38 results about "Skeletal tissue" patented technology

The invention discloses a skeleton tissue subdivision and reconstruction method based on an SAM series model. The method comprises the following steps: converting image data into a format supported by the model; generating an optimized feature map in the convolutional network; performing feature slicing operation on the feature map, calibrating slices and reconstructing the slices into a complete feature map; inputting the feature map into a detection head to generate a candidate box and a confidence score, embedding prompt information into a segmentation decoder, and fusing the prompt information with the feature map to generate a segmentation mask; storing the feature result of the current frame in a memory bank; the prompt information is coded into an embedded mode, and after the prompt information is fused with the feature map, segmentation masks related to the prompt are generated; and formatting the target detection result, adjusting the size of the segmentation mask to be aligned with the input image, and storing the detection and segmentation result as a specified format file. According to the method, the bone tissue can be efficiently segmented, and boundaries can be accurately distinguished under the condition that the upper and lower bones are similar in shape and close in position.

The invention discloses a preparation method of a bionic beetle skeleton implant, and belongs to the field of femoral implantation. The bionic structure characteristics of beetle elytra and cuticle are creatively combined, the mechanical strength and structural stability of the porous nickel-titanium alloy structure implant are effectively improved through the bionic structure design method, and the long-standing stress shielding effect problem of a traditional femoral metal implant is successfully solved; the porous nickel-titanium alloy bionic skeleton structure prepared by adopting a selective laser melting (SLM) technology not only has good mechanical suitability, avoids rejection and shedding reaction with natural bone tissues after implantation, but also can realize a complete shape memory recovery function in a room temperature environment, and has good application prospects in the field of medical orthopedic implantation.

The present invention relates to a cartilage tissue single cell extraction kit and an extraction method thereof, the kit comprises: (1) a first enzyme for enzymatic hydrolysis, the first enzyme for enzymatic hydrolysis comprising one or more of trypsin, chondroitinase ABC and fucosidase; (2) a second enzyme for enzymolysis, wherein the second enzyme for enzymolysis comprises collagenase II, neutral protease II, hyaluronidase and Dnase I; and (3) a basic solution, wherein the basic solution comprises a basic culture medium and / or a buffer solution. The invention also provides a method for extracting single cells from cartilage tissues by using the kit. The cartilage tissue single-cell suspension prepared by the method has the advantages of high cell yield, high activity and the like, and has a wide application prospect.

The invention provides an artificial prosthesis assembly for an ankle joint replacement operation, and belongs to the technical field of ankle joint prostheses. Comprising a talus arc plate, an arc-shaped guide rail is installed at the top of the talus arc plate, rivets are installed in the talus arc plate, a joint soft plate is connected to the top of the arc-shaped guide rail in a sliding mode, and a tibia installation plate is installed above the joint soft plate; and a rivet fixing assembly is mounted at the top of the tibia mounting plate. By arranging the elastic adjusting assembly and the sliding lubricating assembly, the contact area with bone tissue can be remarkably increased, the initial stability of the prosthesis is enhanced, the separation risk of the prosthesis is reduced, and the elastic relaxation degree of the prosthesis is adjusted and controlled, so that the modulus of the prosthesis is dynamically matched with the bone elasticity of a patient, and the bone interface stress concentration risk of the prosthesis is reduced; meanwhile, the movement resistance of the prosthesis is reduced through ball lubrication, material fatigue and loss caused by dry friction between the prostheses are avoided, and the service life of the prosthesis is prolonged.

The present invention discloses an osteosarcoma molecular marker and its application. The osteosarcoma molecular marker is spindle and centriole associated protein 1, the amino acid sequence of which is shown in SEQ ID No: 1. Tissue sequencing revealed that the expression level of spindle and centriole associated protein 1 having the amino acid sequence of SEQ ID No: 1 was significantly higher in osteosarcoma tissue than in normal bone tissue. After knocking down the protein, osteosarcoma proliferation, invasion, and migration were significantly inhibited, and apoptosis was increased. Therefore, the molecular marker can be used as an osteosarcoma marker, playing a role in assisting the diagnosis of osteosarcoma in its early stages, enabling patients to receive timely treatment and preventing the problem of osteosarcoma metastasis.

1. The name of the design product: ultrasonic bone cutter. 2. The use of the design product: installed on the ultrasonic handle, used for cutting bone tissue. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: front view. 5. The rear view is the same as the front view, and the right view is omitted.

The present invention relates to a perforated knee joint, a hole forming method and a forming die. In order to ensure the tight combination of the knee joint implant and the original bone tissue, the present invention adds a threaded hole design to the posterior condylar surface of the knee joint, replacing the conventional rectangular counterbore design. Since the shape of the knee joint metal part is complex and the threaded hole is arranged on the inner wall of the posterior condylar surface, it is easily interfered by the larger anterior condylar surface during machining, which increases the difficulty of processing and manufacturing. The present invention adopts the investment casting method to produce the knee joint metal part.

The invention relates to a mechanical arm ultrasonic grinding and drilling bone grinding mechanical model construction method and device, a medium and equipment, and the method comprises the steps: obtaining an ultrasonic machining motion model of ultrasonic grinding and drilling bone grinding according to the motion process of ultrasonic grinding and drilling grinding; according to the ultrasonic machining motion model, a finite element analysis model of ultrasonic abrasive drill bone grinding is established, and then the bone density, the vibration amplitude of a cylindrical abrasive drill of ultrasonic equipment and the influence rule of the feeding speed on the grinding force are obtained; and according to the finite element analysis model, a mechanical model of ultrasonic bone grinding and drilling is established, and then mathematical characterization among the grinding force, the vibration amplitude and the feeding speed is obtained. According to the mechanical arm ultrasonic grinding, drilling and grinding mechanical model, the dynamic relation among ultrasonic vibration parameters, mechanical arm motion parameters and grinding force can be accurately quantified, the situation that bone tissue is excessively damaged due to the fact that the grinding force is too large or the grinding efficiency is low due to the fact that the grinding force is insufficient is effectively avoided, and the safety of clinical operation is guaranteed.

A method for ultrasound stimulation of musculo-skeletal tissue structures includes generating a plurality of acoustic spatial-temporal modes comprised of a sinusoidal-complex, wherein the sinusoidal-complex has a modulation envelope that enhances spatial-temporal measurement accuracy at a site of a multi-layered biological tissue structure, and a pulse repetition frequency and duty cycle that are osteogenic at the site of the multi-layered biological tissue structure, beam steering the acoustic spatial-temporal modes to the site of the multi-layered biological tissue structure to promote tissue healing, and producing bi-modal stress levels in the multi-layered biological tissue structure that are sufficient to generate bone fracture healing.

The invention belongs to the technical field of passive filling materials for medical instruments, and discloses hydroxyapatite core-spun microspheres for injection filling and a preparation method of the hydroxyapatite core-spun microspheres. The hydroxyapatite core-spun microsphere is composed of inner-layer hydroxyapatite and an outer-layer coating material, the brittleness and roundness of the surface of the hydroxyapatite microsphere can be improved, the inflammatory reaction and granuloma occurrence rate of an injection site can be reduced, more importantly, the risk that the hydroxyapatite microsphere is gathered and fused with surrounding skeleton tissue can be improved, and safety is improved.

The invention relates to the technical field of tissue engineering and regeneration, in particular to a stem cell membrane-stent dynamic co-culture device and a gradient regulation culture process. The stem cell membrane-stent dynamic co-culture device comprises a) a multi-modal mechanical loading module (1), a compression strain unit (2) and a multi-modal mechanical loading module (3), the frequency is adjustable from 0.1 Hz to 2 Hz, the strain amplitude is 5%-15% (the precision is + / -0.5%), and the periodic compression stress of bone tissue can be simulated; (2) a fluid shear force unit: generating 0.1-5Pa laminar shear force (Re < 2000) through a conical flow channel (with a taper angle of 15 degrees) and a peristaltic pump, and simulating a shear microenvironment of a blood vessel or periodontal ligament area; the method has the beneficial effects that multi-modal mechanical synergy is achieved, and the cell differentiation efficiency is remarkably improved through coupling loading of compression and shearing force. Experiments show that the ALP activity reaches 38.2 + / -3.1 U / mg (only 12.5 + / -2.3 U / mg in traditional single-mode stimulation), and the proportion of a CD31 + vascularized region is increased to 41.7 + / -3.8% (plt; 0.01).

The utility model provides a skull plug which comprises a plug body and a plug cap, the plug body is cylindrical, the plug cap is connected with the plug body, the cross section of the plug cap along the center line of the plug cap is arc-shaped, and the diameter of the plug cap is larger than that of the plug body. When the skull plug is plugged into a skull defect position, the plug body is plugged into the defect position so as to be matched with other skull. On one hand, the plug cap covers the whole plug body and makes contact with bone tissue at other positions, the plug body can be prevented from entering the human body skull under the action of external force, and on the other hand, the shape of the plug cap is similar to that of the skull, so that the applicability of the skull plug is improved.

The application discloses an integrally-formed three-dimensional degradable textile structure bone plate and a preparation method thereof. The preparation method is as follows: composite yarns composed of degradable glass fibers and other degradable materials are woven into a preformed body in the shape of a bone plate through three-dimensional weaving, three-dimensional knitting, three-dimensional needle knitting or three-dimensional angle interlocking, and in the weaving process, preformed holes are formed in the preformed body by adding a mold; and then the preformed body is sequentially subjected to heating and solidification and cooling treatment, so that the integrally-formed three-dimensional degradable textile structure bone plate is obtained. The finally-prepared three-dimensional degradable woven bone plate has better plasticity, can better adapt to the shape of a bone, improves the repair effect of the bone plate, has good flexibility and toughness, has better mechanical properties, has higher biocompatibility and degradability, and is suitable for the field of bone tissue repair.

Nanocomposite hydrogels suitable for bone tissue regeneration may include (i) a scaffold comprising serum albumin and a cell adhesion promoter crosslinked with polyethylene glycol and (ii) a nanoparticle dispersed in the scaffold. Said nanocomposite hydrogels may formed from an injectable composition that includes: a nanocomposite hydrogel precursor A comprising that comprises a polyethylene glycol with two or more N-hydroxysuccinimide-terminal groups (PEG-NHS); and a nanocomposite hydrogel precursor B comprising a serum albumin, a nanoparticle, and a cell adhesion promoter; wherein the nanocomposite hydrogel precursor A and the nanocomposite hydrogel precursor B are physically separated.

The present application relates to a kind of extraction kit of cartilage tissue single cell and its extraction method, the kit includes: (1) first enzymolysis enzyme, the first enzymolysis enzyme includes one or more of trypsin, chondroitinase ABC and fucosidase;(2) second enzymolysis enzyme, the second enzymolysis enzyme includes collagenase II, neutral protease II, hyaluronidase and Dnase I;(3) base liquid, the base liquid includes base medium and / or buffer solution.The present application also provides the method for extracting single cell from cartilage tissue using the kit.The cartilage tissue single cell suspension prepared by the present application has the advantages of high cell yield and high activity, and has wide application prospect.

The invention relates to the field of ceramic bulletproof plugboards, in particular to an anti-falling curved surface spliced ceramic bulletproof plugboard and a preparation method thereof. The anti-falling curved surface spliced ceramic bulletproof plugboard comprises a laminated structure and a polyurea layer coating the periphery of the laminated structure, the laminated structure comprises an anti-falling layer, a crack arrest layer, a ceramic layer, a polyethylene layer and a concave reduction foam layer which are sequentially laminated in the direction from the bullet facing surface to the bullet backing surface; the anti-falling layer comprises aramid fiber honeycombs, and hole grids of the aramid fiber honeycombs are filled with a mixture of hollow glass microspheres and silica gel; and the crack arrest layer comprises aramid fiber woven cloth. The anti-falling layer provided by the invention is composed of the aramid fiber honeycomb, the hollow glass microspheres and the silica gel, the structure simulates a human bone tissue structure, the aramid fiber honeycomb provides a structural framework and supports the falling layer not to deform, and the hollow glass microspheres have high compression strength, can resist impact and absorb impact energy through microsphere damage; the silica gel not only can be used for bonding the aramid honeycomb and the microspheres, but also can be used for providing elasticity and restoring the deformation after impact.

The invention relates to the technical field of medical data processing, in particular to a skull repair implant material parameter configuration method and system, and the method comprises the following steps: obtaining the image data of a skull defect area, and determining the boundary information of skull defect based on the image data; according to the boundary information, obtaining physical attribute information of own bones adjacent to the boundary, and based on the physical attribute information, evaluating the bone regeneration capacity of an area adjacent to the boundary; determining skeleton regeneration potential distribution of each position in the skull defect area according to the skeleton regeneration capacity of the area adjacent to the boundary; performing unit division on the skull implant, and obtaining skeleton regeneration potential information corresponding to each unit of the implant according to the skeleton regeneration potential distribution; according to bone regeneration potential distribution of all positions in a skull defect area, material parameters of all units of the implant are finely configured, and precise matching of the degradation rate of the implant and the growth process of new bone tissue is achieved.

The invention discloses a special abrasive drill capable of adapting to different radians of human ankle joints, which comprises an electric drill connecting handle connected with an electric drill, a replaceable file head is arranged on the electric drill connecting handle, and the file head comprises a file head body and bone file teeth arranged on the file head body. The replaceable file head is arranged on the electric drill connecting handle, so that the abrasive drill can be flexibly adjusted according to bone tissues of different parts and shapes, the problem that a tool bit of a traditional fixed structure is prone to slipping is effectively solved, and the positioning precision is improved.

A first waveform comprising a force response of a skeletal tissue undergoing a tetanic contraction during a first time period is obtained. One or more transformed waveforms are generated from the first waveform. The one or more transformed waveforms include at least one transformed waveform which encodes a rate of change of the first waveform over the first time period. Change points are identified within the one or more transformed waveforms. The change points occur at a plurality of time points within the first time period. A kinetic contractility vector is generated from the first waveform based on a comparison of values of the first waveform determined at the plurality of time points. The kinetic contractility vector characterizes the kinetic response of the skeletal tissue over the first time period. An effect is determined based on the kinetic contractility vector.

A perforator for drilling bone tissue has: a drive shaft with a rotational axis A; an inner cutting head with the same rotational axis A; a drive surface provided on the drive shaft; and a connector provided on the inner cutting head. The inner cutting head is displaceable with respect to the drive shaft along the rotational axis between a distal position, in which the inner cutting head is not driveable by the drive shaft, and a proximal position, in which the drive surface abuts the connector to transmit rotational motion from the drive shaft to the inner cutting head. The drive surface is inclined relative to the rotational axis A.

Described are systems. apparatuses. and methods for three-dimensional (3D) printing engineered parts having spatially tunable porosity. Printing ink can include metal / ceramic powders, binder(s), sinterable additive(s), polymer(s), porogen(s), and / or solvent(s). Vapor-based phase separation of the printing material causes at least partial solidification of ink to form a green part. A coagulation bath can be used to complete solidification of the green part and remove porogen material(s). Debinding the green part removes polymer(s) and / or porogen material(s) to form a porous, sinterable part. Sintering densifies the debinded part, controls grain growth / size, and improves mechanical properties of the part. Tuning concentration and particle size of porogen in the ink and / or the inter-filament spacing during printing achieves desired porosity and pore size in the finished part. Biocompatible ceramic coating(s) disposed on the part through microbially-induced biomineralization may increase osseointegration performance for bone tissue engineering applications.

The present invention relates to an implantable device configured to deliver, to an injured bone site, components for revascularisation and bone repair, the device comprising: a first osteoconductive scaffold component adapted to hold and deliver to the injured bone site, growth factors for inducing cellular events that initiate healing; and comprising a second osteoconductive scaffold component adapted to hold and deliver to the injured bone site, viable autologous osteogenic and / or angiogenic cells, and wherein the device also comprises a third scaffold component adapted to promote bone cell proliferation and vascularity, whereby the scaffold components provide a stable mechanical environment for promoting bone cell proliferation and vascularity. The present invention also relates to a method of manufacture of the implantable device.

Nanocomposite hydrogels suitable for bone tissue regeneration may include (i) a scaffold comprising serum albumin and a cell adhesion promoter crosslinked with polyethylene glycol and (ii) a nanoparticle dispersed in the scaffold. Said nanocomposite hydrogels may formed from an injectable composition that includes: a nanocomposite hydrogel precursor A comprising that comprises a polyethylene glycol with two or more N-hydroxysuccinimide-terminal groups (PEG-NHS); and a nanocomposite hydrogel precursor B comprising a serum albumin, a nanoparticle, and a cell adhesion promoter; wherein the nanocomposite hydrogel precursor A and the nanocomposite hydrogel precursor B are physically separated.

The present innovation relates to biomaterials, particularly, to the synthesis method of octacalcium phosphate. The method can be applied in the commercial manufacturing of biomaterials for bone tissue regeneration or dental restoration as well as in drug delivery. The proposed method for the synthesis of octacalcium phosphate (OCP) bioceramic completes in less than one minute or not more than 5 minutes.

The application relates to a biological 3D printed tissue engineering trachea and a construction method and application thereof, namely a cartilage / vascularized fiber tissue alternating tissue engineering trachea. The construction method comprises the following steps: firstly, cartilage specific biological ink is prepared by wrapping cartilage cells with cartilage tissue specific hydrogel; fiber specific biological ink is prepared by wrapping fibroblasts with fiber tissue specific hydrogel; then, through a double-needle extrusion type biological 3D printing technology, alternating printing is realized to form a ring-shaped tubular structure, and a cartilage / fiber tissue alternating tubular structure is constructed through multi-layer accumulation molding; further, vascularization of the fiber tissue is realized through a certain culture mode, and finally, a relatively mature cartilage / vascularized fiber tissue alternating tissue engineering trachea is obtained. The application also provides application of the cartilage / vascularized fiber tissue alternating tissue engineering trachea in tracheal defect repair.