18 results about "Gangrene" patented technology

The utility model discloses a minimally invasive incision protection device for cardiothoracic surgery, which belongs to the technical field of cardiothoracic surgery postoperative recovery, and comprises a silica gel ring which is pasted on the surface of skin and is used for fixing drug delivery cotton, and a protection shell which forms a closed space with the surface of the skin to protect an incision is arranged at the top of the silica gel ring. An air cavity communicated with the closed space is formed in the top of the protective shell; cooling liquid is arranged in the cooling cavity, the cooling cavity is arranged in a circumferential array, a cooling pipe is arranged in the cooling cavity, an air inlet and an air outlet of the cooling pipe are communicated with the air cavity and the closed space respectively, and the air outlet of the cooling pipe is located at the bottom of the closed space and faces the medicine feeding cotton. By means of the protective shell, the cooling pipe, the air cavity and the cooling cavity, ventilation and heat dissipation can be conducted on an incision, skin surface ulceration caused by non-ventilation at the incision is effectively avoided, and meanwhile bacteria in the external environment can be effectively prevented from infecting a wound in an internal circulation ventilation mode.

This invention discloses a traditional Chinese medicine composition and its application for clearing blood vessels, dissolving blood spots, regulating the five internal organs, and preventing and treating arteriosclerosis and its associated coronary heart disease, hypertension, hyperlipidemia, hyperglycemia, hyperuricemia, and diabetic gangrene. It belongs to the field of traditional Chinese medicine composition technology. The preparation method of the traditional Chinese medicine composition is as follows: (1) treating *Salvia miltiorrhiza*, *Polygonatum sibiricum*, and *Polygonum multiflorum* with alcohol using ultrasound to obtain an alcohol extract and residue; (2) extracting *Lycium barbarum*, *Epimedium brevicornu*, *Ligustrum lucidum*, *Angelica sinensis*, *Cuscuta chinensis*, *Astragalus membranaceus*, *Crataegus pinnatifida*, *Ziziphus jujuba*, *Chrysanthemum morifolium*, and *Lycium chinense* with water to obtain an aqueous extract; (3) mixing the residue and aqueous extract and enzymatically hydrolyzing to obtain an enzymatic hydrolysate; (4) mixing the alcohol extract and enzymatic hydrolysate and drying. The enzymes are yeast extractase, cellulase, and bromelain in a mass ratio of 0.5-1:1:0.1-0.3. Compared with existing technologies, this invention can improve microcirculation disorders and can be used to prevent and treat various diseases caused by microvascular circulation disorders.

The utility model belongs to the technical field of dressing change beds, and particularly relates to a dressing change bed for a wound of a gangrene patient, which comprises a bottom plate and a collecting box, dressing change structures are arranged on two sides of the bottom plate, and each dressing change structure comprises an adjusting mechanism and a moving mechanism. The adjusting mechanism comprises a bearing plate, a first moving plate, an electric telescopic rod, an upper body supporting plate and a second moving plate, and the inner side of the bearing plate is in sliding connection with the two ends of the first moving plate. According to the dressing change bed for the wound of the gangrene patient, the height of the upper body supporting plate and the height of the lower body supporting plate can be rapidly and conveniently adjusted, and the problems that due to the fact that the upper body supporting plate and the lower body supporting plate are fixedly connected with each other, the length between the upper body supporting plate and the lower body supporting plate cannot be adjusted, and consequently the too high patient cannot lie flat; the problem that some patients need to be lifted to the bed by medical staff due to the fact that the heights of the upper body supporting plate and the lower body supporting plate are fixed is solved, and the working efficiency of the dressing change bed is improved.

The invention provides an evaluation method and device for diabetic foot ulcers, a storage medium and equipment, and relates to the technical field of smart medical treatment.The method comprises the steps that foot image data to be processed are acquired; carrying out segmentation identification processing on the foot image data by using a pre-trained image segmentation processing model, and determining wound feature information representing a diabetic foot ulcer condition in the image; evaluating the grade of the diabetic foot ulcer based on the wound feature information, and outputting an evaluation result; wherein the types of the wound feature information comprise a wound area, granulation tissue, necrotic tissue, tendon, bone tissue, gangrene and a periinvasive red and swollen area. By applying the method provided by the invention, an auxiliary basis can be effectively provided for referral evaluation of the DFU patient, and the problem of medical treatment delay is avoided.

The present application relates to the fields of ozone medicine and hydrogen medicine and their interactive applications, and specifically discloses an oxidation and antioxidant medical system. The oxidation and antioxidant medical system includes ozone and hydrogen-rich hemodialysis treatment water generation and supply equipment, oxidation and antioxidant saline generation equipment, oxidation and antioxidant intestinal flora reconstruction and fecal bacteria transplantation equipment, oxidation and antioxidant gynecological treatment equipment, oxidation and antioxidant burn and scald infiltration treatment equipment, and oxidation and antioxidant hemodialysis treatment equipment. The system generates ozone dialysis water and hydrogen-rich dialysis water by electrolyzing dialysis water in a dedicated electrolytic cell, and further configures it into ozone and hydrogen-rich dialysis saline. It can be applied to intestinal flora for intestinal flora reconstruction and fecal bacteria transplantation, and is applied to the treatment of gynecological diseases and infiltration rehabilitation treatment of patients with burns and scalds, cleaning treatment of difficult-to-heal tissues, treatment of gangrene, treatment of oral inflammation, and treatment of skin infections and skin diseases caused by fungi and bacteria.

The invention relates to an indole derivative shown in general formula (I-1) and its use in preparing drugs for preventing and / or treating indications of S1P receptor related disorders. The indole derivative of the invention is replaced by R1, R2, R5, and R6 at different sites respectively, and the obtained modified indole derivative has excellent biological activity and is an ideal S1P receptor regulator with high efficiency. Compounds of general formula (I-1) can be used to treat and / or prevent Crohn's disease, ulcerative colitis, psoriasis, rheumatoid arthritis, multiple sclerosis, atopic dermatitis, eosinophilic esophagitis, alopecia areata, primary cholangitis, pyoderma gangrenosum, graft-versus-host disease, amyotrophic lateral sclerosis, systemic lupus erythematosus, type I diabetes arteriosclerosis, atherosclerosis, scleroderma, autoimmune hepatitis, acne, microbial infection, viral infection, and other autoimmune and inflammatory diseases.

The invention discloses an intelligent protection and treatment integrated protection device suitable for lower limb gangrene, and relates to the technical field of medical instruments. The device comprises a protection cover, a pressure adjusting assembly is fixedly connected to the bottom of an inner cavity of the protection cover, an infrared treatment mechanism is fixedly connected to the surface of the protection cover, a contact layer is arranged on the inner wall of the protection cover and located on the outer layer of the pressure adjusting assembly, and a control module is fixedly connected to one side of the surface of the protection cover. The pressure regulation assembly includes an array of airbags. The air bag array and the micro air pump are matched with the pressure sensor to work, the pressure sensor monitors the limb contact pressure in real time, when the pressure reaches 40 mmHg, the micro air pump automatically controls the air bag array to be inflated and deflated, local pressure distribution is dynamically adjusted, the ischemic area is reduced, the pressure sore risk is effectively reduced, and a good pressure environment is provided for wound healing; blood circulation is promoted, and tissue repair is facilitated.

The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a traditional Chinese medicine herbal composition for preventing and treating diabetic complications and a preparation method thereof. The traditional Chinese medicine herbal composition is prepared from folium mori, radix astragali, radix rehmanniae, radix polygonati officinalis, radix ophiopogonis, rhizoma dioscoreae, poria cocos, radix puerariae, opuntia ficus-indica, inulin, rumex hanus, American ginseng and rhizoma curcumae longae. The traditional Chinese medicinal materials are combined to clean sugar scale micro-crystals in blood vessel microcirculation, improve the functions of liver and pancreas islet, regulate the blood sugar level and enhance the anti-oxidation and self-healing capability of a body, so that the blood sugar is stabilized; the occurrence of diabetic complications such as fundus retinopathy, neuropathy, hypertension, cerebral infarction, myocardial infarction, uremia and gangrene is prevented and controlled. Besides, the traditional Chinese medicine composition is a pure herbal traditional Chinese medicine formula, is high in safety and exact in curative effect, and has a wide application prospect in the field of prevention and treatment of diabetic complications.

The invention discloses application of isofulvic alcohol in preparation of a medicine for preventing and treating clostridium perfringens infection, and belongs to the field of biological medicine. A clostridium perfringens sliding motion inhibition test, a biofilm formation inhibition test, a growth curve test and a mouse gas gangrene model treatment test prove that the isofulvic alcohol can obviously inhibit the function of clostridium perfringens IV type fimbriae (TFP) and has no bactericidal or antibacterial activity on clostridium perfringens. An in-vivo infection model treatment test shows that the isofulvic alcohol has a good prevention and treatment effect on the clostridium perfringens gas gangrene of mice. The invention provides a theoretical basis for using the isofulvic alcohol to prevent and treat the clostridium perfringens infection, increases the selectivity of the medicine for preventing and treating the clostridium perfringens infection, has a wide application prospect, and is of great significance to the development of new medicines.

The present invention provides methods and compositions for treating an inflammatory or autoimmune disorder selected from the group consisting of Sjogren's syndrome, neutrophilic eccrine hydradenitis, vitiligo, lichen planus, ophthalmic inflammation, acne, alopecia areata, Sweet syndrome, pyoderma gangrenosum, epidermolysis, and pustular psoriasis. In certain embodiments, the invention provides methods for treating one of the foregoing disorders in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of Compound 1, (I) or a pharmaceutically acceptable salt thereof. In certain embodiments, the present invention provides Compound 1 for use in treating one of the foregoing disorders.

The invention relates to traditional Chinese medicine formula granules for treating gangrene and a preparation method thereof, and belongs to the field of traditional Chinese medicine preparations. The traditional Chinese medicine formula granules for treating gangrene are mainly prepared from the following components in parts by weight: 8-15 parts of peach kernels, 5-10 parts of rheum officinale, 5-10 parts of cassia twigs, 5-10 parts of liquorice, 10-20 parts of poria cocos, 8-15 parts of rhizoma alismatis, 10-15 parts of angelica sinensis and 10-20 parts of salvia miltiorrhiza. The traditional Chinese medicine formula granules have the effects of breaking blood, removing blood stasis, promoting blood circulation and dredging collaterals. The traditional Chinese medicine is mainly used for treating damp-heat toxin exuberance syndrome, blood accumulation syndrome and the like of diabetic foot (gangrene) clinically, and has a remarkable effect.

The utility model discloses a limb exercise device for a diabetic patient, and relates to the technical field of medical instruments. Comprising a bottom plate, a soft cushion, handrails, hand-muscle developers, a leg exerciser and a foot massager, the soft cushion is arranged on the bottom plate, the handrails are arranged on the two sides of the middle of the bottom plate, the hand-muscle developers facilitating hand exercise are arranged on the handrails, and the leg exerciser and the foot massager are arranged at one end of the bottom plate. The limb exercising device is reasonable in structural design, convenient and reliable to operate and capable of effectively exercising the limbs of a diabetes patient, the phenomenon that the hands and feet of the patient suffer from gangrene complications is avoided, and then the pain of the patient is relieved.

The invention relates to a foldable ASO gangrene nursing supporting bracket which comprises a rotary supporting structure (1), a cross brace (2) and a supporting pad (3). The cross brace (2) and the supporting pad (3) are arranged between the two parallel rotary supporting structures (1); each rotary supporting structure (1) comprises a rotary joint (11) and two supporting connecting rods (12), the two supporting connecting rods (12) are connected through the rotary joint (11), and angle adjustment is achieved. Compared with the prior art, the device has the advantages of simple structure, convenience in adjustment and the like.

The invention discloses a traditional Chinese medicine composition for treating diabetic gangrene. The traditional Chinese medicine composition comprises the following components: 4-8 parts of gypsum, 0.1-2 parts of pearl, 0.1-2 parts of borneol, 0.1-2 parts of calomel and 8-12 parts of dragon's blood. The preparation method comprises the following steps: (1) weighing the raw gypsum, the pearls, the borneol flakes, the calomel and the dragon's blood in parts by weight; the preparation method comprises the following steps: 1) preparing raw materials, 2) mixing the raw materials, grinding, and sieving the obtained powder mixture to obtain a traditional Chinese medicinal material powder mixture, and 3) fully and uniformly mixing and packaging the obtained traditional Chinese medicinal material powder to obtain two dosage forms of traditional Chinese medicinal preparations which are flexibly used for wounds of various diabetic patients and can quickly remove necrotic tissue and promote granulation until the wounds are completely healed.

The utility model discloses an auxiliary disinfection device for upper limb gas gangrene, which comprises a pair of lifting brackets, a liquid injection barrel with a liquid injection pump is arranged on one lifting bracket, and a liquid storage barrel with a liquid collecting pipe is arranged on the other lifting bracket; arc-shaped supporting plates are arranged at the lifting ends of the two lifting brackets, an arm support is erected between the two arc-shaped supporting plates, a waterproof cover covers the outer side of the arm support, one end of the waterproof cover is a sealed end, the other end of the waterproof cover is an open end with an elastic band, and a liquid drainage pipe is arranged on the lower surface, close to the open end, of the waterproof cover; a washing ring and a traction unit are arranged on the arm support, a spraying pipe is arranged on the washing ring, and spraying openings are evenly distributed in the inner ring face of the washing ring. The device has the advantages that debridement and flushing of a patient suffering from the upper limb gas gangrene can be completed in the waterproof cover as far as possible, pollution caused by waste liquid splashing is effectively prevented, clostridium is prevented from infecting other limbs of the patient or infecting other people around, and the safety of debridement and flushing of the upper limb gas gangrene is improved.

The present invention relates to a process of purifying a protein. Specifically, the present invention relates to a process of purification of a polyclonal antibody and / or antibody fragments. The present invention employs an adsorptive separation using anion exchange chromatography and cation exchange chromatography along with ultrafiltration and diafiltration to achieve high-purity antibody / or antibody fragments. The process provided in the present invention is applicable for polyclonal antibody and / or antibody fragments, which are associated with conditions but not limited to snake envenomation, scorpion envenomation, diphtheria infection, tetanus infection, rabies virus infection and gas gangrene infection due to Clostridium species.

The utility model provides a multifunctional nursing trousers for patients with arteriovenous ulcers of the lower limbs. Several Velcro strips arranged at intervals are arranged in sequence from top to bottom on the end surface of the main body of the patient's trousers. A symmetrically arranged zipper is arranged at the corresponding position of the front of the main body of the patient's trousers and the abdominal groove. One end of any zipper is located on the side close to the center of the waist, and the other end of any zipper is located on the side away from the placket. A zipper head is arranged on any zipper. The utility model adopts a zipper structure at the front end of the main body of the patient's trousers, which can partially open the groin area of ​​the patient's trousers, solving the problem that when conventional patient trousers in hospitals are put on and taken off, they often rub against the patient's gangrenous limbs, causing the patient's pain to increase or even become infected; it is convenient for nurses to check the patient's coccyx skin, and it is also convenient for doctors to change the dressing of the femoral artery / vein puncture / incision wound after surgery. It is also convenient for patients who undergo arteriovenous catheterization and thrombolysis to fix the catheter after surgery and check the catheter status in time.

The invention belongs to the field of bioengineering, and particularly relates to a clostridium gangrene subunit protein as well as a preparation method and application thereof. The subunit protein of clostridium gangrene provided by the invention is a protein formed by artificially designing, combining, recombining, expressing and optimizing according to main core antigenic fragment sequences of various main immunogenic proteins of clostridium gangrene, such as cytotoxin CctA, flagellin FliA, cell wall surface anchoring protein and the like; when the protein is used as an antigen to prepare the clostridium gangrene subunit vaccine, the clostridium gangrene subunit vaccine can effectively resist the infection of clostridium gangrene, the safety and effectiveness of the vaccine can be ensured to the greatest extent, the preparation process is simplified, and the production cost is reduced.