30 results about "Skeletal tissue" patented technology

The invention discloses a preparation method of a bionic beetle skeleton implant, and belongs to the field of femoral implantation. The bionic structure characteristics of beetle elytra and cuticle are creatively combined, the mechanical strength and structural stability of the porous nickel-titanium alloy structure implant are effectively improved through the bionic structure design method, and the long-standing stress shielding effect problem of a traditional femoral metal implant is successfully solved; the porous nickel-titanium alloy bionic skeleton structure prepared by adopting a selective laser melting (SLM) technology not only has good mechanical suitability, avoids rejection and shedding reaction with natural bone tissues after implantation, but also can realize a complete shape memory recovery function in a room temperature environment, and has good application prospects in the field of medical orthopedic implantation.

The present invention relates to a cartilage tissue single cell extraction kit and an extraction method thereof, the kit comprises: (1) a first enzyme for enzymatic hydrolysis, the first enzyme for enzymatic hydrolysis comprising one or more of trypsin, chondroitinase ABC and fucosidase; (2) a second enzyme for enzymolysis, wherein the second enzyme for enzymolysis comprises collagenase II, neutral protease II, hyaluronidase and Dnase I; and (3) a basic solution, wherein the basic solution comprises a basic culture medium and / or a buffer solution. The invention also provides a method for extracting single cells from cartilage tissues by using the kit. The cartilage tissue single-cell suspension prepared by the method has the advantages of high cell yield, high activity and the like, and has a wide application prospect.

1. The name of the design product: ultrasonic bone cutter. 2. The use of the design product: installed on the ultrasonic handle, used for cutting bone tissue. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: front view. 5. The rear view is the same as the front view, and the right view is omitted.

The invention relates to a mechanical arm ultrasonic grinding and drilling bone grinding mechanical model construction method and device, a medium and equipment, and the method comprises the steps: obtaining an ultrasonic machining motion model of ultrasonic grinding and drilling bone grinding according to the motion process of ultrasonic grinding and drilling grinding; according to the ultrasonic machining motion model, a finite element analysis model of ultrasonic abrasive drill bone grinding is established, and then the bone density, the vibration amplitude of a cylindrical abrasive drill of ultrasonic equipment and the influence rule of the feeding speed on the grinding force are obtained; and according to the finite element analysis model, a mechanical model of ultrasonic bone grinding and drilling is established, and then mathematical characterization among the grinding force, the vibration amplitude and the feeding speed is obtained. According to the mechanical arm ultrasonic grinding, drilling and grinding mechanical model, the dynamic relation among ultrasonic vibration parameters, mechanical arm motion parameters and grinding force can be accurately quantified, the situation that bone tissue is excessively damaged due to the fact that the grinding force is too large or the grinding efficiency is low due to the fact that the grinding force is insufficient is effectively avoided, and the safety of clinical operation is guaranteed.

A method for ultrasound stimulation of musculo-skeletal tissue structures includes generating a plurality of acoustic spatial-temporal modes comprised of a sinusoidal-complex, wherein the sinusoidal-complex has a modulation envelope that enhances spatial-temporal measurement accuracy at a site of a multi-layered biological tissue structure, and a pulse repetition frequency and duty cycle that are osteogenic at the site of the multi-layered biological tissue structure, beam steering the acoustic spatial-temporal modes to the site of the multi-layered biological tissue structure to promote tissue healing, and producing bi-modal stress levels in the multi-layered biological tissue structure that are sufficient to generate bone fracture healing.

The invention relates to the technical field of tissue engineering and regeneration, in particular to a stem cell membrane-stent dynamic co-culture device and a gradient regulation culture process. The stem cell membrane-stent dynamic co-culture device comprises a) a multi-modal mechanical loading module (1), a compression strain unit (2) and a multi-modal mechanical loading module (3), the frequency is adjustable from 0.1 Hz to 2 Hz, the strain amplitude is 5%-15% (the precision is + / -0.5%), and the periodic compression stress of bone tissue can be simulated; (2) a fluid shear force unit: generating 0.1-5Pa laminar shear force (Re < 2000) through a conical flow channel (with a taper angle of 15 degrees) and a peristaltic pump, and simulating a shear microenvironment of a blood vessel or periodontal ligament area; the method has the beneficial effects that multi-modal mechanical synergy is achieved, and the cell differentiation efficiency is remarkably improved through coupling loading of compression and shearing force. Experiments show that the ALP activity reaches 38.2 + / -3.1 U / mg (only 12.5 + / -2.3 U / mg in traditional single-mode stimulation), and the proportion of a CD31 + vascularized region is increased to 41.7 + / -3.8% (plt; 0.01).

The utility model provides a skull plug which comprises a plug body and a plug cap, the plug body is cylindrical, the plug cap is connected with the plug body, the cross section of the plug cap along the center line of the plug cap is arc-shaped, and the diameter of the plug cap is larger than that of the plug body. When the skull plug is plugged into a skull defect position, the plug body is plugged into the defect position so as to be matched with other skull. On one hand, the plug cap covers the whole plug body and makes contact with bone tissue at other positions, the plug body can be prevented from entering the human body skull under the action of external force, and on the other hand, the shape of the plug cap is similar to that of the skull, so that the applicability of the skull plug is improved.

The application discloses an integrally-formed three-dimensional degradable textile structure bone plate and a preparation method thereof. The preparation method is as follows: composite yarns composed of degradable glass fibers and other degradable materials are woven into a preformed body in the shape of a bone plate through three-dimensional weaving, three-dimensional knitting, three-dimensional needle knitting or three-dimensional angle interlocking, and in the weaving process, preformed holes are formed in the preformed body by adding a mold; and then the preformed body is sequentially subjected to heating and solidification and cooling treatment, so that the integrally-formed three-dimensional degradable textile structure bone plate is obtained. The finally-prepared three-dimensional degradable woven bone plate has better plasticity, can better adapt to the shape of a bone, improves the repair effect of the bone plate, has good flexibility and toughness, has better mechanical properties, has higher biocompatibility and degradability, and is suitable for the field of bone tissue repair.

Nanocomposite hydrogels suitable for bone tissue regeneration may include (i) a scaffold comprising serum albumin and a cell adhesion promoter crosslinked with polyethylene glycol and (ii) a nanoparticle dispersed in the scaffold. Said nanocomposite hydrogels may formed from an injectable composition that includes: a nanocomposite hydrogel precursor A comprising that comprises a polyethylene glycol with two or more N-hydroxysuccinimide-terminal groups (PEG-NHS); and a nanocomposite hydrogel precursor B comprising a serum albumin, a nanoparticle, and a cell adhesion promoter; wherein the nanocomposite hydrogel precursor A and the nanocomposite hydrogel precursor B are physically separated.

The present application relates to a kind of extraction kit of cartilage tissue single cell and its extraction method, the kit includes: (1) first enzymolysis enzyme, the first enzymolysis enzyme includes one or more of trypsin, chondroitinase ABC and fucosidase;(2) second enzymolysis enzyme, the second enzymolysis enzyme includes collagenase II, neutral protease II, hyaluronidase and Dnase I;(3) base liquid, the base liquid includes base medium and / or buffer solution.The present application also provides the method for extracting single cell from cartilage tissue using the kit.The cartilage tissue single cell suspension prepared by the present application has the advantages of high cell yield and high activity, and has wide application prospect.

The invention relates to the field of ceramic bulletproof plugboards, in particular to an anti-falling curved surface spliced ceramic bulletproof plugboard and a preparation method thereof. The anti-falling curved surface spliced ceramic bulletproof plugboard comprises a laminated structure and a polyurea layer coating the periphery of the laminated structure, the laminated structure comprises an anti-falling layer, a crack arrest layer, a ceramic layer, a polyethylene layer and a concave reduction foam layer which are sequentially laminated in the direction from the bullet facing surface to the bullet backing surface; the anti-falling layer comprises aramid fiber honeycombs, and hole grids of the aramid fiber honeycombs are filled with a mixture of hollow glass microspheres and silica gel; and the crack arrest layer comprises aramid fiber woven cloth. The anti-falling layer provided by the invention is composed of the aramid fiber honeycomb, the hollow glass microspheres and the silica gel, the structure simulates a human bone tissue structure, the aramid fiber honeycomb provides a structural framework and supports the falling layer not to deform, and the hollow glass microspheres have high compression strength, can resist impact and absorb impact energy through microsphere damage; the silica gel not only can be used for bonding the aramid honeycomb and the microspheres, but also can be used for providing elasticity and restoring the deformation after impact.

The invention relates to the technical field of medical data processing, in particular to a skull repair implant material parameter configuration method and system, and the method comprises the following steps: obtaining the image data of a skull defect area, and determining the boundary information of skull defect based on the image data; according to the boundary information, obtaining physical attribute information of own bones adjacent to the boundary, and based on the physical attribute information, evaluating the bone regeneration capacity of an area adjacent to the boundary; determining skeleton regeneration potential distribution of each position in the skull defect area according to the skeleton regeneration capacity of the area adjacent to the boundary; performing unit division on the skull implant, and obtaining skeleton regeneration potential information corresponding to each unit of the implant according to the skeleton regeneration potential distribution; according to bone regeneration potential distribution of all positions in a skull defect area, material parameters of all units of the implant are finely configured, and precise matching of the degradation rate of the implant and the growth process of new bone tissue is achieved.

The invention discloses a special abrasive drill capable of adapting to different radians of human ankle joints, which comprises an electric drill connecting handle connected with an electric drill, a replaceable file head is arranged on the electric drill connecting handle, and the file head comprises a file head body and bone file teeth arranged on the file head body. The replaceable file head is arranged on the electric drill connecting handle, so that the abrasive drill can be flexibly adjusted according to bone tissues of different parts and shapes, the problem that a tool bit of a traditional fixed structure is prone to slipping is effectively solved, and the positioning precision is improved.

A perforator for drilling bone tissue has: a drive shaft with a rotational axis A; an inner cutting head with the same rotational axis A; a drive surface provided on the drive shaft; and a connector provided on the inner cutting head. The inner cutting head is displaceable with respect to the drive shaft along the rotational axis between a distal position, in which the inner cutting head is not driveable by the drive shaft, and a proximal position, in which the drive surface abuts the connector to transmit rotational motion from the drive shaft to the inner cutting head. The drive surface is inclined relative to the rotational axis A.

The present invention relates to an implantable device configured to deliver, to an injured bone site, components for revascularisation and bone repair, the device comprising: a first osteoconductive scaffold component adapted to hold and deliver to the injured bone site, growth factors for inducing cellular events that initiate healing; and comprising a second osteoconductive scaffold component adapted to hold and deliver to the injured bone site, viable autologous osteogenic and / or angiogenic cells, and wherein the device also comprises a third scaffold component adapted to promote bone cell proliferation and vascularity, whereby the scaffold components provide a stable mechanical environment for promoting bone cell proliferation and vascularity. The present invention also relates to a method of manufacture of the implantable device.

Nanocomposite hydrogels suitable for bone tissue regeneration may include (i) a scaffold comprising serum albumin and a cell adhesion promoter crosslinked with polyethylene glycol and (ii) a nanoparticle dispersed in the scaffold. Said nanocomposite hydrogels may formed from an injectable composition that includes: a nanocomposite hydrogel precursor A comprising that comprises a polyethylene glycol with two or more N-hydroxysuccinimide-terminal groups (PEG-NHS); and a nanocomposite hydrogel precursor B comprising a serum albumin, a nanoparticle, and a cell adhesion promoter; wherein the nanocomposite hydrogel precursor A and the nanocomposite hydrogel precursor B are physically separated.

The present innovation relates to biomaterials, particularly, to the synthesis method of octacalcium phosphate. The method can be applied in the commercial manufacturing of biomaterials for bone tissue regeneration or dental restoration as well as in drug delivery. The proposed method for the synthesis of octacalcium phosphate (OCP) bioceramic completes in less than one minute or not more than 5 minutes.

The application relates to a biological 3D printed tissue engineering trachea and a construction method and application thereof, namely a cartilage / vascularized fiber tissue alternating tissue engineering trachea. The construction method comprises the following steps: firstly, cartilage specific biological ink is prepared by wrapping cartilage cells with cartilage tissue specific hydrogel; fiber specific biological ink is prepared by wrapping fibroblasts with fiber tissue specific hydrogel; then, through a double-needle extrusion type biological 3D printing technology, alternating printing is realized to form a ring-shaped tubular structure, and a cartilage / fiber tissue alternating tubular structure is constructed through multi-layer accumulation molding; further, vascularization of the fiber tissue is realized through a certain culture mode, and finally, a relatively mature cartilage / vascularized fiber tissue alternating tissue engineering trachea is obtained. The application also provides application of the cartilage / vascularized fiber tissue alternating tissue engineering trachea in tracheal defect repair.

The application provides a scaffold preparation method for promoting collagen fiber assembly and internal and external mineralization, and comprises the following steps: A) adding glycine and potassium chloride into a complex solution formed by non-collagen protein analogs chelating calcium ions to prepare an assembly solution; wherein the non-collagen protein analogs are one or both of polycarboxylic acid substances and glucuronic acid; B) adding a collagen protein solution into the assembly solution obtained in step A) to obtain a mixed solution, the pH of the mixed solution is adjusted to 7.0±0.2; the mixed solution is placed in a 37±0.5 DEG C incubator, and is incubated for 12-24 hours, so that the collagen protein is assembled, and collagen fibers are obtained; C) the collagen fibers prepared in step B) are placed in a collagen fiber mineralization solution to be mineralized, mineralized collagen fibers are obtained, and the mineralized collagen fibers are washed, frozen and dried to obtain a mineralized collagen fiber scaffold; the application simulates the bone tissue generation process in a safer and more bionic manner, so that the collagen fiber scaffold is more efficiently assembled and mineralized.

The present invention relates to nanoparticles capable of crossing biological barriers. In particular, it refers to lipid nanoparticles configured to cross the blood-brain barrier, target skeletal tissues and effectively penetrate the skin barrier. The invention also encompasses compositions and applications thereof.

The present application relates to a kind of high-strength porous metal bone filling block. The bone filling block includes reinforcing frame and the porous metal material of porosity 60-95% filled inside reinforcing frame;Reinforcing frame and porous metal material material are same. The porous metal bone filling block of the present application can improve compression strength and bone tissue regeneration capacity.

This invention discloses a method and apparatus for reconstructing orthopedic case images. The method, after determining that the skeleton in the orthopedic case image meets the reconstruction requirements based on diagnostic needs information, uses an edge detection algorithm to identify the contours of the skeletal tissue and lesion tissue in the orthopedic case image and extracts the image to obtain a tissue contour image. Based on the tissue feature parameters of the skeletal tissue within the tissue contour image, the severity of the lesion features is determined, and the tissue contour image is rendered according to the severity of the lesion features to obtain a tissue rendering image. Finally, grayscale parameters are obtained from the tissue rendering image, and pixel enhancement processing is performed on the tissue in the tissue rendering image to obtain the orthopedic reconstructed image. This invention determines the severity of lesion features based on the tissue feature parameters of the image and reconstructs the image according to the severity of the lesion features, allowing doctors to intuitively determine the patient's lesion condition based on image color and brightness, thereby improving the doctor's diagnostic efficiency.

An implantable mesh including demineralized bone fibers mechanically entangled into a biodegradable or permanent implantable mesh is provided. A method of preparing the implantable mesh is also provided. The method of preparing the implantable mesh includes mechanically entangling demineralized bone fibers with non-bone fibers to form the implantable mesh. The mechanical entanglement of the bone fibers into the implantable mesh is achieved by applying needle punching with barbed needles, spun lacing, entanglement with water jets or air jets or ultrasonic entanglement with ultrasonic waves. A method of implanting an implantable mesh at a target bone tissue site is also provided.

The invention relates to the technical field of bone treatment, in particular to an autogenous bone taking-bone treatment composite device which comprises a bone taking device, and the bone taking device comprises a positioning bone taking mechanism used for accurately obtaining a bone block in a specific form and a positioning bone cutting mechanism used for integrally cutting off bone tissue. The bone taking device, the bone grinding device, the clamping and implanting mechanism and other components are arranged, accurate positioning is achieved through cooperation of the drill sleeve body, the first fixing nail and the kirschner wire, the trephine assembly takes bones under guiding, the bone cutting mechanism is positioned to achieve overall bone cutting, the bone grinding device machines the cut bones into filling materials, and the bone cutting efficiency is improved. According to the clamping and implanting mechanism, reliable clamping and precise implanting of bone blocks are achieved through sliding fit of a conical protrusion and a sleeve, then the functions of bone taking, bone treatment and implanting are integrated, sterile and efficient operation in the whole process is achieved, and the effects that the tool switching frequency, the bone block pollution risk and iatrogenic injuries in an operation are remarkably reduced are achieved.

The invention discloses a multifunctional bone repair 3D printing composite material and a preparation method and application thereof, and belongs to the technical field of bone repair material preparation. The multifunctional bone repair 3D printing composite material is prepared from the following raw materials: a degradable polymer, a compatilizer, fishbone hydroxyapatite and SrO-NaF loaded fishbone gelatin microspheres. The multifunctional bone repair 3D printing composite material has good mechanical performance, biocompatibility, mineralization ability and antibacterial performance, can be used as a bone repair material, is prepared into a multifunctional bone repair 3D printing wire through extrusion molding and then is used for preparing a bone repair product through 3D printing, and a novel material solution is provided for bone tissue regeneration and repair.