170 results about "Gel preparation" patented technology

The invention relates to the technical field of gel separation and extraction, in particular to a precipitation and separation device for elastin gel preparation, which comprises a precipitation cylinder, a liquid outlet is arranged above the circumferential side wall of the precipitation cylinder, and a cleaning ring for cleaning attached gel is arranged in the precipitation cylinder. A cleaning ring is arranged in the precipitation cylinder, a filtering mechanism for intercepting gel is arranged at the center of the cleaning ring, the filtering mechanism is rotatably connected with the cleaning ring, and a driving mechanism for driving the cleaning ring to slide up and down is arranged at the top end of the cleaning ring. The cleaning ring is arranged on the bottom of the precipitation cylinder, elastin gel attached to the inner wall of the precipitation cylinder is effectively scraped, meanwhile, the filtering mechanism moves downwards along with the cleaning ring, the water-phase solution is allowed to penetrate through the filtering mechanism to intercept gel particles, floating and floating of the gel particles in the water-phase solution are avoided, it is ensured that the gel particles can be smoothly precipitated to the bottom of a container, and the recovery efficiency of the gel is improved.

The invention belongs to the technical field of emulsion gel preparation, and discloses a preparation method of interpenetrating cross-linked network emulsion gel for improving the stability of anthocyanin and xanthophyll. According to the invention, a whey protein network induced by TG enzyme and a sodium alginate network induced by Ca < 2 + > are mutually crosslinked to form emulsion gel with an interpenetrating network structure, and purple sweet potato anthocyanin extract and xanthophyll are jointly loaded. The whey protein and sodium alginate interpenetrating cross-linked network emulsion gel is good in rheological property, uniform in micro-pore distribution and high in anthocyanin and xanthophyll stability, has the advantages of being natural, environmentally friendly, green and sustainable, and has wide application prospects in the field of functional food.

The invention discloses a collagen injection for tendon repair as well as a preparation method and application thereof, and belongs to the technical field of collagen preparation. The preparation method disclosed by the invention comprises the following steps: by taking a collagen dry product as a raw material, sequentially dissolving, carrying out secondary filtration, separating, preparing fibrotic collagen slurry A, preparing gelatinized collagen slurry B, preparing the solution, homogenizing and filling to prepare the collagen injection capable of being used for tendon repair. The collagen injection provided by the invention shows multiphase transformation during refrigeration and contact with body fluid with body temperature, and does not have the phenomenon of fiber layering in the long-term storage process. The collagen disclosed by the invention is an injection type gel preparation, can be flexibly injected and applied according to the depth and the area of a wound, is beneficial to promoting tissue regeneration and functional repair, and is particularly suitable for tendon injury and other scenes needing collagen to guide cell repair.

The utility model belongs to the technical field of sepharose gel preparation, and particularly relates to a temperature measuring and blending device for sepharose gel preparation, which comprises an oscillating and blending device, the oscillating and blending device comprises a vibrating plate capable of vibrating, a fixing device for fixing a preparation container is clamped on the vibrating plate, and a temperature measuring device is arranged on the vibrating plate. The fixing device is fixedly connected with a temperature measuring plate for placing a preparation container, and a thermochromic film is arranged on the upper surface of the temperature measuring plate. Compared with the prior art, by arranging the fixing device and the temperature measuring plate on the fixing device, the technical problems that in the prior art, an agarose solution needs to be shaken up manually, and the agarose solution is possibly polluted when a traditional temperature measuring device is used are solved.

This invention discloses a sol-gel preparation method for mesoporous carbon membranes, as well as the mesoporous carbon membranes and their applications. The preparation method includes: (1) dissolving phenolic compounds in a solvent and adding a template agent; (2) adding aldehyde compounds and amine compounds to obtain a mixture; (3) subjecting the mixture to a hydrothermal reaction to obtain an organic membrane precursor; and (4) carbonizing the organic membrane precursor at high temperature; wherein the solid content of the mixture is 20-30 wt%. The method of this invention significantly shortens the production cycle, has high preparation efficiency and success rate, can be molded to any size, and the obtained porous structure can withstand high-temperature treatment without collapsing. The obtained mesoporous carbon membrane can be applied to gas separation or liquid separation.

The invention relates to a microbial single-cell gelation encapsulation method based on aloe gel and application, the method realizes single-cell gelation encapsulation through electrostatic interaction of sterile aloe gel and intestinal anaerobic bacteria (such as Agathobacter rectasis), and the method comprises the specific steps of aloe gel preparation, bacterial suspension culture and oscillation mixing to form a stable structure. The preparation method has the advantages that the acid resistance and biocompatibility of the natural aloe gel are utilized to replace a traditional synthetic material, so that the gastrointestinal tolerance of thalli is improved; meanwhile, the synergistic effect of aloe active ingredients (such as aloe-emodin) and intestinal bacterial metabolites (butyric acid) is combined, so that the anti-inflammatory and intestinal steady-state regulation and control effects are enhanced. Experiments show that the survival rate of the encapsulated bacteria in simulated gastric juice within 4 hours is larger than or equal to 90%, the intestinal colonization rate is effectively increased compared with naked bacteria, the inflammatory factor level of a colitis model mouse can be remarkably reduced, and a safe and efficient new strategy is provided for micro-ecological treatment of inflammatory bowel diseases.

The application discloses a kind of in-situ gel preparation methods, belong to lithium metal battery technical field.The method introduces trace initiator to make 1,3-dioxolane DOL in electrolyte occur ring-opening polymerization reaction, by forming DOL crosslinking in advance, realize liquid ether-based electrolyte in-situ solidification on the surface of lithium negative electrode.After forming gel phase, inject electrolyte in soft pack battery of gel phase, construct gel phase@liquid phase two-phase system.By controlling the ratio of electrolyte and poly-DOL, realize the gradient solidification of ether-based electrolyte in battery, adjust the mechanical properties of gel electrolyte.There is intermolecular interaction between poly-DOL and lithium salt anion, significantly improve the ionic conductivity and lithium ion transference number of gel electrolyte, the in-situ gel phase formed has good interface compatibility with lithium negative electrode, and the growth of lithium dendrite is inhibited.This in-situ gel preparation method is low in cost and easy to operate, and is a simple method to realize high capacity and high cycle stability of lithium metal battery.

The invention discloses a controllable gel separation and purification device and method. The controllable gel separation and purification device comprises a feed liquid tank unit, a special gel separation and purification protection barrel, a controllable gel separation and purification device controller, a cooling and flow slowing unit and a membrane separation unit. The protective cylinder can enable gel materials in various shapes to be always suspended in the area of the central axis to do circular motion, so that the rheological characteristics of gel and the stability of functional activity are guaranteed. The invention aims at the current situation that the preparation reaction of a gel material cannot be subjected to quality control because a special gel separation and purification device is not sold in the market at present. Different from an uncontrollable or random method which is generally adopted in the previous literature that the gel preparation reaction is completed by observing the formation of the gel with naked eyes and then simply cleaning the gel with clear water or soaking the gel in water for multiple times, the device and the method provided by the invention can overcome the defect that the quality of the previous gel material preparation reaction cannot be effectively controlled; technical controllability and process repeatability which do not exist in previous literatures are achieved, and the technical problems of stability and uniformity of the gel material are solved.

The invention discloses a microchannel device, a slow-release essential oil gel microcapsule and a preparation method of the slow-release essential oil gel microcapsule, and relates to the technical field of gel preparation. The micro-channel device comprises four sample injection flow channels, two filtering flow channels, one sample outlet flow channel, three mixing flow channels, five feed ports and one discharge port. The preparation method comprises the following steps: uniformly mixing polyphenol and plant essential oil to obtain a first solution; mixing the first solution and the second solution through a micro-channel device to form uniform liquid drops; the liquid drops and a metal ion solution are mixed, polyphenol and metal ions are cross-linked to form a metal-polyphenol network on the surfaces of the liquid drops, and essential oil particles are obtained; and mixing the essential oil particles with a sodium alginate solution to obtain the slow-release essential oil gel microcapsule. According to the invention, a metal-polyphenol network is induced to gather on an interface by utilizing a behavior that water-soluble polyphenol diffuses from an oil phase to a water phase, and a double-network gel shell is formed by utilizing secondary cross-linking on the surface of sodium alginate, so that the aim of encapsulating and slowly releasing the plant essential oil is fulfilled.

The invention relates to an application of Quercetin (QUE) or a derivative thereof in a medicine for resisting vocal cord fibrosis and a preparation of the Quercetin or the derivative thereof. The quercetin can significantly inhibit abnormal deposition of extracellular matrix (ECM) after vocal cord injury, improve reduction of hyaluronic acid (HA) and elastic fibers (EF), and reduce overexpression of type I collagen (COL1A1) and fibronectin (FN1). Besides, by regulating PI3K / AKT and MAPK signal channels, the quercetin inhibits proliferation and migration of fibroblasts and promotes apoptosis of the fibroblasts, so that vocal cord fibrosis is effectively relieved. The invention also provides an application of a preparation of the quercetin and the derivative thereof combined or not combined with other anti-fibrosis drugs (such as 5-fluorouracil and dexamethasone) in treatment of vocal cord fibrosis, wherein the dosage forms of the preparation comprise an oral preparation, an injection, a spray or a local gel preparation.

The present application relates to the technical field of oil gel preparation, and discloses a multi-component oil gel loaded with resveratrol and a preparation method thereof, which comprises an oil gel made of base oil, a gelling agent, resveratrol and a surfactant; during preparation, the base oil, the gelling agent and the resveratrol are heated and mixed until homogeneous; the temperature is lowered and the light transmittance is monitored, and the surfactant is added at the phase transition critical point; when the torque step rises, the stirring speed and the cooling rate are lowered for solidification, and then the oil gel is left to stand and mature. The surfactant is attached to the interface of the precipitated gel network and combined with resveratrol, so that the distribution state of resveratrol is changed to inhibit the crystallization and precipitation of resveratrol; the light transmittance and torque monitoring are combined to control the micro network forming process and eliminate residual internal stress, so that the loading capacity of the oil gel for resveratrol, the uniformity of the network structure and the long-term physical stability are improved.

The invention discloses a nano-realgar temperature-sensitive gel preparation for intratumor injection as well as a preparation method and application of the nano-realgar temperature-sensitive gel preparation. The preparation method comprises the following steps: S1, obtaining a nano-realgar suspension with the mass concentration of 0.1%-5%; s2, adding a dispersing agent into the nano-realgar suspension, performing ultrasonic uniform mixing in an ice bath, and performing vacuum freeze drying to obtain nano-realgar freeze-dried powder; wherein the mass of the dispersing agent is 0.01%-0.2% of the mass of the nano realgar suspension; s3, obtaining a temperature-sensitive gel matrix, adding the nano-realgar freeze-dried powder into the temperature-sensitive gel matrix, and performing ice-bath ultrasonic treatment to obtain a nano-realgar temperature-sensitive gel preparation; wherein the mass of the nano realgar freeze-dried powder is 0.1%-5% of the mass of the temperature-sensitive gel matrix. The method provided by the invention is simple in equipment, low in cost and suitable for industrialization; the preparation can realize local slow drug release in tumors, has long action time, and avoids the problems of low bioavailability and systemic toxicity of realgar.

The preparation method comprises the following steps: digesting and collecting stem cells, separating high-purity mitochondria for later use, dropwise adding a prepared beta-sodium glycerophosphate solution into a chitosan solution to prepare blank gel for later use, mixing the mitochondria stock solution with the blank gel, and carrying out freeze drying to obtain the mitochondria-loaded gel preparation. The gel preparation loaded with the mitochondria is prepared. According to the invention, the stability of mitochondria in an in-vitro environment can be maintained, the mitochondrial transplantation efficiency and the treatment effect are improved, and technical support is provided for mitochondrial transplantation treatment of mitochondrial dysfunction related diseases.

The invention relates to the technical field of sustained-release gel preparations, and discloses a sustained-release gel preparation capable of responding to glucose to release growth factors as well as a preparation method and application of the sustained-release gel preparation. According to the invention, a gel preparation containing a'growth factor-FPBA-polylysine-hyaluronic acid 'quaternary composite system is constructed, hyaluronic acid is used as a gel matrix, and FPBA-grafted polylysine and the hyaluronic acid matrix are compounded to form a gel carrier framework; the gel carrier framework is used for realizing mechanical protection and specific condition response type delivery on the growth factors, and the utilization of organisms on the growth factors is realized through a synergistic effect. Wherein the hyaluronic acid can promote the contact between the gel and a wound, the existence of the FPBA-grafted polylysine makes the active component of the growth factor difficult to degrade, and when the gel is in contact with the wound, the glucose responsive release effect of the growth factor is realized through the reversible combination of the FPBA and the glucose; therefore, the gel is suitable for dressing application of diabetes wound healing.

The utility model discloses a kind of supramolecular biological extract gel preparation configuration devices, it relates to biological extraction technical field, the supramolecular biological extract gel preparation configuration device, including inner container, heating jacket and heat preservation layer that are successively sleeved from inside to outside, drive motor is equipped on heat preservation layer upper end, its rotating shaft is through inner container and is connected anchor type paddle, propeller and turbine paddle, heat preservation layer is equipped with multiple sensor components with PT100 temperature probe on, rear end is inserted with automatic cleaning shower nozzle's PH electrode module through flange pipe, left lower end is equipped with adding pump, upper end is equipped with outlet valve, medium inlet pipe and electric three-way valve, right end is equipped with control unit module through L type support. Through three-layer paddle layered stirring, global temperature monitoring, real-time pH adjustment and PID closed-loop control, accurately maintain reaction temperature 37±3 ℃, pH7.2±0.4, guarantee supramolecular aggregate (molecular weight 438kDa-1000kDa) stable formation, improve gel preparation function effect, suitable for supramolecular gel preparation of biological active ingredient.

The invention relates to the technical field of medical preparations or cosmetics, in particular to the technical field of preparation of plant-derived active ingredients in the medical preparations or cosmetics, and discloses a preparation process of a centella asiatica extract, which comprises the following steps: extracting centella asiatica to obtain a centella asiatica concentrated product from centella asiatica by adopting an enzyme-assisted hot ethanol extraction method in combination with a resin purification technology; the preparation method comprises the following steps: preparing centella asiatica extract molecularly imprinted polymer resin, filling a solid-phase extraction empty column with the centella asiatica extract molecularly imprinted polymer resin to prepare a resin column, and purifying a centella asiatica concentrated product through the resin column to prepare the centella asiatica extract with the purity as high as 99%. The centella asiatica extract prepared by the invention has repairing and soothing effects, can be used as an active ingredient in medical preparations or cosmetics, is used for preparing a gel preparation for treating skin injury, or is added into a repairing skin care product, and realizes the combination of a medical-grade skin care effect and daily care by promoting skin barrier repairing and soothing damaged parts.

The application discloses a gel carrier suitable for low-temperature sewage treatment, a preparation method and application, and the gel carrier is divided into two layers, the upper layer of the gel carrier is a light-heat conversion layer, and the lower layer of the gel carrier is a microbial growth layer, anaerobic ammonia oxidation bacteria are embedded in the lower layer of the gel carrier, the thickness ratio of the light-heat conversion layer to the microbial growth layer is controlled to be 1-1.5:4, magnetic nanoparticles are added in the gel preparation process to form a heterojunction, the microenvironment temperature is improved through a light-heat-magnetic heat synergistic effect, the low-light limitation in winter is broken, and the reactor can be rapidly started under a low-temperature condition of 15 DEG C. The prepared gel carrier can decompose nitrogen-containing pollutants in wastewater in an anaerobic environment.

The invention discloses a temperature-sensitive gel preparation containing a glutaminase inhibitor as well as a preparation method and application of the temperature-sensitive gel preparation, and belongs to the technical field of biological medicines. The temperature-sensitive gel preparation comprises outer-layer gel and inner-layer gel, the inner-layer gel is coated with the outer-layer gel, the outer-layer gel accounts for 40-75% of the total mass of the temperature-sensitive gel preparation, and the inner-layer gel accounts for 25-60% of the total mass of the temperature-sensitive gel preparation; the outer-layer gel is prepared from the following raw materials: an outer-layer gel matrix, a glutaminase inhibitor, a photosensitizer and a stabilizer; the raw materials of the inner-layer gel comprise an inner-layer gel matrix and an immune checkpoint inhibitor. According to the temperature-sensitive gel preparation, through photo-thermal control, the glutaminase inhibitor is firstly released to relieve the immunosuppression state, then the immune checkpoint inhibitor is released to kill tumors, and the glutaminase inhibitor and the immune checkpoint inhibitor act synergistically, so that efficient anti-tumor immunotherapy is achieved.

The invention relates to the technical field of gel preparations, in particular to selenium disulfide gel and a preparation method thereof. The raw materials for forming the selenium disulfide gel are selected from selenium disulfide, a metal ion complexing agent, carbomer, a pH regulator, lauryl sulfate salt and a solvent. The selenium disulfide gel has excellent stability, and particularly, the selenium disulfide gel is not prone to discoloring and layering after being stored at high temperature for a long time.

The invention relates to the technical field of gel preparations, in particular to ropivacaine phospholipid gel as well as a preparation method and application thereof. The invention provides ropivacaine phospholipid gel. The ropivacaine phospholipid gel is prepared from ropivacaine, mixed lipid and a hydration solvent, wherein the mixed lipid comprises neutral phospholipid, negative phospholipid and cholesterol, the neutral phospholipid comprises at least one of phosphatidylcholine and phosphatidylcholine derivatives, and the negative phospholipid is phosphatidic acid or phosphatidylglycerol. According to the ropivacaine phospholipid gel, the encapsulation effect and the release characteristic of the ropivacaine phospholipid gel are improved by improving phospholipid raw materials and a preparation process.

The invention belongs to the technical field of emulsion gel preparation, and discloses stable high-internal-phase Pickering emulsion gel only based on ellagic acid particles and 3D printing application of the stable high-internal-phase Pickering emulsion gel. The preparation method of the emulsion set comprises the following steps: dispersing ellagic acid powder in water, performing ultrasonic treatment to obtain a suspension, then centrifuging the suspension, collecting supernate, and drying to obtain ellagic acid nanoparticles; weighing the ellagic acid nano-particles, putting the ellagic acid nano-particles into a non-polar solvent, and mixing to obtain an oil dispersion liquid of the ellagic acid nano-particles; and mixing the prepared oil dispersion liquid with water, and carrying out high-speed shearing emulsification to obtain the stable high-internal-phase Pickering emulsion gel only based on ellagic acid particles. According to the invention, the single ellagic acid nanoparticles are used as a stable medium for the first time, so that the process complexity and safety risk caused by multi-component compounding are avoided, and the simplification and greenization of system components are realized.

The invention discloses a ZnO varistor uniformly doped with Y element and a sol-gel preparation method of the ZnO varistor, and belongs to the technical field of electronic ceramic materials. The preparation method comprises the following steps: (1) preparing a resistor raw material containing Y (NO3) 36H2O; (2) adding a citric acid solution into the yttrium nitrate solution to adjust the pH value to 3.0-5.0, adding polyethylene glycol, and performing ultrasonic treatment to obtain a precursor solution; (3) dropwise adding ammonia water, and pouring the Bi2O3 powder to form sol wrapping Bi2O3; (4) standing and aging to form wet gel wrapping Bi2O3 powder; (5) drying and calcining; (6) preparing total slurry; (7) preparing a green body; and (8) sintering to obtain the ZnO piezoresistor uniformly doped with the Y element. According to the preparation method, a sol-gel method is adopted, a citric acid complexing system is combined with polyethylene glycol, and the technical bottlenecks that in a traditional process, Y elements are prone to agglomeration, and the grain sizes are not uniform are solved through pH value gradient regulation and an ultrasonic dispersion process.

The invention relates to the technical field of gel preparations, in particular to phospholipid gel as well as a preparation method and application thereof. The invention provides phospholipid gel. The phospholipid gel comprises a raw material medicine, mixed lipid and a hydration solvent, wherein the mixed lipid comprises neutral phospholipid, negative phospholipid and cholesterol, the neutral phospholipid comprises at least one of phosphatidylcholine and phosphatidylcholine derivatives, and the negative phospholipid is phosphatidic acid or phosphatidylglycerol. According to the invention, the encapsulation effect and the release characteristic of the phospholipid gel are improved by improving the phospholipid raw material and the preparation process.

The invention belongs to the technical field of gel preparation, and particularly relates to mussel mucoprotein physical barrier protective gel and a preparation method thereof. The mussel mucin polymer disclosed by the invention can quickly form a compact and flexible isolating membrane with self-repairing capability on the surface of vaginal mucosa. The isolating membrane can be firmly attached to the surface of a mucous membrane based on the strong biological adhesiveness of mussel mucin, can directly block sperm penetration and limit sperm swimming, and also can effectively block pathogenic microorganisms such as viruses and bacteria from contacting the mucous membrane. The acid environment provided by the lactic acid-citric acid buffer system not only can directly inhibit sperm activity, but also can enhance the stability and adhesiveness of the mussel mucin polymer, so that the mussel mucin polymer can be better attached to vaginal mucosa, and the action time of a physical barrier is prolonged. The chitosan quaternary ammonium salt has the effects of killing bacteria and viruses and the like, and the hydroxypropyl methyl cellulose serving as a thickening agent can improve the viscosity and the stability of the gel, so that the gel can be better retained in the vagina, and the action time is prolonged.

The invention relates to the technical field of food, in particular to a method for preparing gel based on succinylation modified rice protein alkali heat induction. The preparation method comprises the following steps: firstly, acylating rice protein by adopting succinic anhydride to prepare rice protein with different acylation degrees; the influence of different alkaline solutions and alkaline environments with different pH values on the performance of inducing the rice protein to prepare the gel is further investigated. Compared with a traditional alkali heat induction process, the brand new rice protein gel preparation process provided by the invention is milder and safer. The application range of the rice protein in the food industry is expanded, and meanwhile, an important foundation is laid for developing safe, nutritional and palatable foods easy to swallow.

The invention belongs to the technical field of medicines, and particularly relates to application of IR808 in preparation of a medicine for treating eye bacterial infection diseases. According to the invention, IR808 is taken as a photosensitizer, laser irradiation is combined, and singlet oxygen generated by IR808 is utilized to play an antibacterial role. The developed eye drops, intraocular injections, sustained-release nanoparticles and gel preparations are designed aiming at the eye environment, and have good biocompatibility and stability. The treatment scheme in an animal model proves that pathogens including drug-resistant bacteria can be efficiently killed at low concentration, intraocular tissue damage caused by infection can be effectively relieved, and observable toxicity to intraocular cells and the whole body of an experimental animal is not shown. The invention provides a novel effective method for treating bacterial infection of eyes, especially for solving the drug resistance of antibiotics and improving the treatment safety.

The application relates to the technical field of catalyst preparation, in particular to a surface-modified Cu-based catalyst, a preparation method thereof and application of the surface-modified Cu-based catalyst in CO hydrogenation to prepare ethanol. The preparation method comprises the following steps: S1, precursor solution preparation; S2, dry gel preparation; S3, modification: S301, loading; S302, lithium niobate modification; S303, hybrid modification; and S4, surface-modified Cu-based catalyst preparation. The application provides a surface-modified Cu-based catalyst, a preparation method thereof and application of the surface-modified Cu-based catalyst in CO hydrogenation to prepare ethanol, so as to solve the problem of low ethanol selectivity in the related art.

The application discloses a gel preparation preparation method for improving cervical HPV infection and establishing a preventive barrier, relates to the technical field of gel preparation, and aims to solve the technical problems that the existing treatment methods are mostly focused on treating infected patients, and there are obvious deficiencies in the prevention of HPV infection, especially in establishing an effective preventive barrier in uninfected people, including: a crushing mechanism, which is mainly used for crushing raw materials, the crushing mechanism comprises a cabinet body, a cabinet door is arranged on one side of the cabinet body, a crushing barrel is arranged in the cabinet door, and a rotating motor matched with the crushing barrel is arranged on the cabinet door; a reverse osmosis mechanism, which is mainly used for controlling the osmotic pressure of the gel. The application has the advantages of activating local immune cells of the cervix, promoting cytokine secretion, enhancing the immune clearance ability of the body to HPV virus, providing long-acting preventive protection for the cervix, and reducing the risk of HPV infection.

The invention relates to an extracellular vesicle-frozen gel scaffold as well as an integrated preparation method and application thereof, and belongs to the technical field of biotechnology and tissue engineering materials. The problems that in the prior art, extracellular vesicles are prone to being damaged by low temperature in the frozen gel preparation process, a traditional cryoprotectant is not compatible with a stent process, and burst release and action time is short in a vesicle physical adsorption method are solved. The method comprises the following steps: mixing extracellular vesicles with a trehalose solution, and standing to obtain a vesicle-trehalose mixed solution; mixing with the support material prepolymer solution, and adding a photoinitiator to form a composite precursor solution; freezing the solution, and performing cross-linking solidification to form a three-dimensional porous gel scaffold; and unfreezing and washing to obtain the stent. The trehalose is introduced as a cryoprotectant, vesicle activity protection and stent structure forming are synchronously achieved in low-temperature forming, and the prepared stent can achieve controllable slow release of vesicles and has good application prospects in the field of tissue repair and regeneration.

The invention provides a budesonide temperature-sensitive gel preparation as well as a preparation method and application thereof, and the budesonide temperature-sensitive gel preparation is mainly prepared from the following components: budesonide, poloxamer 407, poloxamer 188, propylene glycol, hydroxypropyl methyl cellulose, sodium benzoate and pure water. After the budesonide temperature-sensitive gel drug delivery system based on poloxamer 407, poloxamer 188 and hydroxypropyl methylcellulose is applied to a cavity, semi-solid gel can be quickly formed, and strong retention and slow release effects are shown, so that the bioavailability is increased, the formed semi-solid gel can be retained at a drug delivery part and cannot be lost, and the budesonide temperature-sensitive gel drug delivery system is suitable for clinical application. In addition, budesonide can be gradually released, and a remarkable curative effect is shown in short-term clinical application of recurrent chronic sinusitis with nasal polyp.