1 results about "Wedelia" patented technology

This invention belongs to the field of pharmaceutical formulation technology and provides a topical formulation for herpes lesions and its preparation method. This invention employs a synergistic design of three nanocarriers: a polyvinyl alcohol and sodium alginate composite film-forming matrix, core-shell nanoparticles N1 (chitosan-sodium tripolyphosphate ion-crosslinked core + tannic acid-coated shell), plant polyphenol-phospholipid composite nanoparticles N3 (lecithin composite of Phyllanthus urinaria and Wedelia trifoliata alcohol water extract), and agarwood volatile oil-cyclodextrin inclusion complex N2 (agarwood volatile oil O and hydroxypropyl-β-cyclodextrin inclusion complex). This achieves low viscosity (2-80 mPa·s) and uniform spraying performance that can be atomized by a mechanical pump, dense film coverage and wet-state erosion resistance, and sustained drug release and dispersion stability under high load of multiple nanocarriers. It solves the technical contradiction of existing systems in balancing low viscosity atomization, film density, multi-carrier stability, and low irritation, and has broad application value.