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70 results about "Mixed Cellular Population" patented technology
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A morphologic finding indicating the presence of a cellular infiltrate with a mixed population of cells in a tissue sample.
Selection of cells using biomarkers
InactiveUS20080113358A1Easy to separateIncrease the number ofMicrobiological testing/measurementMaterial analysisFetal abnormalityFetal cell
The present invention provides systems, apparatuses, and methods to isolate, select or detect the presence of a target cell (e.g., fetal cells) in a sample comprising mixed populations of cells that vastly outnumber the target cells. Target cells include fetal cells, such as nucleated red blood cells, and methods of selecting such cells include diagnosis of fetal abnormalities, i.e., aneuploidy. Furthermore, methods comprise utilizing fetal biomarkers to select fetal cells in a sample comprising fetal and adult cells.
Owner:THE GENERAL HOSPITAL CORP +2
Elimination of heterogeneous or mixed cell population in tumors
InactiveUS20060233814A1High activityImprove stabilityAntibacterial agentsOrganic active ingredientsMixed cellAbnormal tissue growth
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.
Owner:IMMUNOGEN INC
Apparatus and Methods for Cell Isolation
ActiveUS20100285588A1Reduce cloggingMaximize surface areaBioreactor/fermenter combinationsBiological substance pretreatmentsMixed cellMixed Cellular Population
A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.
Owner:INGENERON
Methods and reagents for identifying rare fetal cells in the maternal circulation
This invention provides methods and compositions useful for identifying and diagnosing rare fetal cells in a mixed cell population such as a maternal blood sample. The methods entail the use of specific nucleic acid probes that hybridize to fetal cell associated RNAs to identify the rare fetal cells or antibodies that bind to polypeptides encoded by the fetal cell associated RNAs for fetal cell detection. The cells detected by the methods of the present invention are useful for diagnosing the fetal cells for a genetic trait of interest, such as trisomy 21. Novel methods for simultaneous screening for fetal cells and diagnosing the fetal cells are also provided. Compositions comprising the fetal cell associated nucleic acids of the invention and their encoded proteins are also provided. The present invention further provides kits useful for practicing the present methods.
Owner:ROCHE DIAGNOSTICS OPERATIONS
Diagnosis of fetal abnormalities by comparative genomic hybridization analysis
InactiveUS20100112586A1Microbiological testing/measurementMaterial analysisFetal abnormalityComparative genomic hybridization
Owner:STOUGHTON ROLAND +1
Mixed cell populations for tissue repair and separation technique for cell processing
The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use. In such embodiments, the final composition is a substantially purified and concentrated cell mixture suspended in a physiologic solution suitable for immediate use in humans without further washing, volume reduction, or processing. Embodiments are also applicable to harvesting (and / or washing) particles within a liquid or solution within a chamber.
Owner:VERICEL
Detection of Changes in Cell Populations and Mixed Cell Populations
InactiveUS20100291575A1Microbiological testing/measurementMaterial analysis by optical meansMixed cellMixed Cellular Population
The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
Owner:X BODY
Methods for identifying multiple epitopes in selected sub-populations of cells
InactiveUS20180320241A1Maximize probabilityInhibition formationMicrobiological testing/measurementAssay labelsEpitope specificitySub populations
A method for identifying a sub-population within a mixed population of cells is disclosed. The method involves contacting the mixed population of cells with at least one unique binding agent, wherein the at least one unique binding agent is designed to bind to a target molecule present in the sub-population, and wherein the at least one unique binding agent is attached to an epitope specific barcode that represents the identity of the target molecule. The method further involves sequentially attaching two or more assayable polymer subunits to the epitope specific barcode to create unique cell origination barcodes that represent the identities of individual cells to which the at least one unique binding agent has bound; and decoding the epitope specific barcode and cell origination barcodes, thereby identifying the sub-population within the mixed population of cells.
Owner:ROCHE SEQUENCING SOLUTIONS INC
Separation of low-abundance cells from fluid using surface acoustic waves
InactiveUS20170232439A1Enhance cell viabilityImprove integrityMicrobiological testing/measurementLaboratory glasswaresCancer cellVolumetric Mass Density
An apparatus for sorting cells from a mixed population of cells using surface acoustic waves is described. Methods for separating cancer cells from a mixed population of cells are provided. Methods for separating cells or particles having different size, density and / or compressibility properties are also provided.
Owner:MASSACHUSETTS INST OF TECH +1
System and Methods for Genetic Analysis of Mixed Cell Populations
InactiveUS20150154352A1Reduce error rateMicrobiological testing/measurementBiological testingMixed cellPrenatal diagnosis
Methods and systems are provided for massively parallel genetic analysis of single cells in emulsions or droplets. A biological sample is divided into subsamples of single cells or cell supbopulations, and a fusion complex is formed by molecular linkage and amplification techniques. Methods, apparatuses, and systems are provided for high-throughput, massively parallel analysis of the subsamples. These methods integrate molecular, algorithmic, and engineering approaches. They have broad and useful application in a number of biological and medical fields, including immunology, noninvasive prenatal diagnosis, and noninvasive cancer diagnosis.
Owner:GIGAGEN
Bispecific antibody or antibody mixture having common light chain
ActiveCN105820251AStability is not affectedSolving the problem of heavy and light chain mismatchesHybrid immunoglobulinsImmunoglobulins against cell receptors/antigens/surface-determinantsBispecific antibodyMixed Cellular Population
The invention relates to a bispecific antibody or antibody mixture, and more specifically relates to the bispecific antibody or the antibody mixture having a common light chain, and a preparation method of the bispecific antibody or the antibody mixture. The invention also relates to nucleic acid molecules for coding the bispecific antibody or the antibody mixture, a recombinant vector containing the nucleic acid molecules and recombinant cells, and a detection and quantification method for the bispecific antibody or the antibody mixture. The bispecific antibody or the antibody mixture is prepared by a common light chain technology, the preparation method is simple and controllable, mismatching of the light chains in the bispecific antibody can be avoided, the antibody mixture can be expressed in same host cell, difficulty for culturing the mixed cell groups is reduced, and the amplification production is easily achieved.
Owner:JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO LTD
Hybrid tissues for tissue engineering
InactiveUS20050002982A1Fast shapingFast modelingBiocideGenetic material ingredientsMixed Cellular PopulationReconstructive surgery
The present invention comprises an implantable device that provides artificial tissues for repair, augmentation and reconstructive surgery which have mechanical properties comparable to the natural tissues that they supplement or replace. Such devices can be produced by a tissue engineering method comprising seeding a polymer matrix with a first cell type and a second cell type and culturing the seeded matrix under conditions suitable for cell growth or maintenance, whereby a tissue comprising a mixed cell population containing both the first and second cell types is produced. The tissue produced by this method contains a mixed population in which the two cell types are intimately associated without apparent stratification and has mechanical properties which are intermediate between similarly produced tissues containing either one of the two cell types. This invention is particularly useful in forming implantable structural members.
Owner:MOONEY DAVID J +5
Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells
InactiveUS20100143313A1Rapid and direct differentiationImprove survivalBiocideHepatocytesLiver morphologyBioartificial liver device
One of the major hurdles of cellular therapies for the treatment of liver failure is the low availability of functional human hepatocytes. Although embryonic stem (ES) cells represent a potential cell source for therapy, current methods for differentiation result in mixed cell populations or low yields of the cells of interest. The present invention provides for a rapid, direct differentiation method that yields a homogeneous population of endoderm-like cells with 95% purity. In one embodiment, mouse ES cells cultured on top of collagen-sandwiched hepatocytes differentiate and proliferate into a uniform and homogeneous cell population of endoderm-like cells. The endoderm-like cell population was positive for Foxa2, Sox17 and AFP, and could further differentiate into hepatocyte-like cells that demonstrate hepatic morphology, functionality, and gene and protein expression. Incorporating the hepatocyte-like cells into a bioartificial liver device to treat fulminant hepatic failure improved animal survival, thereby underscoring the therapeutic potential of these cells.
Owner:THE GENERAL HOSPITAL CORP
Separation system for CTCs (circulating tumor cells)
InactiveCN103589629AHigh purityEasy to implementBioreactor/fermenter combinationsBiological substance pretreatmentsMixed cellMedicine
The invention belongs to the field of biological and medical detection, and relates to a system for separating CTCs (circulating tumor cells) in a blood sample from a mixed cell group in high purity. The separation system for the CTCs comprises a sample preparation module, a sample injection module, a first micro-fluidic chip, a release module and a collection module, wherein the sample preparation module is used for processing blood into a detection sample; the sample injection module is used for injecting the detection sample into the first micro-fluidic chip; the first micro-fluidic chip is used for extracting the CTCs in the detection sample; the release module is used for separating the CTCs from the first micro-fluidic chip and obtaining a collection sample; and the collection module is used for collecting the collection sample. According to the technical scheme, compared with the prior art, the separation system for the CTCs is simple, easy to implement, lower in cost, simple to operate and high in automation degree.
Owner:SHANGHAI KANGWEI HEALTH TECH CO LTD
Method for producing mixed cell population of cardiomyocytes and vascular cells from induced pluripotent stem cell
ActiveUS20150297794A1Improve heart functionBiocideSkeletal/connective tissue cellsMixed cellMixed Cellular Population
Owner:IHEART JAPAN
Method for isolating and purifying oligodendrocytes and oligodendrocyte progenitor cells
InactiveUS8263402B1Easy to learnSignificant acceleration in the studyNervous disorderGenetically modified cellsProgenitorMixed Cellular Population
The present invention is directed to a method of separating oligodendrocyte cells or progenitor cells thereof from a mixed population of cells. It comprises selecting a promoter which functions only in the oligodendrocyte cells or progenitor cells thereof, introducing a nucleic acid molecule encoding a fluorescent protein under control of that promoter into the mixed population cells, allowing the oligodendrocyte cells or progenitor cells thereof to express the fluorescent protein, and separating the fluorescent cells from the mixed population cells, where the separated cells are the oligodendrocyte cells or progenitor cells thereof. The invention also relates to the isolated and enriched human oligodendrocyte cells or progenitor cells thereof.
Owner:CORNELL RES FOUNDATION INC
Equipment, system and method for separating CTCs (circulating tumor cells)
InactiveCN107287107ASolve the characteristicsSolve technical bottlenecks such as circulating tumor cells that cannot be enriched and capturedBioreactor/fermenter combinationsBiological substance pretreatmentsMixed cellPeristaltic pump
The invention belongs to the field of biological and medical detection and relates to equipment, a system and a method for separating CTCs (circulating tumor cells) in a blood sample from mixed cell groups with high purity. The equipment and system for separating the CTCs comprise, but not limited, a control module, a sample injection module, a separation module and a collection module, wherein the control module is used for setting equipment operation parameters including diluents volume, reaction time, sample injection speed, cleaning parameter and the like; the sample injection module adopts a multi-way valve module and a peristaltic pump module and is used for automatically diluting detected samples and starting multi-channel synchronous separation of the samples; the separation module comprises a magnet module and a separator module, the magnet module is used for separating and adsorbing magnetic particle immunolabeled blood leukocytes, and the separator module is used for enriching and separating CTCs from multiple cell groups; the collection module is used for collecting a separated CTC suspension. The invention provides the equipment and the system for separating the CTCs as well as the method for separating and identifying the CTCs.
Owner:WUXI NAAO BIO PHARM
Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
InactiveUS20160362661A1Therapy is simpleConvenient researchSkeletal/connective tissue cellsElectrical/wave energy microorganism treatmentPluripotential stem cellHeart Muscle Cell
The invention provides methods for depleting extraneous phenotypes from a mixed population of cells comprising the in vitro differentiated progeny of primate pluripotent stem cells, The invention also provides cell populations enriched for target cell populations which are the differentiated in vitro progeny of primate pluripotent stem cells.
Owner:ASTERIAS BIOTHERAPEUTICS INC
Enriched or purified population of motor neurons and its preparation from a population of embryonic stem cells
ActiveUS20050003544A1Microencapsulation basedNervous system cellsPrimary motor neuronMixed Cellular Population
The present invention is directed to a method of isolating an enriched or purified population of motor neurons from a population of embryonic stem cells. This method involves providing a population of embryonic stem cells and selecting a promoter or enhancer which functions only in the motor neurons selected. A nucleic acid molecule encoding a marker protein under control of the promoter or enhancer is introduced into the induced population of embryonic stem cells. The motor neurons are allowed to express the marker protein and, the cells expressed in the marker protein are separated from the population of embryonic stem cells. The population of embryonic stem cells can be induced to produce a mixed population of cells comprising motor neurons before or after a nucleic acid molecule encoding the marker protein under control of the promoter enhancer is introduced into the population of embryonic stem cells. As a result, an enriched or purified population of motor neurons is isolated.
Owner:CORNELL RES FOUNDATION INC
Apparatus and methods for cell isolation
ActiveUS8309342B2Avoid cloggingReduce cloggingBioreactor/fermenter combinationsBiological substance pretreatmentsMixed cellMixed Cellular Population
A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population. A cell seeding chamber may be attached to the cell isolation apparatus. The components of the apparatus may be packaged in modular kit form.
Owner:INGENERON
Lymphatic endothelial cells materials and methods
InactiveUS20060269548A1Improve abilitiesAmeliorating a lymphatic disorderSenses disorderPeptide/protein ingredientsLymphatic vesselMixed Cellular Population
The present invention is directed to methods and compositions for isolating lymphatic endothelial cells from a mixed population of cells. More particularly, the inventors have found that certain antibodies that recognize the extracellular domain of VEGFR-3 can be used to specifically isolated lymphatic endothelial cells substantially free of other contaminating non-lymphatic endothelial cells. Methods and compositions for producing such cells and using such cells are described.
Owner:LUDWIG INST FOR CANCER RES
Compositions and methods of treating no-option critical limb ischemia (CLI)
InactiveUS20120100108A1Improve the quality of lifeImprove mobilityBiocideMammal material medical ingredientsTissue repairGangrene
The present invention provides methods for treating critical limb ischemia (CLI), including increasing wound healing, decreasing wound size, increasing survival-free amputation, preventing amputation, preventing or delaying de novo gangrene, increasing survival probability, and preventing or delaying death, in subjects who prevent a vascular occlusion that cannot be resolved by using a standard method of revascularization, i.e. a subject with “no-option” CLI. Methods of the invention include administering to a subject with no-option CLI an isolated cell composition for tissue repair comprising a mixed population of cells of hematopoietic, mesenchymal and endothelial lineage, wherein the viability of said cells is at least 80% and the composition contains: a) about 5-75% viable CD90+ cells with the remaining cells in said composition being CD45+; b) less than 2 μg / ml of bovine serum albumin; c) less than 1 μg / ml of a enzymatically active harvest reagent; and d) substantially free of mycoplasma, endotoxin, and microbial contamination.
Owner:AASTROM BIOSCI
Methods for identifying multiple epitopes in selected sub-populations of cells
InactiveUS20210002733A1Microbiological testing/measurementAssay labelsEpitope specificityCellular origin
Owner:ROCHE SEQUENCING SOLUTIONS INC
Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes
ActiveUS8323966B2Reduce in quantityGastrointestinal cellsMicrobiological testing/measurementCell phenotypePluripotential stem cell
The invention provides methods for depleting extraneous phenotypes from a mixed population of cells comprising the in vitro differentiated progeny of primate pluripotent stem cells. The invention also provides mixed cell populations enriched for a target cell phenotype where the mixed cell population comprises the differentiated in vitro progeny of primate embryonic stem cells.
Owner:ASTERIAS BIOTHERAPEUTICS INC
Detection of specific antigens in a population of antigens
ActiveUS20120214176A1Increase in sizeAccelerated precipitationBiological testingMagnetic immunoreagent carriersAntigenFetal-Maternal Hemorrhage
Methods for detecting the presence or absence of, and for quantifying, one set of cells in a mixed cell population of at least two sets of cells especially Rh positive cells in a mixed population with Rh negative cells, as is found in a fetal maternal hemorrhage (FMH).The magnetic particles coated with anti-D antibodies are reacted with the Rh positive fetal cells in Rh negative maternal blood followed by a specific separation and quantifying technique.Gravitational forces or magnetic forces are used to move reacted magnetic particles to isolate, distinguish and quantify cells differentiated by antigenic composition.Rh positive cell volume is correlated to the volume of the original blood sample as an indication of the number of doses of RhIG needed to be administered to the mother to prevent subsequent Rh immunization.
Owner:CHROME RED TECH
Method and related kit for detecting c-MET/CEP7 gene status based on rare cells
The invention relates to a method and a related kit for detecting c-MET / CEP7 gene status based on rare cells, wherein the method comprises the following steps: 1. acquiring a blood sample or a body fluid sample, wherein the sample includes a mixed cell population of circulating tumor cells or other rare cells and white blood cells; 2. diluting the sample by virtue of a buffer solution, removing plasma and recovering CTC or other rare cells; 3. cracking by virtue of a red blood cell lysis buffer, removing red blood cells and recovering CTC or other rare cells; 4. recovering cells with magnetic particles coated with related anti-human leucocyte antigens and antibodies, uniformly mixing and breeding, and fully combining so as to form a magnetic particle-white blood cell mixture; 5. isolating the magnetic particle-white blood cell mixture from other cells so as to obtain a mixed cell population containing CTC or other rare cells and a few of white blood cells; and 6. by virtue of a method combining immunofluorescence cytochemistry and fluorescence in-situ hybridization, determining the status of c-MET / CEP7, and simultaneously identifying CTC or other rare cells.
Owner:北京莱尔生物医药科技有限公司
Elimination of heterogeneous or mixed cell population in tumors
InactiveUS20090076263A1High activityImprove stabilityAntibacterial agentsOrganic active ingredientsMixed cellCytotoxic drug
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.
Owner:IMMUNOGEN INC
Methods of selecting retinal pigmented epithelial cells
ActiveUS20150010922A1Cell dissociation methodsBiological material analysisFluorescenceMixed Cellular Population
A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises:(a) analyzing the cells of the mixed population of cells for at least one of the following parameters:(i) cells which autofluorescence above a predetermined threshold;(ii) cells which express CD81 above a predetermined threshold; and(iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and(b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.
Owner:HADASIT MEDICAL RES SERVICES & DEVMENT
Apparatus and method for rapid separation of cells without using density gradient and antibodies
InactiveUS20060134597A1Easy to separateRapid and simple procedureBioreactor/fermenter combinationsBiological substance pretreatmentsWhite blood cellRetention time
A method and an apparatus for rapid cell separation without using density gradient and antibody but using a column packed with resin particles. The interactions between cell surfaces and resin particles resulting in the different retention time of different cells in the column contribute to the separation of the specific cells from the mixed cell population. Therefore, no antibodies and specific chemical reagents are used in cell separation maintain the physiological status of separated cells. This invention can also apply to clinical use for fast and massive separation of blood sub-population, for the remove of leukemia cells from normal leucocytes in vivo or in vitro, and particularly for drug screening through the interaction between drugs and specific and non-specific cells.
Owner:CHIH SHIN BIOMEDICAL TECH
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