41 results about "Skeletal tissues" patented technology

The invention relates to the medical field of bones and particularly relates to a bone CT value and elastic modulus relation determination method and a test loading device thereof. Under a precondition of not destroying bone tissues, an accurate relation between the CT value and the bone elastic modulus is determined, and a loading device (with a caliber of 10 cm) of a large testing range and suitable for being used in a micro-CT is established, so that large joints such as femur head can be disposed, and the sample integrity is ensured; and by a finite element inversion calculation method, the elastic modulus of a bone tissue corresponding to a CT sweeping solid is obtained. The bone CT value and elastic modulus relation determination method provided by the invention is a more correct CT value and bone elastic modulus relation determination method, which provides more accurate material valuation for bone stress simulative research, improves accuracy of simulative calculation, and can be more accurately applied to clinic prediction and treatment scheme programming.

The present invention relates to a cell-free, multi-layered medical device having bespoke, multifunctional bioactivity for the purpose of regeneration of skeletal tissues. The medical device may actively promote homing of stem cells into the medical device and promote their differentiation into the required cell type and promote de-novo tissue formation. The invention includes methods of making the medical device, uses of the medical device in promoting regeneration of the articular cartilage of a joint surface and in promoting healing and regeneration of skeletal tissues, for example, meniscal cartilage, tendon and ligament tissues and also healing of bone tissue indications such as fractures.

Pharmaceutical compositions and methods of use in regulation of mammalian bone forming activities of sFRPs (secreted frizzled-related proteins) are disclosed. sFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes like tissue polarity, embryonic development, and tumorigenesis. A sFRP was isolated from human osteoblast cells and identified as sFRP-1 (also known as SARP-2) and shown to be regulated by osteogenic agents in hOB cells in a differentiation selective manner, modulating the life of osteoblasts / preosteocytes. An sFRP-1 knock-out mouse was generated and deletion of sFRP-1 was found to not affect nonskeletal tissues, skeletal morphology or cortical bone development, while resulting in increased trabecular bone formation, decreased osteoblast and osteocyte apoptosis and increased osteoprogenitor differentiation.

Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.