20 results about "Tumor surgery" patented technology

The invention relates to a medical instrument for gynecologic operation, in particular to a uterus traction device capable of avoiding tumor cell diffusion and a using method thereof.The traction device comprises a bag, the bag is provided with a closed end used for wrapping the bottom of the uterus and an open end used for facing the cervix uteri opening, and the bag is provided with an opening. The open end is provided with an adjusting and tightening mechanism, the cervix uteri, the uterus body and the double accessories of the cervix uteri and the uterus body can be wrapped in the bag by pulling the open end, and then the open end is tightened through the adjusting and tightening mechanism. A wrapping path in the direction from the bottom of the uterus to the cervix uteri opening is adopted, it is ensured that the uterus and contents of the uterus are completely wrapped and isolated in the bag by tightening the opening end, the operation concept that isolation is carried out in advance is achieved, the operation view is protected in the whole process, and tumor-free traction in the operation process is facilitated; in addition, the risks of incision planting and abdominal cavity spreading in malignant tumor surgery can be greatly reduced, the possibility of tumor cell spreading is avoided, and iatrogenic injury is reduced.

The application discloses a radio-positioning glove and belongs to the technical field of medical devices. The glove comprises an elastic inner layer glove and a non-elastic outer layer glove sleeved on the outer side of the inner layer glove, and both of them are made of X-ray non-developing material. The surface of the non-elastic outer layer glove is provided with a surface developing coordinate grid formed by developing material, and physical mark holes penetrating through the outer layer and the inner layer along the thickness direction are arranged at the intersection points of the longitudinal and transverse coordinate lines of the grid. The inner layer glove and the outer layer glove are connected through magic tape at the hand insertion end, and the remaining parts are in a superimposed and relatively slidable state. The application effectively eliminates the interference of the sliding of the soft tissue and the skin of the hand on the positioning accuracy by using the rigid constraint of the non-elastic outer layer. After locking the lesion coordinates through the X-ray image, the doctor can directly use the physical mark holes to accurately mark on the skin of the patient, realizes 1:1 lossless conversion of the image coordinates to the body surface mark, greatly improves the accuracy of the hand tumor surgery and reduces the surgical damage.

The application belongs to the technical field of fluorescent probe, and particularly relates to an aminopeptidase fluorescent probe and a preparation method and application thereof. In order to develop an APN near-infrared fluorescent probe suitable for in vivo imaging, a center-position ester group substituted pentamethine cyanine dye platform (Cy5-COOM) is used, and based on an "ester group to carboxyl group" conversion strategy, an aminopeptidase (APN) fluorescent probe Cy5-APN is developed. The probe is firstly hydrolyzed by APN, then a 1,6-elimination reaction occurs, and finally a strong fluorescent center-position carboxyl group substituted pentamethine cyanine dye Cy5-COO is released. In addition, in view of the characteristics that cancer cell surfaces overexpress APN, the probe can distinguish cancer cells / tissues and normal cells / tissues with high contrast, and therefore has great application potential in fluorescence-guided tumor surgery.

This utility model discloses a bipolar radiofrequency electrode for bone tumor surgery, which includes a cable assembly, a handle, a scalpel, and a scalpel head connected in sequence. The scalpel head includes a suction tube and an outer steel tube that is spaced and sleeved on the suction tube, with a water outlet channel formed between the suction tube and the outer steel tube. The scalpel head includes an insulating head fixed to the distal end of the outer steel tube. The insulating head is provided with a first strip electrode and a second strip electrode arranged side by side. The insulating head located at the first strip electrode and the second strip electrode has several suction holes, which are connected to the suction tube. Several water outlet holes connected to the water outlet channel are provided on both sides of the distal end of the outer steel tube. This solution uses radiofrequency electrodes to irrigate the incision after the resection of benign spinal tumors, which can accurately stop bleeding at soft tissue bleeding points, effectively reducing the amount of bleeding. Furthermore, by utilizing the circulating supply of physiological saline, the first strip electrode and the second strip electrode are effectively wrapped by physiological saline, thereby ensuring the plasma excitation efficiency.

The invention belongs to the technical field of medical apparatus and instruments, and particularly relates to a gynecological tumor operation picking device which comprises a connecting plate, a handle is fixedly connected to one end of the connecting plate, a sliding block is slidably connected to one side of the connecting plate, a displacement plate is fixedly connected to one side of the sliding block, clamping rods are slidably connected to the two sides of the displacement plate, and the clamping rods are slidably connected to the two sides of the displacement plate. The end part of the clamping rod is fixedly connected with a picking block; the device further comprises a picking and storing assembly. According to the tumor picking and storing device, by means of the picking and storing assembly, every time one tumor is picked, the tumor can be placed in the storing barrel, each tumor has an independent placing area, and the situation that the placed tumor falls out until all the tumors are picked due to the fact that the next tumor is placed is avoided. In the whole process, the picking block does not need to go in and out of the body of a patient repeatedly, so that the operation time is remarkably shortened, meanwhile, additional trauma caused by frequent friction of incision tissue is avoided, and the pain degree of the patient after an operation is relieved.

The invention relates to the technical field of tissue specimen preservation, in particular to tumor specimen auxiliary storage equipment for tumor surgery. The device comprises a base, the top of the base is rotationally connected with an adjusting sealing cover, a low-temperature cavity is defined by the interior of the adjusting sealing cover and the top of the base, and the top of the adjusting sealing cover communicates with an air inlet; when the tumor specimen in the low-temperature cavity is taken out, the top of the side, away from the axis, of the specimen temporary storage piece is in sliding fit with the inner bottom wall of the sealing block, it is ensured that the space size of the buffer cavity is gradually reduced, and it is ensured that the upper portion of the buffer cavity is always kept sealed, so that a positive pressure space is formed in the buffer cavity; cold air originally coming from the low-temperature cavity in the inner part is discharged from an opening which is opened due to the rising of the sealing block; when a new clinical tumor specimen is stored in the low-temperature cavity, external air in a buffer cavity space below the low-temperature cavity is driven away through the downwards-pressed sealing block.

The invention relates to the technical field of gynecological tumor, and provides tumor stripping equipment for gynecological tumor surgery, which comprises a rod body, a stripping end for mounting a stripping assembly and a control end for mounting a control assembly are respectively arranged at two ends of the rod body, and the control end and the stripping end are connected through a connecting straight rod. A handle is further fixedly connected to one side of the control end, a guide assembly used for guiding a pull rope is arranged between the stripping assembly and the control assembly, through arrangement of a damper, a centering guide wheel and other structures, the damper and a spring act synergistically, the impact force generated when the clamping jaw is opened and closed is effectively absorbed, tissue damage is prevented, and the service life of the clamping jaw is prolonged. And the centering guide wheel groups which are uniformly distributed on the circumference ensure that the pull rope is always conveyed along a central path through rolling support, so that transmission deviation and clamping stagnation are avoided, the stability and the safety of equipment operation are obviously improved, and the problems of instability and insufficient precision in the prior art are solved.

A method for preparing a bionic injectable polypeptide hydrogel is provided. The hydrogel is formed using a brain extracellular matrix laminin-derived peptide DDIKVAV modified with 9-fluorenylmethoxycarbonyl (Fmoc) (Fmoc-DDIKVAV) and an immunostimulatory peptide FTKPRF modified with Fmoc (Fmoc-FTKPRF) as hydrogel monomers. These monomers further utilize non-covalent bond forces such as hydrogen bonds, hydrophobic interactions, and x-x stacking to co-assemble into a hydrogel within a short time at 37° C. The bionic hybrid polypeptide hydrogel is injectable and can serve as a drug reservoir implanted into cavities formed after tumor surgery. The drugs loaded in the hydrogel are slowly released at a stable and controlled rate and appropriate concentration within the post-surgical cavity, thereby effectively killing residual tumor cells while avoiding the toxic side effects of systemic drug administration.

The invention belongs to the technical field of bone repair materials, and discloses a preparation method of a cross-scale gradient structure, a bone repair material and an application method. The preparation method comprises the following steps: preparing a semiconductor biological material into a biological heterojunction suspension, and mixing the biological heterojunction suspension with photocuring hydrogel to form a system; a bone implant base material and a conductive material are respectively used as a positive electrode and a negative electrode to be placed in a system, an electric field is applied to enable the biological heterojunction particles to directionally deposit to form a gradient, the bone repair material with a cross-scale gradient structure is obtained through photo-curing fixation, and a porous scaffold can be preset as required. The material prepared by the method simulates a natural gradient structure of a human skeleton, has composite functions of electric conduction, antibiosis and the like, can give consideration to mechanical support and biological activity, is adaptive to scenes of spine repair, tumor postoperative bone defects and the like, solves the problems that a traditional bone repair material is not matched in structure and single in function, and improves osseointegration efficiency and clinical safety.

This invention provides a wound healing dressing for postoperative care of tumor patients and its preparation method, belonging to the field of postoperative dressing technology. The dressing comprises boric acid-grafted GelMA, caffeoyl tartaric acid-grafted CSMA, aldehyde-modified diallyl tartaramide, sodium alginate, catechins, ferric chloride, and calcium chloride. Its preparation process utilizes dynamic imine bonds, UV-induced covalent cross-linking, ionic cross-linking, and metal coordination to construct a multi-layered cross-linked interpenetrating network structure. The resulting dressing possesses both high strength and good toughness, allowing it to closely adhere to irregular wound surfaces. The rapid initial release of catechins provides immediate antioxidant and hemostatic effects, while catechols are continuously and slowly released under the influence of the microenvironment. Simultaneously, cationic chitosan, catechins, and iron ions synergistically provide antibacterial effects, and calcium alginate promotes coagulation, while GelMA promotes cell adhesion and proliferation, comprehensively promoting wound healing, reducing the risk of infection, and making it suitable for the care of complex wounds after tumor surgery.

The application discloses a composite nano-silicon ball drug delivery system and a preparation method and application thereof. The system takes mesoporous silica nanoparticles as a carrier, loads gefitinib, and is coated with a PD-L1 antibody modified platelet membrane on the surface. The application prepares a composite multifunctional mesoporous silica nanoparticle which loads gefitinib and is coated with a PD-L1 antibody modified platelet membrane on the surface, so that the composite multifunctional mesoporous silica nanoparticle can be directed to reach a tumor surgery blood vessel damage site, kill residual tumor cells, reduce matrix hardness in the microenvironment, enhance the permeability and toxicity of immune cells, the two effects are interdependent and mutually enhanced, and the application overcomes the invalidity of colorectal tumor immunotherapy and prolongs the survival period of patients.

The present invention relates to a method and reagents for detecting DNA methylation. Specifically, the present invention relates to a method for diagnosing the presence or absence of a tumor in a subject, a method for diagnosing the presence of microresidual lesions after tumor surgery, a method for determining the postoperative prognosis of a subject with a tumor, a method for predicting postoperative recurrence in a subject with a tumor, or a method for evaluating the therapeutic effect on a subject with a tumor, by detecting a methylation marker in free DNA in a sample derived from the subject and determining the methylation level of the DNA. The present invention also relates to a marker, a kit, and a detection reagent used in the above method.

This application discloses a method, system, and device for in-situ 3D reconstruction of tumor surgical boundaries and intraoperative navigation, relating to the medical field. The method includes: obtaining a set of two-dimensional pixel coordinates of key points of the tumor tissue detection probe based on image frame data using a constructed key point detection model; calculating the 3D coordinates of the probe detection focus in the camera coordinate system using a determined rigid body transformation matrix and pre-calibrated probe detection focus model coordinates; generating a point cloud with cancerous / non-cancerous pathological attributes based on timestamps, spectral data, and 3D coordinates; connecting the point cloud with cancerous pathological attributes in chronological order to form a continuous spatial contour line; and dynamically overlaying this contour line onto the current image frame based on camera intrinsic parameters to achieve intraoperative navigation. This application overcomes the limitations of current methods, such as being limited to single-point detection and unable to construct continuous spatial geometric information, as well as the pain point of the detection probe's tip being easily occluded during continuous movement close to the affected area, leading to positioning loss.

This invention relates to the field of surgical navigation technology for tumor treatment, specifically to an intelligent navigation system for nasal skull base tumor surgery based on multimodal image fusion. The system includes an image acquisition module for acquiring and rigidly registering CT and MRI images to determine the initial tumor region; a tumor invasion degree acquisition module for quantifying the local tumor invasion degree by combining CT grayscale distribution characteristics and MRI apparent diffusion coefficient characteristics; an invasion path acquisition module for simulating a fully covered digital invasion path based on anisotropic diffusion of image features; a risk infiltration degree acquisition module for comprehensively considering distance, direction, and invasive activity to assess the risk of invasion path infiltrating key structures; and a tumor boundary acquisition module for obtaining the tumor biological boundary by correcting the anatomical boundary through risk infiltration degree. This invention effectively improves the accuracy and safety of nasal skull base tumor surgery by acquiring the tumor biological boundary.

The utility model relates to the technical field of medical instruments, in particular to a gastrointestinal tumor surgery diversion device. The gastrointestinal tumor surgery diversion device comprises a diversion bottle, a thickening layer is arranged at the bottom of the diversion bottle, and a plurality of clamping grooves distributed in the circumferential direction are formed in the thickening layer; a rotating shaft is fixed on the thickening layer, and a limiting rotating disc is rotationally connected to the rotating shaft; a thickening layer is additionally arranged at the bottom of an original flow guide bottle, and a supporting mechanism, a supporting ring, a sleeving piece, anti-skid lines, a hand screwing bolt, a connecting strip, a limiting rotating disc, a rotating shaft, a limiting groove, an embedding opening, an elastic clamping head, a positioning groove and a clamping groove are arranged, so that the sleeving piece can be fixed to an infusion support, and therefore the flow guide bottle is placed in a suspended mode; and moreover, the flow guide bottle is fixed on the infusion support, so that medical staff can conveniently observe the internal liquid amount, diagnosis and treatment of the patient are facilitated, and the infusion support is high in practicability.

The application discloses a nerve tumor surgery postoperative rehabilitation nursing device, and relates to the technical field of nerve tumor surgery, which comprises a nursing helmet, and an air bag neck ring is arranged at the bottom of the nursing helmet. The nerve tumor surgery postoperative rehabilitation nursing device can continuously cool the top of the head of a patient, so that the wound site is kept in a dry state at all times, a good nursing and healing environment is provided for the rapid recovery of the wound site, the head of the patient is helped to dissipate heat in a large area, the feeling of stuffiness and discomfort of the head caused by long-time wearing of the nursing helmet is eliminated, the wound site is prevented from being excessively pressed, a child lock mode is provided, direct scratching of the wound site by the hands of children is effectively prevented, the normal recovery of the wound site is protected, wound healing is accelerated, scarring is prevented, automatic diffusion type medicine application wet nursing effect on the wound site of the head of the patient is realized, and slow medicine application on the wound site is realized.

The invention discloses a composition based on a paclitaxel derivative as well as a preparation method and application of the composition, and belongs to the technical field of biological medicines. The composition is formed by dynamically assembling phenylboronic acid modified paclitaxel and saccharides through boric acid ester bonds, and the dosage form of the composition comprises gel, injection or freeze-dried powder. According to the composition, the dissolving property of the paclitaxel is remarkably improved, the solubility of the paclitaxel reaches the milligram level for direct intravenous injection, and the composition does not need to depend on a solubilizer. In addition, based on the dynamic assembly characteristic, micromolecule self-assembly gel can be constructed and is suitable for tumor postoperative local treatment. The invention provides a new thought for development of an indissolvable drug delivery system, and provides a safe and effective drug delivery strategy for tumor treatment.

This application discloses a home care system and procedure for postoperative care of gynecological malignant tumors. The method includes: determining patient information for the patient requiring care, including physiological data and postoperative data related to the malignant tumor; determining the real-time health status of the patient based on the physiological data and postoperative data; inputting the real-time health status into a preset nursing method atlas library to determine the corresponding home care method for the patient; acquiring personalized data for the patient and revising the home care method based on the personalized data to obtain the target home care method for the patient. This application can significantly improve the scientific rigor, safety, and patient compliance of home care, providing more clinically valuable and individualized rehabilitation support for postoperative patients with malignant tumors.

The utility model provides a kind of precision positioning's tumor operation sterile interventional instrument package, belong to medical instrument technical field, including bearing mechanism, package shell, hand-held groove being arranged in package shell lateral wall, fixedly installed in the stacking block of package shell lateral wall, fixedly installed in the tenon of package shell surface, fixedly installed in the spring of package shell inner wall, and set in the protection assembly of package shell inner cavity;Sealing mechanism, including the cover plate of being movably connected in the surface of package shell, the sealing groove of being arranged in the lateral wall of cover plate, and the shift block of being fixedly installed in the lateral wall of cover plate.The utility model is through the setting of bearing mechanism and sealing mechanism, realized the efficient operation and strict sterile protection of instrument package, the joint action of the multilayer material structure of installation shell, magic tape, elastic band and connecting component in protection assembly, ensure the precision positioning, safe fixation and sterile preservation of instrument, simultaneously provide flexible adaptability and excellent protective performance.

The present application relates to the technical field of medical devices, and is especially a suction device for gynecological tumor surgery, comprising a pipe internal separation module that separates the inside of a suction pipe into a biopsy sampling channel and a tissue fluid suction channel; the pipe internal separation module comprises a switching mechanism in the center of the suction pipe and two groups of separation plate pieces in fixed connection with the inner wall of the suction pipe; the outer side of the connecting column is fixedly connected with guide shafts arranged symmetrically, and the other end of the connecting column is fixedly connected with a switching plate for switching channels; the pipe internal separation module can separate the suction pipe into a biopsy sampling channel and a tissue fluid suction channel, the biopsy sampling channel is used for sucking liquid such as blood, tissue fluid, pus and flushing liquid in surgery, the switching channel can be switched by inflating the pipe internal separation module, the tissue fluid suction channel is closed, the tissue fragments that need to be biopsied are sucked out through the biopsy sampling channel, and the sample can be collected synchronously when the tissue fragments are sucked out for rapid pathological detection in surgery, thereby reducing secondary operation.