequency shift and the at least one input frequency.

System for performing chemical spectroscopy on samples from the scale of nanometers to millimeters or more with a multifunctional platform combining analytical and imaging techniques including dual beam photo-thermal spectroscopy with confocal microscopy, Raman spectroscopy, fluorescence detection, various vacuum analytical techniques and / or mass spectrometry. In embodiments described herein, the light beams of a dual-beam system are used for heating and sensing.

An optical module for spatially offset Raman spectroscopy, the optical module comprising: a laser source mounted on a substrate and configured to emit electromagnetic radiation at a target; a plurality of sensors mounted on the substrate and configured to detect electromagnetic radiation scattered from a plurality of depths in the target; and a first plurality of filters, each disposed over one or more of the plurality of sensors, wherein, the plurality of sensors and filters are arranged on the substrate at spatially offset positions from the laser source; and wherein the first plurality of filters are substantially transparent to a first wavelength band corresponding to a Raman scattering wavelength of a first molecule of the target and substantially opaque to wavelengths outside the first wavelength band.

A sensor module for Raman spectroscopy includes a sensor package which encloses an application specific integrated circuit (ASIC), a light emitter arrangement, a light detector arrangement and a filter arrangement. The light emitter arrangement is electrically connected to the ASIC and operable to emit light with multiple excitation wavelengths to excite Raman scattering in an external probe to be placed outside of the sensor module. The light detector arrangement is operable to generate sensor signals from incident light emitted back from the external probe due to the Raman scattering. The filter arrangement is operable to filter the incident light according to a target passband. The ASIC is operable to drive the light emitter arrangement at the excitation wavelengths to shift a Raman spectral band of the external probe into the passband of the filter arrangement.

The invention provides an optical system and a monitoring method for monitoring a stimulated Brillouin scattering effect, and the optical system for monitoring the stimulated Brillouin scattering effect comprises the steps: firstly, conveying a narrow-linewidth seed source into a laser amplifier through a first optical device, and carrying out the narrow-linewidth laser amplification; and the stimulated Brillouin scattering light generated by the laser amplifier is guided out to the return light monitoring module, so that the return light power and the spectral component of the stimulated Brillouin scattering light are detected in real time through the return light monitoring module, and the purposes of simultaneously and accurately measuring the power of the stimulated Brillouin scattering light and observing the laser component are achieved. Whether the stimulated Brillouin scattering effect occurs or not can be judged more easily; furthermore, according to the optical system, the narrow-linewidth seed source and a spectrograph in the return light monitoring module can be protected from being damaged by return light to the maximum extent by adjusting the light splitting proportion of the first optical device and the return light monitoring module, and the purposes of accurately judging the stimulated Brillouin scattering effect and protecting system safety are achieved.

A composite optical filter may include a substrate, a communal optical filter, one or more first optical filters, and one or more second optical filters. The communal optical filter may be formed on a first surface of the substrate. The one or more first optical filters may be formed on one or more first portions of a second surface of the substrate and may be configured to pass light associated with a first wavelength. The one or more second optical filters may be formed on one or more second portions of the second surface of the substrate and may be configured to pass light associated with a second wavelength.

In some instances, a system for rapid spectral unmixing using spectrally interpolated background reduction (SIBR) is provided. The system comprises a device comprising an excitation light source and a detector. The system further comprises a control system configured to: obtain a plurality of excitation spectra for a plurality of fluorophores that are used to stain a sample; determine a plurality of chosen wavelengths and a plurality of chosen light intensities for the plurality of fluorophores; obtain a first detection of the sample based on using a set of first wavelengths from the plurality of chosen wavelengths and a set of first light intensities; obtain a second detection of the sample based on using a set of second wavelengths from the plurality of chosen wavelengths and a set of second light intensities; and output a SIBR quantity.

Optical spectrometers and polarization state hybrid sensors may be used to determine the spectral and polarization state components of electromagnetic waves. Hybrid sensors may be bulky devices and require waves to enter at a nearly direct angle of incidence to record a measurement. What is disclosed is an ultra-compact polarization state sensor with nanophotonic components. Nanophotonic components may contain metasurfaces and Bragg filters. Each metasurface may contain light scattering, anisotropic nanostructures that may be randomized to create a large input angle, and the Bragg filter may result in the light dispersion independent of the input angle. The sensor may be capable of handling about 200 nm bandwidth. The sensor may be able to read image data in the visible and to read spectral and polarization state data in the infrared wavelength range. The surface area of the sensor may be about 1 mm2, allowing it to fit on mobile devices.

A reference material for and a method of calibrating at least one Raman spectrometer are disclosed. The reference material includes quantum dots distributed in a transparent condensed phase material such that light emitted by the reference material in response to receiving excitation light having an excitation wavelength provided by the Raman spectrometer(s) has a predetermined spectral intensity distribution in a spectral measurement range of the Raman spectrometer(s). The method includes designing, manufacturing and providing the reference material, determining an emission spectrum of the reference material, and calibrating each Raman spectrometer by determining a reference spectrum of the reference material and by adjusting a determination of spectral intensity values of intensity spectra performed by the Raman spectrometer based on the reference spectrum and the emission spectrum of the reference material.

The invention discloses a single molecule positioning method based on high-speed phase-locked detection, which can perform high-precision single molecule positioning and imaging on a fluorescent sample under the condition of using a single laser light source. Molecular excitation of a sub-diffraction limit region is generated by using nonlinear characteristics of excitation and fluorescence emission when a fluorescence sample is excited by laser, and meanwhile, positioning information is obtained by surrounding a single molecule of a region of interest by using an illumination light beam; and the laser intensity is continuously improved, and the positioning precision is also improved until sub-five-nanometer precision information is obtained. And the detection end adopts a high-speed lock-in amplifier to lock fluorescence signal information of characteristic frequency in real time, and meanwhile, the final signal-to-background ratio is also improved. Compared with traditional high-precision positioning based on double laser light sources, the method has the advantages of a single laser light source, does not need special fluorescent dye, does not need special matching between double-wavelength lasers, and has universality; and the damage caused by phototoxicity and photobleaching due to over-high illumination intensity is avoided.

A cap having a closed end and one or more openings is attached to the tip of an optical Raman probe sensor. The cap serves to block stray light noise from entering the tip of the sensor. In this way, Raman spectra may be more accurate and consistent. Further, the cap may be permanently affixed or removably attached to the sensor. In some embodiments, a reflective surface may be included on the interior surface of the closed end of the cap. This reflective surface may reflect Raman scattering light toward the tip, enhancing the received signal by a factor of 2 to 100.

The invention provides a transient fluorescence detection system with sub-gate pulse width time resolution, and the system comprises a gate pulse generation system which is configured to generate a gate pulse needed by transient fluorescence detection based on first fundamental frequency light inputted into the gate pulse generation system; the ultrashort pulse generation system is configured to generate a few-period femtosecond pulse based on the second fundamental frequency light input into the ultrashort pulse generation system; the fluorescence generation system is positioned at the downstream of the ultrashort pulse generation system and is configured to excite a sample to generate fluorescence by taking a few-cycle femtosecond pulse as fluorescence excitation light; and the optical parametric fluorescence amplification system is positioned at the downstream of the gate pulse and the fluorescence and is configured to amplify the overlapped part of the fluorescence and the gate pulse in time and space through optical parametric amplification, so that transient fluorescence detection is realized. When an ultrashort pulse is used as an excitation light source, the optimal time resolution of transient fluorescence detection can reach 60 femtoseconds, the time resolution limit of optical parameter transient fluorescence detection can be broken through, and the sub-gate pulse width time resolution smaller than the gate pulse width is achieved.

The present invention relates to a method and an apparatus for measuring surface-enhanced Raman scattering. The present invention provides an apparatus for measuring surface-enhanced Raman scattering, comprising: a Raman scattering measurement unit capable of detecting an optical signal resulting from incident light in a plurality of polarization states applied to a sample including nanoparticles enabling surface-enhanced Raman scattering measurement; a spectrometer for generating a spectral signal by spectroscopically analyzing the optical signal detected by a detector of the Raman scattering measurement unit; and a correction value calculation unit for calculating a correction value for the spectral signal, on the basis of the spectral signal resulting from irradiation with light in the plurality of polarization states.

An imaging system includes an imager having first and second light sensors, the first light sensor being configured to record light in a first wavelength range and the second light sensor being configured to record light in a second wavelength range, an alignment mechanism configured to be attached to the imager, an illumination source configured to generate a supercontinuum light beam, and a light shaping mechanism configured to transform the supercontinuum light beam into a linear strip of light. The alignment mechanism is configured to adjust a position of the light shaping mechanism so that a back scattered light, resulting from a scattering of the linear strip of light from a target, has an intensity above a given minimum for each of the first and second light sensors.