Ph/reduction double-sensitive carrier material formed by cys and its derivatives and polyester polymer and its preparation method and application

A polymer and sensitive technology, which is applied in the field of functional polymer materials and biomedicine, can solve the problems of poor biological safety, poor circulation stability, poor targeting, etc., and achieve short reaction cycle, excellent biological safety and few reaction steps Effect
CN109232875BActive Publication Date: 2021-06-29SUN YAT SEN UNIV
1 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2021-06-29

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a pH / reduction double-sensitive carrier material formed of Cys and its derivatives and polyester polymer, as well as its preparation method and application. The present invention uses the aldylated polyester polymer and Cys containing disulfide bonds or its derivatives as raw materials to successfully prepare a pH / reduction dual-sensitive new polymer with imino bonds and disulfide bonds, and successfully constructs Nano-carriers for targeted delivery of anti-tumor drugs; through hydrophilic-hydrophobic interactions, drugs with different hydrophilicity and hydrophobicity can be physically encapsulated to form a uniform particle size and stable environmental dual-responsive nano-drug loading system. In the environment of tumor cells, the dual-sensitive polymer nanoparticles can be quickly disintegrated and the drug-loaded drugs can be released rapidly. The whole system has good biological safety, biodegradability and long-term circulation stability, and has high-efficiency tumor targeting and It has the characteristics of effectively inhibiting the growth of tumor cells; in addition, its preparation method is simple, and it has good application prospects in the field of biomedicine.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical fields of functional polymer materials and biomedicine. More specifically, it relates to a pH / reduction dual-sensitive carrier material formed of Cys and its derivatives and polyester polymer, as well as its preparation method and application. Background technique

[0002] Cancer is one of the major diseases that endanger human health and cause human death. Clinically, advanced cancer patients are mainly treated with chemical drugs, but small-molecule anti-cancer drugs are easily destroyed in the body due to their poor selectivity, short half-life, and large toxic and side effects. It is inevitable to cause damage to normal cells, and the safe and effective delivery of small molecule anticancer drugs into the body is an urgent problem to be solved. With the interdisciplinary development of nanotechnology and various disciplines, the combination of traditional small molecule anti-tumor drugs and nanotechnology to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More