14 results about "Keratoprosthesis" patented technology

The invention discloses an aspheric keratoprosthesis lens column, a keratoprosthesis and an application method of the aspheric keratoprosthesis lens column, the whole lens column is cylindrical, the front surface of the lens column is a convex surface, the rear surface of the lens column is a concave surface, the rear surface of the lens column is a surface close to the retina, the front surface of the lens column is a surface far away from the retina, and the front surface and the rear surface of the lens column are both curved surfaces. And the spherical surfaces are rotationally symmetrical aspheric surfaces. The artificial cornea comprises a lens column and a support, and the lens column is installed on the support. The fixed position of the lens column is that the distance between the vertex of the rear surface of the lens column and the retina is 10-120mm, the focal plane is perpendicular to the optical axis, and the inclination angle of the focal plane is 0 degree. According to the lens column, spherical aberration and coma can be effectively corrected, and the imaging quality is improved; light scattering is reduced, the visual contrast at night and in a low-light environment is improved, and the visual experience of a patient is improved; the deviation tolerance of the implantation position is higher, and the operation difficulty and the risk of postoperative complications are reduced.

The invention provides an ultralow-swelling artificial cornea imitating natural cornea fiber arrangement and a preparation method, and belongs to the technical field of biomedical materials.The preparation method comprises the steps that I-type collagen is dissolved in a PBS buffer solution, a photofunctionalization modified active reagent is added for chemical modification, stirring is conducted in a dark place, freeze drying is conducted, and photofunctionalization collagen is obtained; dissolving the photo-functionalized collagen, and then preparing a collagen fiber membrane through electrostatic spinning; and performing phase change DLP 3D biological printing on the biological ink and the collagenous fiber membrane to obtain the keratoprosthesis with the collagenous fiber sandwich structure. Multi-layer arrangement is achieved through DLP 3D biological printing, the fiber trend of the natural cornea is simulated, and the mechanical anisotropy is remarkably improved; through a composite phase change DLP 3D printing mode of GelMA / HA-DN and photo-crosslinking collagenous fibers, the composite phase change DLP 3D printing material has good manufacturability, maintains high light transmittance and maintains high mechanical strength.

The application discloses a composite artificial cornea and a preparation method thereof. The composite artificial cornea comprises a mirror column and a biological skirt. An annular gap is arranged on the inner side edge of the biological skirt. The outer side edge of the mirror column is embedded into the inside of the biological skirt along the gap, and the outer side edge of the mirror column is fixed in the gap through casting liquid. The application has the beneficial effects that: by arranging the annular gap on the inner side edge of the biological skirt, then embedding the outer side edge of the mirror column into the inside of the biological skirt along the gap, a interference fit structure is formed, preliminary fixation is formed between the mirror column and the gap, and the outer side edge of the mirror column is fixed in the gap through the casting liquid, so that the casting liquid can permeate and fill the gap, the mirror column and the biological skirt are connected into an integrated whole, secondary fixation is formed, the connection strength of the composite artificial cornea is improved, and the risk of the mirror column falling off is reduced.

FIELD: ophthalmology.SUBSTANCE: used to remove residual cortical masses that have migrated to the equatorial region after cataract extraction (CE) in patients after keratoprosthetics. To do this, the optical cylinder of the keratoprosthesis is unscrewed using a key. Residual cortical masses are visualized through the opening of the optical cylinder (OOC) and removed using a Simcoe cannula or a straight cannula with a flat tip mounted on a 10 ml syringe. The optical cylinder is screwed back in using a key.EFFECT: invention reduces the risk of developing intra- and postoperative complications and accelerates visual rehabilitation of patients by reducing the time of surgical intervention and without performing additional approaches.1 cl, 1 ex

The application discloses a composite artificial cornea skirt preparation device and method, which comprises a turnover plate and driving units installed on both sides of the turnover plate, eye ball fixing cups are arranged on the upper end face of the turnover plate in a matrix mode, the upper end of the eye ball fixing cup is open and used for fixing an eye ball, a decellularization liquid tank is arranged below the turnover plate, the driving units are used for driving the turnover plate to overturn by 180 DEG and sink downwards until the cornea of the eye ball is completely immersed below the liquid level of the decellularization liquid tank, and the device further comprises a stroma plate layer cutting knife, a central stroma ring cutter, a stroma bulking device, a stroma plate layer tunnel knife and a peripheral stroma ring cutter. The application has the beneficial effects that the cleaning, material taking, decellularization, bulking and fixing of the corneal stroma are completed at one time, and the whole process is automatically, standardly and normatively produced, so that the decellularized corneal stroma skirt or a biological cornea is obtained.

The application discloses an umbrella-shaped mirror column-based artificial cornea, which comprises a support and a mirror column connected with the support, wherein the support comprises a main body structure in a spherical surface structure, a middle part of the main body structure is provided with an opening, the mirror column is arranged in the opening, a micro-porous gap is formed on the circumferential surface of the main body structure, the top end surface of the mirror column is formed in an arc-shaped umbrella structure, and the bottom end surface of the mirror column is formed in a concave spherical surface structure. The application further discloses a preparation process of the artificial cornea. The artificial cornea is provided with the micro-porous gap on the circumferential surface of the main body structure, so that the healing tissue can pass through the micro-porous gap, the combination force between the support and the cornea is increased, and the stability is improved. In addition, the arc-shaped umbrella structure formed on the top end surface of the mirror column can prevent the growing tissue from covering the mirror surface of the mirror column in the later use of the patient, the light can enter the mirror column, the optical function can be normally played, and the occurrence of the anterior membrane complication is reduced.

The utility model discloses a bracket for an artificial cornea, which is used for improving the bonding strength between the bracket and a chemical central area of the artificial cornea and simultaneously improving the biocompatibility between the bracket and a maternal cornea tissue. The support is a medical metal support and comprises a support body, a central mounting hole penetrating through the support body and a connecting ring coaxially clamped into the central mounting hole from top to bottom, and internal threads are formed in the inner wall of the connecting ring. A hydroxyapatite layer is formed on the surface of the stent body; the material of the connecting ring is the same as or similar to that of a lens column of the artificial cornea; the connecting ring is of a hollow stepped shaft structure, an annular clamping groove is formed in the corner of a stepped shaft, and in the assembled state, the stent body is clamped into the annular clamping groove, so that the connecting ring is prevented from shifting or falling off in the operation.

A keratoprosthesis (100), comprising a support (10) and a lens column (30), the lens column (30) comprising a body (31) and a collar (32). A middle part of the support (10) is provided with a mounting hole (10A), a hole wall of which being provided with an internal thread (111), and the outer peripheral wall of the collar (32) being provided with an external thread (321) fitting with the internal thread (111), so as to detachably assemble the support (10) and the collar (32). The material of the body (31) is polymethyl methacrylate, so as to provide a reliable light path structure, and the collar (32) is titanium metal. The body (31) and the collar (32) are integrally formed, such that the collar (32) is sleeved on the body (31) so as to form a lens column (30), and the outer peripheral wall of the body (31) is provided with a limiting slot (31D) for limiting the collar (32). The support (10) is titanium metal, such that the internal thread (111) and the external thread (321) are metal threads of the same material, and the heat shrinkage ratios of structures of the same material undergoing a temperature change are the same, so that a joint has a high assembly reliability and does not separate or fall off unless an external force is applied thereto. The service life of the artificial cornea is increased, surgical risks are reduced, a patient is protected from secondary injury or being blinded again, and use satisfaction is increased.

The present disclosure relates to a method of manufacturing a keratoprosthesis exhibiting excellent physical properties by stabilizing the interface of an adhesive optical unit and a support unit through a keratoprosthesis mold and UV dose adjustment. The present disclosure can stably adhere an interface between the optical unit and the support unit by manufacturing the optical unit for 1-4 hours using low dose UV in the keratoprosthesis mold, thereby manufacturing the keratoprosthesis in which the optical unit and the support unit are integrated. The artificial cornea manufactured by the manufacturing method has a constant spherical shape and is convenient for center positioning, so that the success rate of an operation can be improved during the operation; the central part of the optical unit shows uniform and excellent physical properties, so that the physical safety in a human body can be further improved; moreover, the interface of the optical unit and the support unit shows excellent physical properties which are equivalent to about 100 times of the existing intraocular pressure, so that the separation of the optical unit and the support unit caused by intraocular pressure in the human body can be prevented at an early stage. Furthermore, by means of the manufacturing method, the eye appearance of a patient to which the artificial cornea is transplanted can be improved, and complications and side effects caused by adhesive substances can be reduced.

The invention discloses a method for analyzing influence of a suture boundary on keratoprosthesis optical imaging, which adopts a method of combining human eye finite element model simulation and human eye optical model simulation, analyzes the effect of the suture boundary on the keratoprosthesis through a finite element model, and can obtain stress response and configuration change of the keratoprosthesis in real time with high efficiency and low cost. And the final imaging effect of the operation can be simulated in real time by combining a human eye optical model. The mechanical-optical double-path hybrid network of the artificial cornea is established, personalized parameter adjustment is provided for an operation according to the postoperative requirements of a patient, the operation effect is optimized, and the postoperative visual recovery quality and precision of the patient can be finally improved.

This invention discloses an integrated artificial cornea and its preparation method, belonging to the field of biomedical engineering technology. The artificial cornea comprises a main corneal layer and a posterior corneal layer. The main corneal layer includes a central optical zone, a transitional junction zone, and a decellularized corneal annular zone. The main corneal layer uses a decellularized cornea as its overall framework. Polymerizable monomers are introduced into the decellularized corneal stroma and then cured using in-situ gradient curing technology. The integrated artificial cornea provided by this invention uses a decellularized cornea as its overall framework, eliminating the need for central perforation, resulting in better morphological stability. The optical zone constructed using gradient curing technology provides a favorable environment for cell ingrowth, promoting healing between the transplanted tissue and the corneal graft material.

The invention provides keratoprosthesis devices and kits and surgical methods of their use.

The invention provides surgical procedures for implanting a keratoprosthesis in an eye of a subject in need using a kit comprising keratoprosthesis comprising a central optical core, a peripheral skirt around said central optical core, comprising at least one biocompatible polymer; and a marking tool comprising a polymeric surface in the shape of said central optical core.

The invention relates to the technical field of medical instruments, and particularly discloses an artificial corneal endothelium sheet which comprises a main body part and an extension part, the main body part is in a vault shape, and the outer diameter of the main body part is larger than or equal to the diameter of a pupil; the plurality of extension parts are arranged on the periphery of the main body part at intervals; each extension part is in an arc-shaped strip shape, the radian of the extension parts is the same as that of the main body part, the width of the extension parts is gradually reduced in the direction away from the center point of the main body part, and a notch is formed between any two adjacent extension parts. The stability of the artificial corneal endothelium sheet is improved.