60 results about "Metastasis tumor" patented technology

In a method for diagnosis and treatment of a patient with a tumor relating to prostate cancer, the following steps are implemented. A differential diagnosis of prostate cancer versus prostatitis and/or BPH is conducted on a patient using a cost-effective diagnosis method. If prostate cancer is diagnosed in the patient using a cost-effective measurement method, a characteristic value for the tumor aggressiveness of the prostate cancer is determined. A watchful waiting treatment is implemented with the patient given a characteristic value below a predeterminable first limit value. The size and position of the tumor is determined using a cost-effective method given a characteristic value above the first limit value. A cost-effective ultrasonic theranosis or a conventional therapy is conducted for a size below a second predeterminable limit value. The presence of metastases in the patient is checked, with a cost-intensive method generating image information, for a size above the second limit value. A metastasis treatment is implemented in the event that metastases are present. In the event that no metastases are present, a tumor treatment based on the aforementioned image information generated is implemented.

Compounds and methods for the diagnosis and treatment of tumors, including breast and prostate tumors and metastases thereof using radiolabelled peptides that bind to GRP receptors. The peptides are Bombesin analogs wherein the first and optionally the third amino acid are modified.

The present invention relates to a method of preventing, treating or inhibiting the development of tumors or metastases in a subject and to an immunomodulator for use in such therapy, in combination with a chemotherapeutic agent. An aspect the present invention is a method of preventing, treating, reducing, inhibiting and/or controlling the formation or establishment of metastasis of a primary neoplasia, tumor or cancer at one or more sites distinct from a primary neoplasia, tumor or cancer, in a subject intended to undergo chemotherapy, wherein the method comprises administering to the subject, a therapeutically effective amount of an antimetabolite pyrimidine analogue and an immunomodulator.

The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.

Methods for treating a patient suffering from a neoplastic disease are disclosed and described. A number of diseases can be treated under the present methods, including without limitation gall bladder cancer, hepato cellular cancer, ovarian cancer, small intestine cancer, lung cancer, mesothelioma, breast cancer, kidney cancer, pancreas cancer, prostate cancer, carcinoid cancer, leiomyosarcoma, or metastasis thereof. A general method for providing such treatment may include: 1) identifying in a patient one or more sentinel and/or metinel lymph nodes draining the neoplasm; 2) resecting the one or more nodes and, optionally all or part of the tumour or metastasis; 3) isolating tumour-reactive T-lymphocytes from said lymph nodes; 4) in vitro expanding said tumour-reactive T-lymphocytes; and 5) administering the thus obtained tumour-reactive T-lymphocytes to the patient.

According to the invention, a carboxylated platinum prodrug is designed and synthesized, and a coordination nano core is prepared by utilizing the coordination effect of ions and the prodrug. Lipid is wrapped outside the nano-core, and a photosensitizer is dispersed in the nano-core to construct the prodrug nano-carrier. A nano prodrug is loaded by utilizing the phagocytic function of macrophages (BMDM), so that a near-infrared light (NIR) activated macrophage-nano prodrug delivery system is prepared. The system has the characteristics of high drug loading capacity, light-operated activation and retention of self activity and functions, and efficient and synchronous drug delivery of primary tumors and metastatic tumors can be realized after intravenous injection. Meanwhile, after primary tumors are irradiated by NIR, drugs can be triggered to be released quickly, chemotherapy-photodynamic combined therapy is achieved, and the purposes of killing tumor cells and activating an immune system are achieved. Through combination of three modes of chemotherapy, photodynamic and immunization, dual treatment of primary and metastatic tumors is finally realized.

The isolation and characterization of a metastasis tumor suppressor gene KAI1 is disclosed and diagnostic methods and gene therapy approaches utilizing reagents derived from the nucleotide and deduced amino acid sequences of the KAI1 gene are provided.

The invention provides a method for diagnosing bone metastases in nuclide bone imaging based on deep learning. The method relates to a bone scanning diagnosis classification model, a bone metastasis tumor region segmentation model and a bone metastasis tumor load evaluation and automatic report generation model. By the adoption of the method, the bone metastasis tumor can be judged, automatic region segmentation can be conducted, the recognition accuracy is high, and full-automatic analysis from original image input to report generation is preliminarily achieved.

The invention provides a transcriptome-based tumor metastasis gene detection system. The transcriptome-based tumor metastasis gene detection system comprises an integration module, a recognition module, an analysis module and a marking module, wherein the integration module is used for integrating a Read counting matrix to obtain a statistical magnitude file of differential expression degree of each gene; the recognition module is used for recognizing the differential expression genes and comparing the differential degree between functions under tumor primary and metastasis conditions; the analysis module is used for analyzing a gene expression mode and classifying and analyzing the expression mode; the marking module is used for marking tumor metastasis genes; the integration module, the recognition module, the analysis module and the marking module are connected in sequence. The transcriptome-based tumor metastasis gene detection system is used for mining the tumor metastasis related genes from high-throughput data, and analyzing the abnormal changes of transcriptomes in primary and metastasis tumors and the dynamic changes of tumor metastasis marker gene expression modes in the metastasis process.

The invention belongs to the technical field of pharmaceutical preparations, and relates to a targeted drug delivery system, specifically to a platelet-like liposome drug delivery system, and a preparation method and an application thereof. The drug delivery system is prepared from a platelet membrane and a traditional liposome through extrusion membrane-filtering and fusing. The drug delivery system has the advantages of both natural targeting of a platelet and in-vivo long circulation of a lipidosome; in-vitro adhesion experiment results prove that the platelet-like lipidosome has the adhesion capacity similar to the adhesion capacity of a pure platelet vesicle to collagen and fibrinogen; in-vitro targeting experiment results prove that the platelet-like liposome has good targeting similar to the targeting of the pure platelet vesicle to tumor cells; pharmacokinetic experiment results prove that the platelet-like lipidosome has long in-vivo circulation time close to the in-vivo circulation time of a traditional lipidosome; and in-vivo targeting experiment results prove that the platelet-like lipidosome has a targeting effect significantly higher than the targeting effect of a traditional lipidosome and the pure platelet vesicle on residual tumors and metastatic tumors.

The invention provides a traditional Chinese medicine composition for treating cancer pain caused by bone metastasis and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from, by mass, 10-50 parts of milkvetch roots, 10-50 parts of glossy privet fruits, 5-35 partsof herba taxilli, 5-35 parts of radix aucklandiae, 5-35 parts of radix sophorae subprostratae, 5-35 parts of spina gleditsiae, 5-35 parts of pseudobulbus cremastrae seu pleiones, 5-30 parts of rhizomasparganii, 5-30 parts of rhizoma curcumae, 5-30 parts of spica prunellae, 5-35 parts of cortex moutan, 5-35 parts of caulis spatholobi and 5-30 parts of radix glycyrrhizae preparata. The traditionalChinese medicine composition can achieve the analgesic effect and is free of side effects on the human body.

The present invention relates to methods for preparing an animal tissue for fluorescence microscopy, to an animal tissue obtainable by said methods, to methods for analyzing said animal tissues, and to methods for the detection of metastases, for analyzing the biodistribution of a biopharmaceutical drug, and for analyzing the biodistribution of nanoparticles. The methods for preparing an animal tissue according to the present invention encompass whole-body labeling, clearing and imaging methods. The methods of the invention are advantageous in that they, for instance, allow the visualization of single cells within mammalian tissues including pig and human brains, tumor metastases at the single cell level and of the distribution of biopharmaceutical drugs (e.g. the distribution of cancer-targeting therapeutic antibodies in whole animals such as intact mice) at single cell level in whole mouse.

The invention discloses an application of near-infrared weightless atom Bodipy to photodynamic therapy of metastatic tumor and upconversion and belongs to the fine chemical engineering and life medical field. The reagent parent structure and nanoparticles thereof have very good photodynamic treatment effects. The nanoparticles are combined with immune drugs, and a tumor animal model verifies the outstanding metastatic tumor treatment effect. The photosensitive molecules are simple to synthesize and lower in cost, have high absorption capability in the long wavelength area and have super-long triplet state life and higher triplet state quantum yield. Given the excellent performance of the photosensitive molecules, the molecules are expected to become new generation photodynamic therapy reagents and metastatic tumor treatment reagents. Moreover, the invention also relates to a pure organic upconversion system containing no heavy atoms. Because of very high light absorbing capability of the photosensitive molecules, the photosensitive molecules can convert red light into very bright yellow upconversion light and have very high application potential in the biological field.

The invention relates to the technical field of biological medicines, firstly provides a folic acid modified Pluronic P85 copolymer and also relates to a preparation method of a 5-fluorouracil anti-cancer nano drug. Experiments show that the 5-fluorouracil nano drug prepared by adopting the folic acid modified Pluronic P85 copolymer can be used for obviously inhibiting tumour cell growth; meanwhile, in a mouse colonic carcinoma hepatic metastasis model, formation of colonic carcinoma liver metastases can be obviously reduced, and lifetime of a mouse can be obviously prolonged, so that the folic acid modified Pluronic P85 copolymer has a good effect on resisting colonic carcinoma hepatic metastasis, and the 5-fluorouracil anti-cancer nano drug is hopeful to be an anti-tumour drug with a clinical application prospect.

This application provides an application of a medicine in the preparation of drugs for treating metastatic encephaloma and related diseases thereof. The medicine includes at least one TRPV4 agonist capable of promoting calcium ion influx of a TRPV4 signal channel, and the metastatic encephaloma and related diseases thereof include metastatic encephaloma, diseases arising during the formation of metastatic encephaloma, complications and sequelae caused by metastatic encephaloma, and diseases related to metastatic encephaloma. The medicine is applied in the preparation of the drugs for treatingmetastatic encephaloma-related diseases, a significant anti-tumor effect can be played through a clear mechanism of action, the therapeutic effects are good, and the application prospects are good.