12 results about "Musculoskeletal tissue" patented technology

Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and / or controlling disease in mechanically-loaded musculoskeletal tissues.

A method for ultrasound stimulation of musculo-skeletal tissue structures includes generating a plurality of acoustic spatial-temporal modes comprised of a sinusoidal-complex, wherein the sinusoidal-complex has a modulation envelope that enhances spatial-temporal measurement accuracy at a site of a multi-layered biological tissue structure, and a pulse repetition frequency and duty cycle that are osteogenic at the site of the multi-layered biological tissue structure, beam steering the acoustic spatial-temporal modes to the site of the multi-layered biological tissue structure to promote tissue healing, and producing bi-modal stress levels in the multi-layered biological tissue structure that are sufficient to generate bone fracture healing.

The invention discloses an interpenetrating polymer network-based hydrogel material and a preparation method thereof, and the preparation method comprises the following steps: sequentially adding an acellular extracellular matrix solution, astragaloside IV, polyethylene glycol diacrylate and a photoinitiator into a polyvinyl alcohol solution, and uniformly mixing; refrigerating the mixture overnight, and then carrying out cross-linking reaction under ultraviolet light; the cross-linked hydrogel is sequentially subjected to CaCl2 solution soaking, NaOH solution soaking and multiple times of freezing and thawing cycle treatment. The astragaloside IV is used as a part of a hydrogel matrix, and the hydrogel with excellent mechanical properties and biological activity is formed through the synergistic effect of the astragaloside IV, the polyvinyl alcohol and the acellular extracellular matrix. The interpenetrating polymer network hydrogel based on the polyvinyl alcohol and the acellular extracellular matrix can be applied to preparation of motor system tissue repair or replacement materials, and is particularly applied to repair and replacement of bone, cartilage or ligament defects and promotion of tissue regeneration.

Methods for increasing local blood circulation in soft tissue, treating musculoskeletal tissue, and treating soft tissue of a subject are described. Continuous, non-pulsed ultrasound energy can be applied to a target tissue region, such as with a wearable ultrasound transducer. The ultrasound energy can be delivered at an intensity suitable for sustained application for at least 60 minutes. A statistically significant increase in local blood circulation can be achieved within 10 minutes of initiating application, occurring before a statistically significant increase in tissue temperature. In some embodiments, a topical non-steroidal anti-inflammatory drug (NSAID) is applied to the target region during ultrasound application. In some embodiments, local blood circulation is monitored using laser Doppler flowmetry until a statistically significant increase in perfusion units is detected. The increase in local blood circulation can be effective to alleviate pain and accelerate recovery from a soft tissue injury.

A system and method for pulsed electromagnetic fields (PEMF) tissue engineering enhances musculoskeletal tissue stimulation. A tissue engineering device may include both low and high pulse frequency signal generation components that may alternatively drive one or more coils to generate PEMFs. These PEMFs may be applied to bone tissue, tendons, ligaments, and / or cartilage. A prescribed treatment regimen using the tissue engineering device may include a first period of time where a first pulse frequency is used in treatment that supports tissue proliferation followed by a second period of time where a second pulse frequency (less than the first pulse frequency) is used in treatment that supports tissue differentiation. A treatment regimen may also include, with the frequency characteristic, applying a slew rate to the pulse characteristics that is on the order of around 30 to 100 Tesla per second to drive tissue differentiation in a targeted manner.

The invention relates to a muscle-bone ultrasonic multi-parameter imaging method based on a physical information neural network. The method comprises the following steps: S1, obtaining an observation signal; s2, constructing a generator and a discriminator; s3, generating an analog ultrasonic signal generated at the position of the ultrasonic transducer; s4, inputting the simulated ultrasonic signal and the observation signal into a discriminator together, and training the discriminator based on a generative adversarial task objective function; and S5, updating the current sound velocity distribution and the current medium density distribution of the generator, generating the simulated ultrasonic signal again, if the difference between the simulated ultrasonic signal and the observation signal is smaller than a threshold value and does not reach the training period, returning to S3, and otherwise, taking the current sound velocity distribution and the current medium density distribution at the moment as a multi-parameter imaging result of the muscle bone tissue. Compared with the prior art, the method has the advantages that the physical consistency of imaging results is improved, and then multi-parameter imaging of sound velocity and density of muscle bone tissue is accurately achieved.

The present invention relates to an implantable device configured to deliver, to an injured bone site, components for revascularisation and bone repair, the device comprising: a first osteoconductive scaffold component adapted to hold and deliver to the injured bone site, growth factors for inducing cellular events that initiate healing; and comprising a second osteoconductive scaffold component adapted to hold and deliver to the injured bone site, viable autologous osteogenic and / or angiogenic cells, and wherein the device also comprises a third scaffold component adapted to promote bone cell proliferation and vascularity, whereby the scaffold components provide a stable mechanical environment for promoting bone cell proliferation and vascularity. The present invention also relates to a method of manufacture of the implantable device.

A method for creating multiple finite element models of pelvic bone pin distribution optimization in a single operation includes: creating a three-dimensional model of the damaged pelvic musculoskeletal tissue and bone pins; developing an ABAQUS script file using ABAQUS / Python software to create several finite element models at once; and having the ABAQUS software read this script file to create n finite element models of pelvic musculoskeletal tissue containing bone pins in a single operation. This invention, based on ABAQUS / Python software, utilizes a script file for the simultaneous creation of multiple finite element models of pelvic musculoskeletal tissue containing bone pins, avoiding repetitive work in finite element modeling and effectively improving model creation efficiency.

The present invention relates to the use of Salvia haenkei extract as an active agent in the treatment of musculoskeletal disorders, being able to offer a significant contribution in slowing, relieving, reducing and / or preventing alterations and damages of the musculoskeletal tissues. Furthermore, the present invention also relates to a pharmaceutical composition comprising Salvia haenkei extract and suitable pharmaceutically acceptable excipients, for use in the treatment of musculoskeletal disorders.

The invention relates to method and system for monitoring musculoskeletal loading of a user during remote or longitudinal activity. The method includes collecting, by a primary sensor device operably attached to the user, primary sensor data indicative of biomechanical loading of a musculoskeletal tissue; collecting, by a secondary sensor device operably attached to the user, secondary sensor data indicative of physical activity of the user; synchronizing the primary sensor data with the secondary sensor data over a training interval; training, using the synchronized primary and secondary sensor data, a calibration model specific to the user to estimate a musculoskeletal loading metric from the secondary sensor data; and estimating, by applying the calibration model, the musculoskeletal loading metric during a period in which only the secondary sensor data is available.

This invention provides a probe device, a readable storage medium, and an orthopedic navigation robot. The navigation system of the orthopedic navigation robot can read a program from the readable storage medium to obtain the structural configuration of the probe device. After osteotomy, the navigation system obtains the spatial pose of the actual osteotomy plane that the measurement plane is attached to based on the structural configuration of the probe device. The probe device includes: a connecting rod; a target support disposed at one end of the connecting rod; an optical positioning mark disposed on the target support, the optical target plane being parallel or intersecting the connecting rod; and a measuring component disposed at the other end of the connecting rod, the measuring component including a horizontal plate having at least one measuring plane, the connecting rod being parallel or intersecting the measuring plane of the horizontal plate; the probe device is configured to attach to all osteotomy planes on the knee joint through at least one measuring plane. This invention can reduce interference between the probe and musculoskeletal tissue during osteotomy measurement and also allows the optical target to be better aligned with the navigation system.