8 results about "Skeletal tissues" patented technology

A method for ultrasound stimulation of musculo-skeletal tissue structures includes generating a plurality of acoustic spatial-temporal modes comprised of a sinusoidal-complex, wherein the sinusoidal-complex has a modulation envelope that enhances spatial-temporal measurement accuracy at a site of a multi-layered biological tissue structure, and a pulse repetition frequency and duty cycle that are osteogenic at the site of the multi-layered biological tissue structure, beam steering the acoustic spatial-temporal modes to the site of the multi-layered biological tissue structure to promote tissue healing, and producing bi-modal stress levels in the multi-layered biological tissue structure that are sufficient to generate bone fracture healing.

The present invention relates to an implantable device configured to deliver, to an injured bone site, components for revascularisation and bone repair, the device comprising: a first osteoconductive scaffold component adapted to hold and deliver to the injured bone site, growth factors for inducing cellular events that initiate healing; and comprising a second osteoconductive scaffold component adapted to hold and deliver to the injured bone site, viable autologous osteogenic and / or angiogenic cells, and wherein the device also comprises a third scaffold component adapted to promote bone cell proliferation and vascularity, whereby the scaffold components provide a stable mechanical environment for promoting bone cell proliferation and vascularity. The present invention also relates to a method of manufacture of the implantable device.

The invention provides a bone slice three-dimensional positioning adaptive adjustment method and device in combination with big data, and relates to the technical field of positioning adjustment, and the method comprises the steps: building a bone tissue three-dimensional model of a surgical site; calling historical operation case data to perform feature extraction and training, and constructing a bone slice positioning prediction model; inputting the bone tissue three-dimensional model into a bone slice positioning prediction model, and screening out an optimal position and an optimal angle; determining a bone sheet lifting shape design scheme; manufacturing a bone sheet lifting entity according to the bone sheet lifting shape design scheme, and performing implantation simulation in the virtual environment to obtain a bone sheet simulation implantation result; and the space interference state of the bone slice lifting entity is collected in real time and is dynamically adjusted. The technical problem that accurate matching of the bone structure of the patient is further affected due to the fact that changes of the bone form and damage characteristics cannot be effectively handled in the prior art can be solved, and the technical effect of improving the matching accuracy of the bone sheet and the bone structure is achieved.

The present invention relates to nanoparticles capable of crossing biological barriers. In particular, it refers to lipid nanoparticles configured to cross the blood-brain barrier, target skeletal tissues and effectively penetrate the skin barrier. The invention also encompasses compositions and applications thereof.

The invention relates to a joint prosthesis and a preparation method thereof, the joint prosthesis comprises a 3D printing joint prosthesis, the 3D printing joint prosthesis comprises a prosthesis joint and a prosthesis handle connected with the prosthesis joint, and the surface of the prosthesis joint is sprayed with polyether-ether-ketone. After the surface of the 3D printed joint prosthesis reaches the preheating temperature, polyether-ether-ketone powder is sprayed to the surface of the prosthesis joint through flame spraying, a firm, hard and compact polyether-ether-ketone coating with a crystal structure is formed on the surface of the prosthesis joint, mutual contact of the bone joint surfaces is facilitated, and the joint surface of the joint is protected; and meanwhile, the biocompatibility of the medical metal can be utilized for the non-sprayed part. In the actual use process, the contact surface is the contact between the polyether-ether-ketone and the cartilage, the friction factor is reduced to about 0.235, and the smoothness of the contact surface is greatly improved. And meanwhile, the polyether-ether-ketone has a water lubrication characteristic, is beneficial to the flow of interstitial fluid on the surface, has better lubricity than a medical metal surface, and is more beneficial to the surface contact between the implant and an original bone tissue.

The invention discloses a reconstruction method and device for an orthopedic case image. The method comprises the following steps: determining that a skeleton of the orthopedic case image meets a reconstruction requirement according to diagnosis requirement information; according to the diagnosis demand information, calling an edge detection algorithm to identify a bone tissue contour and a focus tissue contour of the orthopedic case image, and intercepting the image to obtain a tissue contour image; determining focus feature severity based on tissue feature parameters of bone tissues in the tissue contour image, and rendering the tissue contour image according to the focus feature severity to obtain a tissue rendering image; and obtaining a gray value parameter according to the tissue rendering image, and carrying out pixel enhancement processing on the tissue of the tissue rendering image to obtain an orthopedic reconstructed image. The lesion feature severity is determined based on the tissue feature parameters of the image, and the image is reconstructed according to the lesion feature severity, so that a doctor can intuitively determine the lesion condition of the patient according to the image color and brightness, and the diagnosis efficiency of the doctor is improved.

This invention discloses a method and apparatus for reconstructing orthopedic case images. The method, after determining that the skeleton in the orthopedic case image meets the reconstruction requirements based on diagnostic needs information, uses an edge detection algorithm to identify the contours of the skeletal tissue and lesion tissue in the orthopedic case image and extracts the image to obtain a tissue contour image. Based on the tissue feature parameters of the skeletal tissue within the tissue contour image, the severity of the lesion features is determined, and the tissue contour image is rendered according to the severity of the lesion features to obtain a tissue rendering image. Finally, grayscale parameters are obtained from the tissue rendering image, and pixel enhancement processing is performed on the tissue in the tissue rendering image to obtain the orthopedic reconstructed image. This invention determines the severity of lesion features based on the tissue feature parameters of the image and reconstructs the image according to the severity of the lesion features, allowing doctors to intuitively determine the patient's lesion condition based on image color and brightness, thereby improving the doctor's diagnostic efficiency.