Devices, systems and methods are provided to treat damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a
benign tumor, a malignant tumor, a
cyst, or an area of diseased tissue, etc) by delivering specialized pulsed
electric field (PEF) energy to
target tissue areas. The energy is delivered in a manner so as to be non-thermal (i.e. below a threshold for causing
thermal ablation). Consequently, when
extracellular matrices present, the
extracellular matrices are preserved, and the targeted tissue maintains its structural architecture including blood vessels and lymphatics. Thus, sensitive structures, such as biological lumens, blood vessels, nerves, etc, are preserved which are critical to maintaining the integrity and functionality of the tissue. The energy is delivered with the use of systems and devices advantageously designed for superior access to
target tissue throughout the body, particularly in locations previously considered inaccessible to
percutaneous approaches.