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41 results about "Skeletal tissues" patented technology
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Hyaline cartilage is also a supportive skeletal tissue. The human windpipe, called the trachea, and the structures that extend the form the windpipe into the lungs, referred to as bronchi, are composed of this type of cartilage.
Bone Morphogenetic Protein Compositions
InactiveUS20100015230A1Improve stabilityEfficient preparationPowder deliverySenses disorderDiseaseSkeletal tissues
The present invention relates to compositions of bone morphogenetic proteins, particularly solid and liquid formulations of such proteins comprising one or more stabilizing excipients. The invention further provides methods of producing the compositions, kits comprising the compositions and methods of using the compositions in the treatment of diseases of skeletal and non-skeletal tissues.
Owner:STRYKER CORP
Dietary supplements containing extracts of nelumbo and processes of using same
InactiveUS20100227007A1Improve athletic performanceImprove enduranceOrganic active ingredientsBiocideInsulin signallingDietary supplement
Materials derived from Nelumbo are administered orally to humans or animals for the purpose of enhancing creatine transport into skeletal tissue and for purposes of enhancing lean body mass. Enhancing creatine transport through improved insulin signaling is a new method of depositing creatine and enhancing lean body mass. Such administration is also used for enhancing athletic performance and controlling bodyweight and body fat levels. More specifically, such administration is used for the purpose of enhancing creatine transport into excitable tissues such as skeletal muscle. The material is administered as extracts of Nelumbo and administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.
Owner:IN INGREDIENTS
Scaffolds for Bone-Soft Tissue Interface and Methods of Fabricating the Same
PendingUS20200163752A1Additive manufacturing apparatusBone implantMechanical integritySkeletal tissues
A device for regenerating musculoskeletal tissue having a scaffold comprised of fiber layers adapted to provide mechanical integrity to the scaffold in the form of increased tensile and compressive resistance and one or more other layers adapted to provide mechanical integrity and to provide a suitable biochemical environment.
Owner:STC UNM
'Gelei' tea
InactiveCN101164423AHigh nutritional valueEasy to eatPre-extraction tea treatmentPlant ingredientsActive componentMedicine
The present invention belongs to the field of health-care beverage technology, in particular, it relates to a pueraria root pound-prepared tea containing rich mineral matters and nutrient substances, and also containing lots of isoflavone active component with several health-care functions of delaying senility, preventing osteoporosis, reducing bone calcium loss and nourishing face, etc. Said pueraria root pound-prepared tea is made up by using (by weight portion) 60-80 portions of pueraria root powder, 3-8 portions of sesame, 3-8 portions of peanut, 0.5-3 portions of tea, 1-4 portions of lyceum berry and 1-3 portions of haw apple through a certain pound-preparation process.
Owner:徐庆云
Plasmid encoding fibroblast growth factor for the treatment of hypercholesterolemia or diabetes associated angiogenic defects
The present invention relates to the use of a plasmid encoding a fibroblast growth factor as therapeutic agent for the prevention and treatment of hypercholesterolemia or diabetes associated myocardial or skeletal angiogenic defects. The present invention also relates to a method for enhancing formation of both collateral blood vessels and arterioles in myocardial or skeletal ischemic tissues in a mammalian subject suffering from hypercholesterolemia or diabetes. The present invention further relates to a method of promoting collateral blood vessels in ischemic myocardial or skeletal tissues without inducing VEGF-A factor expression and causing edema in the treated muscles.
Owner:AVENTIS PHARMA INC
Formulations of peptides for periodontal and dental treatments
InactiveUS20060193916A1Reduce inflammationAvoid damageBiocideOrganic active ingredientsTooth fillingIrritation
Methods to treat the defects in skeletal tissues characterized by protecting the marrow cells adjacent to the defects from apoptotic and / or necrotic cell death are disclosed. The methods provide additional benefits which are to reduce inflammation and irritation in the marrow tissues and assist promoting new skeletal tissue formation to an application of a simple skeletal formation or regeneration activity such as a bone growth factor. The methods may involve application of pharmacologically active peptidic compounds comprising about 15 to about 28 amino acids in their sequences characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan attachment motif, and / or a calcium binding motif. The sequence may be a 23 amino acid sequence formulated for injection, topical application, or dispersed in a matrix such as collagen or a tooth filling composition or gum patch and administered to enhance bone / tooth growth or prevent loss.
Owner:ACOLOGIX
Body volume substitute comprising cartilage for grafting by injection, and dual needle-type syringe for injecting same
InactiveCN105530967ALeave no scarsLess swellingMedical devicesJoint implantsHuman bodySkeletal tissue
The present invention relates to a body volume substitute comprising cartilage for grafting by injection, and a dual needle-type syringe for injecting same. The volume substitute of the present invention is characterized by comprising one or more types selected from ground cartilage, physiological saline, and body fluid. According to the present invention, it is possible to graft a volume substitute not only for repairing skin tissue damage caused by an external injury and augmenting skin from a cosmetic point of view, but also for repairing skeletal tissue loss and augmenting skeletal tissue volume, by a simple method of injection. In addition, using the syringe of the present invention, it is possible to finely adjust the amount of injection solution being injected when injecting the body volume substitute into a human body, thereby precluding the danger to a patient caused by an overdose of the injection solution.
Owner:柳胜皓
Bioresorbable composition for repairing skeletal tissue
Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethylene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.
Owner:UNIVERSITY OF SOUTH CAROLINA
Bioresorbable composite for repairing skeletal tissue
Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethyl-lene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.
Owner:UNIVERSITY OF SOUTH CAROLINA
Compositions and methods for templating three-dimensional mineralization
InactiveUS20150335790A1Promote mineralizationOvercame excessive swellingOrganic active ingredientsDental implantsMedicineSkeletal tissues
The invention provides novel compositions and methods for three-dimensional mineralization templated by synthetic scaffolds having zwitterionic mediators. The invention enables 3-D mineralization nucleation and growth of minerals in a well-controlled and defined manner. The composite materials prepared by the disclosed methods are cytocompatible and / or biodegradable and are suitable for use as medical implants in a variety of applications in skeletal tissue repair and regeneration. For example, cytocompatible zwitterionic sulfobetaine ligands are employed to facilitate 3-D mineralization of HA across covalently crosslinked hydrogels. The overall charge-neutral zwitterionic hydrogel effectively recruited oppositely charged precursor ions while overcame excessive swelling exhibited by anionic and cationic hydrogels under physiological conditions, resulting in denser and structurally well-integrated mineralized composite materials.
Owner:UNIV OF MASSACHUSETTS MEDICAL SCHOOL
Animal tissue transparentizing method
PendingCN111735681AAchieve observationLow toxicityPreparing sample for investigationFluorescence/phosphorescenceDeglovingBone tissue
The invention provides an animal tissue transparentizing method, which belongs to the technical field of animal tissue observation, and comprises the following steps of: 1) anesthetizing an animal, and sequentially pouring heart perfusate and tissue fixing liquid into the heart of the animal; dissecting and separating animal tissues; 2) placing the bone tissue in a decalcification solution for decalcification for 5-12 days to obtain a decalcified bone tissue, wherein in the decalcification process, the liquid is changed once every 1-3 days; 3) respectively putting the decalcified bone tissue and soft tissue into a decolorizing solution for decolorizing to obtain a decolorized tissue; 4) placing the decolorized tissue in a degreasing liquid for gradient degreasing, and then placing the tissue in a dehydration liquid for dehydration to obtain a dehydrated tissue; and 5) placing the dehydrated tissue in a transparent liquid for transparentizing to obtain a transparent tissue. Through themethod, large-view, multi-angle and deep observation of the tissue can be realized.
Owner:SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
Bionic repair method for bone tumors
ActiveCN110008506AGood biocompatibilityImprove mechanical propertiesImage enhancementImage analysisFree formComputer aid
The invention discloses a bionic repair method for bone tumors, and belongs to the computer-aided biomedical engineering, and the method comprises the steps: carrying out segmentation with semantic characteristics on tumor image data of a patient, accurately segmenting and extracting an area corresponding to a target bone tissue, and realizing accurate reconstruction of a segmentation result basedon an envelope and approximation bone surface model three-dimensional reconstruction algorithm; constructing a bionic constraint set and a recovery framework for bone loss caused by bone tumors according to biomedical characteristics of a bone system, realizing accurate recovery of a bone loss form, and designing a constrained free form internal fixation prosthesis based on a bone loss form recovery result; designing an internal bionic porous scaffold structure with good mechanical property and machinability according to the information characteristics of the classified bone area and in combination with a skeleton kinematic mechanical analysis result; and finally, generating an integrated implant prosthesis through fusion, so that a personalized and accurate bone tumor repair system is realized.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS +1
Dietary supplements containing extracts of Nelumbo and processes of using same
InactiveUS8613959B2Promote absorptionHigh gainBiocideOrganic active ingredientsInsulin signallingDietary supplement
Materials derived from Nelumbo are administered orally to humans or animals for the purpose of enhancing creatine transport into skeletal tissue and for purposes of enhancing lean body mass. Enhancing creatine transport through improved insulin signaling is a new method of depositing creatine and enhancing lean body mass. Such administration is also used for enhancing athletic performance and controlling bodyweight and body fat levels. More specifically, such administration is used for the purpose of enhancing creatine transport into excitable tissues such as skeletal muscle. The material is administered as extracts of Nelumbo and administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.
Owner:IN INGREDIENTS
Pharmaceutical compositions and methods of using secreted frizzled related protein
InactiveUS20080166356A9Peptide/protein ingredientsGenetic material ingredientsOsteoblastSkeletal tissues
Pharmaceutical compositions and methods of use in regulation of mammalian bone forming activities of sFRPs (secreted frizzled-related proteins) are disclosed. sFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes like tissue polarity, embryonic development, and tumorigenesis. A sFRP was isolated from human osteoblast cells and identified as sFRP-1 (also known as SARP-2) and shown to be regulated by osteogenic agents in hOB cells in a differentiation selective manner, modulating the life of osteoblasts / preosteocytes. An sFRP-1 knock-out mouse was generated and deletion of sFRP-1 was found to not affect nonskeletal tissues, skeletal morphology or cortical bone development, while resulting in increased trabecular bone formation, decreased osteoblast and osteocyte apoptosis and increased osteoprogenitor differentiation.
Owner:WYETH LLC
Oral cavity bone mineral density measuring method and equipment thereof
PendingCN112842379AAvoid the problem of poor accuracy of bone density accuracy assessmentEnables density measurementRadiation diagnostic image/data processingComputerised tomographsHigh energySkeletal tissues
The invention discloses an oral cavity bone mineral density measuring method and equipment thereof. The oral cavity bone mineral density measuring method comprises the following steps: S1, sending high-energy X-rays and low-energy X-rays to a scanned body; S2, respectively receiving the high-energy X-ray and the low-energy X-ray which penetrate through the scanned body through a detector; and S3, by a processing unit, obtaining the high-energy X-rays and the low-energy X-rays penetrating through the scanned body, and obtaining a density image of the bone tissue through an image reconstruction algorithm. By means of the method, the density image of the bone tissue can be obtained, and therefore the problem that in the prior art, an oral clinician needs to observe a dental film of a patient through naked eyes, oral jaw bone mineral density evaluation is conducted through the sparse degree of spatial arrangement of bone trabecula in a reconstructed image, and consequently the accuracy of bone mineral density evaluation is poor is solved.
Owner:LARGEV INSTR CORP LTD
Ganglion block treatment training model for pain medical clinical practical training and control method thereof
ActiveCN113147038AImprove piercing techniqueAdditive manufacturing apparatusEducational modelsMuscle tissueHuman body
The invention relates to a ganglion block treatment training model for pain medical clinical practical training. The ganglion block treatment training model comprises a neck model, a blood vessel wall model, a nervous tissue model, a visceral tissue model, a respiratory tract, a bone tissue model, a muscular tissue model, a puncture needle, a multimeter, a power supply, a water pump, a flow meter, a water tank and a flow control valve. According to the training model, mathematical modeling can be carried out through ultrasonic scanning images of all tissues of a neck, an established mathematical model is combined with human tissue design software, image data representing all the tissues of a human body is combined with a three-dimensional model of the human body, all the tissue models of the neck are printed through the 3D printing technology, due to the fact that different materials are adopted during printing and injection molding of all the tissues of the human body, the puncture technology of doctors can be improved by testing potential / resistance range changes of all the tissues, star-shaped ganglions can be aligned in the puncture simulation training process, and important guiding significance is achieved for ganglion block treatment practical operation.
Owner:THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
Skeleton model construction method and device, computer equipment and storage medium
PendingCN112712594AImprove bionic precisionAccurate simulation calculation resultsImage enhancementImage analysisBone structureElement model
The invention discloses a skeleton model construction method and device, computer equipment and a storage medium, and the method comprises the following steps: carrying out the preprocessing of a skeleton tissue, so as to determine the contour boundaries of a cortical bone and a cancellous bone; extracting contour boundaries of the cortical bone and the cancellous bone, carrying out three-dimensional curved surface modeling, and obtaining a preliminary model; and further processing the preliminary model to obtain a finite element model with continuously variable cortical bone thickness. According to the method and device, skeleton tissues are preprocessed, cortical bones and cancellous bones of skeletons are distinguished, contour boundaries of the cortical bones and the cancellous bones are determined, the contour boundaries of the cortical bones and the cancellous bones are extracted, and three-dimensional curved surface modeling is carried out, so that a constructed preliminary model is closer to a real skeleton structure, and skeleton characteristics are accurately reproduced in the medical field; and the preliminary model is further processed to obtain a finite element model which reflects the continuous variable cortical bone thickness in a real bone structure.
Owner:SHENZHEN TECH UNIV
Skeleton tissue anchoring apparatus
An anchor device for the stitching between skeletal tissue and soft tissue is composed of an implantative part with one or several flexible walls which has several orifices, an internal space and a filling opening, one or several stitching silks with one end fixed to said implantative part and another end extended outside the skeletal tissue, and a medical material filled in said internal space of implantative part for anchoring it in skeletal tissue.
Owner:SPIRIT SPINE HLDG CORP
Teeth and alveolar bone segmentation and reconstruction method and device
A method and device for segmentation and reconstruction of teeth and alveolar bone, wherein the method includes: segmenting a bone tissue area (101) in a three-dimensional CT image of the oral cavity; segmenting teeth and alveolar bone tissue from the bone tissue area Region (102); segment the two-dimensional outline of each independent tooth and the two-dimensional outline of alveolar bone (103) from the tooth and alveolar bone tissue area; reconstruct the digitization of each independent tooth according to the two-dimensional outline of each independent tooth A three-dimensional model, reconstructing a digital three-dimensional model of the alveolar bone according to the two-dimensional contour of the alveolar bone (104). This scheme can simultaneously segment the two-dimensional contours of the individual teeth and the two-dimensional contours of the alveolar bone, and then realize the reconstruction of the digital three-dimensional model of each independent tooth according to the two-dimensional contours of the individual teeth. The digital three-dimensional model of the alveolar bone is reconstructed from the contour to facilitate the realization of digital orthodontic treatment assistance.
Owner:SHENZHEN INST OF ADVANCED TECH
System and methods of maintaining space for augmentation of the alveolar ridge
An implantable screw for maintaining space during bone grafting procedures is provided, where the screw has a highly-polished contoured head having a region adapted to support soft tissue, a threaded shaft and a tip adapted to penetrate bone tissue. Also provided, a device combining multiple implantable screws in series in order to increase the available space to grow new bone and a method for implanting the implantable screw. The implantable screws provided may be used in conjunction with bone graft materials and are removable once a desired amount of new bone is generated.
Owner:WARSAW ORTHOPEDIC INC
Vascularity affinity precursor structure for musculo-skeletal tissue healing
PendingUS20190142996A1Stable environmentHindering progressTissue regenerationProsthesisSkeletal tissueSkeletal tissues
The present invention relates to an implantable device configured to deliver, to an injured bone site, components for revascularisation and bone repair, the device comprising: a first osteoconductive scaffold component adapted to hold and deliver to the injured bone site, growth factors for inducing cellular events that initiate healing; and comprising a second osteoconductive scaffold component adapted to hold and deliver to the injured bone site, viable autologous osteogenic and / or angiogenic cells, and wherein the device also comprises a third scaffold component adapted to promote bone cell proliferation and vascularity, whereby the scaffold components provide a stable mechanical environment for promoting bone cell proliferation and vascularity. The present invention also relates to a method of manufacture of the implantable device.
Owner:PHARMA BUSINESS CONSULTANTS LTD +1
Body volume substitute material for injectable graft including cartilage and double-needle syringe for its injection
InactiveCN105530967BLeave no scarsLess swellingMedical devicesJoint implantsSkeletal tissuesBody fluid
The present invention relates to a body volume substitute comprising cartilage for grafting by injection, and a dual needle-type syringe for injecting same. The volume substitute of the present invention is characterized by comprising one or more types selected from ground cartilage, physiological saline, and body fluid. According to the present invention, it is possible to graft a volume substitute not only for repairing skin tissue damage caused by an external injury and augmenting skin from a cosmetic point of view, but also for repairing skeletal tissue loss and augmenting skeletal tissue volume, by a simple method of injection. In addition, using the syringe of the present invention, it is possible to finely adjust the amount of injection solution being injected when injecting the body volume substitute into a human body, thereby precluding the danger to a patient caused by an overdose of the injection solution.
Owner:柳胜皓
Method for Determining the Relationship between Bone CT Value and Elastic Modulus
ActiveCN106447787BIntegrity guaranteedAccurate assignmentImage enhancementImage analysisVoxelLarge joint
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY
Use of FGF-18 Protein, Target Proteins and Their Respective Encoding Nucleotide Sequences to Induce Cartilage Formation
InactiveUS20100137205A1Organic active ingredientsPeptide/protein ingredientsProtein targetBeta-catenin
The use of fibroblast growth factor (FGF)-18 protein, certain of its downstream target genes and respective expressed proteins, in particular sonic hedgehog (Shh), Shh protein, β-catenin, β-catenin protein, and the Wnt family of proteins that stimulate β-catenin, and the respective nucleotide sequences encoding this protein, particularly for inducing cartilage formation, particularly for the purpose of generating, repairing, reconstructing, or de novo formation of, cartilaginous tissue. Therapies for which FGF-18 and the target proteins are useful include repair and reconstruction of various tissues in conducting airways such as the trachea, bronchi, lung and larynx caused by, for example, tracheal-bronchial abnormalities, tracheal-laryngo or bronchial malaria. Other therapies for which FGF-18 and the target proteins would be useful include other cartilaginous tissues, such as those of joint and skeletal tissue caused by, for example, arthritis and meniscus abnormalities in joints.
Owner:CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
Method for measuring bone mineral density through DR shooting and DR shooting equipment
PendingCN112716517AImprove imaging resolutionAvoid the problem of poor accuracy of bone density accuracy assessmentRadiation diagnostics for dentistryBone TrabeculaeHigh energy
The invention discloses a method for measuring bone mineral density through DR shooting and DR shooting equipment, wherein the method for measuring bone mineral density through DR shooting comprises the following steps: S1, transmitting X-rays to a scanned object, to obtain an intraoral film; S2, respectively acquiring high-energy X-rays and low-energy X-rays which penetrate through the scanned object; and S3, enabling the processing unit to obtain high-energy X-rays and low-energy X-rays penetrating through the scanned body, and obtaining a density image of a bone tissue through an image reconstruction algorithm. According to the method, the density image of the bone tissue can be obtained, so that the problems that in the prior art, an oral clinician needs to observe a dental film shot before an operation of a patient through naked eyes, grading judgment of jaw bone density is carried out through the sparse degree of spatial arrangement of bone trabecula, and an accurate bone density numerical value is lacked as an accurate reference, large errors are easily caused, and the success rate of the operation is influenced are solved.
Owner:LARGEV INSTR CORP LTD
Medical implant
ActiveUS10765779B2Promote stem cell homing into the implantEncourage differentiation in situPeptide/protein ingredientsJoint implantsArticular surfacesSkeletal tissue
The present invention relates to a cell-free, multi-layered medical device having bespoke, multifunctional bioactivity for the purpose of regeneration of skeletal tissues. The medical device may actively promote homing of stem cells into the medical device and promote their differentiation into the required cell type and promote de-novo tissue formation. The invention includes methods of making the medical device, uses of the medical device in promoting regeneration of the articular cartilage of a joint surface and in promoting healing and regeneration of skeletal tissues, for example, meniscal cartilage, tendon and ligament tissues and also healing of bone tissue indications such as fractures.
Owner:UNIV OF SHEFFIELD
Rotator cuff prosthesis, preparation method thereof and rotator cuff prosthesis device
The invention relates to a rotator cuff prosthesis. According to the rotator cuff prosthesis, a protective structure with a low friction coefficient is arranged on the outer surface of the rotator cuff prosthesis, so that the effect of improving the wear resistance of the rotator cuff prosthesis is achieved, and the service life of the rotator cuff prosthesis can be greatly prolonged. The protective structure may be a coating structure, a membrane structure, or a combination of the two. The rotator cuff prosthesis comprises a selectable prosthesis sleeve, the prosthesis sleeve can be arranged outside the prosthesis in a sleeving mode, and after the rotator cuff prosthesis is implanted into a body, the prosthesis sleeve can provide a proper movable space for the prosthesis while protecting the prosthesis, so that the rotator cuff prosthesis can adapt to skeleton tissues in a rotator cuff in a self-adaptive mode. When the prosthesis sleeve is included, the protective structure is arranged on the outer surface of the prosthesis sleeve. The invention further provides a preparation method of the rotator cuff prosthesis and a rotator cuff prosthesis device.
Owner:SHANGHAI ENDOPHIX CO LTD
A kind of high-strength steel with nano, layered and metastable skeletal tissue and its preparation method
The invention relates to a high-strength steel with nanometer, layered and metastable skeletal tissue, the weight percent of the alloy composition is: C: 0.01-0.1wt.%, Mn: 7.0-11.0wt.%, Cu: 1.5-4.0wt. .%, Ni: 1.0-3.0wt.%, Al: 1.0-2.0wt.%, and the balance is Fe; the present invention also relates to a preparation method of high-strength steel with nanometer, layered and metastable skeletal tissue, Including the processes of weighing alloy components, smelting, casting, forging, hot rolling, cold rolling and heat treatment, the purpose of the present invention is to provide a high-strength steel with nano, layered and metastable skeletal tissue and its preparation method. It has excellent mechanical properties, low production cost and wide process window, and has great application prospects.
Owner:DONGGUAN UNIV OF TECH
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