58 results about "Skeletal tissue" patented technology

The invention discloses a knee prosthesis implantation method, an osteotomy module for usage and a using device, the knee prosthesis implantation method comprises the following steps of measuring the data of knee joint bone tissues, extracting the data of articular cartilage and the skeleton profile, establishing a three-dimensional model in an image processor, designing the osteotomy module, determining the size and the type of the used knee prosthesis and determining an osteotomy module model and the implantation of the knee prosthesis. The knee prosthesis implantation method of the invention can reduce the trauma of a patient, lower the cost, shorten the implantation time, reduce the risk of complications of a user of the knee prosthesis and have comparatively small error and higher precision.

A polymer material capable of gradient degradation. The polymer material is formed by at least two types of aliphatic polyesters having different degradation velocities, the aliphatic polyesters being arranged in an ascending order or descending order of the degradation velocities and fused together. The polymer material may be manufactured as thread materials, barrier materials, tube materials, and controlled drug release carriers, which specifically comprise sutures, medical dressings, adhesion prevention material, hemostasis material, guided tissue regeneration barriers, tissue repair materials, enhancement surgical meshes, drug carriers, cartilage tissue culture scaffolds, scaffolds, and especially urethral scaffolds.

The invention provides novel compositions of hydroxyapatite and block co-polymers, methods of their preparation, and uses thereof, wherein the co-polymers have degradable hydrophobic blocks and hydrophilic blocks for stable interfacing with hydroxyapatite, resulting in stable polymer-hydroxyapatite suspensions. The super-hydrophilicity, strengthened mechanical integrity, and retained structural integrity of the HA-PELA composite in aqueous environment represent major advantages over the HA-PLA composites for skeletal tissue engineering applications.

A method for fusing spinal bone is provided. The method comprises placing a sac between two or more adjacent sections of the spine to be fused, inserting a cage into the sac, and filling the sac with bone tissue. The surfaces of the sac abutting the sections of the spine comprise porous material for allowing bone to grow between the spine and the sac. Surfaces of the sac not abutting the sections of the spine are nonporous to bodily fluids and thereby prevent premature deterioration of the bone tissue inside the sac. The cage maintains the sac in an expanded state upon filling. A kit comprising the sac and cage is also provided. In other embodiments of the invention, the method comprises placing an inner sac inside the inventive sac and filling the sacs with bone tissue for fusion of spinal bone.

The invention discloses a tissue engineering cartilage stent and a method for preparing the same. The method includes a step A, extracting II-type collagen; a step B, preparing a primary CII-HA-CS-HAP three-dimensional cartilage stent by the aid of the II-type collagen, hyaluronic acid, chondroitin sulfate and hydroxyapatite; a step C, crosslinking the primary CII-HA-CS-HAP three-dimensional cartilage stent by the aid of an EDC/NHS system and freezing and drying the CII-HA-HAP three-dimensional cartilage stent to obtain the CII-HA-CS-HAP three-dimensional tissue engineering cartilage stent. The tissue engineering cartilage stent and the method have the advantages that the tissue engineering cartilage stent is excellent in biocompatibility, low in toxicity and easy to degrade, and degradation products are nontoxic; the tissue engineering cartilage stent is compact in appearance, and various performance parameters are adaptive to repairing cartilage tissues of human bodies; the constructed tissue engineering cartilage stent is made of wide material sources and easy to shape, and can be used for repairing wide-area wound, and the like.

The invention discloses a bacterial cellulose/collagen/hydroxyapatite composite material and a preparation method thereof. In the method, the capillary force of internal pores and an ultrasonic-assisted collagen molecule diffusion method are adopted, a bacterial cellulose dry film, collagen, procyanidine, CaCl2 and simulated body fluid are taken as raw materials, and the mass ratio of the bacterial cellulose dry film to the collagen to the procyanidine to CaCl2 is (10-200):(1-50):(4-6):(6-10); the collagen is uniformly distributed in the network structure of the bacterial cellulose in an irregular shape, and the obtained compound is prepared into the bacterial cellulose/collagen/hydroxyapatite composite material by adopting a biomimetic mineralization method. The composite material disclosed by the invention has superior mechanical property and a unique three-dimensional nano-network structure, is more similar to human skeletal tissues on the aspects of structure and component, and is expected to meet the application requirement of a skeletal tissue engineering stent material.

The invention discloses a method for correcting CT ray beam hardening artifact. The method compensates an original image based on X-ray energy spectrum analysis to eliminate hardening artifacts of X-ray beams; that is, according to the known scanning conditions, the energy spectrum distribution of X-rays is obtained and the equivalent energy is calculated. Then, scanning is carried out, the original image is reconstructed according to the image building conditions, the original image is divided into soft tissue, bone tissue and air parts, and energy spectrum projection and equivalent energy projection are carried out on different parts respectively; the difference between the equivalent energy projection and the energy spectrum projection is calculated; the projection difference is backprojected to obtain a compensation image, and the compensation image and the original image are added to obtain a target image corrected by beam hardening artifacts.

An interactive segmentation framework for 3-D teeth CT volumetric data enables a user to segment an entire dental region or individual teeth depending upon the types of user input. Graph cuts-based interactive segmentation utilizes a user's scribbles which are collected on several 2-D representative CT slices and are expanded on those slices. Then, a 3-D distance transform is applied to the entire CT volume based on the expanded scribbles. Bony tissue enhancement is added before feeding 3-D CT raw image data into the graph cuts pipeline. The segmented teeth area is able to be directly utilized to reconstruct a 3-D virtual teeth model.

The invention discloses a cartilage tissue cutting and cell separating and extracting integrated device. The device comprises a device shell, a crushing assembly and a separating and extracting assembly are sequentially arranged on the device shell from top to bottom, the crushing assembly comprises a crushing barrel, a crushing assembly body is arranged in the crushing barrel, and a plurality ofbutt-joint sinking grooves are formed in the lower bottom surface of the crushing barrel in the circumferential direction; and the separating and extracting assembly comprises centrifugal barrels anda lifting ring, the lifting ring is connected with the inner wall of the lower part of the device shell through a plurality of groups of lifting motors, the number of the centrifugal barrels is the same as that of the butt-joint sinking grooves, the two sides of each centrifugal barrel are connected with the fracture of the lifting ring through a rotating motor, and butt-joint clamping covers forbutt joint with the butt-joint sinking grooves are arranged at the upper end and the lower end of each centrifugal barrel correspondingly. The cartilage tissue cutting and cell separating and extracting integrated device can carry out integrated automatic cartilage tissue cutting and centrifugal separation treatment, and improves the working efficiency of cartilage tissue cutting and cell separation and extraction.

The invention discloses a combined-type soft tissue horizontal dental implant which comprises a base of the dental implant, an implant root and a fixing screw which connects the base with the implant root. An outer thread is arranged at the implant root, and the surfaces of dental sides of one or more sides of the outer thread are rough surfaces. By means of the combined-type soft tissue horizontal dental implant, 'synostosis' between the dental implant root and the surrounding bone tissue is more facilitated, and meanwhile the phenomenon of spin of the implant under the action of external force can be hindered.

The invention relates to the field of medical titanium alloys, in particular to a medical titanium alloy special for a narrow-diameter high-strength implant capable of being immediately implanted anda preparation method of the medical titanium alloy. The medical titanium alloy is prepared from, by weight percent, 14%-17% of Zr, 3.0%-10% of Cu and the balance Ti. The preparation method of the medical titanium alloy comprises the steps that after cogging and forging and before rolling, heat preservation is carried out for 0.5-6 hours at the temperature of 900 DEG C to 1200 DEG C, and water cooling is carried out to reach the room temperature; and rolling is carried out at the temperature of 720 DEG C to 850 DEG C, the strain rate is larger than 0.1 s<1>, and a bar obtained after rolling iscarried out is used for subsequent implant processing. According to the medical titanium alloy special for the narrow-diameter high-strength implant capable of being immediately implanted, immediate planting can be achieved without any surface treatment, and firm combination of the implant and bone tissue is achieved. According to the preparation method of the medical titanium alloy, the implant narrow in diameter (3.0-3.5 mm) can be prepared and is high in strength, and the aim of firm implanting on the narrow edentulous gum is achieved.

The present invention provides novel acyl, sulfur, carbamate, thiocarbamate, and related compounds that inhibit cytokine-mediated inflammatory responses in cultured cells and improve bone tissue in animal models of arthritis disrupts, and lowers blood glucose levels in animal models of type 2 diabetes. The present invention discloses that the compound can be used in various treatments, including the treatment of diabetes, insulin resistance, inflammation, inflammatory diseases, immune diseases, and cancer.

The invention discloses a modified bamboo fiber enhanced chitosan-based porous material and a preparation method thereof. The porous material is prepared by ultrasonically stirring modified bamboo fibers and a compound of chitosan and inorganic particles in an aqueous solution, then performing uniform mixing, then adding a small amount of glacial acetic acid to obtain a compound gel substance, putting the compound gel substance in a culture dish, pre-cooling the compound gel substance and then performing lyophilization. Because carboxyl with the surface-modified bamboo fibers and cations of chitosan acidic solutions have a strong ionic crosslinking effect, compared with a porous material with non-modified bamboo fibers or without the bamboo fibers, the porous material disclosed by the invention has the advantage that the mechanical performance and the degradation performance are greatly improved. The novel porous material disclosed by the invention has the advantages that the used rawmaterials are rich in sources, and the preparation method is simple; and through content of the components of the porous material, the mechanical performance, the degradation performance, the osteoconductivity and the antibacterial performance of the porous material are regulated and controlled, and the porous material is expected to be used as a bone tissue engineering scaffold material.

A surgical system includes a first implant support that is engageable with a receiver of a first fastener having a shaft fixed with vertebral tissue. At least one adaptor includes a first adaptor extending longitudinally along and being engageable with the first implant support. The first adaptor is oriented to releasably engage a surgical instrument to distract and/or compress the vertebral tissue. An angulation module is connected to at least one of the first adaptor, the first implant support and the surgical instrument. Surgical instruments, constructs, implants and methods are disclosed.

The invention discloses a titanium-based functional material with an aperture gradient structure and a preparation method and application. The method comprises the steps that firstly, a pure titanium or titanium alloy matrix plate is prepared through a selective laser melting technology, then holes are drilled in the plate and filled with pure aluminum powder, then a friction stir method is adopted for machining, the aluminum powder and a friction stir machining area are fully mixed, finally, acid washing or alkali washing treatment is conducted on the aluminum powder to remove aluminum particle clusters and form a porous structure, and accordingly, the titanium-based functional graded material of which the surface and a matrix have aperture gradient is obtained. By means of the friction stir machining technology, alloy grains can be refined, the porosity of the material is reduced, and the comprehensive performance of the material is improved. The material is of a rough porous structure, the aperture of the surface layer is inconsistent with the aperture of the matrix, the growth requirements of different cells can be met, bone tissue can grow towards an implant easily, and the material has very good clinical application value. The preparation process is simple, low in cost and beneficial to market promotion.

The invention discloses a surface modification treatment method for a titanium metal implant material. According to the method, titanium metal is subjected to reduction treatment to obtain the surface characteristic rich in surface oxygen vacancies, so that the osseointegration capacity of the titanium metal and a matrix is promoted. According to the titanium metal surface rich in oxygen vacancies, the proportion of the oxygen vacancies is 5% to 40%. The prepared titanium metal rich in oxygen vacancies on the surface has the excellent capability of accelerating osseointegration of an implant and the matrix. The adopted treatment and preparation method is simple, high in controllability and suitable for industrial preparation and treatment of bone tissue repair titanium metal materials for biomedicine.

The invention relates to the technical field of Mo alloys, in particular to a Mo-Re-T series alloy as well as a preparation method and application thereof. The Mo-Re-T series alloy comprises Re, Mo and inevitable impurities as well as further comprises T, wherein the content of T is less than that of Mo; and T is selected from at least one element of K, Al, Si, Mn, Ga, Ge, Sr, Ru, Rh, Cd, In, Sn, Ag, Ta, W, Au, Cu, Sb, Ba, Ir, Bi or rare earth. The material strength of the Mo-Re-T series alloy is remarkably improved; the mechanical and biological compatibilities between the modulus, the hardness, the abrasion resistance and the fatigue performance of the Mo-Re-T series alloy and bone tissues are better; meanwhile, the Mo-Re-T series alloy has excellent ray impermeability and low magnetic susceptibility; and the accurate tracking during radiography is further facilitated.

The invention discloses a flexible clamping device for orthopedic joint trauma, which comprises a first clamping block and a second clamping block; the first clamping block and the second clamping block are all provided with a hard layer and a flexible layer, and the hard layers are arranged on the outer sides of the flexible layers; the first clamping block and the second clamping block are provided with a connecting mechanism, the connecting mechanism comprises a plurality of fastening pieces, one ends of the fastening pieces are connected with the first clamping block, and the fastening pieces are connected to the hard layer of the first clamping block; a plurality of adjusting holes are formed in the other ends of the fastening pieces; a plurality of threaded holes are formed in the second clamping block and the plurality of threaded holes are correspond to the adjusting holes; the fastening pieces are connected with the threaded holes through bolts. By arranging the flexible layers in the hard layer, slight vibration of the joint cartilage tissue is not completely limited, which conforms to the biomechanical characteristic of human body joint tissue with certain elasticity, damage to the cartilage tissue is small, growth of the cartilage tissue is facilitated, and the postoperative recovery efficiency is improved.

Disclosed herein are materials and methods suitable for treating injured, damaged or diseased mineralized and non-mineralized skeletal tissues, including bones, joints, tendons, ligaments, cartilage and/or other non-mineralized skeletal tissues. The affected structure can be treated by contacting a surface of the skeletal element at or adjacent to or in the vicinity of an area of injury, damage or disease with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected structure. A composition comprising a biocompatible matrix and cells engrafted therein or thereon can be used to treat the affected structure. The composition can be a flexible planar material or a flowable composition.

The invention relates to a method for promoting cartilage repair based on tissue engineering cartilage constructed by a co-culture system. The method comprises the following steps: obtaining a small amount of cartilage tissue from a non-weight-bearing area of a knee joint, and separating and culturing primary chondrocytes; separating and culturing umbilical cord mesenchymal stem cells from Wharton's jelly in fresh full-term healthy umbilical cord tissue; performing wet grinding for decellularization by adoption of healthy adult pig knee cartilage tissue, and performing freeze-drying in a vacuum negative pressure environment to obtain an acellular cartilage extracellular matrix oriented scaffold; mixing the primary chondrocytes with the umbilical cord mesenchymal stem cells, planting the cells in a dry scaffold carrier by a cell pendant drop method, performing incubation to construct co-culture tissue, and transplanting the co-culture tissue to full-thickness cartilage defect in the weight-bearing area of the knee joint for articular cartilage repair.

The invention provides novel compositions and methods of surface mineralization for metallic or ceramic implants and devices and the resulting enhancement of properties and performance in skeletal tissue engineering, orthopedic applications and dental care. The novel approach utilizes zwitterionic brushes (e.g., of poly(sulfobetaine methacrylate) or pSBMA) covalently grafted on the surface of titanium or its alloy substrates (e.g., Ti6Al4V) to promote surface-mineralization of hydroxyapatite with enhanced surface mineral coverage and mineral-substrate interfacial adhesion. The zwitterionic surface brushes, capable of attracting both cationic and anionic precursor ions during hydroxyapatite-mineralization, significantly increase the surface mineral coverage and significantly reinforce the attachment of the surface apatite crystals on the titanium alloy substrate which withstood supersonication treatment.

An illuminated translucent endoscopic probe system includes a handle and rigid elongate body for passage into and through hard and/or bony tissue and includes an integrated camera and light source positioned distally from the handle and adjacent a distal tip that includes a transparent driving head. The system provides real time visualization at the distal end as it passes into and through tissue.