16 results about "Buccal mucosa" patented technology

A fluid administration device is disclosed. According to one example implementation, the fluid administration device includes a connector, a tube, and an applicator. The connector is configured to connect to a corresponding device, such as a syringe or other vessel filled with medication, colostrum, or other fluid. A proximal end of the tube can be affixed to the connector. A distal end of the tube can be connected to the applicator. Fluid from the corresponding device can flow into the fluid administration device via the connector, into the tube, and into the foam applicator. The applicator can be inserted into the buccal cavity of a patient and massaged along the buccal mucosa to administer the fluid.

The present invention relates to a drug-loaded filament comprising topiramate and a pharmaceutical preparation for preventing or treating obesity prepared using same. Topiramate contained in the filament exhibits an amorphous nature, and thus can be used in the preparation of a pharmaceutical preparation that is easily dissolved, thereby facilitating application and absorption in the body. The drug-loaded filament comprising same can be applied to 3D printing such as fused deposition modeling (FDM) and effectively used in the preparation of a pharmaceutical preparation that can be administered via various mucosal administration routes, such as oral mucosa, e.g., sublingual and buccal mucosa, and nasal mucosa in the nasal cavity or the like.

The present invention relates to a formulation of toothpaste for the treatment of various disorders or diseases in the human body by incorporating or adding appropriate active ingredients in therapeutic amount or pharmaceutically effective amount for a particular disorder or disease intended to be treated. In particular, the present invention relates to a toothpaste formulation comprising of one or more active ingredients, oral mucosal absorption enhancers, gelling agents, preservatives, and one or more inactive agents. The present invention provides a novel toothpaste formulation and the process of preparing the same. Oral cavity offers relatively consistent and friendly physiological conditions for drug delivery or drug absorption. Thus, absorption through oral buccal mucosa in the toothpaste under invention by-passes the undesirable first-pass effects in the liver ensuring rapid and better bioavailability and greater efficacy.

The invention relates to the technical field of medicine, and provides a semeglutide oral patch for buccal mucosa administration and application of the semeglutide oral patch, the semeglutide oral patch comprises a tablet layer I and a tablet layer II, the tablet layer I comprises semeglutide or pharmaceutically acceptable salt thereof, a biological adhesive and an absorption enhancer; the sheet layer II comprises an anti-sticking material; the biological adhesive is carbomer which is subjected to neutralization and drying treatment. The stability of the oral patch can be remarkably improved, the oral patch can permanently and stably act on buccal mucosa, an excellent absorption promoting effect is achieved, meanwhile, invalid release of medicine is further reduced, and bioavailability is improved.

The invention relates to modulation of oral health by nitric oxide synthase pathways. Pharmaceutical compositions and methods for treating or preventing diseases and conditions associated with or characterized by at least one of xerostomia and periodontal disease by modulating the nitric oxide synthase pathway are provided, as well as animal models and drug screening methods. This modulation may be accomplished by administering tetrahydrobiopterin (BH4), or a prodrug and / or salt thereof. Treatment and prevention of xerostomia may also have downstream effects of preventing periodontitis, decayed teeth, parotid gland enlargement, lip inflammation and dehiscence (cheilitis), tongue and buccal mucosa inflammation or ulcer, oral candidiasis, salivary gland infection (salivary adenitis), halitosis, and oral mucosa dehiscence and dehiscence.

The invention discloses artificial saliva and a preparation method of artificial saliva hydrogel. The artificial saliva is prepared from the following raw materials in parts by mass: 0.5 to 1 g of KCl, 0.2 to 0.4 g of K2HPO4, 0.2 to 0.8 g of NaCl, 0.2 to 0.4 g of KH2P O4, 10.04 to 20.8 g of CaCl2, 1.5 to 3 g of Nacaboxymethlecellulose, 60 to 120 mg of brown moss alcohol, 495 to 1000 ml of natural coconut juice and 5 to 10 ml of herba sarcandrae extract. By selecting the glabrous sarcandra herb extract, anti-inflammatory and anti-tumor treatment is realized, so that the traditional Chinese medicine composition has a remarkable effect on dry mouth caused by radiotherapy; through the form of a gel bead preparation, the beverage is more portable and unique in taste. The gel beads serve as one of oral local administration preparations, and after the gel beads are exploded, drugs can target small glands which are located below oral mucosa and secrete saliva, and the rapid drug effect is achieved. Direct local administration to the oral mucosa may provide rapid drug action, activate small salivary glands within the buccal mucosa, while avoiding systemic drug exposure and off-target effect.

The present invention relates to an applicator (100) for arranging a mucoadhesive surface (202), in particular a mucoadhesive film (204) loaded with an active agent (e.g., a drug), on the nasal or oral mucosa, in particular buccal mucosa of a patient, the invention also relates to a disposable component for use with an applicator for arranging a mucoadhesive surface on a nasal mucosa or oral mucosa of a patient, and to a kit, the kit includes a disposable component having a mucoadhesive surface and an applicator for disposing the mucoadhesive surface on a nasal or oral mucosa of a patient.

The invention provides an automatic optical detection method and system for visible foreign matters in a midazolam buccal mucosa solution, and relates to the technical field of drug detection.The automatic optical detection method comprises the steps that the midazolam buccal mucosa solution is controlled to flow in a transparent flow cell, and suspended particles in the solution are dynamically observed and recognized by means of an optical imaging system; controlling a polarized light source of the optical imaging system to rotate relative to the transparent flow cell, and collecting optical response data of each suspended particle at a plurality of rotation angles; then, according to the data, determining the change information of the light intensity along with the relative rotation angle, synchronously extracting color distribution information, and generating key feature data representing the optical response characteristics of the particles; and finally, comparing the key characteristic data with preset standard characteristic data of the raw material medicines and the auxiliary materials, so that the suspended particles are judged as raw material medicine crystals, auxiliary material precipitates or visible foreign matters, and automatic and accurate classification of the suspended particles in the midazolam buccal mucosa solution is realized.

The utility model discloses a tooth extraction saliva aspirator with a buccal mucosa protection function, which relates to the technical field of tooth extraction saliva aspirators and comprises a saliva aspirator tube, one end of the saliva aspirator tube is provided with a probing contact structure, the probing contact structure is used for probing into an oral cavity, the probing contact structure comprises a buccal draw hook, the buccal draw hook is connected to one end of the saliva aspirator tube, and the other end of the saliva aspirator tube is connected with the buccal mucosa protection device. The cheek drag hook is used for being in contact with the interior of the oral cavity, and a hollow pipeline is formed in the cheek drag hook; the connecting assembly is arranged between the cheek drag hook and the saliva suction tube, and the connecting assembly is used for connecting the cheek drag hook and the saliva suction tube; the rotating sleeve is arranged on the outer side of the connecting assembly in a sleeving manner; and the limiting assembly is arranged between the rotating sleeve and the connecting assembly. According to the utility model, the probing contact structure is arranged to replace a saliva suction tube to be in contact with the buccal mucosa of the oral cavity of a patient, so that the buccal mucosa can be prevented from being directly damaged when facing larger suction force, and the saliva suction tube and the buccal draw hook can be conveniently connected or detached due to the arrangement of the connecting assembly.

The invention discloses oral mucosa scraping equipment and aims to improve sampling efficiency of bilateral buccal mucosa and relieve discomfort of an extracted person and an operator. The equipment comprises a shell, bilateral supports, a sleeve rod, an elastic rope, a connecting rope, a rotating rod, a rope body adjusting mechanism and a transmission mechanism, and the bilateral buccal mucosa in an oral cavity can be scraped at the same time; by means of the double-loop-bar structure, the elastic rope and the connecting rope are combined, the device can enable the scraping rod to stretch and open in the oral cavity, the requirement for the opening degree of the mouth is reduced, the device is more friendly to individuals with small oral cavities, in addition, the transmission mechanism triggers the scraping rod to rotate, a traditional manual rotating mode is replaced, operation is smoother, and operation is more convenient. The oral mucosa sampling device is simple in structure and reasonable in design, has the innovative effects of improving sampling efficiency, relieving discomfort, reducing fatigue and the like, is suitable for long-term and high-frequency oral mucosa sampling scenes, and has wide application prospects.

This invention provides an oral mucosal exudate collection device and method, relating to the field of oral sampling technology. The device includes an outer shell, with a collection tube fixedly mounted at one end. The collection tube has a collection hole at its end. Inside the collection tube are a rotating connector and a telescopic sleeve. The rotating connector has multiple elastic plates, and the telescopic sleeve covers all the elastic plates. The advantages of this invention are: the operator only needs to insert the collection tube into the oral cavity once, and can sequentially collect exudates from multiple different locations such as the gingiva, sublingual region, and buccal mucosa by switching the collection head within the oral cavity. This significantly simplifies the operation process, reduces the patient's mouth-opening time and discomfort, and is particularly suitable for applications requiring multi-point comparative analysis or large-area screening. During the collection process, the unused collection head remains sealed inside the collection tube, effectively preventing accidental mixing of exudates from different collection sites and ensuring the uniqueness of each sample's origin and the accuracy of the test.

We offer a new type of all-around cleaning toothbrush that reduces blind spots during cleaning and improves cleaning effectiveness. [Solution] The new all-directional cleaning toothbrush is equipped with a toothbrush handle 1, a toothbrush body 2 is provided at the upper end of the toothbrush handle, and a toothbrush head 3 is fixed to the upper end of the toothbrush body. A silicone strip 5 is fixed to the side of the toothbrush head, and a silicone pad 4 is fixed to the back surface of the toothbrush head. The silicone strip is formed in a U shape. A rotating shaft 6 is fixed to the upper end of the toothbrush handle, an annular groove is formed inside the toothbrush handle, and a locking mechanism is provided inside the annular groove, and the locking mechanism includes a connecting ring. In this invention, the silicone strip can effectively clean the space between the buccal tooth surface and the buccal mucosa. The U-shaped silicone strip follows the arc shape of the dentition well, and can perform gentle and comprehensive cleaning of the tooth surface and gingival margin during brushing.

The application provides a method and system for automatically optically detecting visible foreign matters in midazolam buccal mucosa solution, and relates to the technical field of drug detection. The application controls the flow of midazolam buccal mucosa solution in a transparent flow cell, dynamically observes and identifies suspended particles in the solution by means of an optical imaging system. Then, the polarized light source of the optical imaging system is controlled to rotate relative to the transparent flow cell, and optical response data of each suspended particle at multiple rotation angles is collected. Next, the change information of light intensity with the relative rotation angle is determined according to the data, and the color distribution information is synchronously extracted to generate key feature data representing the optical response characteristics of the particles. Finally, the key feature data is compared with the preset standard feature data of the raw materials and excipients, so that the suspended particles are determined as raw material crystals, excipient precipitates or visible foreign matters, and the automatic and accurate classification of the suspended particles in the midazolam buccal mucosa solution is realized.

The utility model discloses a kind of oral cavity openers for rodent posterior teeth experiment, belong to medical instrument field.This oral cavity opener includes two posterior teeth occlusion pads, the end of each posterior tooth occlusion pad is connected with buccal mucosa protection pad, the other end of buccal mucosa protection pad is connected with mouth outside connecting rod, tongue side concave connecting rod is set between two mouth outside connecting rods located in oral cavity side, and large spring with ring is set between two mouth outside connecting rods located outside oral cavity.This oral cavity opener can effectively expose relevant parts in oral cavity under the premise of not damaging oral cavity tissue, suitable for long-time experimental operation, with good stability and flexibility, at the same time, this oral cavity opener is convenient to operate, ensure the efficiency and accuracy in experimental process.

The oral medicine cleaning and disinfecting device comprises a shell body, a connecting hose, a spherical nozzle and a flushing nozzle are arranged on the shell body, a control assembly is arranged in the shell body, an adjusting assembly is further arranged on the shell body, and a limiting assembly and a telescopic assembly are correspondingly arranged above the adjusting assembly; a first liquid conveying pipe is rotationally connected into the shell body, one end of the first liquid conveying pipe is rotationally connected with the connecting hose, the other end of the first liquid conveying pipe is fixedly connected with the spherical nozzle, and the first liquid conveying pipe communicates with the flushing nozzle through a second liquid conveying pipe. No-dead-corner disinfection and stable positioning are coordinated, the spherical nozzle is driven by the control assembly to automatically rotate, the spherical nozzle can uniformly spray disinfection liquid medicine by 360 degrees, hidden areas such as buccal mucosa, lingual surface and periodontal pocket can be fully covered by combining the adaptability of the spherical structure to the curved surface of the oral cavity, and disinfection blind areas are thoroughly eliminated.

The ketorolac tromethamine (KT) buccal mucosa microneedle KT-BMN system suitable for the complex oral environment is designed and prepared on the basis of the physiological characteristics that buccal mucosa tissue is rich in blood flow, the barrier thickness is small, and the liver first-pass effect does not exist. The KT-BMN adopts polyvinyl alcohol / sodium carboxymethyl cellulose as an adhesive layer and ethyl cellulose as a waterproof layer to form a microneedle system with a double-layer backing structure, so that the retention capacity of the microneedle system in a wet oral environment is enhanced, and the analgesic effect is quickly and effectively exerted.