30 results about "Postoperative chemotherapy" patented technology

The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine compound preparation for treating ovarian cancer and a preparation method of the traditional Chinese medicine compound preparation. According to the traditional Chinese medicine compound preparation, extracts of bulk medicine such as astragalus mongholicus, codonopsis pilosula, rehmannia root, sculellaria barbata, asparagus cochinchinensis, medlar, cornu cervi, fiveleaf akebia fruit, elecampane and radix paeoniae alba are prepared into solid and liquid preparations. Animal experiment results show that the weight loss and the white cell reduction can be relieved, the T lymphocyte function is improved, the bax expression is increased, the cancer cell apoptosis is promoted, the anti-tumor angiogenesis effect is realized, the oxygen deficiency microenvironment of tumor cells is improved, and the sensitivity of ovarian cancer cells on chemotherapeutics is enhanced. Clinical test results show that the clinical symptoms of later-stage ovarian cancer patients can be relieved, and the survival quality of patients is improved; the chemotherapy toxic and side effect is lightened, and the chemotherapy tolerance and the compliance of the patients are improved; and the uncontrolled and recurrence rate of later-stage ovarian cancer can be reduced, and the five-year survival rate is improved; and no obvious adverse reaction exists, and good safety is realized. The traditional Chinese medicine compound preparation is applicable to the treatment on ovarian cancer and ovarian cancer postoperative chemotherapy patients.

The invention discloses a medicament for treating colon cancer and a preparation method thereof. The medicament is prepared from medicinal active ingredients and pharmaceutic adjuvant, wherein the medicinal active ingredients comprise 3 beta-hydroxyl-28-deletion-12,17(18)-diene ursane. The preparation method comprises the following steps of: (1) adding methanol or ethanol into crushed charred sanguisorba root serving as a medicinal raw material, filtering the mixture, concentrating filtrate under normal pressure or reduced pressure to obtain extractum liquidum; (2) dispersing the extractum liquidum obtained by the step (1) with water, and extracting with chloroform to obtain extractum; (3) carrying out silicagel column chromatographic separation on the extractum obtained by the step (2) recovering a solvent, placing the solvent to separate white powder out, filtering the mixture to obtain the 3 beta-hydroxyl-28-deletion-12,17(18)-diene ursane; and (4) preparing the medicament from 20 to 90 weight percent of the 3 beta-hydroxyl-28-deletion-12,17(18)-diene ursane, and the balance of the pharmaceutic adjuvant by a conventional preparation method. The medicament mainly treats non-metastatic symptoms of the colon cancer, has no toxic or side effects, and is used by matching postoperative chemotherapy so as to relieve pain of patients.

The invention discloses a medicine for alleviating postoperative chemotherapy-induced nausea and vomiting of a patient with an encephaloma and a preparation method. The medicine comprises the following raw materials: hyacinth bletilla, rhizoma zingiberis, cortex magnoliae officinalis, oxhide gelatin, liquorice, pig tripe, pig skin, semen strychni, valeriana officinalis, hindu datura flowers, eucommia, wild ginger, globose phaenosperma herb, silverweed cinquefoil roots, rabdosia amethystoides, radix morindae officinalis, rhizoma atractylodis, auriculate swallowwort roots, elecampane, katsumade galangal seeds, hindu lotus leaf-base, desmodium, fiveleaf akebia fruits, princesplume ladysthumb fruits, chirita fimbrisepala, ghostplant wormwood herb, false Chinese swertia herb, rust-coloured crotalaria herb with roots, ficus esquiroliana, astragalus smicus, fewflower wildrice fruits and ganoderma lucidum. The medicine has the beneficial effects that the medicine takes treatment principles of regulating a spleen, harmonizing a stomach, stopping vomiting, strengthening the spleen, replenishing qi, excreting dampness, protecting gastric mucosa and enhancing the immunity; a preparation process is simple; the curative effect is definite; the toxic and side effects are little; the dosing is convenient; the medicine is easy to prepare and low in cost; the possibility of relapse after treatment is low; the medicine property is specific; and the medicine can treat a specific disease rapidly and effectively.

The invention discloses the application of HDS in predicting the prognosis of gastric cancer patients, guiding postoperative adjuvant chemotherapy and predicting the curative effect of immunotherapy. The present invention screens and obtains 103 genes related to the prognosis of gastric cancer, constructs the HDS score based on the PCA method, and the analysis results prove that the gastric cancer patients in the high HDS group have a longer survival time than the low HDS group; gastric cancer patients with high HDS are more suitable for the use of immune Treatment; patients with stage II low-HDS gastric cancer benefited more from postoperative chemotherapy than those with high-HDS gastric cancer. The HDS evaluation system of the present invention provides a new method for predicting the prognosis of gastric cancer and selecting postoperative adjuvant chemotherapy and immunotherapy, and has good clinical application prospects.

The invention discloses a medicament for treating breast cancer and a preparation method thereof. The medicament comprises a preparation which is prepared from 3-beta-oxygen-alpha-L-arabinofuranosyl-based-28-norepinephrine ursolic-12, 17-diene serving as a medicinal active ingredient and medicinal auxiliary materials. The medicament comprises 1 to 90 weight percent of the medicinal active ingredient and 10 to 99 weight percent of the medicinal auxiliary materials. The medicinal active ingredient has a structural formula shown in the specification. The preparation method for the medicament fortreating the breast cancer comprises the following steps of: (1) crushing sanguisorba carbon serving as a medicinal raw material; extracting and filtering repeatedly; and concentrating filtrate to obtain a liquid extract; (2) dispersing the liquid extract obtained in the step (1) with water; extracting the dispersed liquid extract with chloroform; and recovering a solvent from extract liquid under normal pressure or a reduced pressure to obtain an extract; (3) performing silica column chromatography separation on the extract obtained in the step (2); performing recrystallization on solid obtained by suction filtering to obtain the medicinal active ingredient of a compound; and (4) preparing the preparation by using 20 to 90 weight percent of the medicinal active ingredient and the balanceof the medicinal auxiliary materials. The medicament is used for treating the breast cancer, has a good treatment effect, and can replace oral Western medicament in a postoperative chemotherapy period.

The invention discloses a medicinal composition with effects of improving the immunity of organisms and liver functions. The medicinal composition consists of Chinese caterpillar fungus, bear gall, Chinese wolfberry, donkey-hide glue, virgate wormwood herb, villous amomum fruit, pangolin scales and golden hair grass. The medicinal composition is prepared into clinically-acceptable honeyed paste, tablets, capsules, granules, pills, powder or oral liquid by adding the conventional auxiliary materials according to the conventional process. The medicinal composition can improve the immunity of the organisms and the liver functions, and has the obvious effect on postoperative chemotherapeutic patients or patients in poor health.

The invention discloses an assisted drug for postoperative chemo-treatment of non-small cell lung cancer and solves the problem of treatment of postoperative chemo-treatment. The assisted drug is characterized by being prepared from the following drug substances in weight ratio: elsholtzia rugulosa, leaves of tomentosecalyx elsholtzia, Leycesteria formosa Wall, fermented pinellia, fleece-flower root, red clover, groundsel, honey locust, grassleaf sweelflag rhizome and cassia twig. Clinical trials prove that the assisted drug is good in effect and relatively high in security in chemo-treatment and synergism, and is worthy of clinical application and popularization.

The invention discloses a preparation method of an assisted drug for postoperative chemo-treatment of non-small cell lung cancer and solves the problem of treatment of postoperative chemo-treatment. The preparation method is characterized by comprising the following steps: 1, extracting volatile oil from groundsel, grassleaf sweelflag rhizome and fleece-flower root crude powder for standby use; 2, smashing honey locust into fine powder for standby; 3, performing water-extraction to elsholtzia rugulosa, leaves of tomentosecalyx elsholtzia, Leycesteria formosa Wall, fermented pinellia (wrapped during decocting), red clover, cassia twig and herb residue obtained in step 1, and obtaining primary material through concentrating under reduced pressure and drying; 4, spraying the volatile oil into the primary material, adding the honey locust fine powder, well mixing, sieving with a 60-mesh screen, and placing the product into capsules to obtain the assisted drug. Clinical trial proves that the assisted drug has good effect and relatively high security in chemo-treatment and synergism and is worthy of clinical application and popularization.

The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine compound preparation for treating ovarian cancer and a preparation method of the traditional Chinese medicine compound preparation. According to the traditional Chinese medicine compound preparation, extracts of bulk medicine such as astragalus mongholicus, codonopsis pilosula, rehmannia root, sculellaria barbata, asparagus cochinchinensis, medlar, cornu cervi, fiveleaf akebia fruit, elecampane and radix paeoniae alba are prepared into solid and liquid preparations. Animal experiment results show that the weight loss and the white cell reduction can be relieved, the T lymphocyte function is improved, the bax expression is increased, the cancer cell apoptosis is promoted, the anti-tumor angiogenesis effect is realized, the oxygen deficiency microenvironment of tumor cells is improved, and the sensitivity of ovarian cancer cells on chemotherapeutics is enhanced. Clinical test results show that the clinical symptoms of later-stage ovarian cancer patients can be relieved, and the survival quality of patients is improved; the chemotherapy toxic and side effect is lightened, and the chemotherapy tolerance and the compliance of the patients are improved; and the uncontrolled and recurrence rate of later-stage ovarian cancer can be reduced, and the five-year survival rate is improved; and no obvious adverse reaction exists, and good safety is realized. The traditional Chinese medicine compound preparation is applicable to the treatment on ovarian cancer and ovarian cancer postoperative chemotherapy patients.

The invention discloses use of lacca acid in reversing paclitaxel medical resistance in ovarian cancer. Ovarian cancer is one of the three major malignant tumors of female reproductive system, and thesurvival time of most patients with advanced ovarian cancer is less than 5 years. Clinical treatment of ovarian cancer usually uses cytoreductive surgery and postoperative chemotherapy with platinumand paclitaxel. However, ovarian cancer cell resistance to chemotherapy drugs leads to high recurrence rate and mortality, so it becomes the bottleneck of clinical treatment. The invention discloses that lacca acid, lacca acid alkyd and cedric acid can enhance the proliferation inhibition effect of Taxol on A2780 / Taxol cells in different degrees, improve the sensitivity of cells to Taxol, and canbe developed as a medicine for reversing the resistance of ovarian cancer to taxol. The invention is characterized in that the lacca acid, lacca acid alkyd and cedric acid can enhance the proliferation inhibition effect of Taxol on A2780 / Taxol cells in different degrees and improve the sensitivity of cells to Taxol.

The invention discloses a medicament for treating breast cancer and a preparation method thereof. The medicament comprises medicament effective components which are 3beta-hydroxyl-28- norursol-12 and 17-diene-22-ketone and a medicament which is prepared from a medicinal auxiliary material, wherein the medicament effective components are 1-90 percent by weight, and the medicinal auxiliary materialis 10-99 percent. The structural formula of the medicament effective components is shown in the specification. The preparation method comprises the following steps of: (1) pulverizing garden burnet carbon as a medicament raw material, adding carbinol or ethanol, extracting and filtering and concentrating filter liquor to obtain fluid extract; (2) dispersing the fluid extract in the step (1) by water, extracting by chloroform and recovering a solvent of extract liquor to obtain extract; (3) carrying out silica gel column chromatography separation on the extract in the step (2) and sucking and filtering the obtained solid and recrystallizing to obtain the medicament effective components of the compound; and (4) taking the medicament effective components according to the weight proportion and retaining the medicinal auxiliary material for preparing the medicament. The invention has good treatment effect on treating breast cancer and can replace western medicines for oral administration in the postoperative chemotherapy period.

The invention discloses a use of cedar acid in reversing paclitaxel medical resistance in ovarian cancer. Ovarian cancer is one of the three major malignant tumors of female reproductive system, and the survival time of most patients with advanced ovarian cancer is less than 5 years. Clinical treatment of ovarian cancer usually uses cytoreductive surgery and postoperative chemotherapy with platinum and paclitaxel. However, ovarian cancer cell resistance to chemotherapy drugs leads to high recurrence rate and mortality, so it becomes the bottleneck of clinical treatment. The invention disclosesthat yew antler acid, yew antler alkyd and cedric acid can enhance the proliferation inhibition effect of Taxol on A2780 / Taxol cells in different degrees, improve the sensitivity of cells to Taxol, and can be developed as a medicine for reversing the resistance of ovarian cancer to taxol. The use is characterized in that the yew antler acid, yew antler alkyd and cedric acid can enhance the proliferation inhibition effect of Taxol on A2780 / Taxol cells in different degrees and improve the sensitivity of cells to Taxol.

The invention discloses a use of yew antler alkyd for reversing ovarian cancer resistance to paclitaxel. Ovarian cancer is one of the three major malignant tumors of female reproductive system, and the survival time of most patients with advanced ovarian cancer is less than 5 years. Clinical treatment of ovarian cancer usually uses cytoreductive surgery and follows by postoperative chemotherapy with platinum and paclitaxel. However, ovarian cancer cell resistance to chemotherapy drugs leads to high recurrence rate and mortality, so it becomes the bottleneck of clinical treatment. The inventiondiscloses that yew antler acid, yew antler alkyd and cedric acid can enhance the proliferation inhibition effect of Taxol on A2780 / Taxol cells in different degrees, improve the sensitivity of cells to Taxol, and can be developed as a medicine for reversing the resistance of ovarian cancer to taxol.