145 results about "Advanced cancer" patented technology

The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, the present invention relates to novel adamantyl or adamantyl group derivatives containing retinoid compounds and their usage for treatment and/or prevention of cancer, keratinization disorders, dermatological conditions, and other therapies More specifically, it has been shown that such adamantyl compounds, e.g., 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, 2-[3-(1-adamantyl)-4-methoxyphenyl]-5-benzimidazole carboxylic acid, and 6-[3-(1-adamantyl)-4,5-methylenedioxyphenyl]-2-naphthoic acid, can be used to treat or prevent cervical cancers and precancers such as cervical dysplasias, including high grade and low grade dysplasias.

The invention discloses an extraction method for high-purity tetrodotoxin, which is mainly used for extracting tetrodotoxin from animal feed puffer fish seeds and livers by jointly utilizing the methods of ultrasonic fast dissolving out, organic solvent derosination, plate frame multi-level filtration, positive ion exchange resin, small film filtration, high-performance liquid preparation and the like and obtaining high-purity high-stability tetrodotoxin crystals. Tetrodotoxin has the effect of blocking a sodium ion channel is obvious in analgesic effect and free of dependency and is widely used in advanced cancer, postoperative pain relieving, de-addiction curing of drug abuse and the like. Extraction and preparation of high-purity tetrodotoxin can provide the possibility of developing a novel high-efficiency pain killer free of dependency.

The present invention relates to methods of treating patients with advanced forms of cancer, such as metastatic melanoma and non-small cell lung cancer, in which X4P-001 is administered as monotherapy or in combination with immune checkpoint inhibitors, such as pembrolizumab. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.

The invention discloses a pharmaceutical composition with effects of resisting cancer and alleviating pain, which is prepared from 40 traditional Chinese medicines: toad venom, pangolin scales, centipede, scorpion, honeycomb, leech, szechuan aconite, wild aconite, arisaema tuber, tuber pinellia, euphorbia kansui, knoxia corymbosa, rhizoma sparganii, rhizoma zedoariae, polyporus umbellatus, rhubarb, amur corktree bark, baikal skullcap root and the like. The pharmaceutical composition of the invention has obvious curative effects on various cancers of early, middle and late stages, and has the efficacies of resisting cancer and inhibiting tumor, promoting blood circulation and removing stasis, removing the necrotic tissue and promoting granulation, and promoting circulation of qi and relieving pain. The pharmaceutical composition of the invention controls cancer pain by resisting cancer and inhibiting tumor, draws out cancer poison, enables the tumor to shrink and disappear to achieve the purposes of improving living quality and prolonging life, and has convenient and safe use and no toxic and side effect. The efficacies are better by pasting the pharmaceutical composition of the invention on corresponding points of a human body.

A drug of treating cancers, its preparation method and application. The drug comprises 26 chinese medicines, including red sage root,gecko, cordate houttuynia,medicated leaven and so on. The detailedformulation and preparation method are seen in the specification. The drug could be used to treat liver cancer, lung cancer and so on.

The invention discloses an amine compound containing aromatic ring shown in the general formula I and salts thereof. In the formula, X represents CH or N atom; R1 represents H atom or F atom or chlorine atom or substituted alkyl or substituted alkoxy; R2 represents H atom or F atom or chlorine atom or substituted alkyl or substituted alkoxy; R3 represents phenyl or substituted alkyl or substituted phenyl or substituted pyridyl or substituted benzpyrole; Y represents substituted alkyl or substituted alkanoyl; and Y1 represents substituted alkyl or substituted alkanoyl. The invention also provides an application and preparation method of the compound in preparation of medicine for preventing and treating tumormetastasis, advanced cancer, non-entity cancer, and the like.

There is disclosed a method for treating advanced cancer in patients in need of such treating. Temozolomide and alpha interferon are administered in combination in amounts sufficient to achieve a clinical response.

The present invention discloses a Chinese medicine for curing advanced cancers and chronic hbv hepatitis and a preparation method. The present invention is proportionally manufactured by a medicinal active component made of dry toad skin and a medicine-acceptable carrier; the medicine carrier contains sodium carboxymethylcellulose and starch. Compared with the prior dosage, the present invention with advanced process and high medicine content strengthens the curing effect, reduces the toxic side effect of the medicine and ensures safer and more convenient medicine taking for patients.

The present invention is directed to compounds having the structure (I) wherein R₁, R₂, R₃, R₄, R₅ and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

Methods for the treatment of patients with HER2-positive, HER2-amplified and/or HER2-mutated advanced cancer by administration of pertuzumab plus trastuzumab are disclosed. In one aspect, the cancer is advanced HER2-positive, HER2-amplified and/or HER2-mutated colorectal, biliary, bladder, urothelial, salivary, lung, pancreatic, ovarian, prostate, or skin cancer. In another aspect, the cancer is HER2-positive, HER2-amplified and/or HER2-mutated colorectal, biliary, bladder, urothelial, salivary, lung, pancreatic, ovarian, prostate, or skin cancer that is refractory to one or more other treatment regimens.

The invention relates to a traditional Chinese medicine for treating respiratory tract cancer, which comprises the following bulk drugs by weight portion: 190 to 210 portions of croton, 40 to 60 portions of arsenic, 20 to 30 portions of black pepper, 450 to 550 portions of red date, 3 to 5 portions of onion, and 1 to 3 portions of ginger. The drug is the drug for the respiratory tract, so that active components are not absorbed by the gastrointestinal tract, but are directly delivered to lesion parts through 'qi and blood' without any side effects on each organ in a body. The traditional Chinese medicine is mainly used for treating the respiratory tract cancer, can prevent metastasis in early cancers, and relieve the pain of in the treatment of advanced cancers so as to greatly improve the life quality of patients. The traditional Chinese medicine has certain curative effect on respiratory tract cancers such as lung cancer, bronchial cancer, nasopharyngeal carcinoma and larynx cancer, and postoperative recurrence.

The present invention is directed to compounds having the structure Formula (I) wherein R₁, R₂, R₃, R₄, R₅ and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

The invention discloses an intermediate-advanced stage cancer imaging detecting system and an intermediate-advanced stage cancer imaging detecting method based on the quantum superstring engine, mainly used for overcoming the defect that the traditional medical device can not efficiently, safely, rapidly and comprehensively detect the cancer cell spreading area of a cancer patient. The intermediate-advanced stage cancer imaging detecting system comprises a quantum light emission source, an optical splitter, a convex lens, a light filter group, a detection unit, an image processing unit and a display. The intermediate-advanced stage cancer imaging detecting method comprises the steps that orthogonal polarized photons generated by the quantum light emission source pass through the optical splitter, and then are transmitted in two paths; one path of the orthogonal polarized photons irradiates the body of the patient through the convex lens and light filters, penetrates through the body and then is received by a detector, and the other path of the orthogonal polarized photons directly passes through the light filters, and are received by another detector; the detection unit carries out combined measurement on the photons detected by the two detectors, and outputs a detection result to the image processing unit, the image processing unit draws a diffusion area imaging picture of cancer cells in the body of the patient, and the diffusion area imaging picture is displayed by the display. With the adoption of the intermediate-advanced stage cancer imaging detecting system and the intermediate-advanced stage cancer imaging detecting method, the diffusion area imaging picture of the cancer cells can be obtained, and thus a basis is provided for the treatment and research on the cancer patient.

Adenine nucleotides such as adenosine 5′-monophosphate (AMP), adenosine 5′-diphosphate (ADP) or adenosine 5′-triphosphate (ATP) and/or adenosine and inorganic phosphate are administered in the treatment of advanced cancer in an out-patient setting and without serious side effects. Administration of up to 100 micrograms/kilogram/minute of continuous intravenous infusions of ATP for 8-10 hours, can be performed on an out-patient basis to patients who do not otherwise require hospitalization. No serious side effects, defined as grades 3 or 4 toxicity are observed during such an infusion.

The invention discloses a pure natural plant extract, composed of alfalfa, raspberry, small areca and pine bark wherein the ratio is 1:1:1:1 by weight. The small areca is from Australia, and the pine bark is Chinese red pine bark. The pure natural plant extract can be made into oral powder, capsule or injection, wherein the powder concentration in injection is 1000 mg/5ml distilled water and 2000mg/15ml distilled water or 3000mg/20ml distilled water. The extract can prevent cancer and effectively repair cancer cell or prevent cancer cell at early-stage of cancer and obviously prevent cancer cell transition and diffusion at late-stage of cancer.