Stent for keratoprosthesis and preparation method thereof

Abstract

The invention provides a stent for keratoprosthesis and a preparation method thereof. The stent comprises: decalcified and decellularized cancellous bone matrix slices->dipping and sticking nanoscale extracellular matrixes (ECM) derived from the cartilage, the umbilical cord and other sources inside and outside the stent->compound autologous mesenchymal stem cells (bone mesenchymal stem cells, adipose-derived mesenchymal stem cells, etc.). After culture, the survived keratoprosthesis stent is placed between layers, on the anterior surface, on the conjunctiva or under the mucosa of the cornea, in order to be used for replacing bones, cartilages or tooth bones in an keratoprosthesis operation, and to be used as a stent / reinforcement material of the keratoprosthesis. According to the invention, the stent for the keratoprosthesis has a microenvironment which is beneficial to in-vitro and in-vivo growth of cells through adsorption and induction, can promote mesenchymal stem cells to be differentiated into cartilaginous tissues and osteogenic tissues in vivo, thus being convenient to fix the keratoprosthesis and improve the in-situ rate of the keratoprosthesis.

Description

technical field

[0001] The invention relates to the technical field of artificial corneas, in particular to a bracket for artificial corneas and a preparation method thereof. Background technique

[0002] Artificial cornea (Keratoprosthesis, Kpro) is an artificial device used to replace the diseased cornea to exert its optical and biological functions. The artificial cornea generally includes two parts: the lens column (optical part) and the bracket (reinforcement material). Among them, the lens column is made of a transparent material with excellent optical properties and stable physical and chemical properties, which is used to replace the turbidity that hinders the optical pathway of the eye after the lesion cornea. In order to achieve the ideal optical effect, most of the artificial corneas currently adopt the penetrating type, that is, the lens column of the artificial cornea penetrates the whole layer of the cornea, and the lens column is fixed in the center of the co...

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