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MOF-based glucose detection system, sensor for detecting glucose concentration in saliva, and non-invasive oral glucose meter
PCT designated stage
WO2026103909A1
Immobilised enzymes
Microbiological testing/measurement
Oral glucose
Concentrations glucose
A method for preparing an MOF-based
glucose detection
system
, wherein a
Zeolitic Imidazolate Framework
(ZIF) is used as a
metal
-organic framework, and
glucose oxidase
(GOx) is loaded in the
zeolitic imidazolate framework
. The preparation method comprises the following steps: S1: adding water to a reaction flask in advance, and then sequentially adding a
metal
ion
, an
enzyme
and an organic ligand in a
molar
ratio of 100-1500:1-10:1-150, and 0.1-0.5% (by weight) of
ammonia
water to the reaction flask, S2: mixing and reacting same at
room temperature
for more than 6 hours, and S3: after
centrifugation
by means of a
centrifuge
, removing the supernatant to obtain a
solid
precipitate of the Gox-MOF material loaded with
glucose oxidase
. A sensor for detecting trace glucose concentration in
saliva
, and an
oral glucose
meter comprising the sensor.
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Owner:
SHANGHAI BIOTECH APPLICATION CO LTD
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