41 results about "Skeletal tissues" patented technology

Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethyl-lene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.

The present invention relates to a body volume substitute comprising cartilage for grafting by injection, and a dual needle-type syringe for injecting same. The volume substitute of the present invention is characterized by comprising one or more types selected from ground cartilage, physiological saline, and body fluid. According to the present invention, it is possible to graft a volume substitute not only for repairing skin tissue damage caused by an external injury and augmenting skin from a cosmetic point of view, but also for repairing skeletal tissue loss and augmenting skeletal tissue volume, by a simple method of injection. In addition, using the syringe of the present invention, it is possible to finely adjust the amount of injection solution being injected when injecting the body volume substitute into a human body, thereby precluding the danger to a patient caused by an overdose of the injection solution.

The invention relates to the medical field of bones and particularly relates to a bone CT value and elastic modulus relation determination method and a test loading device thereof. Under a precondition of not destroying bone tissues, an accurate relation between the CT value and the bone elastic modulus is determined, and a loading device (with a caliber of 10 cm) of a large testing range and suitable for being used in a micro-CT is established, so that large joints such as femur head can be disposed, and the sample integrity is ensured; and by a finite element inversion calculation method, the elastic modulus of a bone tissue corresponding to a CT sweeping solid is obtained. The bone CT value and elastic modulus relation determination method provided by the invention is a more correct CT value and bone elastic modulus relation determination method, which provides more accurate material valuation for bone stress simulative research, improves accuracy of simulative calculation, and can be more accurately applied to clinic prediction and treatment scheme programming.

The use of fibroblast growth factor (FGF)-18 protein, certain of its downstream target genes and respective expressed proteins, in particular sonic hedgehog (Shh), Shh protein, β-catenin, β-catenin protein, and the Wnt family of proteins that stimulate β-catenin, and the respective nucleotide sequences encoding this protein, particularly for inducing cartilage formation, particularly for the purpose of generating, repairing, reconstructing, or de novo formation of, cartilaginous tissue. Therapies for which FGF-18 and the target proteins are useful include repair and reconstruction of various tissues in conducting airways such as the trachea, bronchi, lung and larynx caused by, for example, tracheal-bronchial abnormalities, tracheal-laryngo or bronchial malaria. Other therapies for which FGF-18 and the target proteins would be useful include other cartilaginous tissues, such as those of joint and skeletal tissue caused by, for example, arthritis and meniscus abnormalities in joints.

The present invention relates to a cell-free, multi-layered medical device having bespoke, multifunctional bioactivity for the purpose of regeneration of skeletal tissues. The medical device may actively promote homing of stem cells into the medical device and promote their differentiation into the required cell type and promote de-novo tissue formation. The invention includes methods of making the medical device, uses of the medical device in promoting regeneration of the articular cartilage of a joint surface and in promoting healing and regeneration of skeletal tissues, for example, meniscal cartilage, tendon and ligament tissues and also healing of bone tissue indications such as fractures.

Pharmaceutical compositions and methods of use in regulation of mammalian bone forming activities of sFRPs (secreted frizzled-related proteins) are disclosed. sFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes like tissue polarity, embryonic development, and tumorigenesis. A sFRP was isolated from human osteoblast cells and identified as sFRP-1 (also known as SARP-2) and shown to be regulated by osteogenic agents in hOB cells in a differentiation selective manner, modulating the life of osteoblasts / preosteocytes. An sFRP-1 knock-out mouse was generated and deletion of sFRP-1 was found to not affect nonskeletal tissues, skeletal morphology or cortical bone development, while resulting in increased trabecular bone formation, decreased osteoblast and osteocyte apoptosis and increased osteoprogenitor differentiation.

Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.