180 results about "Stimuli responsive" patented technology

System and method for capturing, concentrating, and detecting a diagnostic target in a liquid, comprising applying a magnetic field to a mixture comprising a co-aggregate in the liquid to provide a collected co-aggregate in the liquid, wherein the co-aggregate comprises a magnetic particle having a stimuli-responsive polymer attached thereto and a non-magnetic particle having a stimuli-responsive polymer and a diagnostic target attached thereto.

The present invention generally relates to stimuli-responsive drug carriers and methods for making. More specifically, the present invention relates to stimuli-responsive lidded particles that respond to a physiological stimulus and dissolve at a target site inside the body thereby releasing therapeutic agents. The present invention further relates to solid, drug-loaded particles that are made from biodegradable polymers. The present invention further relates to methods for fabricating lidded particles and particles for drug delivery.

A method of delivering a therapeutic agent by providing a cross-linked polymer encapsulating the therapeutic agent to a site in a patient. The degradation rate of the cross-linked polymer is correlated with a local concentration of an indicator, and the therapeutic agent is released as the cross-linked polymer degrades.

Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles.

Ligand-responsive chimeric proteins are engineered to cause a detectable output in response to a preselected stimulus. The engineered chimeric proteins are useful in industrial, commercial, medical, and scientific fields as a tool for programming a cellular response to a stimulus of choice and for use with in vitro assays. The engineered chimeric proteins include a detection domain and an interaction domain. Interaction of the engineered chimeric protein with a target biomolecule is modulated by the presence or absence of the preselected stimulus.

A copolymer comprises a first monomer including a hydrophilic group and a hydrophobic group linked to the hydrophilic group, and a second monomer polymerized to the first monomer. The hydrophobic group is oil-repellant. A receding contact angle of a low surface energy fluid on the copolymer is greater than an advancing contact angle of a high surface energy fluid on the copolymer.

A copolymer comprises a first monomer including a hydrophilic group and a hydrophobic group linked to the hydrophilic group, and a second monomer polymerized to the first monomer. The hydrophobic group is oil-repellant. A receding contact angle of a low surface energy fluid on the copolymer is greater than an advancing contact angle of a high surface energy fluid on the copolymer.

The invention relates to a temperature and pH stimuli-responsive intelligent polymer microcapsule and preparation thereof. The microcapsule comprises two polymers sensitive to temperature and pH, and an interpenetrating network structure is formed between the two polymers. Preparation includes the following steps: (1) uniformly blending tetraethyl orthosilicate, aqueous ammonia, water and absolute ethyl alcohol, and then adding surface modifier; (2) adding temperature-sensitive monomer and crosslinking agent into the modified dispersion, and adding initiator for reaction; (3) after diluting the emulsion by five to fifteen times, adding pH-sensitive monomer and crosslinking agent, and adding initiator for reaction; and (4) dispersing the white emulsion of core-shell composite particles with shells formed into a interpenetrating polymer network structure into hydrofluoric acid, and carrying out centrifugal separation or dialysis purification. The microcapsule can respectively respond tothe stimulation of temperature and pH, and moreover, the two types of stimuli responsiveness are independent from each other, and therefore have little interference on each other. The preparation method is simple, and is suitable for industrial production.

A process for making a stimuli responsive liquid crystal-polymer composite fiber comprising mixing a liquid crystal, a polymer, and a solvent; processing the mixture in the presence of an electric potential across a collection distance; phase separating a polymer and said liquid crystal; and encapsulating said liquid crystal within said polymer. The fiber generally comprises a liquid crystal core and a polymer shell wherein the liquid crystal is responsive to chemical changes, thermal and mechanical effects, as well as electrical and magnetic fields. A liquid crystal containing fiber can be utilized as optical fibers, in textiles, and in optoelectronic devices.

The present subject matter relates generally to design, synthesis, and characterization of materials with well-defined porous networks of molecular dimensions in which the size and surface energy of the pores can be externally and reversibly controlled to dynamically modulate the adsorption and transport of molecular species.

The invention designs a preparation method and application of a polymer hollow microcapsule. The method comprises the following steps of using nano cellulose as an emulsifier of a Pickering emulsion,adding an initiator, a monomer and a cross-linking agent into a discontinuous phase of the emulsion, afterwards, using the Pickering emulsion as a template, and preparing the polymer hollow microcapsule through the polymerization and cross linking reactions, in a liquid drop of the emulsion, of the monomer. The nano cellulose used in the method has advantages of being good in biocompatibility, wide in source, low in cost, green and environmental friendly, and the like; the range of a polymer to which the method is applicable is wide; hydrophobic and hydrophilic polymer monomers can be selectedand used; an environmental stimuli-responsive polymer or a polymer with a special function, such as a pH (potential of Hydrogen)-response, temperature-response or conducting polymer and the like, canbe selected and used; moreover, the method is simple, convenient and quick; reaction conditions are simple; the polymer hollow microcapsule is adjustable in particle size, low in cost and easy in quantity production and the obtained polymer hollow microcapsule can be used for the entrapment and the controlled release of a medicine and can be widely applied to the fields of medicines, agricultureand the like.

Disclosed are soil additives comprised of self-situating, stimuli-responsive polymer compositions and methods of their use. In one embodiment, the polymer composition or polymer network comprises permanent cross-links and non-permanent cross-links, wherein the non-permanent cross-links are capable of being removed upon application or exposure to a stimulus, typically located within the soil. In another embodiment, the method of increasing water retention in soils includes applying a soil additive, comprising polymer networks of the present invention admixed with an aqueous solution to form a colloidal dispersion solution or suspension, to a soil surface. The suspension or colloidal dispersion solution facilitates penetration of the polymer composition through the soil surface and into the soil, migrating typically to lower water potential areas and, more typically, along drainage channels located within the soil. After penetration of the soil surface, the polymer network is then exposed to a stimulus, typically present in the soil, whereby the non-permanent cross-links are removed and the polymer composition undergoes a volumetric change. This results in the prevention, arrest or decelerated loss of water from the targeted area, for example the plant root zone, which allows for improved water usage efficiency by plants, grasses, vegetation, etc.

Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles.

The current invention is a novel superparamagnetic site-targeting nanoparticle comprising superparamagnetic nanoparticles encapsulated with a smart polymer. The superparamagnetic site-targeting nanoparticle comprises a functionalized superparamagnetic core that is conjugated with a therapeutic agent and then encapsulated with a smart polymer. The smart polymer can be any polymer that exhibits a reversible conformational or physio-chemical change in response to an external stimulus or stimuli.

The invention relates to a stimuli-responsive composite material made from bacterial nano cellulose as well as a preparation method and application of the stimuli-responsive composite material. A bacterial nano cellulose base material in a hydrogel state is combined with polyelectrolyte macromolecules in an interpenetrating or semi-interpenetrating manner, and then is wholly or partially dehydrated to obtain the composite material. The composite material is high in rehydration and swelling capacities under the condition of a particular Ph, and keeps the characteristics of low swelling capacity and difficulty in rehydration under the condition of an off-design Ph value. The composite material has the characteristics of temperature response; the pore size of network of the composite material can be controlled, and the penetration rate of solute molecules can be controlled to release a drug in a control manner. Meanwhile, the composite material has the characteristics of high strength, high biocompatibility and the like of the bacterial nano cellulose, and can be applied to smart wound dressings, smart drug carriers, sensors, chemical valves and the like. The composite material has the advantages that the preparation process is simple, the cost is low, and a good application prospect is achieved.

The invention relates to an environment-response intelligent weave fabric and relative preparation. Wherein, adding the fabric which is induced by argon microwave low-temperature plasma to generate free group on surface, into the dual monomer solution of 2-acrylamide-2-methanesulfonic acid and N-isopropyl acrylamide that contains N and N'-methylene dual acrylamide cross linker to process graft polymerization reaction, while the bath ratio is 1:40, to graft the dual intelligent gel on the fiber macromolecule of fabric, to attain said inventive product. When the invention is dry, it has no difference from general fabric, but when it is wet, the gel will adsorb water to expand and block the slits between fibers, to reduce the water and gas permeability of fabric, and avoid outer penetrating into the inner layer of fabric to stop heat emission. The invention can be used to produce army waterproof clothes, heat-accumulation temperature adjustable special clothes, etc.

A mechanochromic system comprising a first inorganic / polymer composite layer; and a first elastomer layer bonded to the composite layer to form a composite / elastomer assembly, methods of making, and methods of use thereof are provided.

A hydrogel microdome that can swell in response to a stimuli or target molecule is formed by polymerizing a mixture comprising a monomer capable of forming a hydrogel with a biopolymer. An array of hydrogel microdomes can be formed on a substrate by microspotting the mixture and polymerizing. The array can be used for high-throughput screening of analytes as well as for use as an actuator and biosensor using the swelling property of the hydrogel.

Using a novel water-soluble, active ester amide-containing functionalized controlled radical polymerization initiator, stimuli responsive polymers have been grown from the surface of a protein, exemplified by chymotrypsin or any protein having surface amino acids that will covalently bind to the active ester amide-containing functionalized initiator. It is shown that changes in temperature or pH can change the conformation of the polymer surrounding the enzyme, which in turn enabled the rational tailoring of enzyme activity and stability. This method has afforded an increase in the activity and stability of the enzyme by an order of magnitude at pH's where the enzyme is usually inactive or unstable. Multimodal temperature responsive protein-block copolymer conjugates are described.

To provide a new reductive-stimuli-responsive degradable gel that allows any control of decomposition of the three-dimensional base material for cell culture and production of a completely biological three-dimensional cellular structure consisting only of cells and cells-produced extracellular matrix and that allows safe recovery of the cellular structure produced.A stimuli-responsive hydrogel, characterized by being produced by crosslinking a water-soluble polymer with a compound having a disulfide bond in the molecular chain.

The invention provides a preparation method for a temperature stimuli-responsive nanofiber membrane carrying with a precious-metal nanorod. The preparation method is characterized in that the preparation method comprises the steps that temperature stimuli-responsive polymer of active groups in molecule side chain zone is prepared; the precious-metal nanorod is synthesized through a seed growing method; the temperature stimuli-responsive polymer is dissolved in distilled water and is mixed with aqueous dispersion liquid of the precious-metal nanorod, stirring is conducted to form spinning solution, electrostatic spinning is conducted on the spinning solution, and a hybrid nanofiber membrane carrying with the precious-metal nanorod is formed; heat treatment is conducted on the hybrid nanofiber membrane formed through electrostatic spinning, and the temperature stimuli-responsive nanofiber membrane carrying with the precious-metal nanorod is acquired. The prepared hybrid nanofiber membrane carrying with the precious-metal nanorod is swelled in aqueous medium, so that dissolution does not occur, the temperature stimuli responsiveness is possessed, and the temperature of volume phase transformation ranges from 40 DEG C to 43 DEG C. The hybrid nanofiber membrane possesses a potential application prospect in a surface-enhanced Raman spectroscopy detecting base, a drug control delivery carrier, a sensor and the like.

The invention provides a deformable stimuli responsive material which has local Young modulus differences. The deformable stimuli responsive material is formed by at least one of a thermal response material, a photo-thermal response material, a magnetic thermal response material, an electric heating response material, a humidity response material and a pH response material. The deformable stimuli responsive material can be converted into a three-dimensional structure from a plane two-dimensional structure under one or more outside stimuli conditions of temperature, light, magnetism, electricity, humidity and pH. The material is modified to the back of a planar flexible microelectrode array, so that three-dimensional deformation of the flexible microelectrode array can be implemented through outside stimuli, and precise control over controllable shaping and curvature of the conventional planar flexible microelectrode array can be implemented by further regulating the thickness or crosslinking degree and the like of the stimuli responsive material. The invention further provides a method for preparing the deformable stimuli responsive material and a stimuli responsive flexible microelectrode array.

The invention relates to a composite nano-microsphere having a drug controlled release performance, and a preparation method and an application thereof. The core of the composite nano-microsphere is hollow meso-porous silica, and the shell of the composite nano-microsphere is formed by a pH and temperature stimuli-responsive polymer; and the surface of the hollow meso-porous silica microsphere isgrafted with the pH and temperature stimuli-responsive polymer shell through a solution precipitation polymerization technology to obtain the composite nano-microsphere having the drug controlled release performance. The composite nano-microsphere adopts the hollow meso-porous silica as a drug loading main part and the pH and temperature stimuli-responsive polymer as a drug controlled release switch; and the composite nano-microsphere having the drug controlled release performance can simultaneously realize high drug load capacity and drug controlled release, and has certain tumor passive targeting capability.

The invention provides a preparation method and application of a temperature and oxidant dual stimuli responsive nano-aggregate. According to the invention, the redox inclusion principle of beta-cyclodextrin (beta-CD) and ferrocene (Fc) and the temperature sensitive properties of the polymer poly(N-isopropylacrylamide) (PNIPAM) are utilized to connect PNIPAM-beta-CD with the end containing a beta-CD host group to hydrophilic polyethylene glycol (mPEG-Fc) with the end modified by an Fc guest group in a water solution through a host-guest recognized noncovalent bond, thus forming a supramolecular complex mPEG-Fc / PNIPAM-beta-CD. When the temperature is higher than the LCST (lower critical solution temperature) of PNIPAM, the macromolecular adduct can further gather in water to form a micellar structure. Micelle formation and disintegration can be realized by adjusting the solution temperature and adding an oxidant. cytotoxicity assessment experiments find that the supramolecular complex has very good biocompatibility. The supramolecular micelle packing the anticancer drug doxorubicin has very good effect in inhibiting A549 tumor cell growth. The preparation method of the nano-aggregate is simple, environment-friendly and economical, and the nano-aggregate has great application value in the field of biological medicine.

Stimuli-responsive NPs with excellent stability, high loading efficiency, encapsulation of multiple agents, targeting to certain cells, tissues or organs of the body, can be used as delivery tools. These NPs contain a hydrophobic inner core and hydrophilic outer shell, which endows them with high stability and the ability to load therapeutic agents with high encapsulation efficiency. The NPs are preferably formed from amphiphilic stimulus-responsive polymers or a mixture of amphiphilic and hydrophobic polymers or compounds, at least one type of which is stimuli-responsive. These NPs can be made so that their cargo is released primarily within target certain cells, tissues or organs of the body, upon exposure to endogenous or exogenous stimuli. The rate of release can be controlled so that it may be a burst, sustained, delayed, or a combination thereof. The NPs have utility as research tools or for clinical applications including diagnostics, therapeutics, or combination of both.

The invention discloses a multi-stimuli responsive shell crosslinked polymeric micelle and a preparation method thereof. The polymeric micelle is prepared by: carrying out ATRP and click chemistry reaction to synthesize an amphiphilic diblock polymer with polydimethylaminoethyl methacrylate (PDMAEMA) as the hydrophilic chain and polymethacrylate ferrocenyl formyloxy ethyl ester (PMAFFEE) as the hydrophobic chain, subjecting the polymer to self-assembly in water to form core-shell micelles with uniform size, and then carrying out cross-linking reaction on the micelles and N, N'-di(bromoacetyl)cystamine. The core-shell crosslinked polymeric micelle provided by the invention is responsive to temperature, pH, light, oxidation and reduction stimuli, drugs can be released under single triggering of different stimuli in a controlled release process, and also can achieve controlled release through joint triggering of multiple stimuli. Therefore, the multi-stimuli responsive shell crosslinked polymeric micelle has broad application prospect in controlled release of anti-cancer drugs and other fields.