5 results about "Gangrene" patented technology

The utility model discloses a minimally invasive incision protection device for cardiothoracic surgery, which belongs to the technical field of cardiothoracic surgery postoperative recovery, and comprises a silica gel ring which is pasted on the surface of skin and is used for fixing drug delivery cotton, and a protection shell which forms a closed space with the surface of the skin to protect an incision is arranged at the top of the silica gel ring. An air cavity communicated with the closed space is formed in the top of the protective shell; cooling liquid is arranged in the cooling cavity, the cooling cavity is arranged in a circumferential array, a cooling pipe is arranged in the cooling cavity, an air inlet and an air outlet of the cooling pipe are communicated with the air cavity and the closed space respectively, and the air outlet of the cooling pipe is located at the bottom of the closed space and faces the medicine feeding cotton. By means of the protective shell, the cooling pipe, the air cavity and the cooling cavity, ventilation and heat dissipation can be conducted on an incision, skin surface ulceration caused by non-ventilation at the incision is effectively avoided, and meanwhile bacteria in the external environment can be effectively prevented from infecting a wound in an internal circulation ventilation mode.

The invention relates to an indole derivative shown in general formula (I-1) and its use in preparing drugs for preventing and / or treating indications of S1P receptor related disorders. The indole derivative of the invention is replaced by R1, R2, R5, and R6 at different sites respectively, and the obtained modified indole derivative has excellent biological activity and is an ideal S1P receptor regulator with high efficiency. Compounds of general formula (I-1) can be used to treat and / or prevent Crohn's disease, ulcerative colitis, psoriasis, rheumatoid arthritis, multiple sclerosis, atopic dermatitis, eosinophilic esophagitis, alopecia areata, primary cholangitis, pyoderma gangrenosum, graft-versus-host disease, amyotrophic lateral sclerosis, systemic lupus erythematosus, type I diabetes arteriosclerosis, atherosclerosis, scleroderma, autoimmune hepatitis, acne, microbial infection, viral infection, and other autoimmune and inflammatory diseases.

The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a traditional Chinese medicine herbal composition for preventing and treating diabetic complications and a preparation method thereof. The traditional Chinese medicine herbal composition is prepared from folium mori, radix astragali, radix rehmanniae, radix polygonati officinalis, radix ophiopogonis, rhizoma dioscoreae, poria cocos, radix puerariae, opuntia ficus-indica, inulin, rumex hanus, American ginseng and rhizoma curcumae longae. The traditional Chinese medicinal materials are combined to clean sugar scale micro-crystals in blood vessel microcirculation, improve the functions of liver and pancreas islet, regulate the blood sugar level and enhance the anti-oxidation and self-healing capability of a body, so that the blood sugar is stabilized; the occurrence of diabetic complications such as fundus retinopathy, neuropathy, hypertension, cerebral infarction, myocardial infarction, uremia and gangrene is prevented and controlled. Besides, the traditional Chinese medicine composition is a pure herbal traditional Chinese medicine formula, is high in safety and exact in curative effect, and has a wide application prospect in the field of prevention and treatment of diabetic complications.

The invention relates to traditional Chinese medicine formula granules for treating gangrene and a preparation method thereof, and belongs to the field of traditional Chinese medicine preparations. The traditional Chinese medicine formula granules for treating gangrene are mainly prepared from the following components in parts by weight: 8-15 parts of peach kernels, 5-10 parts of rheum officinale, 5-10 parts of cassia twigs, 5-10 parts of liquorice, 10-20 parts of poria cocos, 8-15 parts of rhizoma alismatis, 10-15 parts of angelica sinensis and 10-20 parts of salvia miltiorrhiza. The traditional Chinese medicine formula granules have the effects of breaking blood, removing blood stasis, promoting blood circulation and dredging collaterals. The traditional Chinese medicine is mainly used for treating damp-heat toxin exuberance syndrome, blood accumulation syndrome and the like of diabetic foot (gangrene) clinically, and has a remarkable effect.

The present invention relates to a process of purifying a protein. Specifically, the present invention relates to a process of purification of a polyclonal antibody and / or antibody fragments. The present invention employs an adsorptive separation using anion exchange chromatography and cation exchange chromatography along with ultrafiltration and diafiltration to achieve high-purity antibody / or antibody fragments. The process provided in the present invention is applicable for polyclonal antibody and / or antibody fragments, which are associated with conditions but not limited to snake envenomation, scorpion envenomation, diphtheria infection, tetanus infection, rabies virus infection and gas gangrene infection due to Clostridium species.