77 results about "Irreversible electroporation" patented technology

High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing bursts of electrical pulses in a positive phase-interphase delay-negative phase-interpulse delay pattern. Despite accumulating evidence suggesting the significance of these delays, their effects on therapeutic outcomes from clinically-relevant H-FIRE waveforms have not been studied extensively. The present invention provides methods of pulse delivery, including delays, that mitigate bubble formation and / or minimize the risk of arcing, such as due to the presence of bubbles, and / or minimize muscle stimulation are described herein.

Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.

Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.

A method includes inserting an ablation catheter into an ablation site in a patient heart. Multiple electrocardiogram (ECG) signals are acquired. A refractory period of the patient heart is detected based on the acquired ECG signals. The ablation site is ablated using the ablation catheter during the detected refractory period.

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

The invention belongs to the technical field of biomedicine and nano material electronics, and particularly relates to a low-voltage efficient sterilization electrode device based on local enhanced electric field treatment. According to the electrode device, vertically-oriented nanoneedles serve as a core functional layer, a nanoneedle array is arranged on a conductive substrate, the intensity of an electric field in a pinpoint area is amplified by multiple times through the lightning rod effect induced by the tips of the nanoneedles so as to achieve irreversible electroporation of a low-potential induced pathogen membrane, the length of the nanoneedles is 5-100 micrometers, and the length of the nanoneedles is 5-100 micrometers. The curvature radius of the needle tip is lt; and the sterilization device can realize nearly complete sterilization on escherichia coli and methicillin-resistant staphylococcus aureus within 5 minutes. The invention further provides a nanometer microneedle sterilization patch based on the local enhanced electric field, a self-power-supply or external-source-power-supply energy supply mode is adopted, and rapid sterilization of a wound can be achieved without medicine adding.

High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing bursts of electrical pulses in a positive phase-interphase delay-negative phase-interpulse delay pattern. Despite accumulating evidence suggesting the significance of these delays, their effects on therapeutic outcomes from clinically-relevant H-FIRE waveforms have not been studied extensively. The present invention provides methods of pulse delivery, including delays, that mitigate bubble formation and / or minimize the risk of arcing, such as due to the presence of bubbles, and / or minimize muscle stimulation are described herein.

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

The application relates to the technical field of medical devices, in particular to a lung tumor treatment device based on irreversible electroporation and cryoablation, which comprises a single needle for generating high-voltage electric pulses, an ice knife for conveying cold gas medium and a CT display module for displaying CT images in real time, comprises a puncture sleeve, the puncture sleeve is provided with a sliding groove, the single needle and the ice knife are in gap cooperation with the sliding groove; a needle head is detachably connected in the sliding groove, the puncture sleeve is communicated with a conveying pipe, and the puncture sleeve is provided with an outlet for discharging the cold gas medium at one end; the sliding groove is also communicated with a collection mechanism for collecting external tissues, and the collection mechanism is used for collecting the external tissues based on the pushing of the needle head, the single needle and the ice knife; the application is convenient for switching surgical tools, reduces the damage to the surrounding tissues in the body during the treatment of lung ground glass nodules, and guarantees the removal effect of the lung ground glass nodules.

A catheter for ablating cardiac tissue through irreversible electroporation, the catheter comprising a flexible circuit having a plurality of flex circuit branches and including an outwardly-facing ablation electrode including a plurality of ablation electrode branches extending proximally along a portion of a respective one of the flex circuit branches, and a support member having a plurality of support member branches, wherein the support member includes an electrically conductive base member covered by an electrically insulative coating, wherein each of the flex circuit branches is secured to a respective one of the support member branches, and the ablation electrode is electrically coupled to the electrically conductive base member.

A catheter for ablating tissue by irreversible electroporation is disclosed. The catheter includes an elongate body having a proximal end and a distal end. The catheter also includes a first electrode spaced proximally from a second electrode along the elongate body, the first electrode and the second electrode each having a transition region terminating at opposing edges. The catheter further includes an insulator disposed on the electrode and extending between the first and second electrodes at the transition region. In the transition region, the electrode thickness of each electrode decreases toward the opposing edges, and the insulator thickness correspondingly increases to maintain a substantially constant total thickness.

An irreversible electroporation (IRE) is provided that includes setting an initial IRE protocol for applying IRE pulses by electrodes of a catheter placed in contact with tissue in an organ. Upon determining that the initial IRE protocol is expected to cause bubbles in blood, a notification is issued to a user. In response to the notification, user input is received from the user that selects between the initial IRE protocol and an alternative protocol that is expected not to cause bubbles. Depending on the user input, the IRE pulses are applied in accordance with the initial IRE protocol or the alternative IRE protocol.

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

The present invention discloses a micellar mixed system for enhancing the therapeutic effect of irreversible electroporation on pancreatic cancer and a preparation method thereof. By mixing CGP37157-loaded PEG-PCL micelles (CGP37157@PEG-PCL) with a CaCl2 solution to form an injectable micellar mixed system, the poorly water-soluble CGP37157 sodium-calcium exchange inhibitor can be delivered into tumor cells. During electroporation therapy, as the permeability of tumor cells increases, the excretion of calcium ions in mitochondria is inhibited, further leading to mitochondrial calcium overload and accelerating tumor cell death. This can effectively improve the efficiency of IRE treatment and has good clinical application prospects.

This application provides a pulse generation system, an irreversible electroporation device, and a related method. The pulse generation system generates a high-voltage pulse signal by controlling the conduction of a pulse transmission circuit according to a control signal. This high-voltage pulse signal is applied to biological tissue through at least one pair of electrodes, causing irreversible electroporation and cell death within the tissue. Furthermore, the pulse generation system can also generate a low-voltage pulse signal to collect electrical information from the biological tissue. This electrical information is then used to determine the effectiveness of the irreversible electroporation and whether to continue the high-voltage pulse treatment. Thus, a single pulse generation system can generate both high-voltage and low-voltage pulses without requiring additional equipment, making it more convenient to use. Moreover, since it is a single circuit, the control effect is better.

The application discloses a tumor irreversible electroporation ablation operation parameter optimization system, comprising an initialization population module, an individual grade division module, a first generation sub-population generation module, a new population determination module, a new parent population establishment module, a new parent population update module, a merging module and a result selection module. The NSGA-II algorithm in the genetic algorithm is adopted to optimize the operation parameters, and a threshold setting is added. The system can assist doctors in formulating the best operation parameter scheme, so as to achieve the operation target of maximizing killing of tumor tissues, minimizing damage to normal tissues and minimizing the number of pulses.

To provide a device and method for irreversible electroporation of tissue.SOLUTION: A device and a method for the electroporation are described. An exemplary embodiment of the device has a catheter and a signal generator-evaluation unit connected to the proximal end of the catheter.SELECTED DRAWING: Figure 1

The invention discloses a steep pulse generator for high-frequency irreversible electroporation, which is characterized in that a pulse generation module simultaneously conducts positive and negative Sic MOSFETs (Metal Oxide Semiconductor Field Effect Transistor) through a bipolar push-pull structure to ensure that the rising / falling time, amplitude and pulse width of positive and negative pulses are strictly symmetrical and reduce tissue damage or non-uniform energy distribution caused by waveform asymmetry. Meanwhile, an adopted voltage closed-loop feedback control network can automatically compensate energy loss caused by tissue impedance fluctuation, it is ensured that the electric field intensity is stable, the penetration depth of the electric field can be accurately controlled, and the system is suitable for scenes with high treatment precision requirements. And multi-path output is expanded through the decoder, and flexible configuration of different electrode arrays is supported. Different modules are arranged independently in a split-board mode, high-voltage and low-voltage circuits are designed in a full-isolation mode, whole machine repair is not needed when faults occur, the equipment maintenance cost is reduced, and the expansibility of the modules is high.

An energy delivery therapy system facilitates determining various characteristics of a lesion and / or tissue at a treatment site, such as the size and / or location of the lesion; stiffness and / or elasticity of the tissue; an impedance or resistance of the tissue (which may affect the form of energy, such as electroporation and / or irreversible electroporation applied to the tissue); and / or the effect of the treatment applied to the lesion. The collected information about the treatment site may be used to assist in predicting and measuring lesions, and / or to determine an appropriate treatment plan based on the condition of each patient. After the energy delivery assembly has been withdrawn from the treatment site, indicia may be used to facilitate localization of the treatment site.

A catheter for ablating tissue by irreversible electroporation is disclosed. The catheter includes an elongate body having a proximal end and a distal end. The catheter also includes a first electrode disposed proximally spaced along the elongate body from the second electrode, each of the first and second electrodes having a transition region terminating at opposing edges. The catheter also includes an insulator disposed over the electrode in the transition region and extending between the first electrode and the second electrode. In the transition region, the electrode thickness of each electrode decreases toward the opposite edge, and the insulator thickness of the insulator correspondingly increases to maintain a substantially constant combined thickness.

A system for ablating cardiac tissue through irreversible electroporation is disclosed. The system includes an electroporation and mapping catheter, a graphical display, and a controller coupled to the graphical display and the catheter. The catheter includes an electrode assembly defining a distally located central hub portion and splines, each spline including a distal end portion extending from the central hub portion, and a proximal end portion attached to and constrained by an outer shaft. The electrode assembly includes electrodes having sensing electrodes located on each spline. The controller determines an impedance from a four-terminal configuration wherein a current is injected to a current carrying pair of electrodes and a volage is measured across a sensing pair of electrodes comprising sensing electrodes. The controller generates a graphical representation of a model of the impedance of the spline on the graphical display.

The invention relates to the technical field of medical instruments, in particular to a lung tumor treatment device based on irreversible electroporation and cryoablation, which comprises a single needle used for generating high-voltage electric pulse, an ice knife used for conveying a cold air medium and a CT display module used for displaying a CT image in real time, and further comprises a puncture cannula, the single needle and the ice skate blade are in clearance fit with the sliding groove; a needle head is detachably connected in the sliding groove, a conveying pipe is communicated in the puncture cannula, and an output port for discharging a cold air medium is formed in one end of the puncture cannula; one side of the sliding groove further communicates with a collecting mechanism used for collecting external tissue, and the collecting mechanism is used for collecting the external tissue based on pushing of the needle head, the single needle and the ice skate blade. Operation tools can be conveniently switched, damage to peripheral tissues in the body in the process of treating the ground vitreous nodules is reduced, and the removing effect on the ground vitreous nodules is guaranteed.

The cryo-assisted Irreversible Electroporation (IRE) ablation system includes an IRE ablation generator, a coolant supply, cryo-assisted IRE ablation stylet(s), and a cryo-assisted IRE ablation controller for controlling the IRE ablation generator and the cryo-assisted IRE ablation stylet(s). The ablation stylets include a stylet needle having longitudinally directed strip electrode(s) and a freezing module for cooling a longitudinal directed ice-forming surface for freezing a generally hemi-ellipsoidal volume of target tissue. The controller repeatedly switches the ablation stylets between an IRE ablation energy mode and a non-cryoablation freezing mode whereupon, in an absence of ice formation, each cryo-assisted IRE ablation stylet generates a pre-ice 3D electric field pattern in target tissue and, subsequent to a generally hemi-ellipsoidal ice formation, the ice formation modifies the pre-ice 3D electric field pattern to a post-ice 3D electric field pattern different from the pre-ice 3D electric field pattern.

Disclosed herein is an electroporation system including a catheter shaft, at least one electrode coupled to the catheter shaft at a distal end thereof, and a signal generator. The signal generator is coupled in communication with the at least one electrode. The signal generator supplies a biphasic pulse to the at least one electrode, the biphasic pulse including a first phase having a first polarity, a first initial voltage amplitude, and a first pulse width. The biphasic pulse includes a second phase having a second polarity opposite to the first polarity, a second initial voltage amplitude, and a second pulse width, wherein at least one of the first initial voltage amplitude or the first pulse width is different from the second initial voltage amplitude or the second pulse width, respectively. A leading edge of the second phase occurs after an interphase delay following a trailing edge of the first phase.

An energy supply treatment system that enables determination of various characteristics of the lesion and / or tissue at the treatment site, such as the size and / or location of the lesion, the stiffness and / or elasticity of the tissue, the impedance or resistance of the tissue (which can affect the form of energy applied to the tissue, such as electroporation and / or irreversible electroporation), and / or the effect of the treatment applied to the lesion. Information collected regarding the treatment site can be used to help predict and measure the lesion and / or determine an appropriate treatment plan for each patient. Markers can be used to enable localization of the treatment site after the energy supply assembly has been withdrawn from the treatment site.

A system for performing irreversible electroporation within a tissue under a skin surface of a patient, the system including: a power source configured to generate power; a base; and at least one electrode extending from the base, where the at least one electrode is configured to receive the power and based on the power to generate an electric field sufficient to porate a cell membrane within the tissue while increasing a temperature of the skin surface less than 3 deg C. during poration.

The present disclosed subject matter provides a return electrode, such as a body surface electrode, which includes an accelerometer, for detecting movement of the body at and proximate to the location of the return electrode. The body movement results from pulses from an Irreversible Electroporation (IRE) pulse generator which are delivered to the return electrode, by a pulse delivery electrode. The data associated with the body movement at each location on the body of the return electrode, is used to determine suitable, and in some cases optimal, locations for return electrodes for IRE procedures.

The invention discloses a dual-electrode irreversible electroporation ablation needle, an ablation method and application. The method comprises the steps that the number of ablation needles and an electrode combination ablation mode are selected according to the form and the size of a focus; an irreversible electroporation pulse electric signal is applied in a selected electrode combination ablation mode, so that an irreversible electroporation ablation area is formed in the tissue around the needle body, and the focus tissue is ablated; the ablation mode comprises an ablation mode between the first electrode and the second electrode in the single ablation needle; and ablation modes between the first electrodes, between the second electrodes or between the cross electrodes between the different ablation needles. Multiple ablation modes are achieved through the two needles, the ablation mode is flexible, the electric field coverage range is adjustable, incomplete ablation is effectively avoided, the ablation efficiency is improved, the number of the distributed needles is reduced, the consistency, controllability and reliability of ablation are improved while the surgical operation process is simplified, and good clinical application prospects are achieved.