4 results about "Oral glucose" patented technology

A method for preparing an MOF-based glucose detection system, wherein a Zeolitic Imidazolate Framework (ZIF) is used as a metal-organic framework, and glucose oxidase (GOx) is loaded in the zeolitic imidazolate framework. The preparation method comprises the following steps: S1: adding water to a reaction flask in advance, and then sequentially adding a metal ion, an enzyme and an organic ligand in a molar ratio of 100-1500:1-10:1-150, and 0.1-0.5% (by weight) of ammonia water to the reaction flask, S2: mixing and reacting same at room temperature for more than 6 hours, and S3: after centrifugation by means of a centrifuge, removing the supernatant to obtain a solid precipitate of the Gox-MOF material loaded with glucose oxidase. A sensor for detecting trace glucose concentration in saliva, and an oral glucose meter comprising the sensor.

The invention relates to an oral glucose in-situ gel preparation as well as a preparation method and application thereof, belongs to the technical field of biological medicines, and solves the problem that a glucose preparation in the prior art is not suitable for neonates. The oral glucose in-situ gel preparation comprises glucose, a temperature-sensitive gel matrix, a preservative and a solvent, the temperature-sensitive gel matrix is prepared from poloxamer 407 and poloxamer 188; wherein the poloxamer 407 accounts for 10%-20% by mass, the poloxamer 188 accounts for 2%-8% by mass, and the content of the glucose accounts for 10%-25% by mass. By adjusting the mass percent of poloxamer 407 and poloxamer 188 and optimizing the drug loading capacity, the gel preparation can generate in-situ phase change at the temperature of 31-35 DEG C while increasing the drug loading capacity, so that the glucose gel preparation can be adhered to oral buccal mucosa, dysphagia of newborns caused by swallowing of the preparation is avoided, slow release of glucose can be realized, and the preparation has a good application prospect. And the glucose can be quickly absorbed through oral buccal mucosa.

The invention relates to the technical field of microorganisms, in particular to application of Zymomonas mobilis ZM4 to improvement of diabetes mellitus, which comprises the following steps: performing liquid culture, centrifugation and resuspension on the Zymomonas mobilis ZM4 with the preservation number of ATCC31821 to obtain a bacterial suspension, and then using the bacterial suspension to improve the diabetes mellitus, wherein the Zymomonas mobilis ZM4 in the bacterial suspension still has activity after being centrifuged and resuspended; the bacterial suspension does not contain a fermentation product of the Zymomonas mobilis ZM4. According to the application of the Zymomonas mobilis ZM4 in improvement of diabetes mellitus, the probiotic characteristics of the Zymomonas mobilis ZM4 are utilized to improve the types and abundance of intestinal flora, so that the blood sugar of a mouse with type II diabetes mellitus is reduced, the oral glucose tolerance of the mouse is improved, the contents of glycosylated hemoglobin, blood insulin and GLP-1 are adjusted, and the diabetes mellitus is improved. The level of inflammatory factors related to diabetes mellitus is reduced, and damaged islet cells can be improved and recovered to a certain extent.

The invention relates to a fish maw collagen peptide with effects of improving body weight and regulating blood sugar, and a preparation method and application thereof. The fish maw collagen peptide has the effects of improving type 2 diabetes mellitus and assisting in controlling body weight, and the preparation method of the fish maw collagen peptide comprises the following steps: adding fish maw into a sodium hydroxide solution for pretreatment, then taking out, washing until the fish maw is neutral, and cutting the fish maw into small blocks; immersing the pretreated fish maw into a solution of a deep eutectic solvent, and carrying out heat treatment extraction to obtain a crude fish maw collagen stock solution; performing separation and purification treatment on the crude fish maw collagen stock solution to obtain a high-purity fish maw collagen stock solution; freezing and drying the high-purity fish maw collagen stock solution, carrying out multi-enzyme combined enzymolysis, and carrying out fire extinguishing protease, so as to obtain fish maw collagen peptide enzymatic hydrolysate; and cooling the fish maw collagen peptide enzymatic hydrolysate, and performing centrifugal separation. The enzymolysis product collagen peptide has strong DPP IV inhibitory activity, and can regulate the body weight and fasting blood-glucose of mice with type 2 diabetes mellitus, and improve the oral glucose tolerance and liver function of the mice with type 2 diabetes mellitus.