4 results about "Musculoskeletal tissue" patented technology

A method for ultrasound stimulation of musculo-skeletal tissue structures includes generating a plurality of acoustic spatial-temporal modes comprised of a sinusoidal-complex, wherein the sinusoidal-complex has a modulation envelope that enhances spatial-temporal measurement accuracy at a site of a multi-layered biological tissue structure, and a pulse repetition frequency and duty cycle that are osteogenic at the site of the multi-layered biological tissue structure, beam steering the acoustic spatial-temporal modes to the site of the multi-layered biological tissue structure to promote tissue healing, and producing bi-modal stress levels in the multi-layered biological tissue structure that are sufficient to generate bone fracture healing.

Methods for increasing local blood circulation in soft tissue, treating musculoskeletal tissue, and treating soft tissue of a subject are described. Continuous, non-pulsed ultrasound energy can be applied to a target tissue region, such as with a wearable ultrasound transducer. The ultrasound energy can be delivered at an intensity suitable for sustained application for at least 60 minutes. A statistically significant increase in local blood circulation can be achieved within 10 minutes of initiating application, occurring before a statistically significant increase in tissue temperature. In some embodiments, a topical non-steroidal anti-inflammatory drug (NSAID) is applied to the target region during ultrasound application. In some embodiments, local blood circulation is monitored using laser Doppler flowmetry until a statistically significant increase in perfusion units is detected. The increase in local blood circulation can be effective to alleviate pain and accelerate recovery from a soft tissue injury.

A system and method for pulsed electromagnetic fields (PEMF) tissue engineering enhances musculoskeletal tissue stimulation. A tissue engineering device may include both low and high pulse frequency signal generation components that may alternatively drive one or more coils to generate PEMFs. These PEMFs may be applied to bone tissue, tendons, ligaments, and / or cartilage. A prescribed treatment regimen using the tissue engineering device may include a first period of time where a first pulse frequency is used in treatment that supports tissue proliferation followed by a second period of time where a second pulse frequency (less than the first pulse frequency) is used in treatment that supports tissue differentiation. A treatment regimen may also include, with the frequency characteristic, applying a slew rate to the pulse characteristics that is on the order of around 30 to 100 Tesla per second to drive tissue differentiation in a targeted manner.

The present invention relates to the use of Salvia haenkei extract as an active agent in the treatment of musculoskeletal disorders, being able to offer a significant contribution in slowing, relieving, reducing and / or preventing alterations and damages of the musculoskeletal tissues. Furthermore, the present invention also relates to a pharmaceutical composition comprising Salvia haenkei extract and suitable pharmaceutically acceptable excipients, for use in the treatment of musculoskeletal disorders.