Preparation method and application of temperature and oxidant dual stimuli responsive nano-aggregate
A stimuli-responsive, oxidizing technology, applied in the nanometer field, can solve problems such as distress
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0033] The synthesis of mPEG-Fc was prepared by simple esterification of polyethylene glycol monomethyl ether (mPEG) and ferrocenecarboxylic acid (Fc-COOH) with DMAP as a catalyst and DCC as a coupling agent.
[0034] (1) Synthesis of mPEG-Fc
[0035] Take a clean and dry 100mL round bottom flask, dissolve 5.05g (2.53mmol) mPEG2000, 0.82g (3.57mmol) ferrocenecarboxylic acid and 0.066g (0.54mmol) DMAP in 40mL anhydrous CH 2 Cl 2 0.85 g (4.11 mmol) of DCC was added under stirring in an ice bath, and then the reaction was stirred at room temperature for 24 h under the protection of argon. After the reaction, the by-products DCU and the like were filtered off, and the solvent was evaporated to dryness. The obtained residue was dissolved in chloroform, extracted three times with 0.5M sodium hydroxide solution, the organic layer was separated and dried overnight in anhydrous sodium sulfate, the organic liquid was evaporated to dryness, the obtained solid was dissolved in a small a...
Embodiment 2
[0044] By using NHS as a catalyst and EDC as a coupling agent, polyethylene glycol monomethyl ether carboxylic acid (mPEG-COOH) and ferroceneamine (Fc-NH 2 ) to obtain the synthesis of mPEG-Fc through a simple amidation reaction.
[0045] (1) Synthesis of mPEG-Fc
[0046] Take a clean and dry 100mL round bottom flask, dissolve 5.05g (2.52mmol) mPEG-COOH, 0.72g (3.57mmol) ferroceneamine and 0.061g (0.61mmol) NHS in 40mL anhydrous CH 2 Cl 2 0.77g (3.98mmol) EDCI was added under stirring in an ice bath, and then stirred at room temperature for 24h under the protection of argon. Extract three times with 0.5M sodium hydroxide solution, separate the organic layer, and dry in anhydrous sodium sulfate overnight, evaporate the organic liquid, dissolve the obtained solid in a small amount of chloroform, add a large amount of ether, and filter to obtain a precipitate , so repeated dissolution-precipitation three times to obtain light yellow solid crude product. Then the crude product...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com