300 results about "Gel preparation" patented technology

The invention relates to curcumin-loaded pectin sodium alginate gel as well as a preparation method and application thereof, and belongs to the technical field of gel preparation. The preparation method of the curcumin-loaded pectin sodium alginate gel comprises the following steps: in a dark environment, stirring and mixing curcumin, arjunic acid, ortho-aminophenol and an organic solvent, adding a polyvinyl alcohol aqueous solution, a sodium alginate solution and a pectin solution, uniformly mixing, performing ultrasonic treatment, adding calcium chloride, stirring and mixing, performing ultrasonic treatment, and performing vacuum drying to obtain the curcumin-loaded pectin sodium alginate gel. And adding oxidized hyaluronic acid, continuously stirring, stirring at normal temperature until the organic solvent is completely volatilized, and cleaning the hydrogel with deionized water to obtain the hydrogel. According to the invention, calcium ions and sodium alginate are subjected to physical crosslinking, pectin and polyvinyl alcohol are combined to form a composite hydrogel layer, the compounding of multiple components can effectively control the dissolution and drug release behaviors of active components, the bioavailability of curcumin is increased, the compactness and stability of hydrogel are increased, and the bioavailability of curcumin is improved. The oxidation resistance of the hydrogel can be effectively improved.

The invention relates to the technical field of gel separation and extraction, in particular to a precipitation and separation device for elastin gel preparation, which comprises a precipitation cylinder, a liquid outlet is arranged above the circumferential side wall of the precipitation cylinder, and a cleaning ring for cleaning attached gel is arranged in the precipitation cylinder. A cleaning ring is arranged in the precipitation cylinder, a filtering mechanism for intercepting gel is arranged at the center of the cleaning ring, the filtering mechanism is rotatably connected with the cleaning ring, and a driving mechanism for driving the cleaning ring to slide up and down is arranged at the top end of the cleaning ring. The cleaning ring is arranged on the bottom of the precipitation cylinder, elastin gel attached to the inner wall of the precipitation cylinder is effectively scraped, meanwhile, the filtering mechanism moves downwards along with the cleaning ring, the water-phase solution is allowed to penetrate through the filtering mechanism to intercept gel particles, floating and floating of the gel particles in the water-phase solution are avoided, it is ensured that the gel particles can be smoothly precipitated to the bottom of a container, and the recovery efficiency of the gel is improved.

The invention discloses high-strength oyster protein gel as well as a preparation method and application thereof, and belongs to the technical field of protein gel preparation. The oyster meat is used as a raw material, the oyster protein isolate is obtained by adopting an alkali-solution and acid-isolation method, and the oyster protein isolate is subjected to pre-solidification and high-temperature induced deep crosslinking at a low temperature for an ultra-long time, so that the gel property of the oyster protein isolate can be remarkably improved; the prepared oyster protein isolate gel has the characteristics of smooth surface, high gel strength, high elasticity and the like; according to the method, the aggregation degree, conformation and intermolecular interaction force of oyster protein can be regulated and controlled only by utilizing temperature, so that the oyster protein is induced to form high-quality protein gel. Besides, no organic chemical reagent or food additive is added in the preparation process, and NaCl is not added, so that the oyster protein isolate gel is pure in ingredient, high in safety and simple to operate, and has relatively high application value and industrialization potential.

This invention discloses a high-strength oyster protein gel, its preparation method, and its applications, belonging to the field of protein gel preparation technology. Using oyster meat as raw material, this invention obtains oyster protein isolate through an alkali-dissolution and acid-precipitation method, and pre-coagulates the oyster protein isolate at ultra-long-term low temperatures. High-temperature induction of deep cross-linking significantly improves the gel properties of the oyster protein isolate. The prepared oyster protein isolate gel exhibits characteristics such as smooth surface, high gel strength, and high elasticity. This invention utilizes only temperature to control the aggregation degree, conformation, and intermolecular interactions of oyster proteins, thereby inducing the formation of a high-quality protein gel. Furthermore, the preparation process of this invention involves no organic chemical reagents or food additives, and no NaCl is added, resulting in a pure, safe, and simple oyster protein isolate gel formulation with high application value and industrialization potential.

The invention relates to a preparative protein electrophoresis purification system and a protein purification method. The system comprises an automatic gel preparation device and an electrophoresis device, the automatic glue making device comprises a supporting frame, a clamping arm and a glue filling needle, and a linear module is fixedly arranged on the supporting frame to drive the glue filling needle to synchronously move in the horizontal direction and the vertical direction. The electrophoresis device comprises an outer electrophoresis tank, an electrophoresis frame and a cooling device, the electrophoresis frame and the cooling device are arranged in the outer electrophoresis tank, an inner electrophoresis tank is arranged in the electrophoresis frame, rubber plates are detachably arranged on the two sides of the electrophoresis frame, the rubber plates form side plates of the electrophoresis frame, notch grooves are formed in the inner sides of the tops of the rubber plates, and the rubber filling needles are matched with the rubber plates. The protein purification method is a method based on the protein electrophoresis purification system.

The invention relates to an anti-inflammatory and analgesic external composition, a preparation method and application thereof and a gel preparation, and belongs to the technical field of external pharmaceutical compositions.The anti-inflammatory and analgesic external composition is prepared from, by weight, 3-8 parts of loxoprofen sodium, 500-1000 parts of fried semen brassicae, 300-500 parts of fructus arctii and 10-30 parts of liquorice. The semen brassicae is warm in nature and pungent in taste, belongs to the lung channel, and has the effects of benefiting qi and removing stasis; the fructus arctii is cold in nature, pungent and bitter in taste, belongs to lung and stomach channels and has the effects of detoxifying and promoting eruption, the fructus arctii and the fructus arctii are cold in nature and warm in nature, mutual in medicine property, pungent and divergent in taste and have the effect of transdermal enhancement of the medicine effect, the liquorice is neutral in nature and sweet in taste, belongs to the heart, lung, spleen and stomach channels and has the effects of relieving spasm and pain and harmonizing all the medicines, and the liquorice, the fructus arctii and the liquorice can synergistically play the effects of stimulating menstrual flow and relieving pain. And with the cooperation of loxoprofen sodium, the synergistic interaction effect is achieved in the aspects of diminishing inflammation and relieving pain.

The invention belongs to the technical field of emulsion gel preparation, and discloses a preparation method of interpenetrating cross-linked network emulsion gel for improving the stability of anthocyanin and xanthophyll. According to the invention, a whey protein network induced by TG enzyme and a sodium alginate network induced by Ca < 2 + > are mutually crosslinked to form emulsion gel with an interpenetrating network structure, and purple sweet potato anthocyanin extract and xanthophyll are jointly loaded. The whey protein and sodium alginate interpenetrating cross-linked network emulsion gel is good in rheological property, uniform in micro-pore distribution and high in anthocyanin and xanthophyll stability, has the advantages of being natural, environmentally friendly, green and sustainable, and has wide application prospects in the field of functional food.

To provide a gel preparation kit, a gel preparation material, a medicinal drug, and a medical device that suppress a reaction with a medicine or a cell, and promote inclusion of a hydrophobic medicine into the gel or cell proliferation.SOLUTION: A gel preparation kit comprising a polymer (A) and a polymer (B), where the polymer (A) includes a hydrophilic polymer portion (A1) with 2 to 8 branches, a hydrophobic polymer portion (A2) that is bonded to the side chains or ends of each branch of the hydrophilic polymer portion (A1), and a click-reactive group (A3) that is bonded to at least one side chain or end of the hydrophobic polymer portion (A2), and polymer (B) includes a hydrophilic polymer portion (B1) with 2 to 8 branches, a hydrophobic polymer portion (B2) that is bonded to the side chains or ends of each branch of the hydrophilic polymer portion (B1), and a click-reactive group (B3) that is bonded to at least one side chain or end of the hydrophobic polymer portion (B2). The click-reactive groups (A3) and (B3) can be cross-linked through a click reaction.SELECTED DRAWING: None

The invention relates to a production method of a large primary crystal 13X molecular sieve, and belongs to the technical field of molecular sieve preparation. The method comprises the following steps: mixing water glass with a sodium aluminate solution under a set temperature condition to obtain gel; adding a seed crystal into the gel, and carrying out first-stage crystallization to obtain a first-stage crystallization solution; performing second-stage crystallization on the first-stage crystallization solution to obtain a second-stage crystallization solution; and respectively separating, washing and drying the second-stage crystallization liquid to obtain the 13X molecular sieve product with the original crystal size of 3-4 microns. The technical problem of increasing the original crystal size of the 13X molecular sieve is successfully solved by finely regulating and controlling a plurality of key steps such as gel preparation, seed crystal introduction, segmented crystallization and post-treatment. According to the technical scheme, the adsorption performance and the bulk density of the molecular sieve are improved, and a new thought and method are provided for industrial production of the molecular sieve.

The invention belongs to the technical field of medical polymer materials, relates to an amphiphilic block copolymer, a hydrogel material containing the amphiphilic block copolymer and a preparation method and application of the amphiphilic block copolymer, and particularly discloses a poly (2-ethyl-2-oxazoline)-polyamino acid block copolymer and a preparation method and application of a hydrogel material of the poly (2-ethyl-2-oxazoline)-polyamino acid block copolymer. The hydrogel material provided by the invention has excellent injectability, and the modulus and gelation temperature of a gel preparation can be adjusted by changing the molecular weight and concentration of the amphiphilic block copolymer, so that the hydrogel material adapts to different physiological environments, is applied to different indications, and can be applied to various diseases. Compared with other hydrogel in which the chemical structure of the polymer needs to be changed, the hydrogel is more convenient.

The invention discloses a method for preparing high-nutrition oil gel from a soybean protein typing aggregate-hyaluronic acid compound, and belongs to the technical field of food processing. The method comprises the following steps: (1) preparing a soybean protein typing aggregate; (2) preparing a hyaluronic acid solution; (3) preparing a soybean protein typing aggregate-hyaluronic acid compound; and (4) preparing the oil gel. The oleogel with high nutrition, good stability and better structural performance and water-retaining property is prepared by fully utilizing the structural and functional advantages of the protein parting aggregate and the hyaluronic acid, so that the effective application of the oleogel prepared from the soybean protein isolate in the food industry is enhanced. The oil gel is simple and convenient in preparation step, high in efficiency, environment-friendly and suitable for being used in actual continuous production.

The invention relates to the technical field of health care products, in particular to silver ion polypeptide antibacterial gel. The invention discloses a silver-polypeptide-containing shampoo, which is prepared from the following ingredients including 0.1 to 1 percent of silver ions, 0.5 to 3 percent of polypeptide, 60 to 85 percent of deionized water, 1 to 5 percent of jingnaoji leaf extracts, 1 to 5 percent of herba portulacae extracts, 1 to 5 percent of radix notoginseng extracts, 1 to 5 percent of radix sophorae flavescentis extracts, 1 to 5 percent of saffron crocus extracts, 1 to 5 percent of apple seed extracts, 1 to 5 percent of herba violae extracts, 1 to 5 percent of fructus cnidii extracts, 1 to 5 percent of sunflower extracts, 1 to 5 percent of herba centellae extracts and 0.5 to 3 percent of herba menthae extracts. The preparation method comprises the following steps: extraction preparation, silver ion preparation, mixing and stirring, and gel preparation. The invention has the beneficial effects of scientific and reasonable formula, obvious synergistic effect and strong antibacterial effect; the preparation process is simple and feasible, effective activity of each component can be fully reserved, and stable product quality is guaranteed; the product is mild and non-irritant, is suitable for daily cleaning, health care and health care of private parts, does not destroy normal microbial balance of the private parts, and is high in use safety.

The invention provides a temperature-sensitive gel composition for slowly releasing nitric oxide as well as a preparation method and application thereof, and relates to the technical field of medical gels, the temperature-sensitive gel composition comprises the following components: a temperature-sensitive gel matrix, an NO donor composition, and an optional pH regulator and oxidant; wherein the temperature-sensitive gel matrix comprises the following components: a temperature-sensitive matrix, a phase-change temperature regulator and a solvent, after the temperature-sensitive gel preparation is used, NO gas can be slowly released, the release time can last for more than 12 hours, and the temperature-sensitive gel preparation has a remarkable curative effect in the aspect of long-acting bacteriostasis.

The invention discloses a preparation method of an intestinal flora transplantation liquid temperature-sensitive sustained-release gel preparation and the preparation. The invention belongs to the technical field of biological medicine, and relates to a preparation method of an intestinal flora transplantation liquid temperature-sensitive sustained-release gel preparation and the preparation. According to the method, standard intestinal flora suspension is used as a functional raw material, poloxamer 407 and poloxamer 188 are used as matrixes, and some cryopreservation protective agents and other formulas are used as auxiliary materials, and the preparation method comprises the following steps: (1) preparing standard intestinal flora liquid; (2) gradually adding the following components according to the preparation concentration: 15%-22% of poloxamer 407, 0.5%-4% of poloxamer 188, 5%-20% of glycerol, 0.5%-1% of sodium carboxymethyl cellulose and the balance of 0.9% sodium chloride aqueous solution; (3) mixing and stirring the suspension intestinal bacterial liquid at room temperature, stirring the suspension intestinal bacterial liquid by a method of uniformly stirring the suspension intestinal bacterial liquid by an electric stirring blade until the suspension intestinal bacterial liquid does not have blocks and is uniformly dispersed, continuously stirring the suspension intestinal bacterial liquid until the liquid is viscous and uniform, and converting a viscous solution into a gel state at a corresponding temperature; and (4) sequentially putting the prepared intestinal flora gel preparation into freezing refrigerators at-20 DEG C and-80 DEG C for freezing and storing for later use. The preparation process is simple, the preparation is rapid, the auxiliary materials are medicinal and have good biocompatibility, and the activity of bacteria is not damaged.

The invention discloses a collagen injection for tendon repair as well as a preparation method and application thereof, and belongs to the technical field of collagen preparation. The preparation method disclosed by the invention comprises the following steps: by taking a collagen dry product as a raw material, sequentially dissolving, carrying out secondary filtration, separating, preparing fibrotic collagen slurry A, preparing gelatinized collagen slurry B, preparing the solution, homogenizing and filling to prepare the collagen injection capable of being used for tendon repair. The collagen injection provided by the invention shows multiphase transformation during refrigeration and contact with body fluid with body temperature, and does not have the phenomenon of fiber layering in the long-term storage process. The collagen disclosed by the invention is an injection type gel preparation, can be flexibly injected and applied according to the depth and the area of a wound, is beneficial to promoting tissue regeneration and functional repair, and is particularly suitable for tendon injury and other scenes needing collagen to guide cell repair.

The utility model discloses an external gel preparation device, which belongs to the technical field of gel preparation devices and comprises a shell, a connecting cylinder fixedly mounted at the top end of the shell, a top plate fixedly mounted at the top end of the connecting cylinder, a motor fixedly mounted in the top plate, a mounting gear fixedly mounted at the output end of the motor, and a rotating plate rotationally mounted in the top plate. A rotating cylinder is integrally formed at the top end of the rotating plate, a fixed gear is fixedly mounted on the rotating cylinder and meshed with the mounting gear, a fixed disc is fixedly mounted in the rotating plate, a plurality of pinions are rotatably mounted at the top end of the fixed disc, and a fixed round rod is fixedly mounted in the top plate. Through the complex gear transmission system driven by the motor and the heating assembly, efficient stirring and temperature control of gel raw materials are achieved, the stirring effect is enhanced through the design of the reverse rotating assembly, uniform mixing of the raw materials is ensured, the heating assembly can conduct heating and keep the proper temperature, and the stirring effect is improved. The influence of too high or too low temperature on the quality of the gel is prevented.

The invention relates to the technical field of medical gel preparation, in particular to propolis temperature-sensitive in-situ gel as well as a preparation method and application thereof. A gel matrix is screened by adopting a single factor test, a prescription is optimized by adopting a star point design-effect surface method, and the quality of the propolis temperature-sensitive gel is evaluated. The optimal prescription of the propolis temperature-sensitive vaginal gel obtained through experimental optimization is as follows: 22.9% of poloxamer 407, 1.8% of poloxamer P188, 5.4% of polyethylene glycol 400 and 5% of propolis, the gelling temperature before dilution is 25 DEG C, and the gelling temperature after dilution is 37 DEG C. Quality evaluation results show that the antibacterial agent is stable in property, proper in gelling temperature and good in antibacterial activity. The prepared propolis temperature-sensitive vaginal gel is stable in process, uniform in appearance, controllable in quality and good in slow-release effect and antibacterial effect.

The invention discloses a multi-target intervention-based plant compound gynecological anti-HPV (human papillomavirus) gel preparation, which comprises two parts, namely a compound plant extracting solution and an aqueous gel carrier, the compound extracting solution is derived from rheum officinale, scutellaria baicalensis, coptis chinensis, golden cypress, radix sophorae flavescentis, fructus cnidii, alum, gallnut, common carpesium fruit, radix angelicae, cortex dictamni, fructus kochiae, frankincense and myrrh; the anti-HPV gel preparation is obtained by mixing and stirring according to the proportion. Aiming at an intervention window that a patient is continuously infected but does not deteriorate to an operation stage, intervention is carried out by adopting an action mechanism of local epithelial micro-ecological restoration and mucosal immunity, E6 / E7 oncogenic protein expression is inhibited, L1 capsid assembly is damaged, key nodes of a virus life cycle are covered, and escape risks are reduced by multi-target collaborative anti-HPV (Human Papilloma Virus); by inhibiting an NF-kB / EMT signal axis, the cervical lesion progress risk is reduced; the safety is high and the curative effect is obvious.

The utility model belongs to the technical field of sepharose gel preparation, and particularly relates to a temperature measuring and blending device for sepharose gel preparation, which comprises an oscillating and blending device, the oscillating and blending device comprises a vibrating plate capable of vibrating, a fixing device for fixing a preparation container is clamped on the vibrating plate, and a temperature measuring device is arranged on the vibrating plate. The fixing device is fixedly connected with a temperature measuring plate for placing a preparation container, and a thermochromic film is arranged on the upper surface of the temperature measuring plate. Compared with the prior art, by arranging the fixing device and the temperature measuring plate on the fixing device, the technical problems that in the prior art, an agarose solution needs to be shaken up manually, and the agarose solution is possibly polluted when a traditional temperature measuring device is used are solved.

This invention discloses a sol-gel preparation method for mesoporous carbon membranes, as well as the mesoporous carbon membranes and their applications. The preparation method includes: (1) dissolving phenolic compounds in a solvent and adding a template agent; (2) adding aldehyde compounds and amine compounds to obtain a mixture; (3) subjecting the mixture to a hydrothermal reaction to obtain an organic membrane precursor; and (4) carbonizing the organic membrane precursor at high temperature; wherein the solid content of the mixture is 20-30 wt%. The method of this invention significantly shortens the production cycle, has high preparation efficiency and success rate, can be molded to any size, and the obtained porous structure can withstand high-temperature treatment without collapsing. The obtained mesoporous carbon membrane can be applied to gas separation or liquid separation.

The invention relates to a microbial single-cell gelation encapsulation method based on aloe gel and application, the method realizes single-cell gelation encapsulation through electrostatic interaction of sterile aloe gel and intestinal anaerobic bacteria (such as Agathobacter rectasis), and the method comprises the specific steps of aloe gel preparation, bacterial suspension culture and oscillation mixing to form a stable structure. The preparation method has the advantages that the acid resistance and biocompatibility of the natural aloe gel are utilized to replace a traditional synthetic material, so that the gastrointestinal tolerance of thalli is improved; meanwhile, the synergistic effect of aloe active ingredients (such as aloe-emodin) and intestinal bacterial metabolites (butyric acid) is combined, so that the anti-inflammatory and intestinal steady-state regulation and control effects are enhanced. Experiments show that the survival rate of the encapsulated bacteria in simulated gastric juice within 4 hours is larger than or equal to 90%, the intestinal colonization rate is effectively increased compared with naked bacteria, the inflammatory factor level of a colitis model mouse can be remarkably reduced, and a safe and efficient new strategy is provided for micro-ecological treatment of inflammatory bowel diseases.

The utility model discloses a protein vertical electrophoresis gel preparation tank, which relates to the technical field of biological experiments, and comprises a main body gel tank, a thick filling plate, a thin partition plate and a wedge-shaped inserting plate, the main body gel tank comprises a bottom plate, the upper surface of the bottom plate is fixedly connected with two vertical side plates, one ends of the two vertical side plates are fixedly connected with an inclined front plate, and the other ends of the two vertical side plates are fixedly connected with the wedge-shaped inserting plate. The other ends of the two vertical side plates are fixedly connected with a vertical rear plate, and it needs to be explained that the main body glue groove is composed of a bottom plate, the vertical side plates, the vertical rear plate and an inclined front plate. According to the protein vertical electrophoresis gel preparation tank, the integrated main body gel tank design is adopted, the gel leakage condition in the protein gel preparation process is completely eradicated, and the inclined front plate, the wedge-shaped insertion plate, the thick filling plate and the thin partition plate are arranged on the inner wall of the main body gel tank, so that the gel removal process is simple and easy to implement, the gel preparation work efficiency is improved, and the production cost is reduced. And the gel leakage phenomenon in the preparation process of the protein electrophoresis gel is thoroughly avoided.

The invention relates to the technical field of biological medicine, and discloses a platelet-rich plasma exosome gel preparation method, which comprises: carrying out exosome separation on a PRP sample by using a high-speed centrifuge; stuffing the exosome precipitate into the shell-sphere structure to prepare core-shell structure particles so as to coat the exosome and form a thermal insulation layer; mixing thrombin and calcium gluconate according to a mass ratio of 10: 1, and adding the mixture into PRP to prepare a gel matrix; adding a photoinitiator, the magnetic coloring particles and the core-shell structure particles into the gel matrix, and uniformly mixing to prepare exosome gel; the invention further discloses application of the composition in repairing diabetic foot wounds. According to the invention, the irreversible influence of temporary environment change on the system can be weakened, meanwhile, the double mechanisms of healing are disclosed, during application, secondary arrangement is carried out by using a magnetic field, the release efficiency of PRP-Exo is improved under the later photo-thermal cooperation effect, and accurate formulation of a long-term treatment strategy is facilitated.

The application provides a functional gel preparation method, comprising the following steps: mixing a functional filler with liquid metal to obtain a mixture; providing a gel substrate, and forming a pre-pattern layer on the surface of the gel substrate by using the mixture as raw material, wherein the pre-pattern layer comprises a sacrificial layer and the functional filler dispersed in the sacrificial layer, and the sacrificial layer comprises the oxide of the liquid metal; providing an etching liquid, and reacting the etching liquid with the sacrificial layer to remove the sacrificial layer, so that the functional filler is deposited on the surface of the gel substrate to form a pattern layer, and a functional gel is obtained. The application also provides a functional gel and application. Since the viscosity of the oxide of the liquid metal is relatively large, the oxide can be stably attached to the surface of the gel substrate, then the sacrificial layer is consumed, and the functional filler is conformally deposited on the surface of the gel substrate, so that a functional gel with stable structure is obtained. The preparation method can overcome the difficulty that the gel substrate cannot be patterned by general semiconductor means.

The application discloses a kind of in-situ gel preparation methods, belong to lithium metal battery technical field.The method introduces trace initiator to make 1,3-dioxolane DOL in electrolyte occur ring-opening polymerization reaction, by forming DOL crosslinking in advance, realize liquid ether-based electrolyte in-situ solidification on the surface of lithium negative electrode.After forming gel phase, inject electrolyte in soft pack battery of gel phase, construct gel phase@liquid phase two-phase system.By controlling the ratio of electrolyte and poly-DOL, realize the gradient solidification of ether-based electrolyte in battery, adjust the mechanical properties of gel electrolyte.There is intermolecular interaction between poly-DOL and lithium salt anion, significantly improve the ionic conductivity and lithium ion transference number of gel electrolyte, the in-situ gel phase formed has good interface compatibility with lithium negative electrode, and the growth of lithium dendrite is inhibited.This in-situ gel preparation method is low in cost and easy to operate, and is a simple method to realize high capacity and high cycle stability of lithium metal battery.

The present invention relates to the technical field of functional gel preparation, and in particular to a method for preparing a functional gel. The functional gel preparation steps provided by the present invention are as follows: 50 parts of 50°C water, 11 parts of carbomer, and 5 parts of xanthan gum are mixed and stirred at 150 rpm for 10 minutes to obtain material 1; material 1 is mixed with 6 parts of isopropyl palmitate and stirred at 200 rpm for 20 minutes to obtain material 2; material 2 is cooled to 23°C, mixed with 25 parts of 80% ethanol by volume, 13 parts of 50% n-butanol by volume, 14 parts of glycerol, and 3 parts of propyl paraben, and stirred at 200 rpm for 20 minutes; and the pH is adjusted to 5.4 using sodium carbonate as a pH adjuster to obtain a functional gel. The functional gel prepared by the present invention does not contain any pharmaceutical ingredients, is safe and non-irritating during use, and has excellent therapeutic effects on male sexual dysfunction, with the therapeutic effects comparable to those of existing drugs.

The invention discloses a controllable gel separation and purification device and method. The controllable gel separation and purification device comprises a feed liquid tank unit, a special gel separation and purification protection barrel, a controllable gel separation and purification device controller, a cooling and flow slowing unit and a membrane separation unit. The protective cylinder can enable gel materials in various shapes to be always suspended in the area of the central axis to do circular motion, so that the rheological characteristics of gel and the stability of functional activity are guaranteed. The invention aims at the current situation that the preparation reaction of a gel material cannot be subjected to quality control because a special gel separation and purification device is not sold in the market at present. Different from an uncontrollable or random method which is generally adopted in the previous literature that the gel preparation reaction is completed by observing the formation of the gel with naked eyes and then simply cleaning the gel with clear water or soaking the gel in water for multiple times, the device and the method provided by the invention can overcome the defect that the quality of the previous gel material preparation reaction cannot be effectively controlled; technical controllability and process repeatability which do not exist in previous literatures are achieved, and the technical problems of stability and uniformity of the gel material are solved.

The invention discloses a microchannel device, a slow-release essential oil gel microcapsule and a preparation method of the slow-release essential oil gel microcapsule, and relates to the technical field of gel preparation. The micro-channel device comprises four sample injection flow channels, two filtering flow channels, one sample outlet flow channel, three mixing flow channels, five feed ports and one discharge port. The preparation method comprises the following steps: uniformly mixing polyphenol and plant essential oil to obtain a first solution; mixing the first solution and the second solution through a micro-channel device to form uniform liquid drops; the liquid drops and a metal ion solution are mixed, polyphenol and metal ions are cross-linked to form a metal-polyphenol network on the surfaces of the liquid drops, and essential oil particles are obtained; and mixing the essential oil particles with a sodium alginate solution to obtain the slow-release essential oil gel microcapsule. According to the invention, a metal-polyphenol network is induced to gather on an interface by utilizing a behavior that water-soluble polyphenol diffuses from an oil phase to a water phase, and a double-network gel shell is formed by utilizing secondary cross-linking on the surface of sodium alginate, so that the aim of encapsulating and slowly releasing the plant essential oil is fulfilled.

The invention discloses a manganese urate material, a gel preparation and application thereof, and relates to the technical field of gel preparations. The manganese urate material provided by the invention can enhance anti-tumor immune response, and has good application prospects of adjuvants, vaccines and medicines. Besides, the invention also provides a gel preparation, the preparation is a multifunctional temperature-sensitive hydrogel preparation taking poloxamer as a matrix, and the preparation is combined with artesunate, adriamycin, uric acid and manganese to realize efficient treatment of various tumors such as breast cancer and inhibit postoperative recurrence of the tumors.

The invention relates to an application of Quercetin (QUE) or a derivative thereof in a medicine for resisting vocal cord fibrosis and a preparation of the Quercetin or the derivative thereof. The quercetin can significantly inhibit abnormal deposition of extracellular matrix (ECM) after vocal cord injury, improve reduction of hyaluronic acid (HA) and elastic fibers (EF), and reduce overexpression of type I collagen (COL1A1) and fibronectin (FN1). Besides, by regulating PI3K / AKT and MAPK signal channels, the quercetin inhibits proliferation and migration of fibroblasts and promotes apoptosis of the fibroblasts, so that vocal cord fibrosis is effectively relieved. The invention also provides an application of a preparation of the quercetin and the derivative thereof combined or not combined with other anti-fibrosis drugs (such as 5-fluorouracil and dexamethasone) in treatment of vocal cord fibrosis, wherein the dosage forms of the preparation comprise an oral preparation, an injection, a spray or a local gel preparation.