101 results about "Gangrene" patented technology

The invention discloses a new Chinese medicine composite for treating appendicitis and a preparation method thereof. The Chinese medicine composite is prepared by the following ingredients of grassleaf sweetflag rhizome, squama manitis, styrax, lysimachia foenum-graecum, lignum dalbergiae odoriferae, radix et rhizoma rhei, ligusticum chuanxiong, Lignum aquilariae resinatum, rhizoma cyperi, honeysuckle flower, Chinese violet, weeping forsythia, dandelion, stir-fried frankincense, stir-fried myrrh, radix sophorae flavescentis, ramulus cinnamomi, radix paeoniae alba, radix paeoniae rubra, folium isatidis, common andrographis herb, rhizoma sparganii and rhizoma curcumae, and the like. The Chinese medicine composite can be prepared to be any common oral preparation according to the conventional Chinese medicine preparation method. The Chinese medicine composite can obviously improve right lower quadrant pain, increased body temperature, emesia, neutrophilic leukocytosis and the like, effectively block appendix gangrene and perforation, and complicate localized or diffuse peritonitis, which has definite clinical effect, obvious curative effect and fast desired effect. Due to the combination of the medicines both as food and medicine according to state-promulgated pharmacopoeia, the Chinese medicine composite of the invention has the advantages of low cost, basically no toxic side effect and the like.

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia/reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.

The invention discloses a medicament for treating diabetic complications and a preparation method thereof. The medicament is mainly prepared from astragalus, polygonum orientale, gypsum, honeysuckle, figwort root, szechwon tangshen root, Chinese angelica, rehmanniae praeparatum, cassia bark, Indian buead, large-headed atractylodes rhizome, white paeony root, plantain seed, raw cinnamomvine, notoginseng root and liquorice root according to a certain weight ratio, and can be prepared into any common formulations. The medicament of the invention has obvious curative effect on the treatment of the diabetic complications and obvious effect of antidiabetics, promotes blood circulation, absorbs extravasated blood of fundus quickly, rehabilitates blood vessels and restores vision. In addition, for patients who suffer from gangrene, the medicament can eliminate polyneuropathy, invigorate podiatric thrombus quickly to form normal blood circulation and cure wounds, and the patients do not need amputation; and the diabetic complications become effective completely within one month, the cure rate of fundus hemorrhage (before laser treatment) within three months is 88 percent, the cure rate of nephropathy is 82 percent, the cure rate of the polyneuropathy is 85 percent, the cure rate of the gangrene is 89 percent, and the comprehensive cure rate of other symptoms is 84 percent. Until now, the diabetic complications are difficult to relapse from the follow-up period, and the medicament is well received by the patients.

The present invention provides methods for treating critical limb ischemia (CLI), including increasing wound healing, decreasing wound size, increasing survival-free amputation, preventing amputation, preventing or delaying de novo gangrene, increasing survival probability, and preventing or delaying death, in subjects who prevent a vascular occlusion that cannot be resolved by using a standard method of revascularization, i.e. a subject with “no-option” CLI. Methods of the invention include administering to a subject with no-option CLI an isolated cell composition for tissue repair comprising a mixed population of cells of hematopoietic, mesenchymal and endothelial lineage, wherein the viability of said cells is at least 80% and the composition contains: a) about 5-75% viable CD90⁺ cells with the remaining cells in said composition being CD45⁺; b) less than 2 μg/ml of bovine serum albumin; c) less than 1 μg/ml of a enzymatically active harvest reagent; and d) substantially free of mycoplasma, endotoxin, and microbial contamination.

The invention relates to medical technology and in particular relates to a formula and preparation method of paste capable of removing slough and promoting tissue regeneration for treating skin ulcer. The formula of the paste capable of removing slough and promoting tissue regeneration is characterized by comprising the following components in parts by weight: 50-70 parts of Chinese angelica, 15-20 parts of angelica root, 8-12 parts of bletilla, 8-10 parts of amber, 50-70 parts of beewax, 5-7 parts of lithospermum, 8-10 parts of liquorice, 450-500 parts of sesame oil and 10-12 parts of dragon's blood. The paste capable of removing slough and promoting tissue regeneration is a pure traditional Chinese medicine preparation formed by combining the modern science and technology on the basis of inheriting excellent achievements of the formers, has the effects of removing slough, drawing out pus, pushing toxicity and promoting tissue regeneration, has the advantages of definite curative effect, low cost and no obvious toxic and side effect and is applicable to a patient with canker caused by skin ulceration, especially during treatment of chronic ulceration such as bedsore and diabetes gangrene. The medicine can obviously promote ulcer healing and significantly improve cure rate.

The invention relates to a ruminant clostridial disease quadruple inactivated vaccine and a preparation method thereof. The ruminant clostridial disease quadruple inactivated vaccine is a clostridium putrificum, clostridium perfringens C type, clostridium perfringens D type and clostridium chauvoei quadruple inactivated vaccine. By use of the vaccine, four common cattle and sheep clostridial diseases can be subject to immunoprophylaxis, and the ruminant clostridial disease quadruple inactivated vaccine is used for preventing cattle and sheep blackleg (emphysematous gangrene), malignant oedema (clostridium septicum) and enterotoxaemia (C type and D type). Main ingredients of the vaccine are inactivated bacterial liquid of clostridium chauvoei and clostridium septicum, C type clostridium perfringens toxin and D type clostridium perfringens toxin.

The invention provides an application of a pyrroloquinoline quinone (PQQ) active substance in preparation of medicaments for treating and/or improving a diabetic complication, namely diabetic foot and further provides a health-care product composition or a pharmaceutical composition containing pyrroloquinoline quinone. The active substance, namely the pyrroloquinoline quinone in the composition provided by the invention has significant treatment and/improvement action against the diabetic complication, namely the diabetic foot by improving nerve conduction velocity, reducing sorbitol content, increasing the open number of capillaries, reducing whole blood viscosity, enhancing blood flow, increasing neural blood flow, promoting blood circulation, improving microcirculation of blood vessels and reducing gangrene ulcers of the foot. Therefore, the pyrroloquinoline quinone has great application prospects in prevention, treatment and/or improvement of occurrence and development of the diabetic complication, namely the diabetic foot.

The invention relates to the field of Chinese medicines, in particular to Chinese herbal medicine preparation burn oil, which is used for preventing and removing scars and treating burn and is prepared by sesame oil and the following Chinese herbal medicine components: sensitive plants, hibiscus, folium hibisci, wintersweet flowers, white pear flowers, rheum officinale, radix zanthoxyli, polygonum cuspidatum, radix scutellariae, golden cypress, jasmine, angelica sinensis, saffron crocus, radix angelicae, stone-like omphalia, syzygium aromaticum and gleditschia xylocarpa hance. A preparation method for the scar preventing and removing burn oil is further disclosed. The scar preventing and removing burn oil can enable the heal time for large-area burn to be shortened, is good in pain stopping, fast in flesh regeneration and small in scar after heal, has good curative effects on bedsore, diabetic gangrene fester and chronic ulcer, and has good application prospects.

The invention relates to a clostridium perfringen alpha toxin genetic engineering vaccine and application thereof. The clostridium perfringen alpha toxin genetic engineering vaccine is prepared by designing a specific primer, implementing polymerase chain reaction (PCR) amplification on A-type clostridium perfringen DNA to obtain an alpha toxin gene segment, cloning the gene segment onto a pMD18-T Vector, selecting a positive recon and linking the positive recon onto a PET-28 alpha (+) plasmid; introducing the recombinant plasmid to a receptor strain to successfully construct a recombinant strain BL21 (DE3)-alpha; emulsifying the prepared alpha toxin protein and an aluminum hydroxide adjuvant at a volume ratio of 9:1, and adding 0.01% thiomersal to obtain the clostridium perfringen alpha toxin genetic engineering vaccine. The clostridium perfringen alpha toxin genetic engineering vaccine is easy for realization of industrial production, simple to operate and good in safety, and is capable of effectively preventing such diseases as animal necrotic enteritis, enterotoxemia, and human and animal traumatic gas gangrene caused by the A-type clostridium perfringens.

The invention discloses a traditional Chinese medicine composition used for treating diabetic complications and reducing blood sugar. The composition comprises a formula A composed of an extract of Huidouba, an extract of euonymus alatus, an extract of balsam pear, an extract of Radix Puerariae, an extract of Sophora alopecuroide and Ganoderma broken-down wall spore powder, or comprises the formula A and a formula B which is composed of an extract of haw, an extract of banksia rose, an extract of Radix Astragali, an extract of ginseng leaves, an extract of Radix Puerariae, an extract of mulberry leaves, an extract of bighead atractylodes rhizome, an extract of Chinese angelica, an extract of Ligusticum wallichii, an extract of caulis polygoni multiflori, an extract of eucommia leaves, an extract of raw rehmannia root, an extract of epimeddium and chitosan oligosaccharide. Furthermore, the invention also provides a preparation method for the composition. The traditional Chinese medicine composition can effectively treat the complications of insomnia, gastrointestinal disorder, lower limb gangrene, ulcer, necrosis and erosion, limb numbness and pruritus, blurred vision, oral ulcer and the like caused by diabetes and can effectively reduce blood sugar.

A kind of medicine for treating carbuncle, gangrene, swollen poison and skin ulcer. It is made from Aconitum aconitum, Aconitum aconitum, Forsythia, Rehmannia glutinosa, frankincense, myrrh, wood turtle seed, cinnamon, dried blood, mercury powder, yellow dan, and sesame oil When making this drug, the weighed medicinal material should be immersed in the weighed sesame oil, soaked for 2 hours to 5 days, then heated, fried until the drug is browned, and then the fried drug is filtered out, and Huangdan is added and dried. Stir continuously, after cooling, it is the finished product; since there are fewer drug components in the drug of the present invention, and the price of each component is cheaper, the cost of this drug is lower; these medicinal materials are produced through proper compatibility Good therapeutic effect is obtained; the medicine in the present invention also has the advantage of simpler manufacturing process.

The invention relates to a Chinese medicament for treating diabetic acromelic gangrene, and belongs to the field of Chinese medicaments for treating surgical diseases. The Chinese medicament aims to have good effect and quick response. The Chinese medicament is prepared from raw materials such as hiraute shiny bugleweed herb, Chinese angelica, radix pseudo-ginseng, Japanese honeysuckle stem, suberect spatholobus stem, glossy ganoderma, snakegourd fruit, radix rehmanniae and the like. The Chinese medicament has the effects of strengthening body resistance and archaeus, supplementing qi and nourishing blood, promoting blood circulation by removing blood stasis and relaxing the muscles and removing obstruction in channels, and has the advantages of obvious effect, definite curative effect and quick response.

The invention relates to application of oxymatrine (oxymatrine and matrine) and glycyrrhizic acid or pharmaceutically-acceptable forms of oxymatrine and glycyrrhizic acid or derivatives of oxymatrine and glycyrrhizic, a medicine containing the compositions, also comprises matrine glycyrrhizinate and oxymatrine glycyrrhizinate, and application of the compositions to prepare medicines treating cutaneous vasculitis (allergic cutaneous vasculitis, allergic purpura, erythema elevatum diutinum, acute febrile neutrophilic dermatosis, urticarial vasculitis, pustular vasculitis, polyarteritis nodosa, pyoderma gangrenosum, eosinophilic vasculitis, eosinophilic cellulitis, pigmented purpuric dermatoses, Wegener's granulomatosis, Behcet's disease, erythema nodosum, and erythema induratum).

The invention discloses a nucleic acid detection method based on CRISPR-Cas12a and an application. According to the method, the 5'end of a PCR upstream primer or the 3 'end of a PCR downstream primer is modified with the PAM sequence so as to detect any nucleic acid fragment by using the CRISPR-Cas12a-based method, and even if the target fragment does not contain the PAM sequence, a nucleic acid detection platform can be used for identifying the nocardia gangrene, and has characteristics of simple and convenient detection and high specificity.

The invention discloses a water-soluble matrix traditional Chinese medicine ointment preparation for treating a diabetic foot, and particularly relates to a water-soluble matrix ointment composed of 6 traditional Chinese medicines, namely roots of redroot gromwell, cinnabar, dragon's blood, membranous milkvetch roots, colla corii asini and borneol, and a specific matrix auxiliary material. In addition, the invention further discloses a preparation technology method and application of the preparation. The external-use traditional Chinese medicine compound ointment preparation provided by the invention can control the progress of the diabetic foot and promote the growth of granulation on a wound surface to enable the gangrene to heal. The ointment is easy to clean and remove, has advantages especially for treatment to an erosion wound surface, plays an absorption effect on percolate and secretion of the diabetic foot, has favorable adhesiveness and coating properties, is uniform in dispersing of all raw materials, stable in quality, favorable in property, appropriate in consistency and suitable for clinical application, can be used for treating the diabetic foot for improving a clinical medication situation, widens an application range of a gromwell and cinnabar ointment, and improves the curative effect.

The invention relates to the technical field of traditional Chinese medicine and in particular relates to a traditional Chinese medicine coating liquid for external use for diminishing inflammation, sterilizing and promoting cell neogenesis and a preparation method of the coating liquid. The traditional Chinese medicine coating liquid for external use is prepared from such Chinese herbal raw materials in parts by weight as 18-22g of honeysuckle, 18-22g of safflower, 10-14g of medicine terminalia fruit, 10-14g of Chinese angelica, 10-14g of rhubarb, 18-22g of baical skullcap root, 10-14g of golden cypress, 18-22g of sargentg loryvine stem, 13-17g of light yellow sophora root, 13-17g of rhizome of swordlike atractylodes and 10-14g of sappanwood; 5 times of water is added to the raw materials for soaking for 3 hours, the mixed materials are put into a jacketed kettle, heating is performed until water in an outer liner boils, the Chinese herbs are stirred discontinuously, and then heating is continued for 2 hours, 360-420ml of decoction is filtered, a preservative is added and stirred, and the mixed liquid stands for cooling and then is canned; the traditional Chinese medicine is used for conditioning, the various Chinese herbs are combined to achieve the effects of promoting the cell neogenesis of the tissue of the affected part, promoting blood circulation to remove blood stasis, removing the necrotic tissue and promoting granulation, avoiding anaphylaxis and promoting the wound surface to heal quickly; besides, the traditional Chinese medicine is simple to prepare, low in cost, suitable for skin ulcer and bedsores, and in particular suitable for treating the gangrene of a diabetic foot; as a result, the amputation rate of a patient can be remarkably reduced.

The invention discloses a Chinese patent medicine for external use, in particular to an externally used Chinese patent medicine used for treating skin ulceration and organism gangrene, belonging to the externally used medicine technology field; the invention is characterized in that the invention is prepared with the following medicine materials by weight portion, cinnabar of 0.5 to 1 portion, ice of 2 to 4 portions, pearl of 7 to 10 portions; the invention has the effects of antisepsis and anti-inflammation, facilitating the growth of tissue and muscle and promoting the regeneration of epidermal cells. The invention is the ideal externally used Chinese patent medicine for curing skin ulceration, in particular to organism gangrene.

The present invention relates to a pharmaceutical composition suitable for topical application to the body and which comprises an antibacterial agent that is dissolved and/or suspended within an oily vehicle. The compositions of the present invention are spontaneously spreadable upon application to a surface of the body. The compositions of the present invention are suitable for the topical treatment of bacterial infections on the skin and/or mucosal surfaces, such as, for example, the topical treatment of Methicillin-resistant Staphylococcus aureus (MRSA), and other complicated skin and skin structure infections (cSSSIs), such as, for example, gangrene.

The present invention relates to, inter alia, methods of treatment and combinations of (R)-2-(7-(4-cyclopentyl-3-(triflu-oromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1) useful for the treatment of extra-intestinal manifestations (EIM) in an individual with inflammatory bowel disease (BBD) and for the treatment of pyoderma gangrenosum (PG). In some embodiments, the methods further comprise administering Compound 1, or a harmaceutically salt, solvate, or hydrate thereof, in combination with a therapeutically effective amount of a compound selected from the group consisting of: a corticosteroid, a 5-ammosalicylic acid derivative, and a TNF-alpha inhibitor; or a corticosteroid, an immunosuppressant, a biologic, an anti-inflammatory agent, and an antibiotic.

The invention discloses an external Chinese medicinal preparation for treating peripheral vascular diseases. The external Chinese medicinal preparation is prepared from the following bulk pharmaceuticals in parts by weight: 3-10 parts of Chinese atractylodes, 9-15 parts of large-leaved gentian, 3-9 parts of sappan wood, 3-9 parts of cortex periplocae, 3-30 parts of rhubarb, 6-12 parts of Chinese angelica, 3-9 parts of tree peony bark, 3-9 parts of safflower, 3-15 parts of myrrh, 3-9 parts of willowleaf swallowwort rhizome and 3-9 parts of pseudo-ginseng root. As proved by clinical application, the external Chinese medicinal preparation for treating peripheral vascular diseases disclosed by the invention has a wide application range, can be applied to thromboangiitis obliterans, arteriosclerosis obliterans, deep venous thrombosis, superficial thrombophlebitis, Raynaud's gangrene and the like, and has the advantages of quick response, good curative effect, convenience in using, and the like.

The invention especially relates to a bacteriostatic solution for skin repair, belonging to the field of Chinese herbal preparations. A recipe for the bacteriostatic solution comprises, by volume, 0.3to 0.5% of matrine, 0.5% of pearl powder, 0.1 to 0.5% of the extract of pseudo-ginseng, 0.1 to 0.5% of the extract of common bletilla tubers, 0.2 to 0.5% of the extract of saffron, 0.1 to 0.4% of synthetic musk and 0.3% of purified water, with the balance being pure water. The bacteriostatic solution provided by the invention can effectively inhibit Staphylococcus aureus, Escherichia coli and Candida albicans, is capable of removing necrotic tissue and promoting granulation, enables wounds caused by skin ulcer to rapidly heal, effectively alleviates pain resulting from trauma, burns, scalds and diabetic foot gangrene, and allows wounds to rapidly heal and incrust and new skin to be formed; and during dressing changing, gauze adhered onto wounds does not need to replace, new gauze having been soaked in the bacteriostatic solution directly covers original gauze, so pain and further damage to the wounds caused by peeling of the original gauze are avoided.

The invention discloses firstly non-coding RNA for treating delayed healing of diabetic wounds and diabetes-related complications and application of the non-coding RNA. Upon animal experiments, the non-coding RNA disclosed by the invention is proved to be effective on promoting healing of diabetic wounds, and the non-coding RNA is of great significance for the treatment of delayed healing of wounds in patients of diabetes and for the treatment of ulcer, erosion, gangrene and diabetic foot caused by the diabetes.

The present disclosure is related to a method of managing diabetic foot ulcers (DFUs), pressure ulcers, venous leg ulcers and associated complications such as bacterial infection, gangrene, tissue necrosis, amputation, proximal limb loss and septicaemia. This method of managing is by administration of pharmaceutical composition comprising pentameric type A procyanidin, trimeric procyanidin and tetrameric procyanidin, optionally along with pharmaceutically acceptable excipient.

The invention discloses a traditional Chinese medicine for treating diabetic acromelic gangrene, belonging to the field of traditional Chinese medicines for treating surgery diseases. The invention has good effect and takes effect quickly. The traditional Chinese medicine for treating diabetic acromelic gangrene is prepared from raw materials of caulis tinosporae, pseudo-ginseng, angelica, lucid ganoderma and the like. The traditional Chinese medicine for treating diabetic acromelic gangrene has the functions of supporting the healthy energy, replenishing qi and blood, activating blood circulation and dissipating blood stasis, clearing away heat and promoting diuresis, stimulating the circulation of the blood and causing the muscles and joints to relax; and the invention has the advantages of remarkable effect, exact effect of medicine and fast effect taking.

Compositions and methods for treating skin conditions, ailments or diseases, such as autoinflammatory skin diseases such as psoriasis, dermatitis, pyoderma gangrenosum, palmoplantar pustulosis, prurigo nodularis and/or hidradenitis suppurativa, are described. The compositions comprise an agent that modulates the aryl hydrocarbon receptor, in particular an agent that agonizes the receptor. In one embodiment, the agent is indigo or a derivative of indigo, such as indirubin.