503 results about "Gel preparation" patented technology

The invention relates to curcumin-loaded pectin sodium alginate gel as well as a preparation method and application thereof, and belongs to the technical field of gel preparation. The preparation method of the curcumin-loaded pectin sodium alginate gel comprises the following steps: in a dark environment, stirring and mixing curcumin, arjunic acid, ortho-aminophenol and an organic solvent, adding a polyvinyl alcohol aqueous solution, a sodium alginate solution and a pectin solution, uniformly mixing, performing ultrasonic treatment, adding calcium chloride, stirring and mixing, performing ultrasonic treatment, and performing vacuum drying to obtain the curcumin-loaded pectin sodium alginate gel. And adding oxidized hyaluronic acid, continuously stirring, stirring at normal temperature until the organic solvent is completely volatilized, and cleaning the hydrogel with deionized water to obtain the hydrogel. According to the invention, calcium ions and sodium alginate are subjected to physical crosslinking, pectin and polyvinyl alcohol are combined to form a composite hydrogel layer, the compounding of multiple components can effectively control the dissolution and drug release behaviors of active components, the bioavailability of curcumin is increased, the compactness and stability of hydrogel are increased, and the bioavailability of curcumin is improved. The oxidation resistance of the hydrogel can be effectively improved.

The invention discloses composite gel for osteochondral repair as well as a preparation method and application of the composite gel. Main raw materials of the composite gel are regenerated silk fibroin (RSF) and recombinant humanized III-type collagen (rhCol-III), and auxiliary raw materials of the composite gel are sodium hyaluronate (HA), fibrinogen and thrombin. The preparation method comprises the following steps: firstly, mixing an RSF solution with an rhCol-III solution, obtaining RSF-rhCol particles through a freeze drying technology and mechanical pulverization, dispersing the particles in an HA solution to obtain composite gel, mixing the gel with a thrombin solution, catalyzing fibrinogen to be split and converted into fibrin by thrombin, and performing freeze drying to obtain the rhCol-RhCol-RhCol-RhCol-RhCol-RhCol-RhCol. And crosslinking the fibrous protein monomer to obtain the injectable composite gel preparation capable of immediately gelling. The prepared RSF-rhCol composite gel can adapt to a defect area, has a certain adhesion effect, has excellent biocompatibility, promotes migration of bone marrow mesenchymal stem cells, induces cell differentiation and promotes cartilage tissue regeneration.

The invention relates to the technical field of gel separation and extraction, in particular to a precipitation and separation device for elastin gel preparation, which comprises a precipitation cylinder, a liquid outlet is arranged above the circumferential side wall of the precipitation cylinder, and a cleaning ring for cleaning attached gel is arranged in the precipitation cylinder. A cleaning ring is arranged in the precipitation cylinder, a filtering mechanism for intercepting gel is arranged at the center of the cleaning ring, the filtering mechanism is rotatably connected with the cleaning ring, and a driving mechanism for driving the cleaning ring to slide up and down is arranged at the top end of the cleaning ring. The cleaning ring is arranged on the bottom of the precipitation cylinder, elastin gel attached to the inner wall of the precipitation cylinder is effectively scraped, meanwhile, the filtering mechanism moves downwards along with the cleaning ring, the water-phase solution is allowed to penetrate through the filtering mechanism to intercept gel particles, floating and floating of the gel particles in the water-phase solution are avoided, it is ensured that the gel particles can be smoothly precipitated to the bottom of a container, and the recovery efficiency of the gel is improved.

The invention discloses high-strength oyster protein gel as well as a preparation method and application thereof, and belongs to the technical field of protein gel preparation. The oyster meat is used as a raw material, the oyster protein isolate is obtained by adopting an alkali-solution and acid-isolation method, and the oyster protein isolate is subjected to pre-solidification and high-temperature induced deep crosslinking at a low temperature for an ultra-long time, so that the gel property of the oyster protein isolate can be remarkably improved; the prepared oyster protein isolate gel has the characteristics of smooth surface, high gel strength, high elasticity and the like; according to the method, the aggregation degree, conformation and intermolecular interaction force of oyster protein can be regulated and controlled only by utilizing temperature, so that the oyster protein is induced to form high-quality protein gel. Besides, no organic chemical reagent or food additive is added in the preparation process, and NaCl is not added, so that the oyster protein isolate gel is pure in ingredient, high in safety and simple to operate, and has relatively high application value and industrialization potential.

This invention discloses a high-strength oyster protein gel, its preparation method, and its applications, belonging to the field of protein gel preparation technology. Using oyster meat as raw material, this invention obtains oyster protein isolate through an alkali-dissolution and acid-precipitation method, and pre-coagulates the oyster protein isolate at ultra-long-term low temperatures. High-temperature induction of deep cross-linking significantly improves the gel properties of the oyster protein isolate. The prepared oyster protein isolate gel exhibits characteristics such as smooth surface, high gel strength, and high elasticity. This invention utilizes only temperature to control the aggregation degree, conformation, and intermolecular interactions of oyster proteins, thereby inducing the formation of a high-quality protein gel. Furthermore, the preparation process of this invention involves no organic chemical reagents or food additives, and no NaCl is added, resulting in a pure, safe, and simple oyster protein isolate gel formulation with high application value and industrialization potential.

The invention discloses a preparation method and application of multifunctional antibacterial gel, and relates to the technical field of biomedical injectable hydrogel materials with antibacterial activity. The cationic guar gum (CG) is used as a cross-linked network and is loaded with a water-soluble Fe (II)-based metal organic metal cage (Fe-1SO4), and through in-situ chemical dynamic therapy (CDT) and photodynamic therapy (PDT) induced under irradiation of 660 nm laser, rapid healing of surface wounds is promoted through synergistic antibiosis. Fe-1SO4 is a water-soluble metal cage which takes Fe (II) as a metal node and 5, 10, 15, 20-tetra (4-aminophenyl)-21H, 23h-porphyrin (TAPP) as an organic ligand, and can be quickly degraded within 5 days in a biological environment. According to the present invention, with the application of the fenton-like reaction in the preparation of the antibacterial agent, the obvious PDT effect can be provided under the irradiation of 660 nm laser so as to generate a large amount of singlet oxygen (1O2), and the fenton-like reaction can convert H2O2 generated by bacterial infection into toxic hydroxyl radicals (OH) in situ, such that the excellent antibacterial activity can be provided in vivo and in vitro, and the wound healing can be promoted. The invention provides a simple strategy for the design of the rapidly degradable antibacterial hydrogel dressing, and is an important step for the clinical application of biological materials.

The invention belongs to the technical field of carbon aerogel, and particularly relates to phenolic resin-based carbon aerogel and a preparation method thereof.The preparation method comprises the following steps that 1, phenolic resin is prepared, specifically, a phenolic compound and an aldehyde compound are added into a reaction kettle for a reaction, a catalyst is added for continuous stirring, the heating temperature and stirring time of the reaction kettle are controlled, and phenolic resin is prepared; phenolic resin is obtained; 2, phenolic resin treatment: taking out the prepared phenolic resin, adding an organic solvent, and stirring to prepare a phenolic resin solution; step 3, gel preparation: putting the mixed solution into a reaction kettle, adding an organic solvent, continuously heating, then stopping heating, and cooling a high-pressure kettle to obtain organic aerogel; step 4, gel treatment: activating the organic carbon material to form a carbon aerogel precursor, and activating and cleaning the surface by adopting a normal pressure plasma technology; the organic aerogel is added into a cracking furnace, protective gas is added, the cracking furnace is heated, heat preservation is conducted, cooling is conducted, and the carbon aerogel is obtained.The newly-prepared phenolic resin is adopted, it is avoided that the quality of the phenolic resin is affected by long-time storage, the organic matter is added, and the carbon aerogel is prepared by carbonizing the organic matter after activating treatment; therefore, the forming quality of the carbon aerogel is guaranteed.

The invention relates to a preparative protein electrophoresis purification system and a protein purification method. The system comprises an automatic gel preparation device and an electrophoresis device, the automatic glue making device comprises a supporting frame, a clamping arm and a glue filling needle, and a linear module is fixedly arranged on the supporting frame to drive the glue filling needle to synchronously move in the horizontal direction and the vertical direction. The electrophoresis device comprises an outer electrophoresis tank, an electrophoresis frame and a cooling device, the electrophoresis frame and the cooling device are arranged in the outer electrophoresis tank, an inner electrophoresis tank is arranged in the electrophoresis frame, rubber plates are detachably arranged on the two sides of the electrophoresis frame, the rubber plates form side plates of the electrophoresis frame, notch grooves are formed in the inner sides of the tops of the rubber plates, and the rubber filling needles are matched with the rubber plates. The protein purification method is a method based on the protein electrophoresis purification system.

The invention relates to the technical field of organic silicon elastomers, and discloses a preparation method and equipment of high-brightness organic silicon elastomer gel, and the high-brightness organic silicon elastomer gel comprises the following components in parts by mass: 124 parts of hydrogen-containing silicone oil and 13 parts of vinyl MQ resin. According to the invention, polydimethylsiloxane and isoalkane in a certain mass ratio are used as carrier fluids, and the polydimethylsiloxane and the isoalkane act together, so that the obtained product has more excellent silky feeling, matte feeling, smearing spreadability and skin feeling durability, can provide lasting velvet-like smooth feeling for the product, can bring matte and soft-focus effects for the product, and can be used for preparing a soft-focus soft-focus product. According to the present invention, the product viscosity can be reduced, the refreshing non-greasy skin feeling can be provided for the product, the product can be used as the high transparent system, the good smearing spreading degree and the good water resistance can be provided, the thickening effect can be provided in the anhydrous formula and the water-in-oil formula, and the product stability can be improved.

The invention relates to an anti-inflammatory and analgesic external composition, a preparation method and application thereof and a gel preparation, and belongs to the technical field of external pharmaceutical compositions.The anti-inflammatory and analgesic external composition is prepared from, by weight, 3-8 parts of loxoprofen sodium, 500-1000 parts of fried semen brassicae, 300-500 parts of fructus arctii and 10-30 parts of liquorice. The semen brassicae is warm in nature and pungent in taste, belongs to the lung channel, and has the effects of benefiting qi and removing stasis; the fructus arctii is cold in nature, pungent and bitter in taste, belongs to lung and stomach channels and has the effects of detoxifying and promoting eruption, the fructus arctii and the fructus arctii are cold in nature and warm in nature, mutual in medicine property, pungent and divergent in taste and have the effect of transdermal enhancement of the medicine effect, the liquorice is neutral in nature and sweet in taste, belongs to the heart, lung, spleen and stomach channels and has the effects of relieving spasm and pain and harmonizing all the medicines, and the liquorice, the fructus arctii and the liquorice can synergistically play the effects of stimulating menstrual flow and relieving pain. And with the cooperation of loxoprofen sodium, the synergistic interaction effect is achieved in the aspects of diminishing inflammation and relieving pain.

The invention belongs to the technical field of emulsion gel preparation, and discloses a preparation method of interpenetrating cross-linked network emulsion gel for improving the stability of anthocyanin and xanthophyll. According to the invention, a whey protein network induced by TG enzyme and a sodium alginate network induced by Ca < 2 + > are mutually crosslinked to form emulsion gel with an interpenetrating network structure, and purple sweet potato anthocyanin extract and xanthophyll are jointly loaded. The whey protein and sodium alginate interpenetrating cross-linked network emulsion gel is good in rheological property, uniform in micro-pore distribution and high in anthocyanin and xanthophyll stability, has the advantages of being natural, environmentally friendly, green and sustainable, and has wide application prospects in the field of functional food.

The invention relates to the technical field of medical gel, and particularly discloses a sustained-release gel preparation for endometrial repair and a preparation method of the sustained-release gel preparation. Keratinocyte factor sustained-release microspheres containing keratinocyte factor-glucan particles and lactic acid-glycolic acid copolymer shells are constructed around keratinocyte factors, and the keratinocyte factor sustained-release microspheres are loaded by hyaluronic acid hydrogel containing polylysine, collagen and silk fibroin to form the sustained-release gel preparation for endometrial repair. The sustained-release gel preparation has the effect of promoting proliferation of human endometrial cells, can repair endometrial injury, promote injury healing and prevent uterine cavity adhesion, and has important significance in treating endometrial injury and improving physical and psychological health of women.

To provide a gel preparation kit, a gel preparation material, a medicinal drug, and a medical device that suppress a reaction with a medicine or a cell, and promote inclusion of a hydrophobic medicine into the gel or cell proliferation.SOLUTION: A gel preparation kit comprising a polymer (A) and a polymer (B), where the polymer (A) includes a hydrophilic polymer portion (A1) with 2 to 8 branches, a hydrophobic polymer portion (A2) that is bonded to the side chains or ends of each branch of the hydrophilic polymer portion (A1), and a click-reactive group (A3) that is bonded to at least one side chain or end of the hydrophobic polymer portion (A2), and polymer (B) includes a hydrophilic polymer portion (B1) with 2 to 8 branches, a hydrophobic polymer portion (B2) that is bonded to the side chains or ends of each branch of the hydrophilic polymer portion (B1), and a click-reactive group (B3) that is bonded to at least one side chain or end of the hydrophobic polymer portion (B2). The click-reactive groups (A3) and (B3) can be cross-linked through a click reaction.SELECTED DRAWING: None

The tooth whitening gel preparation machine is characterized in that the tooth whitening gel preparation machine comprises an activation reaction kettle, and the activation reaction kettle comprises an activation reaction kettle electrode driving plate unit, an activation reaction kettle electrode, a liquid inlet and outlet unit, a gas inlet and outlet unit and a liquid activation pool; the activation reaction kettle electrode driving plate unit is positioned at the upper part of the activation reaction kettle electrode; the liquid activation pool is positioned at the lower part of the activation reaction kettle electrode; and the liquid activation pool and the activation reaction kettle electrode form a closed cavity. The hydrogen peroxide liquid prepared by the invention not only has high oxidation activity, but also is mild, non-irritant and non-corrosive.

The invention relates to the technical field of platelet gel preparation, in particular to platelet gel containing zinc ions and a preparation method thereof.The preparation method comprises the steps that the blood sampling amount of single-time blood sampling is determined according to the wound volume; blood is collected according to the blood collection amount, and the collected blood is stored in a preparation device; a zinc-containing reagent strip is prepared, and the zinc-containing reagent strip is placed in the preparation device to be assembled; centrifuging the preparation device, taking out the centrifuged preparation device, and standing; and separating a red blood cell layer generated in the centrifugation process from the platelet gel containing the zinc ions to complete the preparation. Zinc ions are added into the platelet gel, the preparation efficiency and the treatment effect of the gel are promoted and improved, the antibacterial performance of the gel is supplemented, the whole preparation process of the preparation method is conducted in a sealed mode, and the sterility degree is improved; the preparation efficiency is improved, the operation process is simplified, and consistent operation can be realized; the gel efficiency and the antibacterial performance are improved by adding zinc ions.

The invention relates to preparation and application of a methotrexate-loaded silk fibroin gel drug release system, in particular to a methotrexate-containing gel preparation which contains methotrexate, silk fibroin and BDDE in a weight ratio of (1-2): (30-50): (6-10), the invention further provides a preparation method of the gel preparation, and the preparation method comprises the following steps: preparing the methotrexate-loaded silk fibroin gel drug release system by using the methotrexate-loaded silk fibroin gel drug release system, and preparing the methotrexate-loaded silk fibroin gel drug release system by using the methotrexate-loaded silk fibroin gel drug release system. The preparation method comprises the following steps: dissolving lithium bromide in water, adding silk fibroin and methotrexate, adding BDDE, and standing to form gel; the method specifically comprises the following steps: dissolving lithium bromide in water, adding silk fibroin and methotrexate, stirring at 50-70 DEG C for 0.5-2 hours, adding BDDE, and standing at 50-70 DEG C for 2-4 hours to form gel.

The invention relates to a production method of a large primary crystal 13X molecular sieve, and belongs to the technical field of molecular sieve preparation. The method comprises the following steps: mixing water glass with a sodium aluminate solution under a set temperature condition to obtain gel; adding a seed crystal into the gel, and carrying out first-stage crystallization to obtain a first-stage crystallization solution; performing second-stage crystallization on the first-stage crystallization solution to obtain a second-stage crystallization solution; and respectively separating, washing and drying the second-stage crystallization liquid to obtain the 13X molecular sieve product with the original crystal size of 3-4 microns. The technical problem of increasing the original crystal size of the 13X molecular sieve is successfully solved by finely regulating and controlling a plurality of key steps such as gel preparation, seed crystal introduction, segmented crystallization and post-treatment. According to the technical scheme, the adsorption performance and the bulk density of the molecular sieve are improved, and a new thought and method are provided for industrial production of the molecular sieve.

The invention belongs to the technical field of medical polymer materials, relates to an amphiphilic block copolymer, a hydrogel material containing the amphiphilic block copolymer and a preparation method and application of the amphiphilic block copolymer, and particularly discloses a poly (2-ethyl-2-oxazoline)-polyamino acid block copolymer and a preparation method and application of a hydrogel material of the poly (2-ethyl-2-oxazoline)-polyamino acid block copolymer. The hydrogel material provided by the invention has excellent injectability, and the modulus and gelation temperature of a gel preparation can be adjusted by changing the molecular weight and concentration of the amphiphilic block copolymer, so that the hydrogel material adapts to different physiological environments, is applied to different indications, and can be applied to various diseases. Compared with other hydrogel in which the chemical structure of the polymer needs to be changed, the hydrogel is more convenient.

The invention provides gel containing SOD (superoxide dismutase) and a preparation method, and relates to the field of gel preparation. The preparation method of the gel containing the SOD superoxide dismutase comprises the following steps: S1, adding water and glycerol into a stirring pot, and stirring; s2, uniformly stirring, adding carbomer, and homogenizing for a proper time; s3, stirring while heating after mixing, and adding raspberry ketone and 1, 2-hexanediol during the period; s4, continuously raising the temperature, keeping the temperature for a proper time after the designed temperature is reached, and cooling after the temperature is kept; s5, adding SOD (superoxide dismutase) and continuously stirring; s6, stirring until dissolving, adding triethanolamine or sodium hydroxide, and stirring; and S7, uniformly stirring, and cooling to room temperature to obtain the gel containing SOD. In the invention, the gel containing superoxide dismutase not only resists oxidation, but also contributes to promoting skin repair and relieving inflammation, and especially under the condition of sensitivity or susceptibility to stimulation, the gel containing superoxide dismutase possibly contributes to accelerating repair, relieving discomfort and improving comfort.

The invention discloses a method for preparing high-nutrition oil gel from a soybean protein typing aggregate-hyaluronic acid compound, and belongs to the technical field of food processing. The method comprises the following steps: (1) preparing a soybean protein typing aggregate; (2) preparing a hyaluronic acid solution; (3) preparing a soybean protein typing aggregate-hyaluronic acid compound; and (4) preparing the oil gel. The oleogel with high nutrition, good stability and better structural performance and water-retaining property is prepared by fully utilizing the structural and functional advantages of the protein parting aggregate and the hyaluronic acid, so that the effective application of the oleogel prepared from the soybean protein isolate in the food industry is enhanced. The oil gel is simple and convenient in preparation step, high in efficiency, environment-friendly and suitable for being used in actual continuous production.

The invention relates to the technical field of health care products, in particular to silver ion polypeptide antibacterial gel. The invention discloses a silver-polypeptide-containing shampoo, which is prepared from the following ingredients including 0.1 to 1 percent of silver ions, 0.5 to 3 percent of polypeptide, 60 to 85 percent of deionized water, 1 to 5 percent of jingnaoji leaf extracts, 1 to 5 percent of herba portulacae extracts, 1 to 5 percent of radix notoginseng extracts, 1 to 5 percent of radix sophorae flavescentis extracts, 1 to 5 percent of saffron crocus extracts, 1 to 5 percent of apple seed extracts, 1 to 5 percent of herba violae extracts, 1 to 5 percent of fructus cnidii extracts, 1 to 5 percent of sunflower extracts, 1 to 5 percent of herba centellae extracts and 0.5 to 3 percent of herba menthae extracts. The preparation method comprises the following steps: extraction preparation, silver ion preparation, mixing and stirring, and gel preparation. The invention has the beneficial effects of scientific and reasonable formula, obvious synergistic effect and strong antibacterial effect; the preparation process is simple and feasible, effective activity of each component can be fully reserved, and stable product quality is guaranteed; the product is mild and non-irritant, is suitable for daily cleaning, health care and health care of private parts, does not destroy normal microbial balance of the private parts, and is high in use safety.

The invention provides a temperature-sensitive gel composition for slowly releasing nitric oxide as well as a preparation method and application thereof, and relates to the technical field of medical gels, the temperature-sensitive gel composition comprises the following components: a temperature-sensitive gel matrix, an NO donor composition, and an optional pH regulator and oxidant; wherein the temperature-sensitive gel matrix comprises the following components: a temperature-sensitive matrix, a phase-change temperature regulator and a solvent, after the temperature-sensitive gel preparation is used, NO gas can be slowly released, the release time can last for more than 12 hours, and the temperature-sensitive gel preparation has a remarkable curative effect in the aspect of long-acting bacteriostasis.

The invention relates to adapalene benzoyl peroxide gel. The adapalene benzoyl peroxide gel is prepared from adapalene, benzoyl peroxide, docusate sodium, edetate disodium, glycerol, poloxamer 124, propylene glycol and an acrylamide / acryloyl sodium dimethyl taurate copolymer amp, wherein the acrylamide / acryloyl sodium dimethyl taurate copolymer amp is a mixture of sodium acetate and sodium acetate; isohexadecane amp; isohexadecane amp; 80 amp of polysorbate; adding sorbitan oleate and purified water; the preparation method of the adapalene benzoyl peroxide gel comprises the following steps: S1, preparing a solid dispersion; S2, preparing an active component phase; S3, preparing a water phase; and S4, preparing the gel. The adapalene benzoyl peroxide gel and the preparation method thereof provided by the invention are used for solving the problem of uniformity of two raw material medicines in the adapalene benzoyl peroxide gel, so that the uniformity and the particle size of the two raw material medicines in a container in the gel meet regulations, and the preparation quality and the clinical curative effect are guaranteed. The gel preparation is simple in technological process, easy to operate and suitable for industrial large-scale production.

The invention discloses a compound traditional Chinese medicine acne gel preparation as well as a preparation method and application thereof, the traditional Chinese medicine raw materials comprise nine traditional Chinese medicines such as salvia miltiorrhiza, scutellaria baicalensis, oldenlandia diffusa, centella asiatica, wild chrysanthemum flower, safflower, honeysuckle, mangnolia officinalis and liquorice, and the gel preparation is prepared. The acne treatment effect is achieved through the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, promoting qi circulation to remove dampness and the like.

The invention discloses a preparation method of an intestinal flora transplantation liquid temperature-sensitive sustained-release gel preparation and the preparation. The invention belongs to the technical field of biological medicine, and relates to a preparation method of an intestinal flora transplantation liquid temperature-sensitive sustained-release gel preparation and the preparation. According to the method, standard intestinal flora suspension is used as a functional raw material, poloxamer 407 and poloxamer 188 are used as matrixes, and some cryopreservation protective agents and other formulas are used as auxiliary materials, and the preparation method comprises the following steps: (1) preparing standard intestinal flora liquid; (2) gradually adding the following components according to the preparation concentration: 15%-22% of poloxamer 407, 0.5%-4% of poloxamer 188, 5%-20% of glycerol, 0.5%-1% of sodium carboxymethyl cellulose and the balance of 0.9% sodium chloride aqueous solution; (3) mixing and stirring the suspension intestinal bacterial liquid at room temperature, stirring the suspension intestinal bacterial liquid by a method of uniformly stirring the suspension intestinal bacterial liquid by an electric stirring blade until the suspension intestinal bacterial liquid does not have blocks and is uniformly dispersed, continuously stirring the suspension intestinal bacterial liquid until the liquid is viscous and uniform, and converting a viscous solution into a gel state at a corresponding temperature; and (4) sequentially putting the prepared intestinal flora gel preparation into freezing refrigerators at-20 DEG C and-80 DEG C for freezing and storing for later use. The preparation process is simple, the preparation is rapid, the auxiliary materials are medicinal and have good biocompatibility, and the activity of bacteria is not damaged.

The invention belongs to the technical field of microorganisms, and particularly relates to a staphylococcus epidermidis H62-3 metabolite gel preparation as well as a preparation method and application thereof. The staphylococcus epidermidis H62-3 metabolite gel preparation improves skin erythema and scale symptoms of a psoriasis mouse model, remarkably reduces the skin lesion thickness, can reduce the mRNA expression level of inflammatory factors interleukin-17A, interleukin-17F and interleukin-23 at the skin lesion of the psoriasis mouse model, and can be used for treating psoriasis. The compound has a prospect of being developed into drugs for treating inflammatory dermatosis. The staphylococcus epidermidis H62-3 metabolite gel preparation disclosed by the invention is used for improving a psoriasis mouse model, and a new thought for safely and effectively treating inflammatory skin diseases by external use of viable bacteria metabolite is provided.

The invention relates to the technical field of deep-eutectic gel preparation methods, and particularly discloses a method for preparing deep-eutectic gel by quickly initiating deep-eutectic solvent polymerization, which specifically comprises the following steps: step 1, firstly, taking industrial xylan, or cellulose, or glucomannan, or arabinose, or mannan as a raw material, and preparing the deep-eutectic gel by using a one-step method, a one-step method, a one-step method, a one-step method, a one-step method, a one-step method, a one-step method, a one-step method and a one-step method; the preparation method specifically comprises the following steps: respectively adding 20.0 g of industrial xylan into 800mL of deionized water, stirring until the industrial xylan is uniformly dispersed to form a suspension, then weighing 50.0 g of NaIO4, adding the NaIO4 into the suspension, then stirring and reacting for different times at room temperature in a dark place, and after the reaction is finished, filtering, washing and drying to obtain the DAX. Slowly adding 12mL of ethylene glycol into the reaction system to terminate the reaction; the DLPD eutectic gel is prepared by stabilizing LM nano liquid drops by using a dihydroxylan (DAX) solution and rapidly initiating a polymerization reaction of ChCl / AM by using a DAX / LM dispersion liquid in one step, and a free radical initiator and a cross-linking agent are not required to be used in the preparation process.

The invention discloses a long-acting slow-release lyotropic liquid crystal gel preparation and a preparation method and application thereof, the preparation comprises a matrix material, a cosolvent and a raw material medicine, the preparation has a hexagonal phase microstructure, shows a slow-release effect of more than 72 h and even up to 170 h, can prolong the half-life period of the medicine by nearly 10 times, and can realize analgesia or analgesia and anti-inflammatory dual curative effects.

The invention discloses a collagen injection for tendon repair as well as a preparation method and application thereof, and belongs to the technical field of collagen preparation. The preparation method disclosed by the invention comprises the following steps: by taking a collagen dry product as a raw material, sequentially dissolving, carrying out secondary filtration, separating, preparing fibrotic collagen slurry A, preparing gelatinized collagen slurry B, preparing the solution, homogenizing and filling to prepare the collagen injection capable of being used for tendon repair. The collagen injection provided by the invention shows multiphase transformation during refrigeration and contact with body fluid with body temperature, and does not have the phenomenon of fiber layering in the long-term storage process. The collagen disclosed by the invention is an injection type gel preparation, can be flexibly injected and applied according to the depth and the area of a wound, is beneficial to promoting tissue regeneration and functional repair, and is particularly suitable for tendon injury and other scenes needing collagen to guide cell repair.

The invention discloses pranoprofen temperature-sensitive gel for treating xerophthalmia and a preparation method, the gel takes poloxamer 407 and poloxamer 188 as matrixes, the optimal ratio of the poloxamer 407 to the poloxamer 188 is 23.5%: 2%, and the ratio is optimized and determined by a central composite design-response surface method. During preparation, a blank gel solution is prepared firstly, and then auxiliary materials such as pranoprofen and the like are added for dissolution. The in-vitro release characteristic is good, the accumulated dissolution rate within 210 min exceeds 90%, and the zero-level pharmacokinetic process is achieved. An SD rat xerophthalmia model is established, and it is proved that the xerophthalmia treatment effect of the composition is better than that of eye drops. In eye tissue distribution and aqueous humor pharmacokinetic studies, higher target organ distribution characteristics are shown, the aqueous humor AUC0-t is 1.85 times that of eye drops, and the bioavailability is high. The invention further provides a gel preparation method, a drug effect evaluation method and a related research method, and a new effective dosage form and a new treatment thought are provided for xerophthalmia treatment.