304 results about "Intra stent" patented technology

Stent systems and methods for expanding and deploying stents in hard tissue such as bone, more particularly within a vertebral body. One exemplary method includes using a stent body that is coupled to a high speed rotational motor with the stent expandable and detachable from an introducer working end. In one embodiment, the stent is a deformable metal body with zig-zag type struts in an expanded configuration that carries diamond cutting particles bonded to the strut surfaces. The “spin” stent is rotated at high rpm's to remove cancellous bone from the deployment site together with irrigation and aspiration at the end of the probe that carries the stent. The stent may be expanded asymmetrically, such as with first and second balloons or by using an interior restraint, to apply vertical distraction forces to move apart the cortical endplates and support the vertebra in the distracted condition. The cancellous bone about the expanded stent as well as the interior of the stent can be filled with a bone cement, allograft or other bone graft material. In one method of use, the spin stent is designed and adapted for (i) treating a vertebral compression fracture (VCF) or for (ii) reinforcing an osteoporotic vertebral body.

This invention relates to the design and function of a device which allows for retrieval of a previously implanted valve prosthesis from a beating heart without extracorporeal circulation using a transcatheter retrieval system, including a guide component to facilitate the compression of the valve and retraction into a retrieval catheter, as well as an improved prosthetic transcatheter heart valve having one or more of: a series of radially extending tines having a loop terminus to improve sealing a deployed prosthetic mitral valve against hemodynamic leaking, a pre-compressible stent-in-stent design, or an articulating cuff attached to a covered stent-valve and a commissural sealing skirt structure attached to the underside of the articulating cuff.

The specification discloses a cardiovascular ostial stents, a ostial stent balloon, and methods for their use. The stent includes two portions having different degrees of expandability. The distal portion has a normal degree of expandability to support a vessel. The proximal portion has a higher degree of expandability so that it can be formed into a flange-like structure. The balloon is designed to deploy the new stent in a single operation. The balloon includes first and proximal portions having different diameters corresponding to the first and proximal portions of the stent. The distal portion is of normal diameter to deploy the distal portion of the stent in the vessel. The proximal portion is of greater diameter to form the proximal portion of the stent into the flange-like structure. The method involves deploying a conventional stent through one branch of the bifurcation, and then deploying one of the novel stent through a wall of the first stent and into the other branch. The flange-like structure on the novel stent secures the novel stent within the conventional stent. Finally, a one-piece Y-shaped stent is provided for placement in a bifurcated artery.

Assemblies are provided comprising a stent and a sensor positioned on and/or in the stent. Within certain aspects the sensors are wireless sensors, and include for example one or more fluid pressure sensors, contact sensors, position sensors, accelerometers, pulse pressure sensors, blood volume sensors, blood flow sensors, blood chemistry sensors, blood metabolic sensors, mechanical stress sensors and/or temperature sensors. Within certain aspects these stents may be utilized to assist in stent placement, monitor stent function, identify complications of stent treatment, monitor physiologic parameters and/or medically image a body passageway, e.g., a vascular lumen.

The method of complicated tubular netted tissue engineering rack forming technology based on core dissolving technique belongs to the field of tissue engineering rack manufacturing technology. The technological process includes first designing 3D model of rack and rack core; making rack core with water soluble material without biotoxicity through fast laminated formation; compounding solution of biocompatible material with proper amount of pore creating agent and coating the solution onto the rack core; air drying, soaking in distilled water to dissolve out rack core and pore creating agent, taking out and volatilizing water and coating different forming material with or without pore creating agent successively to form the tubular netted rack with complicated spatial structure, different material gradient and different pore gradient.

The invention relates to a supporting frame capable of being taken out. In the invention, a sandwich structure that a support is arranged between an inner membrane and an outer membrane is adopted; the connection part of the inner membrane and the outer membrane is opposite to a mesh of the supporting frame; and the supporting frame can freely wriggle in the space formed by the disconnection part of the inner membrane and the outer membrane, therefore, the supporting frame capable of being taken out, provided by the invention, has particularly good flexibility; a full covering membrane structure is adopted to ensure that granulation tissues cannot grow into the supporting frame; and a detachable design is adopted to ensure that the supporting frame can be conveniently taken out. The supporting frame capable of being taken out can be used for inducing and promoting the growth of a neonatal cavity tube, the covering and the epithelization of a mucous membrane, can be conveniently taken out and detached under the direct vision of an endoscopy after the mucous membrane of the neonatal cavity tube is epithelized and the organization is stable, and can be used for a temporary support under the situations of esophagus rebuilding and injury repairing, trachea rebuilding and injury repairing, urethra rebuilding and injury repairing, esophagus-esophagus anastomosing, intestine-intestine anastomosing, nasal cavity rebuilding and injury repairing, external auditory canal rebuilding and injury repairing and the like.

The invention relates to a thrombus taking device. The thrombus taking device comprises a thrombus taking support, a thrombus breaking support and a conveying assembly, wherein the thrombus taking support and the thrombus breaking support are of support structures capable of contracting and expanding; the far end of the conveying assembly is connected with the thrombus taking support and the thrombus breaking support and used for containing the thrombus taking support and the thrombus breaking support which are in a contracting state; and the conveying assembly can release the thrombus taking support and the thrombus breaking support to an expanding state and can drive the thrombus breaking support to move in the internal space of the thrombus taking support in the expanding state in the axial direction of the thrombus taking support. According to the thrombus taking device, the thrombus taking support is matched with the thrombus breaking support, when the thrombus taking support contains thrombus in blood vessels in the thrombus taking support, the conveying assembly controls the thrombus breaking support to stretch into the internal space of the thrombus taking support, and the thrombus breaking support can move in the axial direction relative to the thrombus taking support to cut the thrombus; and therefore, the thrombus in the thrombus taking support is continuously cut and broken; the intractable, large and hard thrombus can be easily broken, and the thrombus taking effect is improved.

The invention discloses a method for preparing a medicine graded sustained-release bone repair body. The method comprises the following steps of: reconstructing a natural cancellous bone micro-computed tomography (micro-CT) scanned image to obtain a three-dimensional model by using Mimics software, and taking positions with uniform pore distribution as stent inner layer and outer layer matrix models through Boolean operation; designing inner layer and outer layer negative models of which the shapes are matched with those of the matrix models by using Magics software, and preparing through fused deposition modeling; and preparing slurry mixed with different medicines, grouting inner layer and outer layer stent matrixes, preparing a stent by a freeze drying process, and thus obtaining a finished bone repair body product. The bone repair body prepared by the method can meet the requirement of a stent material on structural strength and can be loaded with various medicines, the controlled release of the medicines is realized, a sustained-release effect is achieved, and bone repair is well induced and promoted.

The invention discloses a customized alimentary canal support and a moulding method and an application method thereof. The moulding method comprises the steps of building a three-dimensional model of an alimentary canal structure of an individual object, and the alimentary canal structure comprises an alimentary canal stenosis or an obstruction part; performing data analysis and structure adjusting to the three-dimensional model; designing a virtual support by using a software; manufacturing a die corresponding to the inner contour of the support; and braiding a customized alimentary canal support on the die. The application method comprises the steps of delivering the customized support that has 4-6 different signs to a position to be planted. The support is successfully installed when the signs arrive at the designed installation position and the rotation angle under the monitor of an X-ray flat detector. In the complex alimentary canal obstruction areas like turnovers of stomach-duodenum and intestine-intestine, a traditional support fails easily, and the support provided by the invention can be used for a best treatment effect because of having the advantages like non-symmetry, high dissect precision, low internal stress, and difficult rotation shedding.

The invention relates to an intravascular stent and a preparation method and application thereof. The intravascular stent comprises a positioning section and a supporting section, the positioning section comprises a plurality of first repeat single parts, the supporting section comprises at least two supporting units and at least one connection unit, each supporting unit comprises a plurality of second repeat single parts, the first repeat single parts are not as many as the second repeat single parts, and a plane formed by the front ends of the first repeat single parts are perpendicular to the axis of the intravascular stent. The intravascular stent is especially applicable to iliac veins, effective in iliac vein supporting, less in harms to vein walls and capable of effectively avoiding formation of secondary thrombi in the implanted intravascular stent. In addition, the intravascular stent is capable of well positioning in the iliac veins, release accuracy is improved, and convenience in operation is achieved. Furthermore, the intravascular stent is simple in structure, convenient to produce and low in cost, thereby having important practical significances and promising clinical application prospect.

The invention relates to the field of medical materials and devices thereof, in particular to an implantable metal material degradable in vivo and a vascular stent product. A multi-element zinc alloy is composed of, by mass, 0-5% of Li, 0-1.5% of Ti, 0-1.5% of Mg and the balance of Zn. The vascular stent product made of the zinc-based alloy is of a pipe-network structure. The surface of the stent product is provided with a degradable polymer coating which is coated uniformly. Except for the degradable polymer coating, a medicine coating which is coated uniformly is arranged only on one side of the outer wall of a stent. The zinc-based alloy is excellent in mechanical performance, high in corrosion controllability and remarkable in compatibility. In addition, the vascular stent product is reasonable in structure, excellent in supporting force and flexibility; due to special surface arrangement, endothelialization of the stent is facilitated, and inflammatory reaction is reduced; the medicine coating can realize targeted administration.

The invention discloses an artificial heart valve prosthesis and an artificial heart valve stent. The artificial heart valve stent comprises an outer-layer bracket and an inner-layer bracket, whereinthe inner-layer bracket is fixedly connected with the outer-layer bracket, the outer-layer bracket is provided with an outer-layer inflow channel structure and an outer-layer outflow channel structure, the outer-layer inflow channel structure and the outer-layer outflow channel structure are axially connected, the inner-layer bracket is provided with an inner-layer inflow channel structure and aninner-layer outflow channel structure and is located on the inner side of the outer-layer bracket in the radial direction, the inner-layer inflow channel structure and the inner-layer outflow channelstructure are connected in the axial direction, and an anchoring structure is arranged on the outer side of the inner-layer bracket. According to the artificial heart valve prosthesis and the artificial heart valve stent, the inner-layer bracket bears the artificial valve leaflet, and is high in rigidity and small in diameter, so that the area of the artificial valve leaflet can be reduced, the height required by the opening and closing movement of the valve leaflet is reduced, and the service life of the valve leaflet is prolonged; the outer-layer bracket is weak in relative rigidity, large in diameter and capable of preventing perivalvular leakage; and the anchoring structure is connected with the inner-layer bracket, and the anchoring force for preventing the prosthetic valve from moving is mainly borne by the inner-layer bracket with high rigidity, so that the service life of the stent is prolonged.

The invention provides a thrombectomy instrument and a thrombectomy device, and relates to the technical field of medical instruments. The thrombectomy instrument comprises a far-end fixing end, a first near-end fixing end, a second near-end fixing end and a thrombus extraction bracket; the thrombus extraction bracket includes an inner bracket body and an outer bracket body which are connected at the far-end fixing end; the near end of the outer bracket body is connected with the first near-end fixing end, the near end of the inner bracket body is connected with the fixing end of the second near-end fixing end, and the second near-end fixing end is connected with the first near-end fixing end in a sliding mode so that the inner bracket can move relative to the outer bracket body; the thrombectomy device includes a pre-installation sheath, a delivery catheter, an operation controlling rod and the thrombectomy instrument; the operation controlling rod and the thrombectomy instrument are connected, and the installed thrombectomy instrument and the operation controlling rod enter the delivery catheter through the pre-installation sheath, sent to the position of thrombus through the delivery catheter and then released. The problems that an existing thrombectomy instrument can not hold the thrombus in the thrombus extraction process and the thrombus can not be extracted and the thrombus is easy to fall off to cause secondary embolisms when the thrombectomy device is used for thrombus extraction are alleviated.

The invention discloses an intrusive type heart valve prosthesis and a preparation method thereof, and belongs to the technical field of intrusive type medical apparatuses. The intrusive type heart valve prosthesis comprises an elastic bracket, a covering film and at least two valves, wherein the elastic bracket can extend and retract along the radial direction, the covering film is sewed onto the inner wall or the outer wall of the bracket, the valves are arranged in a cavity of the bracket, the lower edge of each valve is sewed onto the covering film, the adjacent sides of the two adjacent valves are mutually spliced, and the side edges of the valves are sewed onto the bracket. The intrusive type heart valve prosthesis has the advantages that the function of natural valves can be well replaced; by adopting the elastic bracket, the valve structure can be conveniently loaded into a conveying device, and can also be conveniently released to the target position to be tightly combined with the surrounding tissues of the target position; the bracket is coated by the covering film, so the surrounding leakage of the valves is effectively prevented; the bionic degree of the sewing structure of the valve and the covering film is high, the natural valves can be well simulated, and the function of the natural valves is replaced; the structure is stable and firm, the durability and firmness are realized, the elastic extending and retracting requirements in the loading and release processes can be met, and the damage is avoided.

The present application relates to a transcatheter valve replacement system. The system includes a valve replacement prosthesis, a delivery catheter, a control handle and an anchoring device; the valve replacement prosthesis includes a valve stent, an artificial valve leaflet and an adaptive covered stent, the artificial valve leaflet is arranged in the valve stent, the adaptive covered stent is connected to the outer periphery of the valve stent, the valve replacement prosthesis is provided with an anchored unit, and the anchored unit is fixed to heart tissue by the anchoring device; and theanchoring device is arranged in the delivery catheter, the anchoring device includes an anchoring needle, an anchoring needle catheter, an anchoring needle push rod, and a controllable guiding device,the anchoring needle is pre-installed in the distal end of the anchoring needle catheter, the distal end part of the anchoring needle catheter has a flexible structure, one end of the controllable guiding device is detachably connected to the anchored unit, and the controllable guiding device can control the distal end part of the anchoring needle catheter to form a fixed bend angle in the radialdirection and make the distal end of the anchoring needle catheter adhered to the anchored unit.

A prosthetic heart valve includes stabilization features for anchoring the prosthetic heart valve within a native valve annulus. The prosthetic heart valve includes an expandable stent having an inflow end and an outflow end, and a valve assembly disposed within the stent. One such stabilization feature is a collapsible and an expandable frame formed of compliant wires. The frame has a body including a first end coupled to the stent, a second end, and a lumen extending therethrough for receiving the stent and the valve assembly. When the frame is expanded in the native valve annulus, the compliant wires form an indented region in the frame between the first and second ends of the body and a sub-annulus portion of the frame forms a bulge.

The invention relates to the field of coronary stents, specifically to a method for reducing the incidence of in-stent restenosis and its special stainless steel material. The method of the invention adds a proper amount of copper element (2.0-6.0% by weight) into the common clinical coronary stent material 316L stainless steel, and conducts special heat treatment so as to make the copper separated in a copper-rich phase out of the stainless steel substrate. The stent is enabled to continuously release trace amounts of copper ions in a clinical environment, and the coronary stent is endowed with an anti-restenotic function, thus effectively reducing the incidence of restenosis after stent implantation. With a unique function of reducing the in-stent restenosis phenomenon caused by stent implantation into a coronary artery, the 316L type copper-containing stainless steel of the invention is conducive to solve clinical problems such as high incidence of in-stent restenosis after implantation of existing stainless steel coronary stents, and can be applied in coronary stents and other clinical medicine fields, thus providing a new idea and material basis for development and application of coronary stents.

A transcatheter valve prosthesis includes a balloon expandable stent and a prosthetic valve. An inflow portion of the stent includes a plurality of crowns and a plurality of struts with each crown being formed between a pair of opposing struts. Endmost inflow side openings and endmost inflow crowns are formed at the inflow end of the stent and the inflow end of the stent has a total of twelve endmost inflow crowns. An outflow portion of the stent includes a plurality of crowns and a plurality of struts with each crown being formed between a pair of opposing struts. Endmost outflow crowns are formed at the outflow end of the stent and the outflow end of the stent has a total of six endmost outflow crowns. The prosthetic valve is disposed within and secured to the stent.

The invention relates to a thrombus removal system. The thrombus removal system comprises a thrombus removal support and a traction catheter, wherein the traction catheter is connected with the thrombus removal support, the thrombus removal support is used for scraping a thrombus of the inner wall of a blood vessel, and the scraped thrombus enters the thrombus removal support; a thrombus breaking support and a conveying pipe which are both connected into the traction catheter in a sliding mode. In which, the conveying pipe is connected with the thrombus breaking support so as to drive the thrombus breaking support to be discharged from the far end of the traction catheter and enter the thrombus removal support, and the conveying pipe is used for driving the thrombus breaking support to rotate in the thrombus removal support along a circumferential direction to conduct thrombus breaking; and after thrombus breaking, the conveying pipe can further be used for driving the thrombus breaking support to enter the traction catheter from the far end of the traction catheter and driving the thrombus breaking support to be discharged from the near end of the traction catheter.

The invention provides a method for promoting directional differentiation and proliferation of mesenchymal stem cells towards neural precursor cells. The method comprises the following steps: firstly, embedding the mesenchymal stem cells in calcium alginate microbeads which are prepared with the presence of a calcium chloride solution and contains gelatin microspheres and chondroitin sulfate; then, adding a neural induction differentiation medium, and cultivating in a rotary reactor, so as to promote the in vitro directional differentiation and proliferation of the mesenchymal stem cells towards the neural precursor cells; and after differentiation, dissolving the calcium alginate microbeads by virtue of a sodium citrate solution, so that differentiated cells are obtained. The method disclosed by the invention is simple to operate and low in cost; by virtue of the gelatin microspheres, a necessary growth space is provided for internal cells of a stent; by virtue of the chondroitin, the biochemical functions of a neural tissue extracellular matrix can be simulated; by virtue of the calcium alginate microbeads, three-dimensional support, which is similar to the extracellular matrix, is provided; and by virtue of the rotary reactor, a necessary micro-gravity environment is provided, so that mass transfer is further enhanced and proliferation of the cells is achieved.

The invention relates to the technical field of medical instruments, and discloses a thrombus removing device. The device comprises a thrombectomy stent, an inner tube and a pushing tube, the inner tube penetrates through the thrombectomy stent and the pushing tube, the far end of the inner tube is connected with the far end of the thrombectomy stent, and the inner tube can move relative to the pushing tube in the axial direction; the near end of the thrombectomy stent is connected with the far end of the pushing tube; the thrombectomy stent is of an expandable and retractable stent structure and comprises a collecting part and a cutting part; the far end of the collecting part is smoothly connected with the near end of the cutting part, the collecting part is of a tubular structure with the closed far end, meshes are formed in the peripheral wall of the cutting part, and an opening is formed in the near end of the cutting part. According to the embodiment of the invention, the thrombus extraction efficiency and thrombectomy effect can be improved.