7 results about "Valeriana" patented technology

The invention provides a traditional Chinese medicine preparation for improving or treating cognitive impairment, and relates to the technical field of traditional Chinese medicine pharmacy, and the traditional Chinese medicine preparation is prepared from morinda officinalis, eclipta, semen boitae, fructus alpiniae oxyphyllae, bighead atractylodes rhizome, valerian, turmeric, rhizoma acori graminei, leech, rhizoma anemarrhenae, dendrobium officinale, endothelium corneum gigeriae galli, hematoxylon and honey-fried licorice root. The traditional Chinese medicine preparation shows remarkable neuroprotection and cognition improvement effects on the cell level and the animal level, in the cell level, the preparation can effectively resist Abeta1-42 induced cell damage, and the protection effect is achieved through multiple ways of improving the cell activity, enhancing the oxidation resistance, inhibiting neuroinflammation and the like; in animal experiments, the preparation can comprehensively improve cognitive impairment of APP / PS1 model mice, including relieving behavioral abnormality, improving spatial learning and memory ability, enhancing new object recognition ability, and effectively reducing deposition of A beta in hippocampus on a molecular level. The invention provides a new thought for improving or treating cognitive impairment.

This invention provides a traditional Chinese medicine compound for treating viral myocarditis, belonging to the field of traditional Chinese medicine pharmaceutical technology. The compound consists of Forsythia suspensa, Fagopyrum dibotrys, Pseudostellaria heterophylla, Rhodiola rosea, Citrus medica, Allium macrostemon, Poria cocos, Gynostemma pentaphyllum, Salvia miltiorrhiza, Dalbergia odorifera, Cynanchum paniculatum, and Valeriana. This traditional Chinese medicine compound exhibits significant protective effects against viral myocarditis, specifically by significantly reducing damage to H9c2 cardiomyocytes caused by CVB3 virus. Its mechanism of action is closely related to downregulating the expression of inflammatory factors TNF-α and IL-6 and inhibiting the inflammatory response. Simultaneously, within the experimental concentration range, the compound shows no toxicity to cardiomyocytes, demonstrating good biocompatibility. Furthermore, this compound can significantly reduce myocardial tissue damage in a viral myocarditis model mouse by inhibiting the in vivo inflammatory response and regulating oxidative stress imbalance, providing a safe and effective new treatment option for the clinical treatment of viral myocarditis.

The application discloses use of a benzofuran compound in a Chinese herb of Huaze Lan in treatment of diabetes. The benzofuran compound is separated from roots of the Chinese herb of Huaze Lan and is named as: 10 R -2-(10-methyl-10,11-dihydroxy)-5-acetyl-6-hydroxybenzofuran. An improved preparation method of the benzofuran compound is used, roots of the Chinese herb of Huaze Lan are used as raw materials, and the improved preparation method comprises the following steps: green water solvent extraction, macroporous adsorption column chromatography and crystallization separation, and the improved separation method is green and efficient, has high purity and can be suitable for industrial production. The benzofuran compound is found to have a significant effect in treatment of diabetes through animal experiments, data analysis of blood glucose concentration, oral glucose tolerance and liver index of type 2 diabetes mice after administration. The benzofuran compound has a good effect in treatment of diabetes, and is expected to be developed into a new natural medicine for treatment of diabetes.

The invention discloses application of valeriana jatamansi jones. The valeriana jatamansi jones are derived from dry roots and rhizomes of valeriana jatamansi jones, and the valeriana jatamansi jones can regulate cell balance of CD4 < + > helper T cells in a human immune system so as to relieve colon tissue pathological damage and mucoprotein secretion abnormality. The traditional Chinese medicine composition can protect the colon tissue pathological injury and mucous membrane layer of the UC mouse, repair the colon pathological injury, regulate and control the balance of intestinal immune cells, and is high in safety coefficient.

The invention provides a traditional Chinese medicine compound for treating viral myocarditis, and relates to the technical field of traditional Chinese medicine pharmacy, and the traditional Chinese medicine compound consists of fructus forsythiae, wild buckwheat, radix pseudostellariae, rhodiola rosea, citron, allium macrostemon, poria cocos, Chinese alpine rush, semen aesculi, lignum dalbergiae odoriferae, radix cynanchi atrati and valerian. The traditional Chinese medicine compound has a remarkable protective effect on viral myocarditis, specifically, the compound can remarkably relieve H9c2 myocardial cell damage caused by CVB3 virus, and the action mechanism of the compound is closely related to down-regulation of expression of inflammatory factors TNF-alpha and IL-6 and inhibition of inflammatory response; meanwhile, within the experimental concentration range, the compound has no toxic effect on myocardial cells and shows good biological safety. Besides, the compound can remarkably relieve myocardial tissue damage of viral myocarditis model mice by inhibiting inflammatory response in vivo and adjusting oxidative stress imbalance, and a safe and effective new treatment scheme is provided for clinical treatment of viral myocarditis.

The application provides a traditional Chinese medicine pill for treating intractable insomnia and a preparation method thereof. The traditional Chinese medicine pill is prepared from the following raw materials in parts by mass: walnut kernel 8-15 parts, wedelia prostrata 11-18 parts, jujube kernel 10-16 parts, medlar 12-18 parts, radix mori 11-17 parts, platycladus branchlet 7-11 parts, ganoderma 10-14 parts, poria cocos 12-17 parts, white atractylodes 8-13 parts, radix paeoniae alba 16-25 parts, lily 11-17 parts, valeriana 3-8 parts, dragon bone 22-26 parts, oyster 21-26 parts, schisandra 4-8 parts, polygala 7-11 parts and licorice 1-5 parts. The pill can effectively treat intractable insomnia, has a quick effect and small side effects.

The application provides a traditional Chinese medicine preparation for improving or treating cognitive impairment, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from Radix Morindae Officinalis, Herba Hyperici Japonici, Platycladi Seed, Fructus Evodiae, Rhizoma Atractylodis Macrocephalae, Valeriana, Curcuma Longa, Rhizoma Acori Tatarinowii, Hirudo, Rhizoma Anemarrhenae, Dendrobium officinale, Gigeriae Cacumen, and Radix Pini. The traditional Chinese medicine preparation in the application shows significant neuroprotective and cognitive improvement effects at the cell and animal levels: at the cell level, the preparation can effectively resist A 1‑42 induced cell damage, and plays a protective role through multiple pathways such as improving cell viability, enhancing antioxidant capacity and inhibiting neuroinflammation; in animal experiments, the preparation can comprehensively improve the cognitive dysfunction of APP / PS1 model mice, including relieving behavioral abnormalities, improving spatial learning and memory ability, enhancing new object recognition ability, and effectively reducing Aβ deposition in hippocampal tissue at the molecular level. The application provides a new idea for improving or treating cognitive impairment.