10 results about "Tissue scaffolds" patented technology

The invention relates to a tissue scaffold developed for use in the treatment of cartilage tissue loss and a method for its production.

The present invention relates to PCL / GelMA (polycaprolactone / gelatin methacrylate) tissue scaffolds cultured with HUC-MSCs (human umbilical cord mesenchymal stem cells), a method for their production, and their use in pelvic floor reconstruction. Experimental results demonstrating the efficacy of the tissue scaffolds obtained according to the invention are also presented.

The disclosure relates to biomaterials, specifically non-pyrogenic bacterial cellulose for implantable medical applications, and to a depyrogenation process. It addresses the problem that sterile bacterial cellulose remains pyrogenic due to endotoxin, particularly lipopolysaccharide, which resists standard sterilization and purification. The process involves providing a purified bacterial cellulose membrane in an aqueous medium and subjects it to depyrogenation at about 140°C–250°C under pressure sufficient to maintain the aqueous phase liquid. The treated material is a bacterial cellulose hydrogel having a water holding capacity of at least 100 g water / g dry bacterial cellulose and endotoxin below 0.5 EU / mL as determined by a Limulus amebocyte lysate assay on enzymatically degraded samples. The product and process are useful for manufacturing non-pyrogenic implantable bacterial cellulose devices, including internal implants, tissue scaffolds, and other biocompatible medical components.

Provided herein is a method for producing a tissue graft. The graft may include a living cell and an attachment scaffold. The method may include rinsing a tissue sample; incubating the sample in a hypertonic salt solution to produce a hypertonic solution-treated tissue sample; incubating the treated tissue sample with an ionic detergent to produce a detergent-treated tissue sample; incubating the detergent-treated sample with a DNase to produce a DNase-treated scaffold; incubating the DNase-treated scaffold with a virus-inactivating compound to produce a virus- inactivated scaffold; and contacting the virus-inactivated scaffold with a living cell population to produce a tissue graft.

This specification provides a tissue scaffold (118) which may include one or more surface microstructure patterns that can alter the physical properties of the tissue scaffold. The microstructure patterns may be cell-directed over a larger spatial range than in the prior art using chemically modified substrates. The disclosure further includes a tissue scaffold configured such that cells can infiltrate the tissue scaffold by responding to a pattern of surface energy gradients on the tissue scaffold, and the cells cannot be constrained to the pattern by physical means. As the cells proliferate, they associate and orient themselves in response to the long-range pattern to form a confluent monolayer of cells, constructing a functional macrostructure across the surface of the tissue scaffold.

Devices and methods for treating an intraoral cavity of a patient are provided. In some embodiments, a device includes a tissue scaffold configured to promote growth of oral tissue at a treatment site in the intraoral cavity of the patient, and a positioner. The positioner can include one or more cavities configured to receive one or more teeth of the patient, and an alignment element configured to temporarily couple to the tissue scaffold such that when the positioner is placed on the patient's teeth, the alignment element locates the tissue scaffold at the treatment site.

The application provides an application of an algal composition in plant protein meat and belongs to the technical field of food processing; the carotenoid content in the plant protein meat can be regulated, and a preparation method comprises the following steps: mixing algal cells and a tissue scaffold matrix to obtain a bio-ink, performing 3D printing to obtain an algal composition, cross-linking by using a cross-linking agent, and performing high-density culture and stress induction culture after forming a hydrogel. In the application, microalgae are used as a sustainable nutrient source and an endogenous colorant, and the application first realizes the regulation of microalgae-derived pigments in cultured meat, establishes a low-carbon and reasonable research framework for future food system design customization and obtaining of health-promoting cultured meat products.

The present disclosure provides tissue scaffolds and hydrogels as well as methods of making and using the same. Also provided are tissue scaffolds with improved biological properties and methods of utilizing said tissue scaffolds for the treatment of wounds.

A packaging system (10b) includes a package defining a cavity (14b) and a seal (18b) configured to be coupled to the package to fluidly seal the cavity. The packaging system can also include at least one tissue scaffold (16b) configured to be disposed within the cavity. Cavities having a single size can be configured to receive tissue scaffolds having different sizes. In addition to the cavity, the packaging system can include one or more additional reservoirs configured to hold a quantity of liquid. Such packaging systems can be used to store human or animal tissue for wet or dry storage. The invention also provides a packaged tissue sample and methods of packaging tissue.

Methods for the development and integration of multiple apparatuses and methods for achieving administration of stem cell therapies include precision manufacturing of tissue scaffolds and / or bioreactor substrates. The nano / microscale fiber material extrusion typifying the electrospinning process is married with the fiber alignment and layering characteristic of an additive manufacturing process. The method generates porous fibrous 3-D meshes with precision controlled structures from biopolymer melts and solutions and gels, blends, and suspensions with and without cells. A method of tracking the migration histories and shapes of stem cells on scaffold surfaces relies on immunofluorescent imaging and automated algorithms based on machine learning. The combination of the precision manufacturing method and the method of cell tracking and cell shape statistics, along with understanding of the intimate relationship between the cell shape / phenotype and scaffold architecture leads to an integrated method for cultivating and harvesting cells having desired phenotypes.