25 results about "Functional disability" patented technology

This utility model discloses a rehabilitation device for lower limb dysfunction with adjustable angle, relating to the field of rehabilitation technology. It includes a base frame and a computer operating unit. The computer operating unit is installed on the top of the base frame, which has an adjustable support unit on top and a body support unit on top of the adjustable support unit. The device utilizes four square blocks on both sides inside the foot pedal. Two of the blocks have Velcro fasteners (first type) on top, and the other two have Velcro fasteners (second type) on top. During use, the patient places their foot on the foot pedal, and the Velcro fasteners (first and second types) securely fix the foot to the pedal. This effectively prevents the foot from slipping or becoming unstable on the foot pedal due to weakened muscle strength or poor balance during rehabilitation training, thus ensuring the smooth progress and safety of rehabilitation training.

The application belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to an acupoint sticking medicine for preventing and treating long-term postoperative cognitive impairment of elderly patients and a use method thereof. The traditional Chinese medicine composition of the acupoint sticking medicine comprises Huangrenshen, Baishao, Danggui, Guijianyu, Shichangpu, Yuanzhi, Tianzhuhuang, Longchi, Fushen, Mosha, Huoxiang and Pelian. Under the guidance of the traditional Chinese medicine meridian theory, the physiological characteristics of the elderly patients are combined with the long-term postoperative rehabilitation demand, so that the effective components of traditional Chinese medicine are absorbed through the skin and jointly play a superimposed treatment role. The acupoint sticking medicine has a definite effect on preventing and treating long-term postoperative cognitive impairment of elderly patients, can significantly improve the long-term postoperative cognitive function score of the elderly patients, improve the long-term postoperative life quality and sleep quality, and is beneficial to the long-term postoperative rehabilitation of the elderly patients.

This invention relates to the field of natural active ingredient research technology, specifically to the application of walnut peptides in the preparation of cognitive function improvers. The cognitive function improver is a core functional short peptide derived from walnuts, characterized by high bioactivity, non-toxicity, and favorable pharmacokinetic properties. Its amino acid sequence is AFVHWY. This short peptide is easily synthesized artificially and possesses characteristics such as easy oral administration, easy absorption, strong metabolic stability, and strong blood-brain barrier penetration, providing a novel solution for the prevention and improvement of cognitive impairment.

The present invention relates to a composition for improving cognitive function or learning ability and preventing or treating cognitive impairment or learning disorder. When the pharmaceutical composition or the food composition comprising a complex herbal medicine extract of the present invention is used, the cognitive function or learning ability of a subject can be effectively improved, and thus cognitive impairment or learning disorder can be treated.

The application relates to the field of medical rehabilitation, in particular to a rehabilitation training device for upper limb sensory motor dysfunction. The rehabilitation training device for upper limb sensory motor dysfunction comprises a seat and the like; handrails are arranged on the two sides of the seat; a placing groove is formed in the upper surface of the handrail; a rotating mechanism is rotatably arranged on the side surface of the handrail; the rotating mechanism can be manually or automatically rotated; a resistance adjusting mechanism is arranged between the rotating mechanism and the seat; and a sensory training mechanism is movably arranged on the resistance adjusting mechanism. The rotating mechanism can be used for the motion training of the upper limbs, and the upper limbs can be passively and autonomously trained, so that the device can better adapt to the requirements of patients; the resistance adjusting mechanism can adjust the resistance of the autonomous training, better meeting the training requirements of the patients; and the pressure adjusting mechanism can adjust the pressure of the sensory training, so that the device can better perform the sensory training.

This invention discloses a dynamic prediction method for postoperative cognitive impairment based on multimodal data fusion, specifically relating to the fields of medical data analysis and artificial intelligence. The method involves acquiring and processing preoperative patient data to construct a standardized time-series dataset; extracting static baseline features, time-series dynamic features, and high-dimensional nonlinear features, and dynamically fusing them based on time attention and cross-modal interaction mechanisms to generate a multimodal joint representation vector; constructing a dynamic prediction model based on a long short-term memory network and a Transformer architecture, using the multimodal joint representation vector as input and the postoperative cognitive impairment risk probability and cognitive function score change trajectory within a preset time window as outputs to train the model; inputting real-time collected patient multimodal data into the trained dynamic prediction model, outputting the dynamic predicted probability and risk level of postoperative cognitive impairment, and updating the prediction results in real time based on the inflow of new data.

A self-operated device particularly adapted for massaging a user's jaw, face or head affected by conditions such as muscle tension, headache or disfunction of the jaw, comprising two arms joined near the middle, each having a handle at the bottom and prongs at the top. Massaging members are mounted between the prongs at the top of each arm. A user may place their jaw, face or head between the two massaging members of the device to be acted upon by the massaging members, whereby the jaw, face or head is adjustably clamped between the pair of massaging members and massaged by translating and rotating movements of the handles along an axis parallel to the mounting axes of the massaging members.

The application discloses application of propofol in preparation of a medicine for preventing or treating cognitive dysfunction, and realizes prevention or treatment of cognitive dysfunction by propofol through inhibition of nerve inflammation, reduction of oxidative stress and enhancement of synaptic plasticity, and has advantages of exact curative effect, small side effect, multi-target point intervention and controllable cost, overcomes defects of existing medicines, such as curative effect limitation, obvious side effect and single target point, and realizes timely prevention and treatment of senile cognitive dysfunction.

This utility model relates to a leg exercise device for neurological rehabilitation, belonging to the technical field of leg exercise devices. It includes a seat assembly and two symmetrically arranged leg training mechanisms. Each training mechanism includes a control component and a training component. The training component includes a hip joint mechanism hinged to the seat assembly, a large arm guard hinged to the hip joint mechanism, and a forearm guard hinged to the distal end of the large arm guard. Servo direct drive mechanisms are provided at both the hip and knee joint hinges. A magnetorheological fluid rotary damper is coaxially arranged at the knee joint hinge. A travel limit sensor and a torque sensor for muscle tension detection are provided at the hinge. The servo direct drive mechanism, the magnetorheological fluid rotary damper, and the torque sensor are all electrically connected to the control component. It features a built-in passive, assisted active, and resistance-enhanced three-level training mode and bilateral independent operation. This utility model, through its three-level training mode, can cover the training of patients with lower limb motor dysfunction in neurology, lowering the rehabilitation threshold for patients.

New use of 1-amino-3,5-dimethyladamantane hydrochloride in treating or preventing cognitive impairment, reducing microglia in the cortex and hippocampus, reducing neuron loss in the cortex and hippocampus, and ameliorating the mitochondrial dysfunction state. The cognitive impairment includes cognitive impairment in systemic lupus erythematosus, Parkinson's disease, lateral sclerosis, stroke, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, attention deficit hyperactivity disorder, sepsis-related encephalopathy, or mild cognitive disorder. The present application also provides a corresponding drug and a treatment or prevention method.

The present invention relates to the treatment of executive dysfunction, such as attention deficit hyperactivity disorder (ADHD) and / or autism, with both lacosamide and oxcarbazepine.

Disclosed is a use of a benzamide derivative or a pharmaceutically acceptable salt thereof in the preparation of a medicament for improving cognitive dysfunction, the benzamide derivative having a structural formula of Formula I. The benzamide derivative having the structural formula of Formula I of the present application can improve Aβ 1‑42 induced cognitive dysfunction and APP / PS1 mouse cognitive dysfunction without affecting spontaneous activity of the mice.

This invention belongs to the field of medical device technology, and particularly relates to a multimodal synergistic cognitive improvement oscillation-induced neuromodulation method and device. The method includes: acquiring the patient's electroencephalogram (EEG) signals; obtaining clean signals through signal processing and extracting EEG characteristic parameters; initializing corresponding weights by combining the inherent modulation and safety coefficients of each modality's stimulation; dynamically adjusting the weights; obtaining the final synergistic weights through cross-modal complementary correction; constructing a multimodal parameter coupling optimization model, incorporating safety and coupling constraints, and using an optimization algorithm to solve for the optimal combination of each modality's modulation parameters; synchronously scheduling the frequency and phase of multimodal stimulation, adjusting parameters through real-time feedback, and constructing a cross-modal conflict avoidance mechanism; calculating the synergistic gain state correction coupling and complementarity coefficients, and thereby enhancing the multimodal stimulation effect. This invention effectively improves the effectiveness of treatment methods for cognitive impairment, and reduces treatment difficulty and cost.

This application relates to the fields of rehabilitation medicine and human-computer interaction technology, and discloses a rehabilitation method for elderly patients with osteoporosis and cognitive impairment based on extended reality. The method includes: collecting the patient's motion and physiological data; obtaining a synchronous calibration signal through a fusion algorithm and Kalman filtering; determining the virtual-real environment deviation value by combining rehabilitation progress and pain feedback; optimizing the response parameters and real-time force feedback parameters of the virtual scene through an adaptive adjustment mechanism to extract the patient's dynamic needs characteristics; fusing dynamic needs characteristics, audiovisual, tactile, and interaction delay data through a convolutional neural network to obtain a virtual-real interaction feedback sequence; generating virtual scene update data and simulated values ​​of assistive device support force based on this sequence, and synthesizing a rehabilitation training output signal. This invention provides a precise virtual environment and interactive feedback according to the patient's personalized needs, achieving dynamic and precise matching of the virtual and real environments and real-time adaptation of multimodal feedback in rehabilitation training, thereby improving the immersion of training and rehabilitation effects.

This article provides compounds, methods, and pharmaceutical compositions for reducing the amount or activity of SCN2A RNA in cells or subjects, and in some cases, reducing the amount of SCN2A protein in cells or subjects. Such compounds, methods, and pharmaceutical compositions can be used to improve at least one symptom or marker of a disease or disorder associated with voltage-gated sodium channel proteins, such as, for example, developmental and epileptic encephalopathy, intellectual disability, or autism spectrum disorder. Such symptoms and markers include, but are not limited to, seizures, hypotonia, sensory integration dysfunction, delayed and impaired motor development, intellectual and cognitive impairment, motor and balance impairment, visual impairment, language and speech delay, gastrointestinal disorders, delayed neurodevelopment, sleep problems, and sudden unexpected death in epilepsy.

The application relates to a cognitive dysfunction evaluation method and system based on multi-edge state detection calculation, which can evaluate the cognition of a patient by using two scales, simultaneously determines the FAST score-T (FAST) of the patient in the current treatment stage by using the FAST scale, determines the calculation coefficients of the two scales according to T (FAST) by a background, combines the functional evaluation staging evaluation value of the current patient, sets the calculation coefficients alpha and beta of the two scales respectively, so that when the cognition of the patient is evaluated by using the two scales, the functional evaluation staging is used as an evaluation factor of the cognitive function and participates in the calculation, the calculation result is guided by the feedback of the functional evaluation staging, the result is related to the real-time state of the patient, the evaluation value of the patient in different clinical treatment stages is reflected, and the clinical treatment is not deviated.

The present application relates to the technical field of rehabilitation training planning, in particular to a burn patient joint dysfunction rehabilitation training intelligent planning system, which comprises a multi-dimensional state perception module, a scar tension evaluation module, an intelligent planning generation module, a dynamic self-adaptive adjustment module and a rehabilitation efficiency evaluation module.In the present application, by establishing a state vector oriented to wound recovery and joint state, introducing nonlinear modeling technology to realize accurate evaluation of the constraint relationship between wound tension and range of motion, combining with reinforcement learning algorithm to construct an adaptive training strategy generation mechanism, through optimizing the combination of action type, intensity and frequency to improve the training targeting, and introducing fuzzy control method to realize real-time correction of physiological response and action deviation in the execution process, the training sequence can automatically adjust according to the change of patient state, a prediction and feedback system oriented to training effectiveness progress is built, and closed-loop optimization of the rehabilitation path is realized.

1. The name of the design product: exoskeleton intelligent feedback module. 2. The use of the design product: the design product is an intelligent feedback module for monitoring, evaluating and treating muscle activation state of people with limb dysfunction. It can be used with a special exoskeleton. The exoskeleton is driven by electromyographic signals to perform feedback training. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The present invention features novel peripherally-restricted isoguvacine analogs with reduced blood brain barrier permeability and methods of use thereof for reducing tactile dysfunction, social impairment, and anxiety in a subject diagnosed with Autism Spectrum Disorder, Rett syndrome, Phelan McDermid syndrome, or Fragile X syndrome.

This invention discloses an arm flexion and extension rehabilitation device for patients with limb dysfunction, belonging to the field of medical rehabilitation equipment technology. It includes a housing, within which a rotating shaft is rotatably connected. A rope reel is fixedly connected to the rotating shaft, and a reset component is installed between the rotating shaft and the housing. An operating component and a variable resistance mechanism are also installed on the rope reel. The variable resistance mechanism is installed inside the housing and includes a resistance component and an adjustment component. The resistance component applies resistance to the rope reel, and the adjustment component works in conjunction with the resistance component. By incorporating the resistance and adjustment components, and through their interaction, the resistance of the rope reel can be infinitely adjusted at any time. This resistance adjustment allows the training device to meet the needs of different patients and their varying pulling force requirements at different stages, thus solving the problem in existing technologies where the pulling force of training devices cannot be adjusted, hindering patient rehabilitation.

The application provides a traditional Chinese medicine preparation for improving or treating cognitive impairment, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from Radix Morindae Officinalis, Herba Hyperici Japonici, Platycladi Seed, Fructus Evodiae, Rhizoma Atractylodis Macrocephalae, Valeriana, Curcuma Longa, Rhizoma Acori Tatarinowii, Hirudo, Rhizoma Anemarrhenae, Dendrobium officinale, Gigeriae Cacumen, and Radix Pini. The traditional Chinese medicine preparation in the application shows significant neuroprotective and cognitive improvement effects at the cell and animal levels: at the cell level, the preparation can effectively resist A 1‑42 induced cell damage, and plays a protective role through multiple pathways such as improving cell viability, enhancing antioxidant capacity and inhibiting neuroinflammation; in animal experiments, the preparation can comprehensively improve the cognitive dysfunction of APP / PS1 model mice, including relieving behavioral abnormalities, improving spatial learning and memory ability, enhancing new object recognition ability, and effectively reducing Aβ deposition in hippocampal tissue at the molecular level. The application provides a new idea for improving or treating cognitive impairment.

1. Name of the product in this design: Vibration Rehabilitation Training Bed. 2. Purpose of this design: To improve muscle function, balance, and coordination in patients with motor dysfunction. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The application discloses a flexible driving hand function rehabilitation device combining heat therapy and water exercise therapy, which comprises an exoskeleton rehabilitation glove, a temperature detection module and a water tank, the exoskeleton rehabilitation glove comprises a glove body and flexible driving modules arranged at corresponding positions of five fingers respectively, the flexible driving module is a laminated flexible sheet structure, and comprises a first connecting layer, a transmission layer, a second connecting layer and a driving layer in sequence from the side close to the finger to the side away from the finger, the temperature detection module is arranged in the water tank, and the water tank is used for containing hot water and cooperating with the temperature detection module to monitor the water temperature in real time, so that heat therapy and water exercise training are realized synchronously. The flexible driving module is adopted to drive, the structure is simple, light, soft, the functions of heat therapy, driving and training are fused, and a safe, effective and easy-to-implement rehabilitation scheme is provided for a stroke hand function disorder patient.

The application relates to the field of rehabilitation training course recommendation, in particular to an intelligent course recommendation method and system for rehabilitation training. The method comprises the following steps: receiving user portrait information and original electromyography data; evaluating a pelvic floor muscle evaluation score, a force condition score and a muscle dysfunction severity of a user by using a preset algorithm; matching courses in a course database with the information and the user portrait information to obtain a matching score in each dimension; calculating a total matching degree value by weighting and generating a course recommendation list output; and determining information such as a user advantage item, a disadvantage item, a stage priority order and an improvement urgency, etc. The application achieves the technical effects of accurately evaluating the pelvic floor muscle condition and the training quality of a user and providing personalized rehabilitation training course recommendation for the user.