41 results about "Skeletal tissues" patented technology

Materials derived from Nelumbo are administered orally to humans or animals for the purpose of enhancing creatine transport into skeletal tissue and for purposes of enhancing lean body mass. Enhancing creatine transport through improved insulin signaling is a new method of depositing creatine and enhancing lean body mass. Such administration is also used for enhancing athletic performance and controlling bodyweight and body fat levels. More specifically, such administration is used for the purpose of enhancing creatine transport into excitable tissues such as skeletal muscle. The material is administered as extracts of Nelumbo and administered in a variety of ways including capsules, tablets, powdered beverages, bars, gels or drinks.

The present invention relates to the use of a plasmid encoding a fibroblast growth factor as therapeutic agent for the prevention and treatment of hypercholesterolemia or diabetes associated myocardial or skeletal angiogenic defects. The present invention also relates to a method for enhancing formation of both collateral blood vessels and arterioles in myocardial or skeletal ischemic tissues in a mammalian subject suffering from hypercholesterolemia or diabetes. The present invention further relates to a method of promoting collateral blood vessels in ischemic myocardial or skeletal tissues without inducing VEGF-A factor expression and causing edema in the treated muscles.

Methods to treat the defects in skeletal tissues characterized by protecting the marrow cells adjacent to the defects from apoptotic and/or necrotic cell death are disclosed. The methods provide additional benefits which are to reduce inflammation and irritation in the marrow tissues and assist promoting new skeletal tissue formation to an application of a simple skeletal formation or regeneration activity such as a bone growth factor. The methods may involve application of pharmacologically active peptidic compounds comprising about 15 to about 28 amino acids in their sequences characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan attachment motif, and/or a calcium binding motif. The sequence may be a 23 amino acid sequence formulated for injection, topical application, or dispersed in a matrix such as collagen or a tooth filling composition or gum patch and administered to enhance bone/tooth growth or prevent loss.

Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethylene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.

The invention provides novel compositions and methods for three-dimensional mineralization templated by synthetic scaffolds having zwitterionic mediators. The invention enables 3-D mineralization nucleation and growth of minerals in a well-controlled and defined manner. The composite materials prepared by the disclosed methods are cytocompatible and/or biodegradable and are suitable for use as medical implants in a variety of applications in skeletal tissue repair and regeneration. For example, cytocompatible zwitterionic sulfobetaine ligands are employed to facilitate 3-D mineralization of HA across covalently crosslinked hydrogels. The overall charge-neutral zwitterionic hydrogel effectively recruited oppositely charged precursor ions while overcame excessive swelling exhibited by anionic and cationic hydrogels under physiological conditions, resulting in denser and structurally well-integrated mineralized composite materials.

The invention provides an animal tissue transparentizing method, which belongs to the technical field of animal tissue observation, and comprises the following steps of: 1) anesthetizing an animal, and sequentially pouring heart perfusate and tissue fixing liquid into the heart of the animal; dissecting and separating animal tissues; 2) placing the bone tissue in a decalcification solution for decalcification for 5-12 days to obtain a decalcified bone tissue, wherein in the decalcification process, the liquid is changed once every 1-3 days; 3) respectively putting the decalcified bone tissue and soft tissue into a decolorizing solution for decolorizing to obtain a decolorized tissue; 4) placing the decolorized tissue in a degreasing liquid for gradient degreasing, and then placing the tissue in a dehydration liquid for dehydration to obtain a dehydrated tissue; and 5) placing the dehydrated tissue in a transparent liquid for transparentizing to obtain a transparent tissue. Through themethod, large-view, multi-angle and deep observation of the tissue can be realized.

The invention discloses an oral cavity bone mineral density measuring method and equipment thereof. The oral cavity bone mineral density measuring method comprises the following steps: S1, sending high-energy X-rays and low-energy X-rays to a scanned body; S2, respectively receiving the high-energy X-ray and the low-energy X-ray which penetrate through the scanned body through a detector; and S3, by a processing unit, obtaining the high-energy X-rays and the low-energy X-rays penetrating through the scanned body, and obtaining a density image of the bone tissue through an image reconstruction algorithm. By means of the method, the density image of the bone tissue can be obtained, and therefore the problem that in the prior art, an oral clinician needs to observe a dental film of a patient through naked eyes, oral jaw bone mineral density evaluation is conducted through the sparse degree of spatial arrangement of bone trabecula in a reconstructed image, and consequently the accuracy of bone mineral density evaluation is poor is solved.

The invention relates to a ganglion block treatment training model for pain medical clinical practical training. The ganglion block treatment training model comprises a neck model, a blood vessel wall model, a nervous tissue model, a visceral tissue model, a respiratory tract, a bone tissue model, a muscular tissue model, a puncture needle, a multimeter, a power supply, a water pump, a flow meter, a water tank and a flow control valve. According to the training model, mathematical modeling can be carried out through ultrasonic scanning images of all tissues of a neck, an established mathematical model is combined with human tissue design software, image data representing all the tissues of a human body is combined with a three-dimensional model of the human body, all the tissue models of the neck are printed through the 3D printing technology, due to the fact that different materials are adopted during printing and injection molding of all the tissues of the human body, the puncture technology of doctors can be improved by testing potential/resistance range changes of all the tissues, star-shaped ganglions can be aligned in the puncture simulation training process, and important guiding significance is achieved for ganglion block treatment practical operation.

An implantable screw for maintaining space during bone grafting procedures is provided, where the screw has a highly-polished contoured head having a region adapted to support soft tissue, a threaded shaft and a tip adapted to penetrate bone tissue. Also provided, a device combining multiple implantable screws in series in order to increase the available space to grow new bone and a method for implanting the implantable screw. The implantable screws provided may be used in conjunction with bone graft materials and are removable once a desired amount of new bone is generated.

The invention discloses a method for measuring bone mineral density through DR shooting and DR shooting equipment, wherein the method for measuring bone mineral density through DR shooting comprises the following steps: S1, transmitting X-rays to a scanned object, to obtain an intraoral film; S2, respectively acquiring high-energy X-rays and low-energy X-rays which penetrate through the scanned object; and S3, enabling the processing unit to obtain high-energy X-rays and low-energy X-rays penetrating through the scanned body, and obtaining a density image of a bone tissue through an image reconstruction algorithm. According to the method, the density image of the bone tissue can be obtained, so that the problems that in the prior art, an oral clinician needs to observe a dental film shot before an operation of a patient through naked eyes, grading judgment of jaw bone density is carried out through the sparse degree of spatial arrangement of bone trabecula, and an accurate bone density numerical value is lacked as an accurate reference, large errors are easily caused, and the success rate of the operation is influenced are solved.

The invention relates to a rotator cuff prosthesis. According to the rotator cuff prosthesis, a protective structure with a low friction coefficient is arranged on the outer surface of the rotator cuff prosthesis, so that the effect of improving the wear resistance of the rotator cuff prosthesis is achieved, and the service life of the rotator cuff prosthesis can be greatly prolonged. The protective structure may be a coating structure, a membrane structure, or a combination of the two. The rotator cuff prosthesis comprises a selectable prosthesis sleeve, the prosthesis sleeve can be arranged outside the prosthesis in a sleeving mode, and after the rotator cuff prosthesis is implanted into a body, the prosthesis sleeve can provide a proper movable space for the prosthesis while protecting the prosthesis, so that the rotator cuff prosthesis can adapt to skeleton tissues in a rotator cuff in a self-adaptive mode. When the prosthesis sleeve is included, the protective structure is arranged on the outer surface of the prosthesis sleeve. The invention further provides a preparation method of the rotator cuff prosthesis and a rotator cuff prosthesis device.