773 results about "Gel preparation" patented technology

The gel preparation has the merits of both solution and gel. By means of the combination of different type poloxamers, ocular in-situ gel preparation containing medicine and water soluble polymer supplementary material is prepared. The preparation contains poloxamer 407 and poloxament 188 as well as water soluble polymer supplementary material less than 3%. The preparation has proper phase conversion temperatur and may form gel on the surface of cornea of living body after being applied in liquid state at room temperature. The present invention can delay the disappearance of medicine and raise the biological utilization in some local area and is suitable for various ocular medicines.

A composition is described in which chitosan is prepared in a foamed gel that may be layered onto a suitable backing for use as a wound dressing, or the gel may be directly applied to wounds to effect hemostatic activity as a result of the action of the chitosan. The composition of the foamed chitosan gel has added to it medicaments, which include antimicrobial agents, in order to reduce the risk of microbial infections in wounds where hemostatic agents including the chitosan foamed gel preparation can be applied to effect hemostasis.

The invention discloses a high-density high-rigidity graphene porous carbon material as well as a preparation method and applications thereof. The method comprises the following steps: 1. original colloidal sol preparation: adding graphene-based component or a mixture of graphene-based component and auxiliary components into a solvent for dispersion to obtain the original colloidal for preparing the graphene porous carbon material; 2. graphene-based gel preparation: placing the original colloidal sol prepared in the step 1 into a reaction container, reacting for 0.1-100 hours at the temperature of 20-500 DEG C to obtain the graphene-based gel; and 3. high-density high-rigidity graphene porous carbon material preparation: drying the graphene-based gel at the temperature of 0-200 DEG C, increasing temperature to 100-3600 DEG C at anoxic atmosphere for conducting thermal treatment for 0.1-100 hours, or / and reacting for 0.1-50 hours at the temperature of 200-2000 DEG C by adopting an activation reaction method. Compared with the prior art, the prepared graphene-based material has the advantages of high density, high rigidity, abundant pores, large specific surface area and stable pore structure.

An integrated method is developed to utilise to a maximum extent the fresh biomass of seaweeds such as Kappaphycus alvarezii that can be crushed to release sap and where the sap is useful as a potent liquid fertilizer after suitable treatment with additives and dilution while the residue is a superior raw material for extraction of kappa-carrageenan, thereby enhancing the value of the seaweed. Other advantages of the invention include a reduced drying time and drying area to obtain the raw material for kappa-carrageenan production in dry and storable form, a reduced cost of transporting and storing this raw material because of its lesser bulk, easier handling due to its free flowing granular nature, and its direct use for gel preparation in certain applications.

The present invention relates to amino-functionalized mesoporous silica. The present invention provides amino-functionalized mesoporous silica having hexagonal platelet morphology with short channels perpendicular to the platelet. The lengths of the channels are preferably 10˜1000 nm. The present invention also provides a method for preparing amino-functionalized mesoporous silica having hexagonal platelet morphology comprising a series of steps in sequence which are reactive gel preparation before subjected to the microwave, microwave heating for co-condensation reaction and crystallization, and solvent extraction for surfactant removal. The direct co-condensation approach with microwave heating and adoption of sodium metasilicate as silica source can give great advantage in the view of economy and environment.

The invention relates to a sol-gel preparation method of a lithium vanadate negative electrode material of a lithium ion battery. The sol-gel preparation method comprises the following steps: sequentially adding a precursor containing a vanadium compound and a precursor containing a lithium compound into water, and stirring fully; then adding a water soluble carbon material which is acted as a chelate and a carbon source, stirring the water solution until dry gel is formed, carrying out vacuum drying until the water content is dried completely, putting a gel body into a porcelain boat, pretreating in the reducing atmosphere or the inert atmosphere, and carrying out sintering reaction in the inert atmosphere or the reducing atmosphere so as to obtain the material. According to the method, the technology is simple, the operation is easy, and moreover, the structure of lithium vanadate and the valence state of vanadium cannot be changed by the existence of the carbon material and the reducing atmosphere. The carbon-coated lithium vanadate material synthesized by the method, which acts as the negative electrode material of the lithium ion battery, has excellent performance and low lithium intercalation potential, and is expected to be as the negative electrode material of the next generation of lithium ion batteries. The synthesis method is suitable for producing the negative electrode material of the high-performance lithium ion battery, namely lithium vanadate.

The invention relates to a gel preparation for maintaining the activity of cryopreserved cells and a stem cell gel preparation containing stem cells. The gel preparation comprises the following components by the mass percentage: 1-3% of sodium alginate, 1-5% of dimethyl sulfoxide, 1-5% of propylene glycol, 1-5% of epigallocatechin gallate, 2-10% of dextran, 1-5% of human blood albumin, and water or a phosphate solution added to make the total amount be 100%. The gel preparation has the advantages of good biocompatibility and simple operation, can maintain high activity of cells, can be directly used for low temperature preservation, and has no need of traditional liquid nitrogen cryopreservation; the cell gel preparation after resuscitation can still maintain high activity of the cells and dryness of the cells, and can be applied for treatment of skin injury or mucosal injury.

The invention belongs to the technical field of medicines and discloses an itraconazole temperature-sensitive type gel preparation as well as a preparation method and application thereof. The itraconazole temperature-sensitive type gel preparation is composed of the following components in percentage by weight: 0.02-3% of medicines, 0.05-15% of solubilizing agent, 5-50% of gel matrix, 0-15% of biological adhesive, 0.001-2% of preservative, 0-10% of other additives and the balance of solvent. The itraconazole temperature-sensitive type gel preparation can regulate gelatinization temperature by adjusting composition and control drug release rate and degree, can effectively inhibit growth of candida in vitro and can be used for drug administration on skins, eyes, nasal cavity, oral cavity, straight intestine or vaginal mucosa. The itraconazole temperature-sensitive type gel preparation has obvious slow release and biological adhesion property and can prolong action time of medicines on an infection part, realize long-acting treatment, reduce dosage and toxic and side effects and improve patient compliance.

The invention relates to injectable temperature sensitive in situ gel preparation and a preparation method as well as an application thereof. The components of the preparation of the invention comprise 0.01 percent to 10 percent of anticancer drugs, 15 percent to 25 percent of pluronic F127, 0.01 percent to 20 percent tween and 45 percent to 84.98 percent of water or buffer solution.

The invention discloses a Chinese medicinal in situ forming eye gel preparation, and belongs to the field of Chinese medicament. Active ingredients of the preparation come from Chinese medicinal bulk medicaments, and the gel base materials of the preparation mainly comprise Gellan gum which is 0.4 to 0.7 percent of the weight of a finished product. The technical proposal overcomes the defects of low bioavailability, inconvenient use, short detention time and the like of the prior Chinese medicinal eye preparations, and achieves the effects of reducing applied dosage, prolonging the detention time in the eyes, convenient use, accurate applied dosage and the like.

The invention relates to an external gel used for treating diabetic foot, and a preparation method and an application thereof. Specifically, the invention relates to an external gel preparation with oxygen-carrying and antibacterial materials, and containing recombinant human epidermal growth factor (rhEGF). The preparation basically comprises: a medicine component recombinant human epidermal growth factor (rhEGF), an oxygen-carrying material, an antibacterial material, a gel substrate, a stabilizing agent, a humectant, a penetration enhancing agent, a surfactant, and a pH regulation agent.

The invention discloses a hollow fiber ultrafiltration membrane module casting device, and a casting method thereof. According to the hollow fiber ultrafiltration membrane module casting device, a membrane module composed of membrane silk bundles, a center tube, and a holder is arranged in a membrane shell; the two ends of the membrane shell are connected with a fluid outlet end module and a fluid inlet end module respectively; the fluid outlet end module and the fluid inlet end module are both provided with a first gel inlet pipe interface; the inner end surface of the fluid outlet end module is provided with a cylindrical groove; the inner end surface of the fluid inlet end module is provided with a conical groove, wherein the sidewall of the conical groove is a circular conical surface, and the bottom surface of the conical groove is a small diameter end; the center tube is connected with a second gel inlet pipe; the fluid outlet end module and the fluid inlet end fluid are connected with an end body of the membrane shell via U-shaped clamps. The method used for casting hollow fiber ultrafiltration membrane modules via the hollow fiber ultrafiltration membrane module casting device comprises following steps: 1, the membrane module is prepared; 1, the membrane shell is filled with the membrane module, and membrane silk of the two ends are cut off; 3, membrane silk blocking processing is performed, and module fixing is performed; 4, hard gel preparation is performed; 5, first gel delivering casting is performed; 6, soft gel preparation is performed; 7, second gel delivering casting is performed; and 8, the module is removed, and fluid outlet end cutting is performed so as to expose fiber membrane nematopores and obtain the fluid outlet end of the membrane module.

The invention belongs to the field of medicinal preparations and a novel medical technology and relates to an in situ gel preparation loaded with Kangfuxin and its preparation method and use. The in situ gel preparation loaded with Kangfuxin has temperature sensibility. The in situ gel preparation loaded with Kangfuxin is characterized in that Kangfuxin as a raw material and polymers are dissolved in a buffer solution or purified water according to a ratio. Because of polymer reverse-phase gel properties, the in situ gel preparation loaded with Kangfuxin is in a liquid state and can freely flow at a room temperature (of 20 DEG C) under storage conditions, and when the in situ gel preparation loaded with Kangfuxin is spread on a wound, under the action of a body temperature, the in situ gel preparation loaded with Kangfuxin forms fast semi-solid gel. The in situ gel preparation loaded with Kangfuxin is convenient for patient use, improves patient compliance, can effectively store drugs and can slowly release drugs so that drug action time is prolonged and drug efficacy is improved. Through oral administration, the in situ gel preparation loaded with Kangfuxin can be used for treating blood stasis, stomachache, gastrorrhagia, gastric ulcer and duodenal ulcer and assistantly treating Yin deficiency and pulmonary tuberculosis, and phthisis. Through external administration, the in situ gel preparation loaded with Kangfuxin can be used for treatment and anti-adhesion of metal-inflicted wounds, trauma wounds, ulcer wounds, fistula wounds, burn wounds, scald wounds, bedsore wounds and surgical wounds.

The invention discloses a thin cigarette filter rod containing a single solid aromatic bead particle and a preparation method of the thin cigarette filter rod, and relates to the field of cigarette flavor spices. The solid aromatic bead particle is loaded in the middle of a cigarette filter rod tow and mainly prepared from activated montmorillonite by processes such as gel preparation, crystallization, ball making and flavor attachment, and an approach is provided for adding cigarette flavor with weak aroma keeping effects. In the smoking process, the flavor in the filter rod is not involved in combustion and slowly and uniformly released along with smoke, and the problem of aroma deterioration caused by combustion is solved. The thin cigarette filter rod has the advantages that the singlesolid aromatic bead particle is applied to the cigarette filter rod, the cigarette filter rod is simple in structure, poisonless and tasteless, a consumer does not need to worry about safety of tinyadditives such as zeolite powder, the aromatic bead is simple in preparation process and stable to form, the total control rate of the concentration of the aromatic bead is more stable, the qualification rate and the production stability of the aromatic bead are better than those of an 'explosion bead', additional solvents are omitted in flavor attachment, and aroma is elegant and volatile.

The invention relates to an in-situ gel composition for eyes, comprising the following materials: 50 mu g / ml-400 mu g / ml of nerve growth factor, 1 mg / ml-20 mg / ml of stabilizer, 3 mg / ml-10 mg / ml of ion sensitive gel and water; and the pH value of the in-situ gel composition is 4.5-7.5. In the invention, by using the composition and proportion and controlling the pH value of the in-situ gel composition to be within certain range, the in-situ gel preparation for the eyes containing nerve growth factors can be obtained. When being stored under the normal-temperature state, the preparation is liquid, and becomes a stable semisolid gel state after entering the eyes.

The invention belongs to the field of western medicinal preparation, and relates to a preparation with suitable phase variation, detention time prolonging effects and topically administered in nasal cavity, and its preparation method. The method comprises dispersing momestasone furoate or budesonide in hydrophilic gel substrate prepared from acetyl-removed gellan gum and sodium alginate in micro powder form. the gel preparation is prepared and stored in solution from, and administered in solution spraying form; generates phase variation due to the change of environmental ionic strength, pH, or temperature after contacting with tunica mucosa of nasal cavity, and forms gel. The invention has the advantages of simple preparation and accurate administered dose; can prolong the contact time of medicine and schneiderian membrane; and improves therapeutic effect of the medicine to anaphylactic rhinitis.

The invention relates to prostaglandin microemulsion-gel preparation and a preparation method thereof. The preparation comprises prostaglandin E1 or the derivative thereof, oil, emulsifier, assistant for emulsifying agent, gel substrate and water, and also possibly comprises a permeation accelerator, a preparation stabilizer, an antioxidant and antiseptics. The preparation has the advantages of good percutaneous permeability, no stimulation to skin and mucous membrane, simple preparation technique and stable quality, the preparation can be used for treating diseases such as ulcer of limbs caused by erectile dysfunction and chronic arterial occlusion and rest pain of limbs caused by microcirculatory disturbance.

The invention belongs to the field of new chemically synthesized drugs and medical preparations thereof, particularly discloses a thermal gel controlled-release injection of a platinum-containing antitumor drug and a preparation method of the thermal gel controlled-release injection. The thermal gel controlled-release injection consists of Pt(IV)-containing amphipathic segmented copolymer and a solvent, wherein the water system can generate phase transformation of thermal gelation with temperature rise to spontaneously form physical hydrogel; the bonded Pt(IV) complex is easily reduced into Pt(IV); the amphipathic segmented copolymer consists of a hydrophilic block and a hydrophobic block which can be degraded into polyester, wherein a functional group is connected at the terminal of the block copolymer. The controlled-release gel preparation disclosed by the invention can be used for prolonging the release period of the platinum antitumor drugs. By virtue of an injection way, the preparation is dosed in tumor, around tumor or in a postoperative tumor cavity; after the preparation is gelled in situ in the body, the bonded platinum drugs can be slowly released from the gel, so that the dosing frequency and the whole body toxic and side effects are lowered.

The invention relates to a temperature-sensitive in-situ gel preparation composition for intra-articular injection and a preparation method thereof, and belongs to the field of medicine preparations. The preparation method comprises the following steps: preparing diclofenac sodium-carrying sodium alginate microspheres by combining a microsphere technology with a temperature-sensitive gel technology, and then carrying the medicine-carrying microspheres in a chitosan / beta-sodium glycerophosphate temperature-sensitive in-situ gel system to obtain a diclofenac sodium in-situ gel preparation composition. The composition is in a liquid state at a room temperature, capable of being converted to a semi-solid gel at a body temperature and forming a medicine storeroom at a medication part after being partially injected to enter an articular cavity, and beneficial to slowly releasing the medicine, prolonging the time of staying at the injection part, of the medicine, and enhancing the efficacy. The composition disclosed by the invention can be used for treating arthritis diseases of rheumatism, rheumatoid arthritis, osteoarthritis, synovitis and the like, as well as applicable to both diclofenac sodium and other arthritis treatment medicines of non-steroidal anti-inflammatory medicines, steroid hormone medicines, biological preparations and the like.

The invention discloses a multifunctional microemlusion gel preparation and a preparation process thereof, and belongs to the technical field of medicines. The preparation mainly comprises bulk pharmaceutical chemicals (such as non-steroidal anti-inflammatory drugs-diclofenac sodium, ibuprofen, indometacin, antifungal drugs-ornidazole, antiviral drugs-ganciclovir, hormone drugs-dexamethasone, local anesthesia drugs-lidocaine and irritants-menthol), a cationic polymer and a microemlusion, can further comprise gel or a thickener, and can be used for transdermal drug delivery and local drug delivery. The preparation process is simple, convenient, good in stability and pollution-free. Compared with existing cream and gel, the preparation has the advantages that a novel action mechanism is adopted, the accumulative penetration amount of unit area of drugs is remarkably increased, a certain slow-release effect is achieved, and the drug delivery frequency and the drug delivery amount can be reduced; a chemical penetration enhancer and a conventional preservative are not added, a certain bacterial inhibition effect is achieved, the skin irritation is avoided, and the use safety of the drugs is improved.

The invention belongs to the technical field of aerogel and particularly relates to molybdenum disulfide nanosheet / polyimide based composite aerogel and a preparation method thereof. The composite aerogel is prepared by compounding molybdenum disulfide nanosheets with good water dispersibility, prepared by a solvothermal method, with polyimide, and from molybdenum salt, sulfosalt and one or more of water-soluble polyimide precursor, and polyamide acid. The preparation process comprises the steps of preparing molybdenum disulfide nanosheets with good water dispersibility by the one-step solvothermal method, compounding the molybdenum disulfide nanosheets with polyamide acid, and performing sol-gel preparation, freezing-drying and amidation to obtain the molybdenum disulfide nanosheet / polyimide based composite aerogel. The composite aerogel has the characteristics that internal pores are uniformly distributed and the limit oxygen index is obviously higher than relative performance of macromolecule based aerogel in other documents or patents, and thus the composite aerogel can be taken as an ideal flame retardant material, heat insulation material and noise reduced material.

The invention belongs to the field of pharmaceutical preparations and relates to an in-situ gel sustained-release preparation which is used for vaginal administration and has high drug loading and a preparation method of the in-situ gel sustained-release preparation. The preparation is formed by an effective dose of drugs, a thermosensitive gel matrix material, a suspending agent and water or a buffer solution, wherein the drugs are suitable for vaginal administration, the thermosensitive gel matrix material is poloxamer, and the suspending agent is xanthan gum; and the suspending agent, i.e. the xanthan gum, does not affect the thermosensitivity of the preparation and can exert an excellent suspending effect on the drugs. The preparation has the advantages of simplicity in preparation, high drug loading, convenience in administration and little irritation, good safety, wide source of raw materials and low cost.

The invention provides temperature-sensitive chitosan-carboxymethylcellulose gel and a preparation method and application thereof. The temperature-sensitive chitosan-carboxymethylcellulose gel is prepared by physically crosslinking the chitosan and sodium carboxymethylcellulose at the temperature of 10 DEG C or below. The gel system has rapid temperature-sensitive response performance and can be kept in a liquid state at room temperature or when the temperature is lower than room temperature, and gelatinization can be rapidly realized when the temperature reaches body temperature. The gel preparation method is simple and practicable in operation, the reaction conditions are mild, and organic chemical reagents or other harmful substances can be avoided. The prepared temperature-sensitive gel is suitable for industries such as medicine products, skin care products and foods.

The present invention relates to a Chinese Tibet medicine for mainly curing the diseases of acute and chronic sprain and contusion, rheumatism and rheumatoid disease and its preparation method. It is characterized by that said preparation method includes the following steps: utilizing the Chinese Tibet medicinal materials of lamiophlomis rotate, Jidou, turmeric, zanthoxylum husk, water buffalo horn and myricaria germanica as raw material, making them undergo the processes of decocting, vacuum freeze-drying, pulverizing and making them into any pharmaceutically-acceptable dosage form, including oral preparation or preparation for external application, in particular, it can be made into the adhesive plaster, ointment preparation, spray, gel preparation, film preparation and resin plaster, etc.

The invention belongs to the field of medicinal preparations and relates to a nose temperature-sensitive type hydrogel spray which is prepared by dissolving a nasal decongestant, an anti-allergic rhinitis drug, a temperature-sensitive type material of poloxamer and a low viscosity bioadhesive material without mucosal toxicity into water. A gel preparation is prepared from gel temperature, the viscosity of the preparation in use is considered simultaneously, the temperature sensibility and sprayable performance of the preparation are ensured, then the preparation doses in a liquid spray manner at the room temperature (25 DEG C), the preparation is translated into semisolid gel with suitable intensity after being contacted with nasal mucosa surface, and the preparation is delayed on the nasal mucosa surface for a long time with the mucosa adhesion action of the bioadhesive. By utilizing the nose temperature-sensitive type hydrogel spray, patient medication is convenient. Compared with a common nasal cavity spray, by utilizing the nose temperature-sensitive type hydrogel spray, the residence time of the drug in a nose cavity can be prolonged so as to increase local absorption of the drug and prolong the pesticide effect.

The present invention relates to a heat-sensitive gel preparation containing matrine alkaloid and its preparation method. Said preparation is composed of matrine alkaloid, hydroxypropyl methylcellulose, poloxamer 407, phosphate buffer solution whose pH value is 5.0-7.0, glycerin and preservative. It is flowable fluid at normal temperature, and when the temperature is 28-33 deg.C, it can produce phase change, and can be formed into gel, so that it can be conveniently applied to vagina, mucous membrane of external genitalia, skin and eye.

The invention provides a tacrolimus ophthalmic in-situ gel preparation and a preparation method thereof, which micronizes medicaments or adopts the solid dispersion technology, the cyclodextrin inclusion technology or the like to obviously improve the solubility and then to prepare into an ophthalmic preparation which is in the liquid state in vitro and is in the gel state when being dropped into eyes. The invention is applicable to the treatment for preventing and curing ophthalmic corneal transplantation rejection, keratoconjunctivitis (KC), ocular allergic disorders and the like. The invention prepares tacrolimus into the ophthalmic in-situ gel for the first time. The ophthalmic gel is in the liquid state in vitro, the dosage can be easily and accurately controlled, the operation is convenient, and the ophthalmic gel can be uniformly spread when being dropped into eyes to form the gel. The ophthalmic gel can stay in eyes for long, can not be easily diluted by tears, can maintain the concentration of the effective medicaments, enhances the treatment effect, and has the advantages of less stimulation and good biocompatibility, thereby being an effective new ophthalmic medicine, being applicable to the clinic treatment and having extensive development prospect.

The invention discloses a sol-gel preparation method for carbon-coated ferrous lithium silicate of a lithium ion battery cathode material. According to the method, nano-silica serves as a template, and high-performance carbon-coated ferrous lithium silicate cathode material is further synthesized by a sol-gel method. The synthesized material has high purity, no impurity phase, and high particle uniformity; the particle size is between 20 and 50 nm; the weight percentage of carbon is 8 to 16 percent; under the multiplying power of C / 10, the primary discharge capacity is 190 mAh / g; under the multiplying power of 1 C, the primary discharge capacity is 132 mAh / g, and the specific capacity is 130 mAh / g after 100 cycles; under the multiplying power of 100 C, the discharge capacity is 42 mAh / g; high cycling performance and high power performance are embodied, and the requirements on actual application of the lithium ion battery can be met.

The invention relates to an ophthalmic flurbiprofen ester nano emulsion-in situ gel preparation and a preparation method thereof. The ophthalmic flurbiprofen ester nano-emulsion in situ gel preparation is made from oil, an emulsifier, a thickener, an osmoregulator, a bacteriostatic agent and purified water; and is characterized in that one or a plurality of safe and non-irritating lecithin, Tween60, Tween80, polyoxyethylene castor oil and polyoxyethylene hydrogenated castor oil are taken as the emulsifier; and a high molecular material with ion sensitivity characteristic is taken as the thickener. The ophthalmic flurbiprofen ester nano emulsion-in situ gel preparation is low-viscosity fluid with good fluidity in vitro, and rapidly forms hydrogel after being dropped in eyes. The ophthalmic flurbiprofen ester nano emulsion in-situ gel preparation has the advantages of increasing the residence time of the drug in eyes and increasing bioavailability, has no irritability or other toxic side effect to eyes, and has good biocompatibility and the like.

The invention discloses a preparation method of chitosan in situ gel preparation, which belongs to the medicine technical field. The invention comprises the steps as follows: first, dissolving chitosan into water solution and / or water solution with cosolvent; second, adding medicine into the chitosan solution and stirring sufficiently; third, adding strong base-weak acid salt into the chitosan solution slowly in CO2 atmosphere and under the stirring condition, and keeping stirring; fourth, distributing the evenly mixed chitosan collosol into sterile bottles with stoppers for sealing or filling chitosan collosol into an atomizing device under the protection by CO2 and then obtaining the chitosan in situ gel preparation. The invention not only avoids using organic solvent in the cause of preparation production but also simplifies the preparation production flow and widens the preparation application ways.