225 results about "Functional disability" patented technology

The invention discloses a wearable hand function rehabilitation robot, which is mainly used for assisting the repeated movement function rehabilitation training of the patient with hand movement function disorder which is caused by stroke, brain trauma, spinal cord injury and peripheral nerve injury in communities or families. The robot system extracts the active movement will of the patient by detecting the multi-channel surface myoelectric signals of the affected hand and obtains the state of the affected limb by combining the data which is measured by an angle and force sensor to carry out the rehabilitation training of the affected hand by pneumatic muscle contraction assistance by using the intelligent control algorithm on the basis. The rehabilitation robot has multiple degrees of freedom, which can assist the affected hand to carry out multi-joint complex movement and inosculate the multi-sensor data information fusion during the rehabilitation process to be further used for the evaluation of rehabilitation effect, and the activity and the training interest of the patient can be improved by using the rehabilitation treatment virtual environment on a computer. The invention has the advantages of simple structure, flexible movement, safety and reliability, which can not only realize the rehabilitation training of the movement function of the affected hand, but can also be in line with the physiologic structure characteristics of human hands. The invention is more comfortable to wear.

The present invention relates to methods and compositions for reducing Distress Dysfunction by restoring and maintaining homeostatic balance in the neurotransmitter systems underlying the Stress Response and the experience of distress and hedonic tone. Distress Dysfunction refers to the experience of dysfunctional emotional and physical distress that interferes with the individual's quality of life and functioning. A novel understanding of the bimodal opioid modulation of pain, and its impact, through serotonergic, dopaminergic, epinephrinergic, and norepinephrinergic processes, on hedonic tone, leads directly to new generation pharmaceutical formulations that are remarkably safe and effective for the treatment of a wide variety of Distress Dysfunctions, including anxiety, depression, anger, insomnia, mood disorders, eating disorders, sexual problems, pain, substance and behavioral addictions, gastrointestinal disorders, autistic spectrum disorders, attention-deficit and hyperactivity disorders, and other emotional and physical distress disorders. The foundation of this discovery is the power of Receptor Switchers, such as ultra-low-dose and very-low-dose opioid antagonists and GM1 ganglioside attenuators, in blocking acute and protracted excitatory opioid receptor signaling. Co-administration of Receptor Switchers with Endorphin Enhancers, such as specific cAMP PDE inhibitors and excitatory amino acids, is an excellent formulation for restoring healthy homeostatic balance to the endogenous opioid system, using the body's endorphins to reduce emotional and physical distress, and through synergistic and homeostatic processes, restoring positive hedonic tone. The addition of Synergistic Enhancers, such as amino acids, SSRI and SNRI agents, and non-opioid analgesics, as well as Exogenous Opioids, enhances and prolongs these therapeutic benefits. The novel principles discovered by this invention also teach a new generation of safe and effective formulations for the treatment of respiratory conditions, neuropathy, and nociceptive pain.

The present invention provides an electrode designed for implantation into the central nervous system (CNS) of a mammal, wherein said electrode is substantially coated with interleukin-1 receptor antagonist (IL-1ra) or a coating composition comprising it, and the IL-1ra actively inhibits scarring on or around the surface of the electrode when implanted into the CNS. The electrode of the invention may be used for brain recording and / or stimulation, and can thus be used for treatment of a brain dysfunction, a brain disease or disorder, or a brain injury, as well as for brain computer interface, brain machine interface, or electrotherapy.

A gait management apparatus applies stimulation to a user suffering from a neurological disease (such as Parkinson's Disease) gait dysfunction. Motion sensors are arranged to be worn by a patient, and electrical stimulation electrodes are on the legs for stimulation. A controller receives motion sensing signals, and processes these signals to generate stimulation signals for operation of the electrodes to stimulate limb movement upon detection of a gait abnormality. There may be a user actuator for user actuation of electrical stimulation, and the inputs may be a series of taps. The controller may provide signals to prevent occurrence of freezing of gait when it senses that a patient is walking or has an intention to walk. Also, it may apply stimulation at an intensity level which is insufficient for functional muscle stimulation but sufficiently high to trigger activation of efferent nerves.

The invention relates to a stable preparation of phosphatidylserine and a preparation method, application as well as an application product of the stable preparation. The preparation method comprises the following step of processing the phosphatidylserine through microencapsulation, micro-pelletization or liposome encapsulation. The stable preparation of the phosphatidylserine can be independently applied as a medicine or can be added into daily foods, drinks and health-care products, also has an important effect on health care of brains while guaranteeing the color and the taste of the daily foods and the drinks of people and is of great benefit to brain disorder such as nutritional supplement of brain development of students, overstrain of nerves of the adults, and memory loss, brain atrophy and senile dementia of the middle aged and elderly people.

The present invention relates to a peptide analogue of glucagon-like peptide-1 (7-36), which is useful to prophylactically prevent, improve, or reverse the diminished cognitive function associated with these types of disorders, by increasing (or sustaining) the LTP of synaptic transmission. Moreover, sustaining LTP may find utility in the prophylaxis of neurological disease by delaying the onset of impaired cognitive processes, and could serve as a treatment, not only for the diminished cognitive function caused by neurodegeneration, but also for the dysfunctional cognitive processes associated with trauma or age.

The invention discloses an exoskeleton type biofeedback hand function training device. The exoskeleton type biofeedback hand function training device comprises a hand back adhering face plate, driving mechanisms for five fingers and a motor transmission mechanism; the hand back adhering face plate is worn on a hand of a patient; the driving mechanisms for the five fingers are connected with the hand back adhering face plate; the motor transmission mechanism is connected with the hand back adhering face plate; the motor transmission mechanism comprises a linear motor transmission mechanism which drives the driving mechanism for the thumb and a mini-sized continuous current motor transmission mechanism which drives the driving mechanisms for the other four fingers. The exoskeleton type biofeedback hand function training device aims at the unsolved efficient hand dysfunction rehabilitation training machinery in the domestic clinical rehabilitation treatment.

The present invention discloses a method for establishing a platform for analyzing and predicting the cognitive impairment of diabetes based on metabonomics data. According to the method, a high-performance liquid chromatography-mass spectrometry combined technology is adopted to separate and identify three groups of blood plasma of a healthy person, a diabetic patient who does not suffer from the cognitive impairment and a diabetic patient who suffers from the cognitive impairment; substances obtained by separation are respectively subjected to main component analysis and partial least square discriminant analysis by software; difference metabolites are determined and structures of the difference metabolites are identified; and the obvious difference metabolites are selected to form the platform for analyzing and predicting the cognitive impairment of diabetes. The cognitive impairment of diabetes can be timely analyzed and predicted according to the blood plasma of diabetic patients, can be timely observed and timely treated; the morbidity of the cognitive impairment of diabetes can be reduced; and a series of family and social problems caused by the cognitive impairment of diabetes are avoided.

A system and method for instant and permanent pain relief on pain-spasm-pain neurological reflex cycles that cause pain and functional disability in muscles suffering from acute and chronic soft tissue disorders is disclosed. The invention comprises a device for diagnosing PSP (pain-spasm-pain) cycles by creating a calibrated mechanical stimulation on the Golgi Tendon (GT) receptors of related muscle fibres, over which pain relief is later on provided by simultaneously applying calibrated pressure on said GT receptors. The system involves diagnosis and treatment steps performed instantly, in consequence of which the muscles permanently retain their normal physiological and mechanical values. The system proposed by the invention is characterized by a stimulator tip which is used to apply mechanical pressure the golgi tendon receptors beneath the skin, and which is attached to said tensiometric instrument (8) used for measuring the GT pain pressure thresholds and GT inhibition pressure thresholds.

The invention relates to an automatic discrimination analysis method of mild cognitive impairment based on a support vector machine. According to the automatic discrimination analysis method of mild cognitive impairment based on the support vector machine, multiple detection index data including aresting state fMRI, structure MRI and neuropsychological examination data are used, and methods of Functional Connectivity (FC) analysis, Voxel-based Morphometry (VBM) analysis and Fiber Tractography are adopted to extract a resting state functional connectivity characteristic, a gray matter structure characteristic and a white matter fiber connectivity characteristic, reduction is conducted on the characteristics based on a rough set approach, and finally classifier construction is conducted on multimodal MRI data based on the SVM method, so that automatic discrimination analysis of mild cognitive impairment is achieved, diagnosis accuracy of mild cognitive impairment is improved, and the accuracy rate of the diagnosis in experimental data reaches more than 90 percent. The method can be applied to practical clinical diagnosis.

The invention belongs to the technical field of medicine, and concretely relates to caffeoyl substituted pentacyclic triterpenoid derivatives as shown in a formula I and a purpose thereof in preparing medicaments or health products for preventing and treating brain injury and / or neurological dysfunction and / or cognitive dysfunction caused by cerebral ischemia, hypoglycemia and cerebral anoxia. Experiments verify that the derivatives is capable of protecting nerve cells under conditions of hypoglycemia and hypoxia, can substantially improve neurological damage induced by cerebral ischemia, and thus is expected to be developed as medicaments for preventing and treating the brain injury caused by the cerebral ischemia, the hypoglycemia and the cerebral anoxia as well as improving corresponding neuroethology functions.

The invention relates to a fully-bionic brain-like intelligent electro-mechanical exoskeleton for hands and a comprehensive control system thereof. The electro-mechanical exoskeleton is characterized by comprising finger tip bushes, middle phalanx exoskeletons, proximal phalanx exoskeletons, metacarpal bone exoskeletons, a finger stretching mechanical driving device, a finger bending mechanical driving device, finger stretching artificial tendons, finger bending artificial tendons, finger tip pressure and temperature sensors, force assistance sensors and joint angle sensors. The system comprises a multifunctional human brain computer interface helmet and a movement sensory system, and the multifunctional human brain computer interface helmet is connected with the fully-bionic brain-like intelligent electro-mechanical exoskeleton for the hands through the movement sensory system. With the control system, the electro-mechanical exoskeleton can be directly controlled to generate all kinds of action according to the intention of a human brain, and the electro-mechanical exoskeleton stably operates in balance by means of various methods, and can be widely applied to the fields of rehabilitation, life assistance and the like for people with limb movement and limb sensory function disturbance caused by neural system injury.

The invention belongs to the medical rehabilitation equipment field, and relates to a digitlization simulation mirror image training system comprising a trainee interaction display, a trainee control platform, a host computer, a camera, sound equipment, digit mirror image training box hardware, a specially compiled space imagination training module, a basic motion training module, and a functional motion training module program system; the camera can film hand motion images; digitalized image mirror image equipment is formed by mirror image processing technology; the standard digitlization simulation mirror image treatment training system is provided; visual illusion and visual sense imagination can activate the cerebrum motion sense cortex zone, thus promoting limb motion functions and sense function recovery; optics imaging is converted into digit display, thus increasing mirror image treatment controllability and operationality, improving patient compliance, enriching mirror image training contents, regulating the training scheme enforcement procedure, and obtaining the optimized training effect; the digitlization simulation mirror image training system is suitable for rehabilitation training of hand function obstacles caused by brain damages, and finger cutting, affected limb aches, hand perception deletion or obstacles of hand operation patients.

The invention provides a traditional Chinese medicine composition for improving memory and mild cognitive impairment. The traditional Chinese medicine composition comprises 40-80 parts of thinleaf milkwort root-bark, 40-80 parts of grass leaf sweetflag rhizome, 40-80 parts of ginseng, 80-120 parts of tall gastrodia tuber, 80-120 parts of papermulberry fruit, 80-120 parts of ginkgo leaves and 0.01-3 parts of borneol. The traditional Chinese medicine composition can achieve the effects of obviously increasing the number density and surface density of synapse of the molecular layer of mouse hippocampal CA1, obviously enhancing the SOD activities of central cerebral cortex and hippocampus, reducing the content of lipofuscin of the neuron, obviously improving the learning and memory impairment of spontaneous senile dementia model mice, obviously enhancing the activity and fiber density of NOS1 of the central cerebral cortex and hippocampus and obviously up-regulating the contents of SS, AVP and ACTH of the cerebral cortex and hippocampus, especially the content of SS. The traditional Chinese medicine composition can achieve the effect of obviously improving the clinical symptoms of memory and cognitive impairment and has definite curative effects and great application prospects.

The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and / or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and / of impairment.

The invention provides a hand dysfunction rehabilitation system. The hand dysfunction rehabilitation system comprises a control module, passive rehabilitation gloves, a passive driving module, a motion intention sensor, a hand posture sensing module and a power supply; the hand posture sensing module is connected with the control module and sends hand action signals to the control module; the passive driving module is connected with the passive rehabilitation gloves; the control module is connected with the passive driving module; the passive driving module drives the passive rehabilitation gloves to work; the power supply is connected with the control module, the hand posture sensing module and the passive driving module to supply power; the control module comprises a controller; and themotion intention sensor comprises one or more of an active-side myoelectric sensor, a passive-side myoelectric sensor and a brain machine. Through implementation of the technical scheme provided by the invention, a plurality of different rehabilitation methods can be realized on one device, and the technical effect of promoting rehabilitation can be achieved.

The invention provides methods for predicting therapeutic responsiveness of a subject suffering from cognitive impairments or dysfunctions, psychotic and / or neurodegenerative disorders to an alpha 7 nicotinic acetylcholine receptor activator treatment.

The invention discloses a home rehabilitation nursing system for old people with cognitive impairment. The system comprises a wearable mobile monitoring device, a mobile phone terminal, smart home equipment, a cloud server and a medical rehabilitation management terminal; the wearable mobile monitoring device is in communication connection with the mobile phone terminal and the smart home equipment; the wearable mobile monitoring device is in communication connection with the medical rehabilitation management terminal through the cloud server. The wearable mobile monitoring device comprises awearable monitoring body, wrist straps and a pair of electrode plates, wherein the wrist straps extend out of the two sides of the wearable monitoring body and are buckled with each other, and the pair of electrode plates are embedded into the surfaces of the wrist straps. According to the invention, the online rehabilitation evaluation can be carried out on the old people with cognitive impairment according to the collected physical sign information and limb electric signals of the old people with cognitive impairment, and the full-process intelligent guidance is provided, so that the cognitive mentally handicapped elderly is helped to know the health condition of the cognitive mentally handicapped elderly; and a corresponding rehabilitation training scheme is provided.

The invention discloses a drug combination used for improving cognitive function dysfunctions and treating senile dementia using ginseng, white paeony root and ginkgo leaves as raw materials. The invention also discloses the preparation method of the drug combination. The experiment confirms that the invention combination can significantly improve learning and memory ability of ageing rats dysmnesia caused by scopolamine, and meanwhile can increase acetylcholine content in the hippocampus of the subjective rats.

The invention provides an active upper limb movement rehabilitation assisting exoskeleton which is composed of an arm exoskeleton mechanism, a safety strap mechanism, a back and shoulder supporting mechanism and a power transmission mechanism. The mechanical structure of the active upper limb movement rehabilitation assisting exoskeleton is designed according to ergonomics, is suitable for wearable use, is invented based on human motion bionics principles; key freedom degrees of shoulders, elbows and wrist joints of the upper limbs in the movement process and required effective joint torque are considered; only one driving motor is used; the flexible transmission is realized through an embedded pull wire; shoulders, elbows and wrist joints of the left and right upper limbs of the human body are driven by differential to perform linkage assistance and independent movement under the effective degree of freedom; an energy storage spring can play a role in saving energy and reducing consumption; the active upper limb movement rehabilitation assisting exoskeleton has the advantages that appearance attractive and mechanical properties are considered, each component is designed into a flexible exoskeleton conforming to ergonomics, barrier-free man-machine interaction is effectively reduced, exercise rehabilitation training with good man-machine interaction experience can be provided for patients with upper limb dysfunction, or effective assistance is provided for users with upper limb exercise requirements, and physical consumption is reduced.

Methods for screening, diagnosing, or predicting presence, progression, or treatment effects of a cognitive dysfunction such as dementia based on an analysis of drawing behavior changes by a pre-trained Naïve Bayes method are provided. The methods include steps of obtaining drawing data of at least one image created by a test subject on a digital device and obtaining personal data of the test subject; reconstructing the at least one image based on the drawing data obtained; converting the drawing data to drawing features comprising a plurality of motion features and a plurality of geometric features; and determining probability that the test subject has a cognitive dysfunction based on the drawing features and the personal data by a pre-trained Naïve Bayes method with a greedy variable selection.

The invention belongs to the technical field of medical instruments, particularly relates to an exoskeleton type upper limb rehabilitation robot. The invention aims to solve the problems that conventional upper limb rehabilitation robots has safety risks in use, is poor in comfort and is inconvenient to apply other treatment means at the same time. The exoskeleton type upper limb rehabilitation robot of the invention comprises a shoulder joint training module, an elbow joint training module and a wrist joint training module which are connected in sequence. The exoskeleton type upper limb rehabilitation robot has comprehensive functions, can be used for active rehabilitation training and passive rehabilitation training and is applicable to patients with various upper limb dyskinesia. With astructural design based on human physiology, the robot can realize free adjustment of multiple joint fixing parts and can meet demands of patients with different upper limb lengths. In the process ofuse, the robot is always arranged below a human body, has no interference to the surrounding environment, and improves use comfort while guaranteeing use safety; and physical therapies such as manipulation, electric treatment and magnetic treatment can be applied for auxiliary rehabilitation training in the use process of the robot, so the practicability of the robot is high.

The invention discloses a multifunctional dynamic training system, and relates to the technical field of rehabilitation training equipment. The multifunctional dynamic training system comprises a training rehabilitation subsystem with a net rack, a three-dimensional training subsystem, a motion detection subsystem and a control device; a control circuit and a signal feedback device are arranged inthe control device; the three-dimensional training subsystem is installed in the space formed by the net rack; the motion detection subsystem comprises a sensor and a detection terminal, the sensor is used for collecting motion sensing signals of a trainee, and the detection terminal is used for displaying motion information of the trainee and evaluating the health state of the trainee; a centralcontrol system is electrically connected with the three-dimensional training subsystem and the motion detection subsystem. The multifunctional dynamic training system is capable of monitoring the motion state of the trainee in real time, feeding the motion information, evaluating functional state of the trainee, setting the training mode according to stamina and health conditions of different trainees and motivating the active movement ability of people with limb dysfunction, remarkable in treatment effect and high in efficiency and reduces labor intensity of a curer and curing cost.

The invention discloses an ankle joint fracture assisting treating device. The ankle joint fracture assisting treating device comprises a shank fixing part, a foot fixing part and an L-shaped protecting part. By means of the ankle joint fracture assisting treating device, physical agent therapy and sports therapy are combined, an operator conveniently conducts joint mobilization therapy like passive activities of pushing and pulling, the recovery effect of a dysfunctional ankle joint fracture patient can be improved, the living quality of the patient is improved, and the occurrence of traumatic arthritis or retrogressive arthritis can be effectively prevented; meanwhile, the fixing performance and the fitting performance are good, and the practicability is high; the ankle joint fracture assisting treating device is low in weight, and helps to maintain cleanliness of the part and prevent infection.